CN101151256B - 二苯并*庚因衍生物的制造方法 - Google Patents
二苯并*庚因衍生物的制造方法 Download PDFInfo
- Publication number
- CN101151256B CN101151256B CN2006800106989A CN200680010698A CN101151256B CN 101151256 B CN101151256 B CN 101151256B CN 2006800106989 A CN2006800106989 A CN 2006800106989A CN 200680010698 A CN200680010698 A CN 200680010698A CN 101151256 B CN101151256 B CN 101151256B
- Authority
- CN
- China
- Prior art keywords
- carbonatoms
- atom
- yuan
- atoms
- sauerstoffatom
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
- C07C69/74—Esters of carboxylic acids having an esterified carboxyl group bound to a carbon atom of a ring other than a six-membered aromatic ring
- C07C69/757—Esters of carboxylic acids having an esterified carboxyl group bound to a carbon atom of a ring other than a six-membered aromatic ring having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
- C07C229/34—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton containing six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C227/14—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof
- C07C227/16—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof by reactions not involving the amino or carboxyl groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C67/00—Preparation of carboxylic acid esters
- C07C67/30—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group
- C07C67/307—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group by introduction of halogen; by substitution of halogen atoms by other halogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C67/00—Preparation of carboxylic acid esters
- C07C67/30—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group
- C07C67/333—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group by isomerisation; by change of size of the carbon skeleton
- C07C67/343—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
- C07C69/74—Esters of carboxylic acids having an esterified carboxyl group bound to a carbon atom of a ring other than a six-membered aromatic ring
- C07C69/75—Esters of carboxylic acids having an esterified carboxyl group bound to a carbon atom of a ring other than a six-membered aromatic ring of acids with a six-membered ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
- C07C69/74—Esters of carboxylic acids having an esterified carboxyl group bound to a carbon atom of a ring other than a six-membered aromatic ring
- C07C69/753—Esters of carboxylic acids having an esterified carboxyl group bound to a carbon atom of a ring other than a six-membered aromatic ring of polycyclic acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D313/00—Heterocyclic compounds containing rings of more than six members having one oxygen atom as the only ring hetero atom
- C07D313/02—Seven-membered rings
- C07D313/06—Seven-membered rings condensed with carbocyclic rings or ring systems
- C07D313/10—Seven-membered rings condensed with carbocyclic rings or ring systems condensed with two six-membered rings
- C07D313/12—[b,e]-condensed
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyrane Compounds (AREA)
Abstract
Description
Claims (18)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP162240/2005 | 2005-06-02 | ||
JP2005162240 | 2005-06-02 | ||
PCT/JP2006/311060 WO2006129781A1 (ja) | 2005-06-02 | 2006-06-02 | ジベンズオキセピン誘導体の製造方法 |
Publications (2)
Publication Number | Publication Date |
---|---|
CN101151256A CN101151256A (zh) | 2008-03-26 |
CN101151256B true CN101151256B (zh) | 2011-02-09 |
Family
ID=37481708
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN2006800106989A Active CN101151256B (zh) | 2005-06-02 | 2006-06-02 | 二苯并*庚因衍生物的制造方法 |
Country Status (5)
Country | Link |
---|---|
JP (1) | JP5099830B2 (zh) |
KR (1) | KR101001129B1 (zh) |
CN (1) | CN101151256B (zh) |
TW (1) | TW200716588A (zh) |
WO (1) | WO2006129781A1 (zh) |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2008099900A1 (ja) * | 2007-02-16 | 2008-08-21 | Sumitomo Chemical Company, Limited | ジベンゾオキセピン化合物の製造方法 |
JP5139104B2 (ja) * | 2007-02-16 | 2013-02-06 | 住友化学株式会社 | ジベンゾオキセピン化合物の製造方法 |
WO2011033532A1 (en) | 2009-09-17 | 2011-03-24 | Indoco Remedies Limited | Process for preparation of olopatadine hydrochloride |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4282365A (en) * | 1978-11-24 | 1981-08-04 | Merck & Co., Inc. | Dibenz[b,e]oxepin compounds |
EP1477472A1 (en) * | 2002-02-21 | 2004-11-17 | Asahi Kasei Pharma Corporation | Substituted phenylalkanoic acid derivative and use thereof |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS5821679A (ja) | 1981-07-31 | 1983-02-08 | メルク エンド カムパニー インコーポレーテツド | ジベンツ〔b,e〕オキセピン化合物 |
US6677473B1 (en) * | 1999-11-19 | 2004-01-13 | Corvas International Inc | Plasminogen activator inhibitor antagonists |
-
2006
- 2006-06-01 TW TW095119299A patent/TW200716588A/zh unknown
- 2006-06-02 JP JP2007519078A patent/JP5099830B2/ja active Active
- 2006-06-02 CN CN2006800106989A patent/CN101151256B/zh active Active
- 2006-06-02 KR KR1020077022592A patent/KR101001129B1/ko active IP Right Grant
- 2006-06-02 WO PCT/JP2006/311060 patent/WO2006129781A1/ja active Application Filing
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4282365A (en) * | 1978-11-24 | 1981-08-04 | Merck & Co., Inc. | Dibenz[b,e]oxepin compounds |
EP1477472A1 (en) * | 2002-02-21 | 2004-11-17 | Asahi Kasei Pharma Corporation | Substituted phenylalkanoic acid derivative and use thereof |
Non-Patent Citations (3)
Title |
---|
Etsuo Ohshima,et al..Dibenzoxepin Derivatives:ThromboxaneA2 SynthaseInhibition and Thromboxane A2Receptor AntagonismCombined in One Molecule.J.Med.Chem.36.1993,361613-1618. * |
Harry Finch,et al..The Synthesis of aConformationallyRestrained,CombinedThromboxaneAntagonist/SynthaseInhibitor Usingintramolecular Stille-orGrigg-Palladium-Catalysed CyclisationStrategy.Tetrahedron Letters34 51.1993,34(51),8353-8356. * |
HarryFinch et al..The Synthesis of aConformationallyRestrained |
Also Published As
Publication number | Publication date |
---|---|
JPWO2006129781A1 (ja) | 2009-01-08 |
TW200716588A (en) | 2007-05-01 |
JP5099830B2 (ja) | 2012-12-19 |
KR101001129B1 (ko) | 2010-12-14 |
KR20080011652A (ko) | 2008-02-05 |
CN101151256A (zh) | 2008-03-26 |
WO2006129781A1 (ja) | 2006-12-07 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
AU2019346118B2 (en) | Manufacture of compounds and compositions for inhibiting the activity of SHP2 | |
KR960004531B1 (ko) | 캠프토데신 유도체 및 그의 아미노기에 있어서의 산 부가염 및 4급 암모늄염 및 그의 제조방법 | |
JP2003517484A (ja) | 純粋なシタロプラムの製造方法 | |
CN101151256B (zh) | 二苯并*庚因衍生物的制造方法 | |
US9522934B2 (en) | Acetatic abiraterone trifluoroacetate and preparation method and application of same | |
KR20020019902A (ko) | 피페라진 고리 함유 화합물의 신규한 합성법 및 결정화법 | |
CN105198883B (zh) | 一种11H‑吲哚并[3,2‑c]喹啉类化合物的合成方法 | |
CN103254191B (zh) | 取代芳香四环类抗真菌化合物及其制备方法与应用 | |
WO2002042309A1 (fr) | Dérivés d'indole et leur utilisation dans des médicaments | |
CN102249982B (zh) | 新型截短侧耳素类化合物、其药物组合物及其制备方法和用途 | |
CN110590795B (zh) | 一类多并杂环螺羟吲哚类化合物的合成方法 | |
US6576764B2 (en) | Synthesis and crystallization of piperazine ring-containing compounds | |
EP0755928B1 (en) | 5-aminoflavone derivatives | |
CN107935909B (zh) | 一种尼达尼布(nintedanib)及其中间体的合成方法 | |
CN1420117A (zh) | 一种制备奥氮平的方法 | |
CN104592222A (zh) | 抗血小板药物azd6482的制备方法 | |
KR20050044334A (ko) | 시스-융합된3,3a,8,12b-테트라하이드로-2H-디벤조[3,4:6,7]사이클로헵타[1,2-b]푸란 유도체의 제조 | |
JPS6212778A (ja) | 新規イソキノリン誘導体 | |
JPH07101956A (ja) | ヒドロキシカンプトテシン化合物の製法 | |
CN113754666A (zh) | 一种苯并吡嗪类化合物及其合成方法 | |
US20040176591A1 (en) | Novel synthesis and crystallization of peperazine ring-containing compounds | |
WO2009078029A2 (en) | An improved process for the preparation of trans 3,4- diarylchroman and their derivatives | |
GB2205565A (en) | Imidazo (1,2-a)pyrimidin-2-oyl and imidazo (1,2-a)quinazolin-2-oyl cyclopropane derivatives | |
JP2003508359A (ja) | 接触脱水素反応によるジベンゾスベレノン誘導体の製造 | |
CN1910171B (zh) | 6-11双环红霉素衍生物的制备方法 |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
C06 | Publication | ||
PB01 | Publication | ||
C10 | Entry into substantive examination | ||
SE01 | Entry into force of request for substantive examination | ||
ASS | Succession or assignment of patent right |
Owner name: XIEHE FERMENTATION QILIN CO., LTD. Free format text: FORMER OWNER: KYOWA HAKKO KOGYO CO., LTD. Effective date: 20090424 |
|
C41 | Transfer of patent application or patent right or utility model | ||
TA01 | Transfer of patent application right |
Effective date of registration: 20090424 Address after: Tokyo, Japan Applicant after: Kyowa Hakko Kirin Co., Ltd. Address before: Tokyo, Japan Applicant before: Kyowa Hakko Kogyo Co., Ltd. |
|
C14 | Grant of patent or utility model | ||
GR01 | Patent grant | ||
CP01 | Change in the name or title of a patent holder |
Address after: Tokyo, Japan Patentee after: Union Kirin Co., Ltd. Address before: Tokyo, Japan Patentee before: Kyowa Hakko Kirin Co., Ltd. |
|
CP01 | Change in the name or title of a patent holder |