CN101129837A - Proprietary Chinese medicine for treating retina affection of diabetes - Google Patents

Abstract

The invention relates to a Chinese medicament for treating diabetic retinopathy which is prepared from more than ten kinds of Chinese medicinal herbs including dried rehmannia root, scrophularia root, root of red rooted saliva and kudzu vine root. The medicament has the advantages of assured curative effect, safe and convenient application, no toxic and side effects, and low price.

Description

The Chinese patent medicine that a kind of treatment of diabetic retinopathy becomes

Technical field

The present invention relates to the Chinese patent medicine that a kind of treatment of diabetic retinopathy becomes, is that a kind of treatment of diabetic retinopathy change is the Chinese patent medicine of raw material with the Chinese herbal medicine.Belong to the field of Chinese medicines.

Background technology

Diabetic retinopathy is the common microvascular complication in diabetics optical fundus, is the one of the main reasons of diabetes patient's blinding.The old man of data prompting more than 60 years old arranged, and diabetic history had 31.5% patient's vision decline in 5 years, and 20% is blind.The proliferative retinopathy person is taken place and is reached 50% in the Hary Keen report course of disease 10～25 years.Caird observes and finds that retinopathy accounts for 80% of the concurrent blinding of the whole oculopathy of diabetes.Diabetes are Duoed 25 times than the blind person of non-diabetic.

DR is one of western countries' four big main blinding diseases, by its organic growth rule, can divide early stage simple type, is its main pathological features with microangioma; Later stage causes blind with new vessels formation, vitreous hemorrhage etc.

Investigation of clinical epidemiology shows, strengthens the treatment to DM patient, and strict blood sugar control can make DM patient's blind time retardation 16 years, and can make 2/3 proliferative DR (PDR) patient because of obtaining rational therapy, and avoids losing one's sight.Along with the technical development of fundus fluorescein angiography and electroretinogram etc., help early diagnosis, the early treatment of diabetic retinopathy in recent years.The treatment of diabetic retinopathy does not still have ideal medicine at present, still with the control of diabetes state of an illness, hypertension, adopts the method for the combination of Chinese and Western medicine, is that the control diabetic retinopathy takes place and the basis of developing.

Diabetic retinopathy belongs to the refreshing disease category of traditional Chinese medical science pupil.Pupil god has another name called " pupil ", " gb 1 ", " Jin Jing ", is five water wheels in taking turns, and the planted agent is in kidney.Kidney is the institute that refreshing light rises, and annotates in order on its vital essence to belong to gb 1, can distinguish all things on earth, penetrates deeply into all things.Pupil god is the eyes most important parts, and pupil disease is from the beginning of conscious " look thing dusk vast ", the uncivilized unclear blurring of vission that is called, and pupil disease can be divided into five types by clinical symptoms: (1) stagnation of QI due to depression of the liver, the order network is obstructed; (2) spleen-asthenia with excessive damp, the turbid resistance network of expectorant; (3) deficiency of the liver and kindey, it is dark that water loses order; (4) honor of becoming homeless of QI and blood deficiency, order; (5) hyperactivity of YANG due to deficiency of YIN, burn order network.

The traditional Chinese medical science is divided disease type Coryza Treated by Syndrome Differentiation clinically, obtains very good effect.Invent a kind of not only safety but also effective Chinese medicine preparation, be significant.

Summary of the invention

The present invention develops in conjunction with the latest modern technological scientific achievement on the basis of traditional tcm syndrome differentiation and treatment.The purpose of this invention is to provide the Chinese patent medicine that a kind of treatment of diabetic retinopathy becomes.Have determined curative effect, safe ready, have no side effect, cheap characteristics.

The present invention is made by the following weight proportion raw material:

0.1～2 part of 1.0～4 parts of Flos Eriocauli of 1.5～6 portions of Radix Scrophulariaes of Radix Rehmanniae

0.1～2 part of 1.0～4 parts of Radix Trichosanthis of 1.5～6 parts of Radix Puerariaes of Radix Salviae Miltiorrhizae

0.1～2 part of 1.0～4 parts of Fructus Atriplicis Sibiricae of 1.5～6 parts of Flos Chrysanthemis of Rhizoma Imperatae

0.1～2 part of 1.0～4 parts of Fructus Corni of 1.0～4 parts of Rhizoma Polygonatis of Radix Ophiopogonis.

The weight proportion of each raw material of optimization formula of the present invention is:

0.5～1.5 part of 1.5～2.5 parts of Flos Eriocauli of 2.5～3.5 portions of Radix Scrophulariaes of Radix Rehmanniae

0.5～1.5 part of 1.5～2.5 parts of Radix Trichosanthis of 2.5～3.5 parts of Radix Puerariaes of Radix Salviae Miltiorrhizae

0.5～1.5 part of 1.5～2.5 parts of Fructus Atriplicis Sibiricae of 2.5～3.5 parts of Flos Chrysanthemis of Rhizoma Imperatae

0.5～1.5 part of 1.5～2.5 parts of Fructus Corni of 1.5～2.5 parts of Rhizoma Polygonatis of Radix Ophiopogonis.

The weight proportion of each raw material of optimum formula of the present invention is:

1 part of 2 parts of Flos Eriocauli of 3 portions of Radix Scrophulariaes of Radix Rehmanniae

1 part of 2 parts of Radix Trichosanthis of 3 parts of Radix Puerariaes of Radix Salviae Miltiorrhizae

1 part of 2 parts of Fructus Atriplicis Sibiricae of 3 parts of Flos Chrysanthemis of Rhizoma Imperatae

1 part of 2 parts of Fructus Corni of 2 parts of Rhizoma Polygonatis of Radix Ophiopogonis.

Drug action mechanism among the present invention is as follows:

The Radix Rehmanniae nature and flavor are sweet, cold.GUIXIN, liver, kidney channel.Has clearing away heat and cooling blood, yin nourishing, the effect of promoting the production of body fluid.Can treat that calentura crimson tongue excessive thirst, interior-heat caused by deficiency of YIN, hectic fever due to YIN-deficiency consumptive fever, interior-heat are quenched one's thirst, haematemesis, epistaxis, send out speckle dermexanthesis etc.(Ji Yubin chief editor " Chinese medicine medicine for preventing pharmacology and application " Heilungkiang science tech publishing house 1999 version the 514th page).

Radix Salviae Miltiorrhizae property of medicine hardship is slightly cold.GUIXIN, pericardium, Liver Channel.Have blood circulation promoting and blood stasis dispelling, menstruction regulating and pain relieving, relieving restlessness is calmed the nerves, the effect of removing heat from blood eliminating carbuncle.Can treat menoxenia, dysmenorrhea, amenorrhea, the stasis of blood stagnated and suffered from abdominal pain puerperal, trusted subordinate's pain, lumps in the chest and abdomen, pyretic arthralgia swells and ache, traumatic injury, heat is gone into nutrient blood, dysphoria, vexed insomnia, carbuncle pyogenic infections from tumour or sore etc.(the 647th page of Shanghai science tech publishing house second edition write by " Chinese medicine voluminous dictionary " Nanjing University of Traditional Chinese Medicine).

The Rhizoma Imperatae property of medicine is sweet, and is cold.GUIXIN, lung, stomach, urinary bladder channel.Has clearing away heat and promoting production of body fluid, cooling blood for hemostasis, the effect of inducing diuresis for treating stranguria syndrome.Can treat the calentura excessive thirst, dyspnea and cough due to lung-heat, the gastric heat vomiting, heat in blood is hemorrhage, the puckery pain of dribbling urination, edema, jaundice etc.(the 992nd page of Shanghai science tech publishing house second edition write by " Chinese medicine voluminous dictionary " Nanjing University of Traditional Chinese Medicine).

Sweet, the little hardship of the Radix Ophiopogonis property of medicine is slightly cold.Return lung, stomach, heart channel.Has nourishing YIN and moistening the lung, nourishing the stomach to promote the production of body fluid, the effect of the relieving restlessness that clears away heart-fire.Can treat dryness of the lung dry cough, lung abscess, deficiency of YIN chronic cough, Tianjin wound is thirsty, quenches one's thirst, and vexed insomnia is had sore throat, the dryness of the intestine constipation, heat in blood is told nosebleed etc.(the 1430th page of Shanghai science tech publishing house second edition write by " Chinese medicine voluminous dictionary " Nanjing University of Traditional Chinese Medicine).

The Radix Scrophulariae property of medicine is sweet, bitter, salty, is slightly cold.Return lung, stomach, kidney channel.Has removing heat from blood, nourishing YIN to lower pathogenic fire, antidotal effect.Can treat the warm febrile disease blood of joining the army, fever of the body, excessive thirst, crimson tongue is sent out speckle, the hectic fever due to YIN-deficiency chronic cough, fidgets due to deficiency is insomnia, and constipation is hindered in Tianjin, and order is puckery dim-sighted, laryngopharynx swelling and pain, tuberculous lymphadenitis, skin sore etc.(the 1062nd page of Shanghai science tech publishing house second edition write by " Chinese medicine voluminous dictionary " Nanjing University of Traditional Chinese Medicine).

The Radix Puerariae property of medicine is sweet, hot, and is flat.Return spleen, stomach warp.Have expelling pathogenic factors from muscles and deliver, promoting the production of body fluid to quench thirst, yang invigorating antidiarrheal effect.Cure mainly fever caused by exogenous pathogens, rigidity pain on the head and nape, measles goes out not smooth from the beginning of, rash, and pestilence is thirsty, and diabetes is had loose bowels, dysentery etc.(the 3209th page of Shanghai science tech publishing house second edition write by " Chinese medicine voluminous dictionary " Nanjing University of Traditional Chinese Medicine).

The Flos Chrysanthemi property of medicine is sweet, bitter, is slightly cold.Return lung, Liver Channel.Have wind and heat dispersing, suppressing the hyperactive liver makes eye bright, the effect of removing toxic substances and promoting subsidence of swelling.Can treat affection due to external wind and heat or pathogenic wind-warm from the beginning of, fever and headache, dizzy, conjunctival congestion and swelling pain, furuncle swelling toxin etc.(the 2900th page of Shanghai science tech publishing house second edition write by " Chinese medicine voluminous dictionary " Nanjing University of Traditional Chinese Medicine).

The Rhizoma Polygonati property of medicine is sweet, and is flat.Return spleen, lung, kidney channel.Has nourishing YIN and moistening the lung, invigorating the spleen and replenishing QI, the effect of nourishing kidney replenishing essence.Can treat deficiency of YIN chronic cough, the xeropulmonary cough; Insufficiency of the spleen weak, the lack of appetite xerostomia is quenched one's thirst; The deficiency of the kidney soreness of the waist and knees, impotence and seminal emission, the tinnitus order is dark, early whitening of beard and hair, the body weakness with emaciation is thin, wind favus disease etc.(the 2830th page of Shanghai science tech publishing house second edition write by " Chinese medicine voluminous dictionary " Nanjing University of Traditional Chinese Medicine).

Flos Eriocauli nature and flavor suffering, sweet, flat.Return liver, lung meridian.Have dispelling wind and heat pathogens, make eye bright, the effect of nebula removing.Can treat the wind heat conjunctival congestion, the photophobia that swells and ache, the nebula of looking unfamiliar film, headache due to pathogenic wind-heat etc.(the 143rd page of Chemical Industry Press of Pharmacopoeia of the People's Republic of China version in 2000 is compiled by Chinese Pharmacopoeia Commission).

Sweet, the little hardship of the Radix Trichosanthis property of medicine is slightly cold.Attach to the lung and stomach meridians.Has clearing away heat and promoting production of body fluid, moistening the lung and resolving phlegm, the effect of detumescence and apocenosis.It is thirsty to treat calentura, the polydipsia of quenching one's thirst, lung-heat type cough, sore swollen toxin etc.(the 443rd page of Shanghai science tech publishing house second edition write by " Chinese medicine voluminous dictionary " Nanjing University of Traditional Chinese Medicine).

Fructus Atriplicis Sibiricae property of medicine hardship, suffering, flat.Return liver, lung meridian.Have suppressing the hyperactive liver, resolving depression makes eye bright, the effect of dispeling the wind.Can treat headache, dizzy, distending pain in the chest and hypochondrium, distending pain of the breast ， mass in the abdomen, conjunctival congestion cataracta, rubella pruritus, vitiligo, carbuncle, scrofula etc.(the 1844th page of Shanghai science tech publishing house second edition write by " Chinese medicine voluminous dictionary " Nanjing University of Traditional Chinese Medicine).

The acid of the Fructus Corni property of medicine, tepor.Return liver, kidney channel.Has liver and kidney tonifying, the effect that convergence is taken off admittedly.Can treat and have a dizzy spell, deafness and tinnitus, soreness of the waist and knees, emission and spermatorrhea, frequent micturition, incessant sweating due to debility, woman uterine bleeding etc.(the 248th page of Shanghai science tech publishing house second edition write by " Chinese medicine voluminous dictionary " Nanjing University of Traditional Chinese Medicine).

The present invention follows the principles of formulating prescriptions of the traditional Chinese medical science " monarch ", is monarch drug with Radix Rehmanniae, Radix Salviae Miltiorrhizae and Rhizoma Imperatae; With Radix Ophiopogonis, Radix Scrophulariae, Radix Puerariae, Flos Chrysanthemi and Rhizoma Polygonati is ministerial drug; With Flos Eriocauli, Radix Trichosanthis, Fructus Atriplicis Sibiricae and Fructus Corni is adjuvant.All medicines are harmonious, and are total to the tool nourishing YIN to lower pathogenic fire, the effect of liver heat removing and eyesight improving.The treatment of diabetic retinopathy change has determined curative effect, has no side effect taking convenience, cheap characteristics.

Clinical drug of the present invention uses the result to show that following advantage is arranged:

1, the Chinese herbal medicine each component selected for use of the present invention meets the regulation of The Drug Administration Law of People's Republic of China, utilizes the comprehensive function treatment of diabetic retinopathy of the Chinese medicine of respectively distinguishing the flavor of to become, and is nontoxic to human body.Show that through the acute and chronic toxicity test of animal the animal of being tested does not see any toxic reaction, its main organs does not have tangible change yet, and safety of medicine is reliable.

2, rich in proteins in the medicine of the present invention, glucose, glucuronic acid, volatile oil, pectin, fructose, organic acid, lecithin, vitamin, aminoacid also contains various trace elements such as Saponin, plant sterol and calcium, is beneficial to absorption of human body, health invigorating.

3, the present invention not only effectively treatment of diabetic retinopathy become, the prevention of diabetic renal papillary necrosis is also had good effect, treatment of diabetic retinopathy becomes and has determined curative effect, has no side effect taking convenience, cheap characteristics.

For the therapeutic effect that shows that medicine of the present invention becomes treatment of diabetic retinopathy, as follows through clinical test results; Treatment of diabetic retinopathy becomes patient's 20 examples.Take the embodiment decoction, each 1 bag, two to three times on the one, take half an hour ante cibum.Two months is a course of treatment, take continuously three the course of treatment observe the curative effect.7 examples of fully recovering account for 35%, and 10 examples that take a turn for the better account for 50%, and invalid 3 examples account for 15%, and total effective rate reaches 85%.After three course of therapy, patient does not have any untoward reaction, and three big routine tests and hepatic and renal function detect no abnormal.

The specific embodiment

The embodiment decoction takes by weighing raw material by following weight:

1 part of 2 parts of Flos Eriocauli of 3 portions of Radix Scrophulariaes of Radix Rehmanniae

1 part of 2 parts of Radix Trichosanthis of 3 parts of Radix Puerariaes of Radix Salviae Miltiorrhizae

1 part of 2 parts of Fructus Atriplicis Sibiricae of 3 parts of Flos Chrysanthemis of Rhizoma Imperatae

1 part of 2 parts of Fructus Corni of 2 parts of Rhizoma Polygonatis of Radix Ophiopogonis.

Preparation method is to get above-mentioned raw materials to clean roguing, dries, and is ground into granule, soaks 1 hour, puts and decocts with water secondary in the multi-function extractor, adds up the water of 10 times of amounts of medical material for the first time, decocts 1.5～2 hours, gets decocting liquid, filters.Add up for the second time the water of 7 times of amounts of medical material, decocted 1～1.2 hour, get decocting liquid twice, filter, in the heat-sealing bag, 105 ℃ of high temperature sterilizes, packing is promptly.The decoction that treatment of diabetic retinopathy that the present invention makes becomes is packed into plastic packaging, and every bag of 210ml is oral, one time one bag, every day two to three times.Two months is a course of treatment.

Claims (3)

1. the Chinese patent medicine that becomes of a treatment of diabetic retinopathy is characterized in that it is made by the following weight proportion raw material:

0.1～2 part of 1.0～4 parts of Flos Eriocauli of 1.5～6 portions of Radix Scrophulariaes of Radix Rehmanniae

0.1～2 part of 1.0～4 parts of Radix Trichosanthis of 1.5～6 parts of Radix Puerariaes of Radix Salviae Miltiorrhizae

0.1～2 part of 1.0～4 parts of Fructus Atriplicis Sibiricae of 1.5～6 parts of Flos Chrysanthemis of Rhizoma Imperatae

0.1～2 part of 1.0～4 parts of Fructus Corni of 1.0～4 parts of Rhizoma Polygonatis of Radix Ophiopogonis.

2. the Chinese patent medicine that a kind of treatment of diabetic retinopathy according to claim 1 becomes, wherein the weight proportion of each raw material is:

0.5～1.5 part of 1.5～2.5 parts of Flos Eriocauli of 2.5～3.5 portions of Radix Scrophulariaes of Radix Rehmanniae

0.5～1.5 part of 1.5～2.5 parts of Radix Trichosanthis of 2.5～3.5 parts of Radix Puerariaes of Radix Salviae Miltiorrhizae

0.5～1.5 part of 1.5～2.5 parts of Fructus Atriplicis Sibiricae of 2.5～3.5 parts of Flos Chrysanthemis of Rhizoma Imperatae

0.5～1.5 part of 1.5～2.5 parts of Fructus Corni of 1.5～2.5 parts of Rhizoma Polygonatis of Radix Ophiopogonis.

3. the Chinese patent medicine that a kind of treatment of diabetic retinopathy according to claim 1 becomes, wherein the weight proportion of each raw material is:

1 part of 2 parts of Flos Eriocauli of 3 portions of Radix Scrophulariaes of Radix Rehmanniae

1 part of 2 parts of Radix Trichosanthis of 3 parts of Radix Puerariaes of Radix Salviae Miltiorrhizae

1 part of 2 parts of Fructus Atriplicis Sibiricae of 3 parts of Flos Chrysanthemis of Rhizoma Imperatae

1 part of 2 parts of Fructus Corni of 2 parts of Rhizoma Polygonatis of Radix Ophiopogonis.