CN101129801A - Proprietary Chinese medicine for treating retina affection of diabetes - Google Patents

Abstract

The invention relates to a Chinese medicament for treating diabetic retinopathy which is prepared from more than ten kinds of Chinese medicinal herbs including raw astragalus root, fleece-flower root, wolferry fruit and bark of peony root. The medicament has the advantages of assured curative effect, safe and convenient application, no toxic and side effects, and low price.

Description

A kind of Chinese patent medicine that treatment of diabetic retinopathy becomes

Technical field

The present invention relates to a kind of Chinese patent medicine that treatment of diabetic retinopathy becomes, is that a kind of treatment of diabetic retinopathy change is the Chinese medicine preparation of raw material with the Chinese herbal medicine.Belong to the field of Chinese medicines.

Background technology

Diabetic retinopathy is the common microvascular complication in diabetics optical fundus, is the one of the main reasons of diabetes patient's blinding.The old man of data prompting more than 60 years old arranged, and diabetic history had 31.5% patient's vision decline in 5 years, and 20% is blind.The proliferative retinopathy person is taken place and is reached 50% in the Hary Keen report course of disease 10～25 years.Caird observes and finds that retinopathy accounts for 80% of the concurrent blinding of the whole oculopathy of diabetes.Diabetes are Duoed 25 times than the blind person of non-diabetic.DR is one of western countries' four big main blinding diseases, by its organic growth rule, can divide early stage simple type, is its main pathological features with microangioma; Later stage causes blind with new vessels formation, vitreous hemorrhage etc.

Investigation of clinical epidemiology shows, strengthens the treatment to DM patient, and strict blood sugar control can make DM patient's blind time retardation 16 years, and can make 2/3 proliferative DR (PDR) patient because of obtaining rational therapy, and avoids losing one's sight.Along with the technical development of fundus fluorescein angiography and electroretinogram etc., help early diagnosis, the early treatment of diabetic retinopathy in recent years.The treatment of diabetic retinopathy does not still have ideal medicine at present, still with the control of diabetes state of an illness, hypertension, adopts the method for the combination of Chinese and Western medicine, is that the control diabetic retinopathy takes place and the basis of developing.

Diabetic retinopathy belongs to the refreshing disease category of traditional Chinese medical science pupil.Pupil god has another name called " pupil ", " gb 1 ", " Jin Jing ", is five water wheels in taking turns, and the planted agent is in kidney.Kidney is the institute that refreshing light rises, and annotates in order on its vital essence to belong to gb 1, can distinguish all things on earth, penetrates deeply into all things.Pupil god is the eyes most important parts, and pupil disease is from the beginning of conscious " look thing dusk vast ", the uncivilized unclear blurring of vission that is called, and pupil disease can be divided into five types by clinical symptoms: (1) stagnation of QI due to depression of the liver, the order network is obstructed; (2) spleen-asthenia with excessive damp, the turbid resistance network of expectorant; (3) deficiency of the liver and kindey, it is dark that water loses order; (4) honor of becoming homeless of QI and blood deficiency, order; (5) hyperactivity of YANG due to deficiency of YIN, burn order network.The traditional Chinese medical science is divided disease type Coryza Treated by Syndrome Differentiation clinically, obtains very good effect.Invent a kind of not only safety but also effective Chinese medicine preparation, be significant.

Summary of the invention

The present invention develops in conjunction with the latest modern technological scientific achievement on the basis of traditional tcm syndrome differentiation and treatment.The purpose of this invention is to provide a kind of Chinese patent medicine that treatment of diabetic retinopathy becomes.Have determined curative effect, safe ready, have no side effect, cheap characteristics.

The present invention is made by the following weight proportion raw material:

1.0～4 parts of 1.0～4 portions of Radix Scrophulariaes of 1.5～6 parts of Fructus Lycii of Radix Astragali

1.0～4 parts of 1.0～4 parts of Radix Angelicae Sinensis of 1.5～6 parts of Cortex Moutans of Radix Polygoni Multiflori

1.0～4 parts of 1.0～4 parts of Flos Chrysanthemis of 1.5～6 parts of Fructus Viticises of Radix Rehmanniae

0.1～2 part in 0.1～2 part of Flos Sophorae of 0.1～2 part of Herba Dendrobii of Flos Eriocauli.

The weight proportion of each raw material of optimization formula of the present invention is:

1.5～2.5 parts of 1.5～2.5 portions of Radix Scrophulariaes of 2.5～3.5 parts of Fructus Lycii of Radix Astragali

1.5～2.5 parts of 1.5～2.5 parts of Radix Angelicae Sinensis of 2.5～3.5 parts of Cortex Moutans of Radix Polygoni Multiflori

1.5～2.5 parts of 1.5～2.5 parts of Flos Chrysanthemis of 2.5～3.5 parts of Fructus Viticises of Radix Rehmanniae

0.5～1.5 part in 0.5～1.5 part of Flos Sophorae of 0.5～1.5 part of Herba Dendrobii of Flos Eriocauli.

The weight proportion of each raw material of optimum formula of the present invention is:

2 parts of 2 portions of Radix Scrophulariaes of 3 parts of Fructus Lycii of Radix Astragali

2 parts of 2 parts of Radix Angelicae Sinensis of 3 parts of Cortex Moutans of Radix Polygoni Multiflori

2 parts of 2 parts of Flos Chrysanthemis of 3 parts of Fructus Viticises of Radix Rehmanniae

1 part in 1 part of Flos Sophorae of 1 part of Herba Dendrobii of Flos Eriocauli.

Drug action mechanism among the present invention is as follows:

The Radix Astragali property of medicine is sweet, warm.Return lung, spleen channel.Has benefiting qi and raising yang, strengthening superficial resistance to stop perspiration, inducing diuresis to remove edema, the effect of promoting pus discharge and tissue regeneration strengthening.Can treat the card of all Qi and blood deficiencies, as diarrhea due to hypofunction of the spleen, the cough due to deficiency of the lung, proctoptosis, uterine prolapse, spontaneous perspiration, night sweat, edema, arthralgia due to stagnation of blood, carbuncle is difficult bursts or bursts for a long time and do not hold back etc.(the 2813rd page of Shanghai science tech publishing house second edition write by " Chinese medicine voluminous dictionary " Nanjing University of Traditional Chinese Medicine).

Radix Polygoni Multiflori property of medicine hardship, sweet, puckery, tepor.Return liver, the heart, kidney channel.Have nourishing the blood and yin, loosening bowel to relieve constipation dispels the wind, the antidotal effect.Can treat Light-headedness, cardiopalmus, insomnia, soreness of the waist and knees, early whitening of beard and hair, tinnitus, seminal emission, dryness of the intestine constipation, chronic malaria body void, rubella pruritus, carbuncle sore, scrofula, hemorrhoid etc.(the 1588th page of Shanghai science tech publishing house second edition write by " Chinese medicine voluminous dictionary " Nanjing University of Traditional Chinese Medicine).

The Radix Rehmanniae nature and flavor are sweet, cold.GUIXIN, liver, kidney channel.Has clearing away heat and cooling blood, yin nourishing, the effect of promoting the production of body fluid.Can treat that calentura crimson tongue excessive thirst, interior-heat caused by deficiency of YIN, hectic fever due to YIN-deficiency consumptive fever, interior-heat are quenched one's thirst, haematemesis, epistaxis, send out speckle dermexanthesis etc.(Ji Yubin chief editor " Chinese medicine medicine for preventing pharmacology and application " Heilungkiang science tech publishing house 1999 version the 514th page).

The Fructus Lycii property of medicine is sweet, flat.Return liver, kidney, lung meridian.Has nourishing the liver, nourishing kidney, the effect of lung moistening.Can treat caused by liver and kidney deficiency, have a dizzy spell, visual unclear, soreness of the waist and knees, impotence and seminal emission, cough due to consumptive disease, the taking fluids profusely etc. of quenching one's thirst.(the 2248th page of Shanghai science tech publishing house second edition write by " Chinese medicine voluminous dictionary " Nanjing University of Traditional Chinese Medicine).

Cortex Moutan property of medicine hardship, suffering are slightly cold.GUIXIN, liver, kidney channel.Has clearing away heat and cooling blood, the effect of promoting blood circulation to remove blood stasis.Can treat the epidemic febrile disease pathogenic heat attacking blood system in febrile diseases, send out speckle, tell nosebleed, the calentura later stage, hot Fu Yin divided heating, osteopyrexia and fever, and amenorrhea due to stagnation of blood, dysmenorrhea, mass in the abdomen, carbuncle sore tumefacting virus falls and pounces on the pain of injury, rheumatic arthralgia etc.(the 1578th page of Shanghai science tech publishing house second edition write by " Chinese medicine voluminous dictionary " Nanjing University of Traditional Chinese Medicine).

Fructus Viticis nature and flavor suffering, hardship are slightly cold.Return bladder, liver, stomach warp.Has dispelling wind and heat pathogens, the clear sharp head's effect.Can treat the anemopyretic cold headache, gingivitis, the many tears of conjunctival congestion, poor vision is had a dizzy spell etc.(the 298th page of Chemical Industry Press of Pharmacopoeia of the People's Republic of China version in 2000 is compiled by Chinese Pharmacopoeia Commission).

The Radix Scrophulariae property of medicine is sweet, bitter, salty, is slightly cold.Return lung, stomach, kidney channel.Has removing heat from blood, nourishing YIN to lower pathogenic fire, antidotal effect.Can treat the warm febrile disease blood of joining the army, fever of the body, excessive thirst, crimson tongue is sent out speckle, the hectic fever due to YIN-deficiency chronic cough, fidgets due to deficiency is insomnia, and constipation is hindered in Tianjin, and order is puckery dim-sighted, laryngopharynx swelling and pain, tuberculous lymphadenitis, skin sore etc.(the 1062nd page of Shanghai science tech publishing house second edition write by " Chinese medicine voluminous dictionary " Nanjing University of Traditional Chinese Medicine).

The Radix Angelicae Sinensis property of medicine is sweet, hot, bitter, temperature.Return liver, the heart, spleen channel.Having enriches blood invigorates blood circulation, menstruction regulating and pain relieving, the effect of moisturizing laxation.Can treat all cards of blood deficiency, menoxenia, amenorrhea, dysmenorrhea ， mass in the abdomen knot is poly-, metrorrhagia, asthenia cold abdominalgia, flaccidity syndrome and arthralgia syndrome, numbness of the skin, the dryness of the intestine dyschezia, heavy after the bloody dysentery, ulcer sores, injury from falling down etc.(the 1210th page of Shanghai science tech publishing house second edition write by " Chinese medicine voluminous dictionary " Nanjing University of Traditional Chinese Medicine).

The Flos Chrysanthemi property of medicine is sweet, bitter, is slightly cold.Return lung, Liver Channel.Have wind and heat dispersing, suppressing the hyperactive liver makes eye bright, the effect of removing toxic substances and promoting subsidence of swelling.Can treat affection due to external wind and heat or pathogenic wind-warm from the beginning of, fever and headache, dizzy, conjunctival congestion and swelling pain is treated pyogenic infections from tumour or sore etc.(the 2900th page of Shanghai science tech publishing house second edition write by " Chinese medicine voluminous dictionary " Nanjing University of Traditional Chinese Medicine).

Flos Eriocauli nature and flavor suffering, sweet, flat.Return liver, lung meridian.Have dispelling wind and heat pathogens, make eye bright, the effect of nebula removing.Can treat the wind heat conjunctival congestion, the photophobia that swells and ache, the nebula of looking unfamiliar film, headache due to pathogenic wind-heat etc.(the 143rd page of Chemical Industry Press of Pharmacopoeia of the People's Republic of China version in 2000 is compiled by Chinese Pharmacopoeia Commission).

The Herba Dendrobii nature and flavor are sweet, are slightly cold.Return stomach, kidney channel.Has reinforcing stomach reg fluid, the effect of nourishing YIN and clearing away heat.Can treat cloudy impairment of body fluid and lose, the xerostomia excessive thirst, lack of appetite is retched, deficiency-heat after being ill, poor vision etc.(the 70th page of Chemical Industry Press of Pharmacopoeia of the People's Republic of China version in 2000 is compiled by Chinese Pharmacopoeia Commission).

Flos Sophorae property of medicine hardship is slightly cold.Return liver, large intestine channel.Has cooling blood for hemostasis, the effect of liver heat removing and eyesight improving.Can treat discharging fresh blood stool, hemorrhoid hematochezia, dysentery with red and white feces, stranguria with blood, metrorrhagia, haematemesis, epistaxis, sore swollen toxin etc.(the 3440th page of Shanghai science tech publishing house second edition write by " Chinese medicine voluminous dictionary " Nanjing University of Traditional Chinese Medicine).

The present invention follows the principles of formulating prescriptions of the traditional Chinese medical science " monarch ", is monarch drug with Radix Astragali, Radix Polygoni Multiflori and Radix Rehmanniae; With Radix Scrophulariae, Fructus Lycii, Cortex Moutan, Radix Angelicae Sinensis, Fructus Viticis and Flos Chrysanthemi is ministerial drug; With Herba Dendrobii, Flos Eriocauli and Flos Sophorae is adjuvant.All medicines are harmonious, and are total to the tool supplementing QI and nourishing YIN, the effect of liver heat removing and eyesight improving.The treatment of diabetic retinopathy change has determined curative effect, has no side effect taking convenience, cheap characteristics.

Clinical drug of the present invention uses the result to show that following advantage is arranged:

1, the Chinese herbal medicine each component selected for use of the present invention meets the regulation of The Drug Administration Law of People's Republic of China, utilizes the comprehensive function treatment of diabetic retinopathy of the Chinese medicine of respectively distinguishing the flavor of to become, and is nontoxic to human body.Show that through the acute and chronic toxicity test of animal the animal of being tested does not see any toxic reaction, its main organs does not have tangible change yet, and safety of medicine is reliable.

2, rich in proteins in the medicine of the present invention, glucose, glucuronic acid, volatile oil, pectin, fructose, organic acid lecithin, vitamin, aminoacid also contains various trace elements such as Saponin, plant sterol and calcium, is beneficial to absorption of human body, health invigorating.

3, the present invention not only effectively treatment of diabetic retinopathy become, the prevention of diabetic renal papillary necrosis is also had good effect, treatment of diabetic retinopathy becomes and has determined curative effect, has no side effect taking convenience, cheap characteristics.

For the therapeutic effect that shows that medicine of the present invention becomes treatment of diabetic retinopathy, as follows through clinical test results; Treatment of diabetic retinopathy becomes patient's 25 examples.Take the embodiment decoction, each 1 bag, two to three times on the one, take half an hour ante cibum.Two months is a course of treatment, take continuously three the course of treatment observe the curative effect.11 examples of fully recovering account for 44%, and 12 examples that take a turn for the better account for 48%, and invalid 2 examples account for 8%, and total effective rate reaches 92%.After three course of therapy, patient does not have any untoward reaction, and three big routine tests and hepatic and renal function detect no abnormal.

The specific embodiment

The embodiment decoction takes by weighing raw material by following weight:

2 parts of 2 portions of Radix Scrophulariaes of 3 parts of Fructus Lycii of Radix Astragali

2 parts of 2 parts of Radix Angelicae Sinensis of 3 parts of Cortex Moutans of Radix Polygoni Multiflori

2 parts of 2 parts of Flos Chrysanthemis of 3 parts of Fructus Viticises of Radix Rehmanniae

1 part in 1 part of Flos Sophorae of 1 part of Herba Dendrobii of Flos Eriocauli.

Preparation method is to get above-mentioned raw materials to clean roguing, dries, and is ground into granule, soaks 1 hour, puts and decocts with water secondary in the multi-function extractor, adds up the water of 10 times of amounts of medical material for the first time, decocts 1.5～2 hours, gets decocting liquid, filters.Add up for the second time the water of 7 times of amounts of medical material, decocted 1～1.2 hour, get decocting liquid twice, filter, in the heat-sealing bag, 105 ℃ of high temperature sterilizes, packing is promptly.The decoction that treatment of diabetic retinopathy that the present invention makes becomes is packed into plastic packaging, and every bag of 210ml is oral, one time one bag, every day two to three times.Two months is a course of treatment.

Claims (3)

1. a kind of Chinese patent medicine of becoming of treatment of diabetic retinopathy is characterized in that it is made by the following weight proportion raw material:

1.0～4 parts of 1.0～4 portions of Radix Scrophulariaes of 1.5～6 parts of Fructus Lycii of Radix Astragali

1.0～4 parts of 1.0～4 parts of Radix Angelicae Sinensis of 1.5～6 parts of Cortex Moutans of Radix Polygoni Multiflori

1.0～4 parts of 1.0～4 parts of Flos Chrysanthemis of 1.5～6 parts of Fructus Viticises of Radix Rehmanniae

0.1～2 part in 0.1～2 part of Flos Sophorae of 0.1～2 part of Herba Dendrobii of Flos Eriocauli.

2. a kind of Chinese patent medicine that treatment of diabetic retinopathy according to claim 1 becomes, wherein the weight proportion of each raw material is:

1.5～2.5 parts of 1.5～2.5 portions of Radix Scrophulariaes of 2.5～3.5 parts of Fructus Lycii of Radix Astragali

1.5～2.5 parts of 1.5～2.5 parts of Radix Angelicae Sinensis of 2.5～3.5 parts of Cortex Moutans of Radix Polygoni Multiflori

1.5～2.5 parts of 1.5～2.5 parts of Flos Chrysanthemis of 2.5～3.5 parts of Fructus Viticises of Radix Rehmanniae

0.5～1.5 part in 0.5～1.5 part of Flos Sophorae of 0.5～1.5 part of Herba Dendrobii of Flos Eriocauli.

3. a kind of Chinese patent medicine that treatment of diabetic retinopathy according to claim 1 becomes, wherein the weight proportion of each raw material is:

2 parts of 2 portions of Radix Scrophulariaes of 3 parts of Fructus Lycii of Radix Astragali

2 parts of 2 parts of Radix Angelicae Sinensis of 3 parts of Cortex Moutans of Radix Polygoni Multiflori

2 parts of 2 parts of Flos Chrysanthemis of 3 parts of Fructus Viticises of Radix Rehmanniae

1 part in 1 part of Flos Sophorae of 1 part of Herba Dendrobii of Flos Eriocauli.