CN101112493A - Chinese traditional medicine preparations for treating embryonic diapause - Google Patents

Abstract

The present invention relates to a traditional Chinese medicine preparation for treating slow fetal growth and fetal malnutrition, which takes more than 10 Chinese herbal medicines of pilose Asiabell root, largehead atractylodes rhizome, Chinese angelica, himalayan teasel root etc. as the raw materials. The present invention has the effects of benefiting qi, nourishing blood, quieting spirit and nourishing fetus. Based on the differential treatment of the traditional Chinese medicine, the invention is developed by combining the latest scientific research results with the traditional Chinese medicine. The present invention aims at providing the traditional Chinese medicine preparation to treat slow fetal growth and fetal malnutrition. The present invention is characterized by accurate efficacy, safety, convenience, no toxicity or side effects and low price.

Description

A kind of Chinese medicine preparation for the treatment of the diapause

Technical field

The present invention relates to a kind of Chinese medicine preparation for the treatment of the diapause, is that a kind of diapause for the treatment of is the Chinese medicine preparation of raw material with the Chinese herbal medicine.Belong to the field of Chinese medicines.

Background technology

Fetus is growth retardation in female abdomen, thus pregnant four May venter posterior shape with the palace body be significantly less than normal pregnancy month person, fetus still becomes the reviver on inspection, the title " diapause ".Primary disease head sees " General Treatise on the Cause and Symptoms of Diseases " and is called " non-growth of fetus ".Forefathers have the title of " pregnant retardation of growth of the fetus ", " fetal retardation " again.Primary disease is equivalent to modern medicine " fetal intrauterine growth restriction (FGR) ", or title " fetal intrauterine growth retardation (IUGR) ".The traditional Chinese medical science is divided disease type Coryza Treated by Syndrome Differentiation such as deficient qi and blood card, deficiency of spleen and stomach card clinically, obtains very good effect.Invent a kind of not only safety but also effective Chinese medicine preparation, be significant.

Summary of the invention

The present invention develops in conjunction with the latest modern technological scientific achievement on the basis of traditional tcm syndrome differentiation and treatment.The purpose of this invention is to provide a kind of Chinese medicine preparation for the treatment of the diapause.Have determined curative effect, safe ready, have no side effect, cheap characteristics.

The present invention is made by following raw materials by weight proportions:

1.5～6 parts of 1.5～6 parts of Rhizoma Atractylodis Macrocephalaes of 1.5～6 parts of Radix Astragali of Radix Rehmanniae Preparata

1.0～4 parts of 1.0～4 parts of Radix Codonopsis of 1.0～4 portions of Caulis Spatholobis of Fructus Lycii

1.0～4 parts of 1.0～4 parts of Radix Angelicae Sinensis of 1.0～4 parts of Caulis Polygoni Multiflori of Rhizoma Dioscoreae

0.1～2 part of 0.1～2 part of Radix Dipsaci of 0.1～2 part of Fructus Crataegi of charred Nodus Nelumbinis Rhizomatis.

The weight proportion of each crude drug of optimization formula of the present invention is:

2.5～3.5 parts of 2.5～3.5 parts of Rhizoma Atractylodis Macrocephalaes of 2.5～3.5 parts of Radix Astragali of Radix Rehmanniae Preparata

1.5～2.5 parts of 1.5～2.5 parts of Radix Codonopsis of 1.5～2.5 portions of Caulis Spatholobis of Fructus Lycii

1.5～2.5 parts of 1.5～2.5 parts of Radix Angelicae Sinensis of 1.5～2.5 parts of Caulis Polygoni Multiflori of Rhizoma Dioscoreae

0.5～1.5 part of 0.5～1.5 part of Radix Dipsaci of 0.5～1.5 part of Fructus Crataegi of charred Nodus Nelumbinis Rhizomatis.

The weight proportion of each crude drug of optimum formula of the present invention is:

3 parts of 3 parts of Rhizoma Atractylodis Macrocephalaes of 3 parts of Radix Astragali of Radix Rehmanniae Preparata

2 parts of 2 parts of Radix Codonopsis of 2 portions of Caulis Spatholobis of Fructus Lycii

2 parts of 2 parts of Radix Angelicae Sinensis of 2 parts of Caulis Polygoni Multiflori of Rhizoma Dioscoreae

1 part of 1 part of Radix Dipsaci of 1 part of Fructus Crataegi of charred Nodus Nelumbinis Rhizomatis.

Drug action mechanism among the present invention is as follows:

The Radix Rehmanniae Preparata sweet in the mouth, slightly warm in nature.Have nourishing YIN and supplementing blood, beneficial essence is filled out the effect of marrow.Can treat soreness of the waist and knees, osteopyrexia and fever, the night sweat seminal emission, interior-heat is quenched one's thirst, severe palpitation, menoxenia, metrostaxis, dizzy, tinnitus, early whitening of beard and hair, anemia etc.(the 197th page of chief editor such as the firm Xiao Ying of party " Chinese medicine and health food development and exploitation " People's Health Publisher).

The Radix Astragali property of medicine is sweet, warm.Return lung, spleen channel.Has benefiting qi and raising yang, strengthening superficial resistance to stop perspiration, inducing diuresis to remove edema, the effect of promoting pus discharge and tissue regeneration strengthening.Can treat the card of all Qi and blood deficiencies, as diarrhea due to hypofunction of the spleen, the cough due to deficiency of the lung, proctoptosis, uterine prolapse, spontaneous perspiration, night sweat, edema, arthralgia due to stagnation of blood, carbuncle is difficult bursts or bursts for a long time and do not hold back etc.(the 2813rd page of Shanghai science tech publishing house second edition write by " Chinese medicine voluminous dictionary " Nanjing University of Traditional Chinese Medicine).

Rhizoma Atractylodis Macrocephalae hardship, sweet, temperature.Return spleen, stomach warp.Has invigorating the spleen and benefiting QI, dampness diuretic, hidroschesis, antiabortive effect.Can treat the weak of deficiency-weakness of spleen-QI, lack of appetite abdominal distention is had loose bowels, constipation, the dysuria of fluid-retention stagnating in the interior, edema, dizziness due to fluid-retention, cold-damp numbness, general pain, spontaneous sweating due to deficiency of QI, frequent fetal movement etc.(the 945th page of Shanghai science tech publishing house second edition write by " Chinese medicine voluminous dictionary " Nanjing University of Traditional Chinese Medicine).

The Fructus Lycii property of medicine is sweet, flat.Return liver, kidney, lung meridian.Has nourishing the liver, nourishing kidney, the effect of lung moistening.Can treat caused by liver and kidney deficiency, have a dizzy spell, visual unclear, soreness of the waist and knees, impotence and seminal emission, cough due to consumptive disease, the taking fluids profusely etc. of quenching one's thirst.(the 2248th page of Shanghai science tech publishing house second edition write by " Chinese medicine voluminous dictionary " Nanjing University of Traditional Chinese Medicine).

Caulis Spatholobi property of medicine hardship, little sweet, temperature.Return liver, kidney channel.Has relaxing muscles and tendons to promote blood circulation, the effect of nourishing blood for regulating menstruation.Can treat numb hand and foot, quadriplegia, rheumatic arthralgia, anemia, menoxenia, dysmenorrhea, amenorrhea etc.(the 1689th page of Shanghai science tech publishing house second edition write by " Chinese medicine voluminous dictionary " Nanjing University of Traditional Chinese Medicine).

The Radix Codonopsis property of medicine is sweet, and is flat.Return spleen, lung meridian.Has strengthening the spleen and tonifying the lung, the effect of supplementing QI for promoting the production of body fluid.Can treat weakness of the spleen and stomach, anorexia and loose stool, limbs fatigue, the deficiency of the lung is breathed with cough, the spontaneous perspiration of breathing hard, deficiency of both QI and blood etc.(the 2579th page of Shanghai science tech publishing house second edition write by " Chinese medicine voluminous dictionary " Nanjing University of Traditional Chinese Medicine).

The Rhizoma Dioscoreae property of medicine is sweet, flat.Return spleen, lung, kidney channel.Have spleen reinforcing, support lung, reinforce the kidney, the effect that benefit is smart.Can treat diarrhea due to hypofunction of the spleen, the lack of appetite edema, cough and asthma due to lung deficiency is quenched one's thirst, seminal emission, leukorrhagia, the frequent micturition of suffering from a deficiency of the kidney.Carbuncle is controlled in external, scrofula etc.(the 218th page of Shanghai science tech publishing house second edition write by " Chinese medicine voluminous dictionary " Nanjing University of Traditional Chinese Medicine).

Sweet, the little hardship of the Caulis Polygoni Multiflori property of medicine, flat.GUIXIN, Liver Channel.Has tranquilizing by nourishing the heart, the effect of dispelling wind and removing obstruction in the collateral.But Cure for insomnia, dreaminess, blood deficiency general pain, numbness of the skin, rheumatic arthralgia, rubella pruritus etc.(the 2033rd page of Shanghai science tech publishing house second edition write by " Chinese medicine voluminous dictionary " Nanjing University of Traditional Chinese Medicine).

The Radix Angelicae Sinensis property of medicine is sweet, hot, bitter, temperature.Return liver, the heart, spleen channel.Having enriches blood invigorates blood circulation, menstruction regulating and pain relieving, the effect of moisturizing laxation.Can treat all cards of blood deficiency, menoxenia, amenorrhea, dysmenorrhea ， mass in the abdomen knot is poly-, metrorrhagia, asthenia cold abdominalgia, flaccidity syndrome and arthralgia syndrome, numbness of the skin, the dryness of the intestine dyschezia, heavy after the bloody dysentery, ulcer sores, injury from falling down etc.(the 1210th page of Shanghai science tech publishing house second edition write by " Chinese medicine voluminous dictionary " Nanjing University of Traditional Chinese Medicine).

The charred Nodus Nelumbinis Rhizomatis property of medicine is sweet, puckery, and is flat.Return liver, lung, stomach warp.Has dissipating blood stasis hemostatic effect.Can treat haematemesis, spitting of blood, hematuria is had blood in stool, dysentery, metrorrhagia etc.(the 3799th page of Shanghai science tech publishing house second edition write by " Chinese medicine voluminous dictionary " Nanjing University of Traditional Chinese Medicine).

The acid of the Fructus Crataegi property of medicine, sweet tepor.Return spleen, stomach, Liver Channel.Has promoting digestion and invigorating the stomach, the effect of circulation of qi promoting dissipating blood stasis.Can treat eating accumulation, abdominal distention, dysentery, dysmenorrhea due to blood stasis, amenorrhea, puerperal abdonimal pain, lochiorrhea, hernia or painful and swollen testis, hyperlipemia etc.(the 226th page of Shanghai science tech publishing house second edition write by " Chinese medicine voluminous dictionary " Nanjing University of Traditional Chinese Medicine).

Radix Dipsaci property of medicine hardship, suffering, tepor.Return liver, kidney channel.Has invigorating the liver and kidney, bone and muscle strengthening, blood circulation regulating, the effect of ending metrorrhagia.Can treat aching pain in waist and back, the podomere flaccidity syndrome and arthralgia syndrome falls and pounces on wound, decreases muscle folding bone, and fetal movement is leaked red, metrorrhagia, and seminal emission, leukorrhagia, the carbuncle skin ulcer is swollen etc.(the 3172nd page of Shanghai science tech publishing house second edition write by " Chinese medicine voluminous dictionary " Nanjing University of Traditional Chinese Medicine).

The present invention follows the principles of formulating prescriptions of the traditional Chinese medical science " monarch ", is monarch drug with Radix Rehmanniae Preparata, the Rhizoma Atractylodis Macrocephalae and Radix Astragali; With Fructus Lycii, Caulis Spatholobi, Radix Codonopsis, Rhizoma Dioscoreae, Caulis Polygoni Multiflori with when being classified as ministerial drug; With charred Nodus Nelumbinis Rhizomatis, Fructus Crataegi and Radix Dipsaci is adjuvant.All medicines are harmonious, and are total to the tool benefiting QI and nourishing blood, the effect of the flourish tire of calming the nerves.The treatment diapause has determined curative effect, has no side effect taking convenience, cheap characteristics.

Clinical drug of the present invention uses the result to show that following advantage is arranged:

1, the Chinese herbal medicine each component selected for use of the present invention meets the regulation of The Drug Administration Law of People's Republic of China, utilizes the comprehensive function treatment diapause of the Chinese medicine of respectively distinguishing the flavor of, and is nontoxic to human body.Show that through the acute and chronic toxicity test of animal the animal of being tested does not see any toxic reaction, its main organs does not have tangible change yet, and safety of medicine is reliable.

2, rich in proteins in the medicine of the present invention, glucose, glucuronic acid, volatile oil, pectin, fructose, organic acid, lecithin, vitamin, aminoacid also contains various trace elements such as Saponin, plant sterol and calcium, is beneficial to absorption of human body, health invigorating.

3, the present invention not only can effectively treat the diapause, and the prevention of diapause is also had good effect, and the treatment diapause has determined curative effect, has no side effect taking convenience, cheap characteristics.

For showing the therapeutic effect of medicine of the present invention, as follows through clinical test results to the treatment diapause; Treatment diapause patient 20 examples.Take the embodiment decoction, each 1 bag, two to three times on the one, take half an hour ante cibum.One month is a course of treatment, take continuously three the course of treatment observe the curative effect.10 examples of fully recovering account for 50%, and 8 examples that take a turn for the better account for 40%, and invalid 2 examples account for 10%, and total effective rate reaches 90%.After three course of therapy, patient does not have any untoward reaction, and three big routine tests and hepatic and renal function detect no abnormal.

The specific embodiment

The embodiment decoction is pressed following weight weighting raw materials:

3 parts of 3 parts of Rhizoma Atractylodis Macrocephalaes of 3 parts of Radix Astragali of Radix Rehmanniae Preparata

2 parts of 2 parts of Radix Codonopsis of 2 portions of Caulis Spatholobis of Fructus Lycii

2 parts of 2 parts of Radix Angelicae Sinensis of 2 parts of Caulis Polygoni Multiflori of Rhizoma Dioscoreae

1 part of 1 part of Radix Dipsaci of 1 part of Fructus Crataegi of charred Nodus Nelumbinis Rhizomatis.

Preparation method is to get the above-mentioned raw materials medicine to clean roguing, dries, and is ground into granule, soaks 1 hour, puts and decocts with water secondary in the multi-function extractor, adds up the water of 10 times of amounts of medical material for the first time, decocts 1.5～2 hours, gets decocting liquid, filters.Add up for the second time the water of 7 times of amounts of medical material, decocted 1～1.2 hour, get decocting liquid twice, filter, in the heat-sealing bag, 105 ℃ of high temperature sterilizes, packing is promptly.The decoction of the treatment diapause that the present invention makes is that plastic packaging is packed, and every bag of 210ml is oral, one time one bag, every day two to three times.One month is a course of treatment.

Claims (3)

1. Chinese medicine preparation for the treatment of the diapause is characterized in that it is made by following raw materials by weight proportions:

1.5～6 parts of 1.5～6 parts of Rhizoma Atractylodis Macrocephalaes of 1.5～6 parts of Radix Astragali of Radix Rehmanniae Preparata

1.0～4 parts of 1.0～4 parts of Radix Codonopsis of 1.0～4 portions of Caulis Spatholobis of Fructus Lycii

1.0～4 parts of 1.0～4 parts of Radix Angelicae Sinensis of 1.0～4 parts of Caulis Polygoni Multiflori of Rhizoma Dioscoreae

0.1～2 part of 0.1～2 part of Radix Dipsaci of 0.1～2 part of Fructus Crataegi of charred Nodus Nelumbinis Rhizomatis.

2. a kind of Chinese medicine preparation for the treatment of the diapause according to claim 1, wherein the weight proportion of each crude drug is:

2.5～3.5 parts of 2.5～3.5 parts of Rhizoma Atractylodis Macrocephalaes of 2.5～3.5 parts of Radix Astragali of Radix Rehmanniae Preparata

1.5～2.5 parts of 1.5～2.5 parts of Radix Codonopsis of 1.5～2.5 portions of Caulis Spatholobis of Fructus Lycii

1.5～2.5 parts of 1.5～2.5 parts of Radix Angelicae Sinensis of 1.5～2.5 parts of Caulis Polygoni Multiflori of Rhizoma Dioscoreae

0.5～1.5 part of 0.5～1.5 part of Radix Dipsaci of 0.5～1.5 part of Fructus Crataegi of charred Nodus Nelumbinis Rhizomatis.

3. a kind of Chinese medicine preparation for the treatment of the diapause according to claim 1, wherein the weight proportion of each crude drug is:

3 parts of 3 parts of Rhizoma Atractylodis Macrocephalaes of 3 parts of Radix Astragali of Radix Rehmanniae Preparata

2 parts of 2 parts of Radix Codonopsis of 2 portions of Caulis Spatholobis of Fructus Lycii

2 parts of 2 parts of Radix Angelicae Sinensis of 2 parts of Caulis Polygoni Multiflori of Rhizoma Dioscoreae

1 part of 1 part of Radix Dipsaci of 1 part of Fructus Crataegi of charred Nodus Nelumbinis Rhizomatis.