CN104940611A - Chinese medicine for treating proliferative diabetic retinopathy - Google Patents

Abstract

The invention belongs to the field of medical technologies, and particularly relates to Chinese medicine for treating proliferative diabetic retinopathy. The Chinese medicine comprises, by weight, 5-13 parts of figwort roots, 8-16 parts of sealwort, 8-16 parts of pungent litsea fruits, 11-15 parts of Chinese eriosema roots, 8-16 parts of stachys geobombycis, 8-16 parts of asiatic alectoria filaments, 8-16 parts of whorledleaf solomonseal rhizomes, 8-16 parts of Chinese dodder seeds, 5-13 parts of spinystem araliar root-bark, 5-13 parts of platycarya fruits, 8-16 parts of red paeony roots, 5-13 parts of motherwort, 1-3 parts of gadflies, 5-13 parts of pinellia, 2-4 parts of scorpio, 8-16 parts of common selfheal fruit-spike and 8-16 parts of three-colored amaranth seeds. The Chinese medicine can effectively reduce the intraocular pressure and yellow spot thickness of the diseased eye, decreases the leakage area of the retina neovascular, promotes regression of the retina neovascular, improves the vision of a patient, and improves the living quality of the patient.

Description

A kind of Chinese medicine for the treatment of proliferative diabetic retinopathy

Technical field

The invention belongs to medical art, be specifically related to a kind of Chinese medicine for the treatment of proliferative diabetic retinopathy.

Background technology

One of major disease of main attack during diabetes (diabetes mellitus, DM) are China's 11th Five-Year, 12.Within 2011, whole world diabetes number of patients reaches 3. 66 hundred million; China's diabetics 9,240 ten thousand, occupies first, the whole world.Along with the increase gradually of onset diabetes rate, diabetic renal papillary necrosis (diabetic retinopathy, DR) has become the first cause of developed country 30-74 year adult's blinding.Proliferative diabetic retinopathy (proliferative diabetic retinopathy PDR) is one of microvascular complication that diabetes are serious, there is cure rate low, blinding height, once be difficult to the feature reversed, so the control of PDR is the difficult point Important Problems of ophthalmology always.Current doctor trained in Western medicine still effectively treats Therapeutic Method and the medicine of proliferative diabetic retinopathy symptom.

Summary of the invention

Technical problem to be solved by this invention avoids the weak point existing for above-mentioned prior art, a kind of Chinese medicine for the treatment of proliferative diabetic retinopathy is provided, this Chinese medicine can effectively reduce suffers from eye intraocular pressure and macular thickness, reduce retinal neovascularization leakage area, promote that retinal neovascularization disappears, improve the vision of patient, improve patients ' life quality.

The present invention is achieved through the following technical solutions:

Treat a Chinese medicine for proliferative diabetic retinopathy, be made up of the raw material of Chinese medicine medicine of following weight portion:

Black ginseng 5-13 part, Rhizoma Polygonati 8-16 part, Fructus Litseae pungentis 8-16 part, Radix eriosematis chinensis 11-15 part, Stachys geobombycis C. Y. Wu 8-16 part, black silk grass 8-16 part, Rhizoma Polygonati Verticillati 8-16 part, Semen Cuscutae 8-16 part, Cortex Araliae Echinocaulis Radicis 5-13 part, Fructus Platycaryae strobilaceac 5-13 part, Radix Paeoniae Rubra 8-16 part, Herba Leonuri 5-13 part, Tabanus 1-3 part, Rhizoma Pinelliae 5-13 part, Scorpio 2-4 part, Spica Prunellae 8-16 part, Semen Amaranthi tricoloris 8-16 part.

Preferably, the Chinese medicine of above-mentioned treatment proliferative diabetic retinopathy, be made up of the raw material of Chinese medicine medicine of following weight portion:

Black ginseng 7-11 part, Rhizoma Polygonati 10-14 part, Fructus Litseae pungentis 10-14 part, Radix eriosematis chinensis 13-17 part, Stachys geobombycis C. Y. Wu 10-14 part, black silk grass 10-14 part, Rhizoma Polygonati Verticillati 10-14 part, Semen Cuscutae 10-14 part, Cortex Araliae Echinocaulis Radicis 7-11 part, Fructus Platycaryae strobilaceac 7-11 part, Radix Paeoniae Rubra 10-14 part, Herba Leonuri 7-11 part, Tabanus 1.5-2.5 part, Rhizoma Pinelliae 7-11 part, Scorpio 2.5-3.5 part, Spica Prunellae 10-14 part, Semen Amaranthi tricoloris 10-14 part.

Preferred, the Chinese medicine of above-mentioned treatment proliferative diabetic retinopathy, be made up of the raw material of Chinese medicine medicine of following weight portion:

Black ginseng 9 parts, Rhizoma Polygonati 12 parts, Fructus Litseae pungentis 12 parts, Radix eriosematis chinensis 15 parts, Stachys geobombycis C. Y. Wu 12 parts, black silk grass 12 parts, Rhizoma Polygonati Verticillati 12 parts, Semen Cuscutae 12 parts of, Cortex Araliae Echinocaulis Radicis 9 parts, Fructus Platycaryae strobilaceac 9 parts, Radix Paeoniae Rubra 12 parts, Herba Leonuri 9 parts, Tabanus 2 parts, the Rhizoma Pinelliae 9 parts, Scorpio 3 parts, Spica Prunellae 12 parts, Semen Amaranthi tricoloris 12 parts.

The ratio of above weight proportion is through that science screening obtains, and for especial patient, as serious symptom or mild, fat or modest patient, can the proportioning of amount of corresponding adjustment composition, and increase or reduce being no more than 100%, drug effect is substantially constant.

The weight portion of said medicine, if in units of g, the normally consumption of 1 dose.

The indication of Chinese medicine of the present invention: be used for the treatment of proliferative diabetic retinopathy.

The taboo item of Chinese medicine of the present invention: the fasting for the treatment of period in a medicine is greasy, raw and cold, the smelling of fish or mutton, irritant and stodgy food.

In Chinese medicine of the present invention,

Black ginseng another name Radix Antiotrematis dunniani, Tai Baiyang ginseng, Rhizoma Pedicularis Davidii, coal ginseng, derive from Scrophulariaceae lousewort plant black ginseng Radix seu Herba Pedicularis Pedicularis davidii Franch., Radix seu Herba Pedicularis Pedicularis decora Franch. attractive in appearance and brown hair Radix seu Herba Pedicularis Pedicularis dunniana Bonati [P. aequibarbis Hand.-Mazz.], be used as medicine with root.Sweet, micro-hardship, flat.

Function supplementing QI and nourishing YIN, pain relieving.For body is empty after being ill, deficiency of YIN hectic fever, arthralgia.

Fructus Litseae pungentis another name Fructus Linderae Glaucae, Litsea chenii, Litsea cubeba, Alpinia japonica (Thunb.) Miq., wooden green pepper, Chimonanthus praecox (L.) Link. bavin, large wooden Rhizoma Zingiberis Recens, Litsea mollifolia, the fragrant son of monkey, Rhizoma Zingiberis Recens material, Hemerocallis citrina Baroni, peppery Jiang Zi are the fruit of canella Litsea euosma, Litsea mollifolia and Fructus Litseae pungentis (latin name 1.Litsea euosma W.W.Smith2.Litsea mollis Hemsl. [Litsea mollifolia Chun] 3.Litsea pungens Hemsl.).Nature and flavor are pungent; Bitter; Warm in nature, return through spleen; Stomach warp.The pain relieving of function warming middle-JIAO to promote flow of QI; Drying damp and strengthening spleenly to help digestion; Removing toxic substances and promoting subsidence of swelling.Main cold syndrome of the stomach stomachache; Heat-damp in summer is vomited and diarrhoea; Dyspepsia is glutted; Dysmenorrhea; Colic; Malaria; Skin infection swells and ache

Radix eriosematis chinensis another name mountain Pueraria lobota, energetically cattle, Caput Gallus domesticus potato, Cor Gigeriae Galli potato, Caput Gallus domesticus, yam bean, mountain stilbene potato, Herba Violae mundae.For the tuber of leguminous plant Radix eriosematis chinensis Eriosema chinense Vog..Nature and flavor are sweet; Flat, return through lung; Large intestine; Liver Channel.Function removing heat from the lung and dissipating phlegm; Promoting the production of body fluid to quench thirst; Detumescence.Main cough due to lung-heat; Lung abscess; Heating excessive thirst; Dysentery; Hydrocele of testis, food stagnation does not disappear; Treating swelling and pain by traumatic injury.

Stachys geobombycis C. Y. Wu calls native Cordyceps, white Cordyceps, tapeworm is careless, pulmonary tuberculosis is careless, derives from Labiatae betony Stachys geobombycis C. Y. Wu Stachya geobombycis C. Y. Wu, is used as medicine with tuber.Autumn adopts, and cleans using fresh herb or cooks and dry.Nature and flavor are sweet, flat.The lung moistening of function kidney tonifying, nourishing YIN and supplementing blood, clearing heat and relieving fidgetness.For pulmonary tuberculosis cough, the deficiency of the lung is panted, and spits blood, night sweat, anemia, infantile malnutrition.

Black silk grass another name Alectoria asiatica Du Rietz, derives from lichens Usneaceae and sends out a platymiscium Asia tree Alectoria asiatica Du Rietz, be used as medicine with thallus.Nature and flavor are light, flat.Function tonification Liver and kidney, convergence hidroschesis.For dizziness, clean, kidney deficiency and bodily weakness, seminal emission, night sweat; External is harnessed the Yellow River chickenpox.

Rhizoma Polygonati Verticillati calls smelly youngster ginseng, the wild Pseudobulbus Bletillae (Rhizoma Bletillae), derives from Liliaceae HUANGJING ZANYU CAPSULE Gansu Rhizoma Polygonati Polygonatum kansuense Maxim., is used as medicine with root stock.Nature and flavor are sweet, flat.Function tonification Liver and kidney, YIN nourishing and the production of body fluid promoting.For neurasthenia, hypertension, headache, throat pain, quenches one's thirst, dry mouth and tougue.

Cortex Araliae Echinocaulis Radicis calls red Herba Damnacanthi, llex cornuta, HONGCI cylinder, red Ramulus Kalopanacis seu Araliae, red burr paulownia, red llex cornuta thorn, HONGCI paulownia, brave green pepper thorn, thousand pieces of pins, the large cat thorn of red autumnal leaves, red autumnal leaves umbrella thorn, HONGCI party, Ci Jing Cortex araliae chinensis, is root and the root bark of Araliaceae Ji Jing Cortex araliae chinensis Aralia echinocaulis Hand.-Mazz..Mildly bitter flavor; Pungent; Property is put down.Function expelling wind and removing dampness; Blood-activating and qi-promoting; Removing toxic substances and promoting subsidence of swelling.Main air pain of dampness syndrome; Treating swelling and pain by traumatic injury; Fracture; Epigastric distending pain; Hernia; Metrorrhagia; Osteomyelitis; Carbuncle; Venom.

The Aliasing XIANGSHU ball of Fructus Platycaryae strobilaceac, changing Oleum Linderae, is the infructescence of juglandaceae plant Platycarya strobilacea 1.Platycarya strobilacea Sieb.et Zucc. [P.sinensis Mottet] 2. Platycarya longipes Wu. [P.kwangtungen-sis Chun].Acrid in the mouth; Warm in nature.Function blood-activating and qi-promoting; Pain relieving; Killing parasites for relieving itching.Main internal injury breast is swollen; Stomachache; Traumatic injury; Bones and muscles pain; Carbuncle; Eczema; Scabies.

Semen Amaranthi tricoloris another name not reality, Herba Amaranthi tricoloris, Amaranthus mangostanus L. is sub, is amaranthaceous plant Herba Amaranthi tricoloris Amaranthus tricolor L. [Amaranthus man-gostanus L.; A. gangeticus L.] seed.Sweet in the mouth; Cold in nature.Return liver; Large intestine; Wing takes off warp.Function liver heat removing and eyesight improving; Smoothening secretion.Main optic atrohic blindness cataracta; Poor vision; Nebulousurine hematuria; Constipation and anuresis.

Other drug all records in Chinese Pharmacopoeia 2010 editions.

Diabetic renal papillary necrosis belongs to the traditional Chinese medical science " order disease of quenching one's thirst " category, is equivalent to the category such as " blurring of vission ", " vitreous opacity ", " sudden blindness ", " hyphema and vitreous hemorrhage " in TCM Ophthalmology.Forefathers are early recognized primary disease, and ancient literature also has record to this." secretly hand down key to Diagnosis and Treatment. three disappear " think: " and three disappear for a long time it, essence and blood both lost, or order is ignored, or brothers attach undue importance to one thing to the neglect of the other as wind disease ... "." three disappear opinion ": " the husband person of quenching one's thirst, changeable for Sound, blind, drag, the disease of addiction, seat, paralysis "." the interchannel six scripts. Xuanming Lun Fang, Clear Synopsis on Recipes. introduction of quenching one's thirst ": " quench one's thirst and can be changed into nyctalopia or cataract "." Confucian's Duties to Their Parents. Liu Wansu three disappears opinion " day: " the husband person of quenching one's thirst, changeable Sound is blind ... and so on ", indicate that essence and blood loss is the main pathogenesis of diabetes blinding.

PDR falls ill based on Diabetes Foundation, quenches one's thirst with the passing of time, and cloudy QI consumed exhausts, and by causing impairment of both QI and YIN, the deficiency of vital energy is unable promotion blood then, and causes channels stasis blocking, and the deficiency of YIN then sering is not filled, loss of nutrient of eyes; The deficiency of vital energy with the passing of time then Yishui River is gathered, and is called wet; Wet coagulating then gives birth to expectorant for a long time, and phlegm and blood stasis, order key impatency is sent out as PDR.Often there is the even performance such as vitreous hemorrhage of microangioma, ecchymosis on PDR optical fundus, and these are all relevant with obstruction of collaterals by blood stasis, and optical fundus hard exudate, cotton-wool patches and propagation film are formed and meet the solidifying feature of expectorant.The common pattern of syndrome of PDR is deficiency of both QI and YIN, syndrome of intermin-gled phlegm and blood stasis.Therefore, treatment PDR(deficiency of both QI and YIN, intermingled phlegm and blood stasis type) when with supplementing QI and nourishing YIN, the method treatment of activating blood circulation and dissipating phlegm.

The Chinese prescription mechanism for the treatment of proliferative diabetic retinopathy of the present invention is as follows:

Monarch drug: black ginseng, Rhizoma Polygonati, Fructus Litseae pungentis, Radix eriosematis chinensis, Stachys geobombycis C. Y. Wu, black silk grass, Rhizoma Polygonati Verticillati merit are promoted the production of body fluid with supplementing QI and nourishing YIN; Implied meaning gas foot then blood, blood stasis is from going; Wherein Fructus Litseae pungentis, Radix eriosematis chinensis invigorating the spleen and benefiting QI, the strong then transporting officials of temper, phlegm-damp is from going; Stachys geobombycis C. Y. Wu is enriched blood YIN nourishing, and beneficial essence fills out marrow, and then order is foster to some extent for essence and blood foot; Black silk grass, Rhizoma Polygonati Verticillati have the effect of improving eyesight concurrently on the basis of tonifying liver kidney yin.

Ministerial drug: Cortex Araliae Echinocaulis Radicis, Fructus Platycaryae strobilaceac, Radix Paeoniae Rubra, the Rhizoma Pinelliae, Scorpio merit are with activating blood circulation and dissipating phlegm, and wherein Cortex Araliae Echinocaulis Radicis, Fructus Platycaryae strobilaceac have the effect of circulation of qi promoting concurrently, the capable then blood of gas.

Adjuvant drug: Herba Leonuri, Tabanus merit, with removing blood stasis Hang Qi Xiao Disorder, strengthen effect of blood circulation promoting and blood stasis dispelling; Spica Prunellae, Semen Amaranthi tricoloris merit, with improving acuity of vision and removing nebula, strengthen effect that improving eyesight improves vision.In addition, according to the theory of interdependence between yin and yang, the basis of vital essence replenishing is helped the Semen Cuscutae with warmly nourishing Yangqi, make " positive cloudy helping and biochemical infinite, YIN matched with sufficient YANG making living things fully vivid "; And Semen Cuscutae has effect of nourishing the liver to improve visual acuity, the blurred vision order that compatibility Stachys geobombycis C. Y. Wu, black silk grass is usually used in caused by deficiency of the liver and kindey is dark, visual deterioration.

We's compatibility is reasonable, all medicines share plays supplementing QI and nourishing YIN altogether, the effect of activating blood circulation and dissipating phlegm, link closely PDR(deficiency of both QI and YIN, intermingled phlegm and blood stasis type) etiology and pathogenesis, effectively can reduce and suffer from eye intraocular pressure and macular thickness, reduce retinal neovascularization leakage area, promote that retinal neovascularization disappears, improve the vision of patient, improve patients ' life quality.

Detailed description of the invention

Below in conjunction with specific embodiment, the present invention is further described, so that those skilled in the art more understands the present invention, but does not therefore limit the present invention.

Embodiment 1

Treat a Chinese medicine for proliferative diabetic retinopathy, each crude drug weight proportion is as follows:

Black ginseng 9g, Rhizoma Polygonati 12g, Fructus Litseae pungentis 12g, Radix eriosematis chinensis 15g, Stachys geobombycis C. Y. Wu 12g, black silk grass 12g, Rhizoma Polygonati Verticillati 12g, Semen Cuscutae 12g, Cortex Araliae Echinocaulis Radicis 9g, Fructus Platycaryae strobilaceac 9g, Radix Paeoniae Rubra 12g, Herba Leonuri 9g, Tabanus 2g, Rhizoma Pinelliae 9g, Scorpio 3g, Spica Prunellae 12g, Semen Amaranthi tricoloris 12g.

Embodiment 2

Treat a Chinese medicine for proliferative diabetic retinopathy, each crude drug weight proportion is as follows:

Black ginseng 7g, Rhizoma Polygonati 14g, Fructus Litseae pungentis 10g, Radix eriosematis chinensis 17g, Stachys geobombycis C. Y. Wu 10g, black silk grass 14g, Rhizoma Polygonati Verticillati 10g, Semen Cuscutae 14g, Cortex Araliae Echinocaulis Radicis 7g, Fructus Platycaryae strobilaceac 11g, Radix Paeoniae Rubra 10g, Herba Leonuri 11g, Tabanus 1.5g, Rhizoma Pinelliae 7g, Scorpio 3.5g, Spica Prunellae 14g, Semen Amaranthi tricoloris 10g.

Embodiment 3

Treat a Chinese medicine for proliferative diabetic retinopathy, each crude drug weight proportion is as follows:

Black ginseng 11g, Rhizoma Polygonati 10g, Fructus Litseae pungentis 14g, Radix eriosematis chinensis 13g, Stachys geobombycis C. Y. Wu 14g, black silk grass 10g, Rhizoma Polygonati Verticillati 14g, Semen Cuscutae 10g, Cortex Araliae Echinocaulis Radicis 11g, Fructus Platycaryae strobilaceac 7g, Radix Paeoniae Rubra 14g, Herba Leonuri 7g, Tabanus 2.5g, Rhizoma Pinelliae 11g, Scorpio 2.5g, Spica Prunellae 10g, Semen Amaranthi tricoloris 14g.

Embodiment 4

Treat a Chinese medicine for proliferative diabetic retinopathy, each crude drug weight proportion is as follows:

Black ginseng 5g, Rhizoma Polygonati 16g, Fructus Litseae pungentis 8g, Radix eriosematis chinensis 15g, Stachys geobombycis C. Y. Wu 8g, black silk grass 16g, Rhizoma Polygonati Verticillati 8g, Semen Cuscutae 16g, Cortex Araliae Echinocaulis Radicis 5g, Fructus Platycaryae strobilaceac 13g, Radix Paeoniae Rubra 8g, Herba Leonuri 13g, Tabanus 1g, Rhizoma Pinelliae 5g, Scorpio 4g, Spica Prunellae 16g, Semen Amaranthi tricoloris 8g.

Embodiment 5

Treat a Chinese medicine for proliferative diabetic retinopathy, each crude drug weight proportion is as follows:

Black ginseng 13g, Rhizoma Polygonati 8g, Fructus Litseae pungentis 16g, Radix eriosematis chinensis 11g, Stachys geobombycis C. Y. Wu 16g, black silk grass 8g, Rhizoma Polygonati Verticillati 16g, Semen Cuscutae 8g, Cortex Araliae Echinocaulis Radicis 13g, Fructus Platycaryae strobilaceac 5g, Radix Paeoniae Rubra 16g, Herba Leonuri 5g, Tabanus 3g, Rhizoma Pinelliae 13g, Scorpio 2g, Spica Prunellae 8g, Semen Amaranthi tricoloris 16g.

Carried out clinical pharrnacokinetics test to treatment proliferative diabetic retinopathy Chinese medicine of the present invention, Details as Follows:

1. data and method

1.1 object of study

Choose 200 routine PDR patients (deficiency of both QI and YIN, intermingled phlegm and blood stasis type), suffer from eye for totally 320.

1.1.1 diagnostic criteria

DR diagnostic criteria: with reference to ADA in 1997 to the revised standard of WHO diabetes diagnostic criterion: there is clear and definite diabetes medical history person.There is the microangioma of retinal feature, hemorrhage, hard exudate, softly to ooze out in diabetics optical fundus, retinal neovascularization etc.PDR: new vessels is formed or vitreous body/preretinal hemorrhage.

1.1.2 inclusive criteria

1. age <75 year

2. the patient of type 2 diabetes mellitus diagnosis is met

3. the patient of proliferative diabetic retinopathy is met

4. refracting media is substantially clear, might as well offend the eye end coherence check

5. FFA points out retina to have new vessels to occur, but does not occur the patient of tractional detachment of retina

1.1.3 exclusion standard

1. the age is greater than 75 years old

2. non-proliferative diabetic retinopathy patient

3. the patient of retina other diseases as the retinopathy such as age-related macular degeneration, retina arteriovenous obstruction, optic nerve disease, amblyopia, macular hole and other oculopathy such as glaucoma, uveitis is associated with

4. proliferative diabetic retinopathy patient but merge the patient of tractional detachment of retina

5. type 1 diabetes patient

6. refractive media situation affects fundus observation and treatment

7. the patient of other endocrinopathyes such as thyroid function disease, Cushing syndrome is associated with

8. the patient of severe cardiac, cerebrovascular, liver and disease of hematopoietic system is associated with

9. gestation or women breast-feeding their children, psychotic

10. anaphylactic disease is suffered from or to medicine for treatment allergy sufferers

1.2 method

1.2.1 Therapeutic Method

Adopt Chinese medicine supplementing QI and nourishing YIN, activating blood circulation and dissipating phlegm, prescription is as follows: black ginseng 9g, Rhizoma Polygonati 12g, Fructus Litseae pungentis 12g, Radix eriosematis chinensis 15g, Stachys geobombycis C. Y. Wu 12g, black silk grass 12g, Rhizoma Polygonati Verticillati 12g, Semen Cuscutae 12g, Cortex Araliae Echinocaulis Radicis 9g, Fructus Platycaryae strobilaceac 9g, Radix Paeoniae Rubra 12g, Herba Leonuri 9g, Tabanus 2g, Rhizoma Pinelliae 9g, Scorpio 3g, Spica Prunellae 12g, Semen Amaranthi tricoloris 12g.Be decocted in water for oral dose, day potion, sooner or later sub-service was a course for the treatment of with 2 months.

1.2.2 observation index

(1) vision: visual acuity chart of adopting international standards checks patient's vision.

(2) intraocular pressure: Bian Reichert company AT550 non-contact tonometer, measures and averages for three times.

(3) new vessels: adopt Japanese Topcon company 50DX model fluorescence fundus angiography machine and the capable fundus fluorescein angiography of software system to check (FFA), observe retinal neovascularization (NVE) leakage area and the situation that disappears.

(4) macular thickness: adopt the Japanese Topcon company 3DOCT2000 model optics capable macular area optical coherence tomography of thousand tomoscanners (optical coherence tomography mutually, OCT), and application OCT software carries out from the distance between the recess retina inner surface to retinal pigment epithelium of center and macula lutea central retina thickness (central macular thickness simultaneously, CMT) measure, observe macular thickness change.

1.2.3 statistical method

PASW Statistics 18.0 software is adopted to carry out data analysis.Measurement data represents with mean soil standard deviation, and two groups of samples compare employing independent samples t test.Enumeration data calculates and forms when rate, compares and adopts X2 inspection or exact method method, represent that difference has statistical significance with P<0.05 between group.

2. result

Vision change before and after 2.1 treatments

Before treatment, mean vision is 0.29 ± 0.15, and raising after treatment is 0.73 ± 0.22, and difference has statistical significance (P<0.05).

Retinal neovascularization (NVE) leakage area before and after 2.2 treatments

Before treatment, average N VE is (6.92 ± 1.88) mm ², be reduced to (0.22 ± 0.05) mm2 after treatment, difference has statistical significance (P<0.05).

Before and after 2.3 treatments, new vesselses disappear situation

320 suffer from eyes, new vessels disappear completely 302 (94.37%), partial remission 17 (5.31%), without significant change 1 (0.31%)

Macula lutea central retina thickness (CMT) change before and after 2.4 treatments

Before treatment, average CMT is (542.67 ± 51.25) um, and thinning after treatment is (103.52 ± 21.57) um, and difference has statistical significance (P<0.05).

Intraocular pressure (IOP) change before and after 2.5 treatments

Before treatment, average IOP is (19.22 ± 2.64) mmHg, and be reduced to (10.09 ± 1.98) mmHg after treatment, difference has statistical significance (P<0.05).

Claims (3)

1. treat a Chinese medicine for proliferative diabetic retinopathy, be made up of the raw material of Chinese medicine medicine of following weight portion:

Black ginseng 5-13 part, Rhizoma Polygonati 8-16 part, Fructus Litseae pungentis 8-16 part, Radix eriosematis chinensis 11-15 part, Stachys geobombycis C. Y. Wu 8-16 part, black silk grass 8-16 part, Rhizoma Polygonati Verticillati 8-16 part, Semen Cuscutae 8-16 part, Cortex Araliae Echinocaulis Radicis 5-13 part, Fructus Platycaryae strobilaceac 5-13 part, Radix Paeoniae Rubra 8-16 part, Herba Leonuri 5-13 part, Tabanus 1-3 part, Rhizoma Pinelliae 5-13 part, Scorpio 2-4 part, Spica Prunellae 8-16 part, Semen Amaranthi tricoloris 8-16 part.

2. the Chinese medicine for the treatment of proliferative diabetic retinopathy according to claim 1, is characterized in that, is made up of the raw material of Chinese medicine medicine of following weight portion:

Black ginseng 7-11 part, Rhizoma Polygonati 10-14 part, Fructus Litseae pungentis 10-14 part, Radix eriosematis chinensis 13-17 part, Stachys geobombycis C. Y. Wu 10-14 part, black silk grass 10-14 part, Rhizoma Polygonati Verticillati 10-14 part, Semen Cuscutae 10-14 part, Cortex Araliae Echinocaulis Radicis 7-11 part, Fructus Platycaryae strobilaceac 7-11 part, Radix Paeoniae Rubra 10-14 part, Herba Leonuri 7-11 part, Tabanus 1.5-2.5 part, Rhizoma Pinelliae 7-11 part, Scorpio 2.5-3.5 part, Spica Prunellae 10-14 part, Semen Amaranthi tricoloris 10-14 part.

3. the Chinese medicine for the treatment of treatment proliferative diabetic retinopathy according to claim 2, is characterized in that, be made up of the raw material of Chinese medicine medicine of following weight portion:

Black ginseng 9 parts, Rhizoma Polygonati 12 parts, Fructus Litseae pungentis 12 parts, Radix eriosematis chinensis 15 parts, Stachys geobombycis C. Y. Wu 12 parts, black silk grass 12 parts, Rhizoma Polygonati Verticillati 12 parts, Semen Cuscutae 12 parts of, Cortex Araliae Echinocaulis Radicis 9 parts, Fructus Platycaryae strobilaceac 9 parts, Radix Paeoniae Rubra 12 parts, Herba Leonuri 9 parts, Tabanus 2 parts, the Rhizoma Pinelliae 9 parts, Scorpio 3 parts, Spica Prunellae 12 parts, Semen Amaranthi tricoloris 12 parts.