CN101537087B - Traditional Chinese medicine composition for treating retinal vein obstruction - Google Patents
Traditional Chinese medicine composition for treating retinal vein obstruction Download PDFInfo
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- CN101537087B CN101537087B CN2009100204351A CN200910020435A CN101537087B CN 101537087 B CN101537087 B CN 101537087B CN 2009100204351 A CN2009100204351 A CN 2009100204351A CN 200910020435 A CN200910020435 A CN 200910020435A CN 101537087 B CN101537087 B CN 101537087B
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Abstract
The invention discloses a traditional Chinese medicine composition for treating retinal vein obstruction, which consists of the following components according to the parts by weight: 10-15 of felwort, 10-15 of fructus gardeniae, 10-15 of baikal skullcap root, 10-15 of dried rhizome of rehmannia, 10-20 of semen plantaginis, 10-15 of alisma orientale, 5-10 of fiveleaf akebia, 3-10 of liquorice, 5-15 of angelica, 5-10 of salvia miltiorrhiza and 5-8 of sanchi powder. The traditional Chinese medicine composition is mainly used for treating the retinal vein obstruction and particularly has good curative effects on symptoms of liver-gallbladder fire excess, blurred vision or sudden blindness, accompanied bitter taste and testiness, headache and dizziness, pallescence, wiry and rapid pulse, and the like. The traditional Chinese medicine composition has the advantages that: 1. the traditional Chinese medicine composition is a pure traditional Chinese medicine preparation, is convenient to use and has no obvious toxic side effects; 2. the traditional Chinese medicine composition has quick effect, determined curative effect, wide medicine source and low cost; and 3. the traditional Chinese medicine composition can treat both the symptoms and root causes and has good remote effects.
Description
Technical field
The invention discloses a kind of Chinese medicine composition of treating the retinal vein occlusion.
Background technology
The retinal vein occlusion is more common and bigger to vision harm optical fundus blood vessel disease, is one of main oculopathy of blinding.Clinical manifestation is muscae genetic vision, visual deterioration, visual field segmental defect, the optical fundus show as retinal vein thick, tortuous, block, retinal hemorrhage is flamboyancy, or dense lamellar, severe patient causes vitreous hemorrhage.Be more common in middle-aged and elderly people, normal simple eye morbidity, or differ in length blanking time, other eye morbidity appears, and the most of patients vision restoration is relatively poor.Cause that this sick cause of disease has: 1, the change of vascular lesion venous blood tube wall, hypertensive arteriosclerosis.2, hemorheology sexually revises platelet aggregation and discharges and strengthens.The change of other compositions of blood, like erythrocyte, thrombocytosis, plasma lipid and protein increase.3, vascular inflammation is more common in young patient.
At present, Therapeutic Method mainly contains whole body therapeutic, anticoagulant therapy, light coagulates treatment, the importing of electron ion medicine etc., is western medicine therapy mostly, and therapeutic process is complicated, less patient suffering, and cost is higher.
Chinese medicine is the valuable resource of China, utilizes the treatment by Chinese herbs disease often can play the effect well more a lot of than doctor trained in Western medicine.At present, the comparatively ideal Drugdoc report of clinical treatment retinal vein occlusion effect is less.Publication number is that the patent of invention of CN1850244A discloses a kind of Chinese medicine composition of treating oculopathy, be the retinopathy that is caused by diabetes or other angiopathys but it is directed against, and the preparation process is complicated, and cost is higher.
Summary of the invention
To the deficiency of above-mentioned prior art, the invention provides a kind of Chinese medicine composition of treating the retinal vein occlusion, its therapeutic effect is good, can effect a radical cure, and have no side effect, and cost is low.
The present invention realizes through following technical scheme:
A kind of Chinese medicine composition of treating the retinal vein occlusion is made up of the component of following weight portion: 10～15 parts of Radix Gentianaes, 10～15 parts of SHANZHIZI; 10～15 parts of Radix Scutellariaes, 10～15 parts in the Radix Rehmanniae, 10～20 parts of Semen Plantaginiss; 10～15 parts of Rhizoma Alismatis, 5～10 parts of Caulis Akebiaes, 3～10 parts in Radix Glycyrrhizae; 5～15 parts of Radix Angelicae Sinensis, 5～10 parts of Radix Salviae Miltiorrhizaes, 5～8 parts of Radix Notoginseng powder.
The component of preferred following weight portion is formed: 13 parts of Radix Gentianaes, 13 parts of SHANZHIZI, 13 parts of Radix Scutellariaes, 12 parts in the Radix Rehmanniae, 15 parts of Semen Plantaginiss, 12 parts of Rhizoma Alismatis, 7 parts of Caulis Akebiaes, 7 parts in Radix Glycyrrhizae, 10 parts of Radix Angelicae Sinensis, 8 parts of Radix Salviae Miltiorrhizaes, 6 parts of Radix Notoginseng powder.
A kind of method for preparing of treating the Chinese medicine composition of the retinal vein occlusion: with the dried porphyrize powder of each raw material components, cross 300 mesh sieves, mixing gets final product then.Can process the dosage form of any appropriate medically, like tablet, powder, capsule etc.With the capsule is example, No. 1 capsule of packing into of the powder behind the mixing is got final product every 0.25～0.5 gram.
Chinese medicine composition of the present invention cures mainly the retinal vein occlusion, especially to hepatobiliary hyperactivity, and blurred vision or blind suddenly, with the bitter taste irritability, it is dizzy to have a headache, yellow fur, symptoms such as wiry and frequent pulse have extraordinary curative effect.The side selects eliminating pathogen in the liver intestinal plus-minus.
Usage and consumption: oral, every day three times, each two, 10～15 days courses of treatment.
Side effect and contraindication: the clinical observation on the therapeutic effect through 20 years, patient does not have obvious toxic-side effects and takes place; Anemia of pregnant woman and allergic constitution patient forbidding.
According to China's traditional medical theory and modern medicine viewpoint, the pharmacological action of each medicine and compatibility characteristics are summarized as follows:
Dragon liver grass: bitter, tremble with fear, return liver, gallbladder meridian.Heat clearing and damp drying, eliminating pathogen in the liver gallbladder fire.Be used for jaundice due to damp-heat, swelling of the vulva pudendal pruritus, leukorrhagia, persistent erection of the penis, eczema pruritus, conjunctival congestion, deafness, hypochondriac pain, bitter taste, convulsion with spasms.
SHANZHIZI: hardship, cold, go into the heart, liver, lung, stomach warp.Function cures mainly: heat clearing away, pathogenic fire purging, removing heat from blood; Control the calentura restlessness of asrhenia type and insomnia, jaundice, gonorrhea is quenched one's thirst, conjunctival congestion, pharyngalgia is spitted blood, epistaxis, dysentery, hematuria, pathopyretic ulcer is sprained and is swollen and ache.
Radix Scutellariae: bitter, tremble with fear, return lung, gallbladder, spleen, large intestine, small intestine meridian.Heat clearing and damp drying, eliminating fire and detoxication, hemostasis, antiabortive.Be used for hygropyrexia, fever disease in summer vomiting and nausea uncomfortable in chest, damp and hot feeling of fullness, dysentery, jaundice, the cough due to lung-heat, the hyperpyrexia excessive thirst, heat in blood is told nosebleed, carbuncle sore tumefacting virus, frequent fetal movement.
The Radix Rehmanniae: sweet in the mouth, hardship, cold in nature.GUIXIN, liver, lung meridian.Have the clearing away heat and cooling blood effect, be used for the warm febrile disease blood of joining the army, high fever coma, xerostomia crimson tongue.
Semen Plantaginis: sweet, be slightly cold.Return liver, kidney, lung, small intestine meridian.Clearing away heat and promoting diuresis, eliminating dampness by diuresis is treating stranguria, makes eye bright, and eliminates the phlegm.Be used for the edema distension, the puckery pain of pyretic stranguria, diarrhea due to summer heat and dampness, conjunctival congestion and swelling pain, phlegm-heat cough.
Rhizoma Alismatis: sweet, cold.Return kidney, urinary bladder channel.Diuresis, clearing away damp-heat.Be used for dysuria, edema distension, the oliguria of having loose bowels, dizziness due to fluid-retention, the puckery pain of pyretic stranguria; Hyperlipidemia.
Caulis Akebiae: pathogenic fire purging row water.Promoting blood circulation.Control hot urination, stranguria with turbid discharge, edema, irritable feverish sensation in the chest, sore throat pharyngalgia, inflexible pain all over, women's amenorrhea, galactostasis.
Radix Glycyrrhizae: invigorating the spleen and replenishing QI, heat-clearing and toxic substances removing, expelling phlegm for arresting cough, relieving spasm to stop pain, coordinating the actions of various ingredients in a prescription.Be used for weakness of the spleen and stomach, fatigue and weakness, shortness of breath and palpitation, cough with copious phlegm, gastral cavity abdomen, the anxious pain of extremity contraction, carbuncle sore tumefacting virus, cushion toxicity, strong.
Radix Angelicae Sinensis: sweet, hot, temperature.Return liver, the heart, spleen channel.Enrich blood and invigorate blood circulation, menstruction regulating and pain relieving, loosening bowel to relieve constipation.Be used for blood deficiency and yellow complexion, dizzy cardiopalmus, menoxenia, amenorrhea dysmenorrhea, asthenia cold abdominalgia, dryness of the intestine constipation, rheumatic arthralgia, injury from falling down, ulcer sores.The Radix Angelicae Sinensis (processed with wine) promoting blood circulation to restore menstrual flow.Be used for the amenorrhea dysmenorrhea, rheumatic arthralgia, injury from falling down.
Radix Salviae Miltiorrhizae: hardship is slightly cold.GUIXIN, Liver Channel.Stasis-dispelling and pain-killing, promoting blood circulation to restore menstrual flow, relieving restlessness clears away heart-fire.Be used for menoxenia, the amenorrhea dysmenorrhea, lump in the abdomen, breast ventral spine pain, pyretic arthralgia pain, skin infection swells and ache, dysphoria and insomnia; Hepatosplenomegaly, angina pectoris.
Radix Notoginseng powder: the composition of Radix Notoginseng powder is the same with the Radix Notoginseng main root; Be rich in arasaponin, Radix Notoginseng polysaccharide, dencichine, flavone effective ingredient, have effects such as hemostasis, blood circulation promoting and blood stasis dispelling, subduing swelling and relieving pain, strengthening by means of tonics, resisting fatigue, anoxia enduring, defying age, blood fat reducing, blood sugar lowering, human body immunity improving function.
The pharmacological action of big in recent years quantity research proof drug for invigorating blood circulation and eliminating stasis is to correct microcirculation disturbance, improves hemorheological property, and the hematoblastic cohesion of depolymerization promotes the absorption of retinal hemorrhage and the formation of collateral circulation.Therefore, the blood circulation promoting and blood stasis dispelling method is the main effective ways of treatment primary disease.The inventor is divided into vein obstruction with reference to the related data of motherland's medical science: hepatobiliary hyperactivity, stagnation of QI due to depression of the liver, three types of deficiency of the spleen causing weakness of QI are carried out dialectical executing and are controlled.Prescription of the present invention is the prescription of special for treating hepatobiliary hyperactivity.
Prescription of the present invention is according to China's theory of TCM, in conjunction with inventor's clinical research for many years, thinks that treatment improves the ophthalmic blood circulation with blood circulation promoting and blood stasis dispelling; In the side; Dissipating blood stasis, reducing swelling and alleviating pain but Radix Salviae Miltiorrhizae blood circulation promoting and blood stasis dispelling, but Poria eliminating dampness by diuresis diuresis, spleen-benefiting mind-tranquilizing, Radix Notoginseng can stop blooding; Dragon liver grass has heat clearing and damp drying, eliminating pathogen in the liver gallbladder fire action.The SHANZHIZI heat clearing away, pathogenic fire purging, removing heat from blood; Control calentura restlessness of asrhenia type and insomnia disease.The Radix Scutellariae heat clearing and damp drying, eliminating fire and detoxication, hemostasis.The Radix Rehmanniae plays the clearing away heat and cooling blood effect.The Semen Plantaginis clearing away heat and promoting diuresis, eliminating dampness by diuresis is treating stranguria, makes eye bright, and is used for the edema distension, the puckery pain of pyretic stranguria, diarrhea due to summer heat and dampness, conjunctival congestion and swelling pain, phlegm-heat cough.The Rhizoma Alismatis diuresis, clearing away damp-heat is used for the edema distension, the oliguria of having loose bowels, dizziness due to fluid-retention, the puckery pain of pyretic stranguria; Hyperlipidemia.This prescription has been given prominence to the characteristics of theory of Chinese medical science in therapeutic process; Can make each efficacy of drugs produce synergism; Thereby can stop blooding removing heat from blood, blood circulation-activating eyesight-improving effectively, have effects such as promoting blood circulation to remove obstruction in the collateral, hard masses softening and resolving, dissipating blood stasis hemostasis, reducing swelling and alleviating pain, 10～15 days is a course of treatment; 1～3 day takes effect, and gets final product rehabilitation 3～4 courses of treatment.This prescription is a natural Chinese medicines, and it is little to have an effect, and therapeutical effect is unique, and through clinical 2500 routine patients' application verification, effective percentage is up to 97.38%, and cure rate reaches 77%.
The present invention has the following advantages: 1, pure Chinese medicinal preparation, and easy to use, no obvious toxic-side effects.2, instant effect, determined curative effect, the medicine source is extensive, and is with low cost.3, treating both the principal and secondary aspects of a disease, long-term effect is good.
The specific embodiment
Below in conjunction with embodiment and case the present invention is further described:
Embodiment 1: prepare a kind of Chinese medicine composition of treating the retinal vein occlusion: get Radix Gentianae 10g, SHANZHIZI 10g, Radix Scutellariae 10g, Radix Rehmanniae 10g, Semen Plantaginis 10g; Rhizoma Alismatis 10g, Caulis Akebiae 5g, Radix Glycyrrhizae 3g, Radix Angelicae Sinensis 5g; Radix Salviae Miltiorrhizae 5g, Radix Notoginseng powder 5g, dried porphyrize powder is crossed 300 mesh sieves, and No. 1 capsule of packing into gets final product.
Embodiment 2: prepare a kind of Chinese medicine composition of treating the retinal vein occlusion: get Radix Gentianae 15g, SHANZHIZI 15g, Radix Scutellariae 15g, Radix Rehmanniae 15g, Semen Plantaginis 15g, Rhizoma Alismatis 15g, Caulis Akebiae 10g, Radix Glycyrrhizae 6g, Radix Angelicae Sinensis 10g.Radix Salviae Miltiorrhizae 10g, Radix Notoginseng powder 5g, dried porphyrize powder is crossed 300 mesh sieves, and No. 1 capsule of packing into gets final product.
Embodiment 3: prepare a kind of Chinese medicine composition of treating the retinal vein occlusion: get Radix Gentianae 13g, SHANZHIZI 13g, Radix Scutellariae 13g, Radix Rehmanniae 12g; Semen Plantaginis 15g, Rhizoma Alismatis 12g, Caulis Akebiae 7g; Radix Glycyrrhizae 7g, Radix Angelicae Sinensis 10g, Radix Salviae Miltiorrhizae 8g, Radix Notoginseng powder 6g; Dried porphyrize powder is crossed 300 mesh sieves, and No. 1 capsule of packing into gets final product.
Embodiment 4: prepare a kind of Chinese medicine composition of treating the retinal vein occlusion: get Radix Gentianae 15g, SHANZHIZI 15g, Radix Scutellariae 15g, Radix Rehmanniae 15g; Semen Plantaginis 20g, Rhizoma Alismatis 15g, Caulis Akebiae 9g; Radix Glycyrrhizae 10g, Radix Angelicae Sinensis 15g, Radix Salviae Miltiorrhizae 10g, Radix Notoginseng powder 8g; Dried porphyrize powder is crossed 300 mesh sieves, and No. 1 capsule of packing into gets final product.
Clinical data:
1, data:
The case data is selected in January, 2004--and have complete outpatient service data and inpatient 4930 examples in October, 2008, be divided into treatment at random and organize 2500 examples, matched group 2430 examples.The treatment group age is at 20～80 years old, the course of disease 1～10 year.The matched group age is at 18～79 years old, the course of disease 2～11 years.Men and women's the ratio and the course of disease are through X 2 test (P＞0.05) not statistically significant.
2, Therapeutic Method: the treatment group adopts different wavelength krypton lasers in treatment, and uses prescription capsule of the present invention, divides every day oral 3 ante cibum, and each 2,10 days is a course of treatment.Matched group adopts different wavelength krypton lasers in treatment, and according to circumstances energizes and close microcirculation improvement, and the intravenous drip of FUFANG XUESHUANTONG injection promotes occluding vascular; Iodine is closed in oral lecithin Lip river, facilitate hemorrhage, ooze out absorption.
3, statistical method: two groups clinical uses X 2 test, between two groups relatively, the RIDUT check, the cure rate of treatment group as a result is apparently higher than matched group, not statistically significant relatively between the total effective rate group.(seeing table 1)
Table 1. liang group cure rate synopsis
Annotate: P＞0.001
4, side effect and contraindication:
Side effect: the clinical observation on the therapeutic effect through 20 years, patient does not have obvious toxic-side effects and takes place.
Contraindication: anemia of pregnant woman and allergic constitution patient forbidding.
Case 1: Zhang, the woman, 55 years old, because of blurred vision; Vision descends suddenly to accompanying and is in a very depressed state, and uncomfortable in chest sighing has a dizzy spell institute to go to a doctor, and examination of ocular fundus is the center to look nipple; Along a large amount of flamboyancy retinal hemorrhages of venous tributary, to begin to learn when getting into vitreous body, vitreous opacity appears, can not get a glimpse of the optical fundus; Tremulous pulse obviously attenuates, and vein is obviously expanded tortuous, and color is dark just like the sausage shape; It is red to look the nipple color, obscurity boundary; There is edema at the macula lutea initial stage.Venectasia, congestion, flame-shaped hemorrhage, edema.Adopt two courses of treatment of different wavelength krypton lasers in treatment, take 2 courses of treatment, vision restoration is normal, with examining 1 year, does not have recurrence.
Case 2: Lee so-and-so, the woman, 35 years old, because of blurred vision; Vision descends suddenly to accompanying and is in a very depressed state, and uncomfortable in chest sighing has a dizzy spell institute to go to a doctor, and examination of ocular fundus is the center to look nipple; Along a large amount of flamboyancy retinal hemorrhages of venous tributary, to begin to learn when getting into vitreous body, vitreous opacity appears, can not get a glimpse of the optical fundus; Tremulous pulse obviously attenuates, and vein is obviously expanded tortuous, and color is dark just like the sausage shape; It is red to look the nipple color, obscurity boundary; There is edema at the macula lutea initial stage.Venectasia, congestion, flame-shaped hemorrhage, edema.Adopt two courses of treatment of different wavelength krypton lasers in treatment, take 2 courses of treatment, vision restoration is normal, with examining half a year, does not have recurrence.
Case 3: willow so-and-so, the man, 45 years old, because of blurred vision; Vision descends suddenly to accompanying and is in a very depressed state, and uncomfortable in chest sighing has a dizzy spell institute to go to a doctor, and examination of ocular fundus is the center to look nipple; Along a large amount of flamboyancy retinal hemorrhages of venous tributary, to begin to learn when getting into vitreous body, vitreous opacity appears, can not get a glimpse of the optical fundus; Tremulous pulse obviously attenuates, and vein is obviously expanded tortuous, and color is dark just like the sausage shape; It is red to look the nipple color, obscurity boundary; There is edema at the macula lutea initial stage.Venectasia, congestion, flame-shaped hemorrhage, edema.Adopt two courses of treatment of different wavelength krypton lasers in treatment, take 2 courses of treatment, vision restoration is normal, with examining 1.5 years, does not have recurrence.
Case 4, Wang, the man, 40 years old, the patient was blind because of suddenly, and with the bitter taste irritability, it is dizzy to have a headache, fluorescence fundus angiography: a tremulous pulse and obstruction tremulous pulse of following is normal, blocks the tremulous pulse caliber thickness of a following inequality, attenuates.Can be with the artery and vein crossing compression, branch's small artery white line shape is inaccessible, and arm-retinal circulation time prolongs.Tortuous, the expansion of vein is arranged, and arteriovenous infall compression of vein attenuates, and is the nib shape, and the caliber thickness is uneven, and the blood post is the sections shape, and sees vein cutout phenomenon, and pressurized place fluorescein seepage presents high fluorescent spot; Artery and vein infall vein is the locking of white line shape.The blocked-off region blood capillary is the terraced fields dress does not have perfusion.CME is arranged, be petal appearance seepage.Adopt two courses of treatment of different wavelength krypton lasers in treatment, cooperate and take 2 courses of treatment of capsule of the present invention, vision restoration is very fast, continues to take two courses of treatment, and vision restoration is good, and life can be taken care of oneself basically.
Claims (5)
1. a Chinese medicine composition of treating the retinal vein occlusion is characterized in that, is made up of the component of following weight portion: 10～15 parts of Radix Gentianaes; 10～15 parts of SHANZHIZI, 10～15 parts of Radix Scutellariaes, 10～15 parts in the Radix Rehmanniae; 10～20 parts of Semen Plantaginiss, 10～15 parts of Rhizoma Alismatis, 5～10 parts of Caulis Akebiaes; 3～10 parts in Radix Glycyrrhizae, 5～15 parts of Radix Angelicae Sinensis, 5～10 parts of Radix Salviae Miltiorrhizaes, 5～8 parts of Radix Notoginseng powder.
2. a kind of Chinese medicine composition of treating the retinal vein occlusion according to claim 1 is characterized in that, is made up of the component of following weight portion: 10 parts of Radix Gentianaes; 10 parts of SHANZHIZI, 10 parts of Radix Scutellariaes, 10 parts in the Radix Rehmanniae; 10 parts of Semen Plantaginiss, 10 parts of Rhizoma Alismatis, 5 parts of Caulis Akebiaes; 3 parts in Radix Glycyrrhizae, 5 parts of Radix Angelicae Sinensis, 5 parts of Radix Salviae Miltiorrhizaes, 5 parts of Radix Notoginseng powder.
3. a kind of Chinese medicine composition of treating the retinal vein occlusion according to claim 1 is characterized in that, is made up of the component of following weight portion: 13 parts of Radix Gentianaes; 13 parts of SHANZHIZI, 13 parts of Radix Scutellariaes, 12 parts in the Radix Rehmanniae; 15 parts of Semen Plantaginiss, 12 parts of Rhizoma Alismatis, 7 parts of Caulis Akebiaes; 7 parts in Radix Glycyrrhizae, 10 parts of Radix Angelicae Sinensis, 8 parts of Radix Salviae Miltiorrhizaes, 6 parts of Radix Notoginseng powder.
4. the described a kind of method for preparing of treating the Chinese medicine composition of the retinal vein occlusion of claim 1 is characterized in that: with the dried porphyrize powder of each raw material components, cross 300 mesh sieves, mixing gets final product.
5. a kind of method for preparing of treating the Chinese medicine composition of the retinal vein occlusion according to claim 4 is characterized in that: be made in tablet, powder, the capsule any.
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| CN106880781A (en) * | 2017-02-27 | 2017-06-23 | 梁省春 | Treat the medicine of retinal vein obstruction |
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