CN101087602B - L-肉碱和葡萄糖治疗心血管疾病的应用 - Google Patents

L-肉碱和葡萄糖治疗心血管疾病的应用 Download PDF

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Publication number
CN101087602B
CN101087602B CN2005800234751A CN200580023475A CN101087602B CN 101087602 B CN101087602 B CN 101087602B CN 2005800234751 A CN2005800234751 A CN 2005800234751A CN 200580023475 A CN200580023475 A CN 200580023475A CN 101087602 B CN101087602 B CN 101087602B
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CN
China
Prior art keywords
carnitine
application
acid
glucose
glucose solution
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CN2005800234751A
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English (en)
Chinese (zh)
Other versions
CN101087602A (zh
Inventor
A·科沃里奇
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Alpha Sigma Co ltd
Original Assignee
Sigma Tau Industrie Farmaceutiche Riunite SpA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sigma Tau Industrie Farmaceutiche Riunite SpA filed Critical Sigma Tau Industrie Farmaceutiche Riunite SpA
Priority to CN201110226409.1A priority Critical patent/CN102349923B/zh
Publication of CN101087602A publication Critical patent/CN101087602A/zh
Application granted granted Critical
Publication of CN101087602B publication Critical patent/CN101087602B/zh
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/205—Amine addition salts of organic acids; Inner quaternary ammonium salts, e.g. betaine, carnitine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
    • A61K31/221—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin with compounds having an amino group, e.g. acetylcholine, acetylcarnitine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7004—Monosaccharides having only carbon, hydrogen and oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Cardiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Molecular Biology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Emergency Medicine (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Hospice & Palliative Care (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CN2005800234751A 2004-07-13 2005-06-21 L-肉碱和葡萄糖治疗心血管疾病的应用 Expired - Fee Related CN101087602B (zh)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN201110226409.1A CN102349923B (zh) 2004-07-13 2005-06-21 L-肉碱和葡萄糖治疗心血管疾病的应用

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
ITRM2004A000346 2004-07-13
IT000346A ITRM20040346A1 (it) 2004-07-13 2004-07-13 Uso della l-carnitina per il trattamento di patologie cardiovascolari.
PCT/EP2005/006657 WO2006005415A2 (en) 2004-07-13 2005-06-21 Use of l-carnitine and glucose for the treatment of cardiovascular diseases

Related Child Applications (1)

Application Number Title Priority Date Filing Date
CN201110226409.1A Division CN102349923B (zh) 2004-07-13 2005-06-21 L-肉碱和葡萄糖治疗心血管疾病的应用

Publications (2)

Publication Number Publication Date
CN101087602A CN101087602A (zh) 2007-12-12
CN101087602B true CN101087602B (zh) 2011-09-14

Family

ID=34971575

Family Applications (2)

Application Number Title Priority Date Filing Date
CN2005800234751A Expired - Fee Related CN101087602B (zh) 2004-07-13 2005-06-21 L-肉碱和葡萄糖治疗心血管疾病的应用
CN201110226409.1A Expired - Fee Related CN102349923B (zh) 2004-07-13 2005-06-21 L-肉碱和葡萄糖治疗心血管疾病的应用

Family Applications After (1)

Application Number Title Priority Date Filing Date
CN201110226409.1A Expired - Fee Related CN102349923B (zh) 2004-07-13 2005-06-21 L-肉碱和葡萄糖治疗心血管疾病的应用

Country Status (21)

Country Link
US (2) US7879908B2 (enExample)
EP (1) EP1773314B1 (enExample)
JP (1) JP5230195B2 (enExample)
KR (1) KR101296479B1 (enExample)
CN (2) CN101087602B (enExample)
AT (1) ATE542529T1 (enExample)
AU (1) AU2005262050B2 (enExample)
BR (1) BRPI0513303A8 (enExample)
CA (1) CA2569888C (enExample)
CY (1) CY1112686T1 (enExample)
DK (1) DK1773314T3 (enExample)
ES (1) ES2380913T3 (enExample)
HR (1) HRP20120178T1 (enExample)
IT (1) ITRM20040346A1 (enExample)
ME (1) ME01345B (enExample)
MX (1) MXPA06014665A (enExample)
PL (1) PL1773314T3 (enExample)
PT (1) PT1773314E (enExample)
RS (1) RS52253B (enExample)
SI (1) SI1773314T1 (enExample)
WO (1) WO2006005415A2 (enExample)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR086543A1 (es) * 2011-05-25 2014-01-08 Bg Medicine Inc Inhibidores de galectina-3 y metodos de uso de los mismos, composicion farmaceutica

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004091602A1 (en) * 2003-04-17 2004-10-28 Sigma-Tau Industrie Farmaceutiche Riunite S.P.A. Use of l-carnitine for the treatment of cardiovascular diseases

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1120033B (it) * 1979-10-05 1986-03-19 Sigma Tau Ind Farmaceuti Composizione farmaceutica comprendente-carnitina adatta per l'alimentazione parenterale
JPS6415220A (en) 1987-07-06 1989-01-19 Mitsubishi Electric Corp Tension control device for utilizing maximum torque and maximum electric current of winding motor
JPH06102624B2 (ja) * 1990-08-10 1994-12-14 アース製薬株式会社 非心臓由来の不整脈防止薬
IT1261695B (it) * 1993-06-02 1996-05-29 Sigma Tau Ind Farmaceuti Impiego di l-carnitina e alcanoil l-carnitine nella conservazione del sangue per trasfusioni e soluzioni stabilizzatrici che le contengono.
US5998386A (en) * 1997-09-19 1999-12-07 Feldman; Arthur M. Pharmaceutical compositions and method of using same for the treatment of failing myocardial tissue
WO2000030637A1 (en) * 1998-11-26 2000-06-02 Sigma-Tau Industrie Farmaceutiche Riunite S.P.A. Use of fumarate salt of l-carnitine or its alkanoyl derivatives in ischaemia
KR100642731B1 (ko) * 1999-10-11 2006-11-03 시그마타우 인두스트리에 파르마슈티케 리우니테 에스.피.에이. 의료용 용액에서 삼투제로서 ｌ-카르니틴 및 그의알카노일 유도체의 용도
JP4674046B2 (ja) * 2002-04-01 2011-04-20 ザ ガバナーズ オブ ザ ユニバーシティ オブ アルバータ グルコース利用を刺激する化合物および使用方法

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004091602A1 (en) * 2003-04-17 2004-10-28 Sigma-Tau Industrie Farmaceutiche Riunite S.P.A. Use of l-carnitine for the treatment of cardiovascular diseases

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
Grandi M. et al.Effect of acute carnitine administration on glucose insulinmetabolism in healthy subjects.Int. J. Clin. Pharm. Res. 4.1997,(4),143-147. *
Michael A. Arsenian et al.Safety, Tolerability, and Efficacyof a GIucose-lnsulin-Potassium-Magnesium-Carnitine Solution in Acute MyocardialInfarction.THE AMERICAN JOURNAL OF Cardiology78.1996,78476-479. *
崔俊友 等.急性心肌梗塞早期应用L-肉碱临床疗效观察.江苏临床医学杂志3 4.1999,3(4),331. *
张钧.肉碱在心血管疾病发生中的作用.心血管康复医学杂志12 6.2003,12(6),565-566. *
马宏星 等.肉碱与心血管疾病.心血管病学进展21 5.2000,21(5),309-310. *

Also Published As

Publication number Publication date
RS52253B (sr) 2012-10-31
ITRM20040346A1 (it) 2004-10-13
HK1166003A1 (zh) 2012-10-19
MXPA06014665A (es) 2007-03-12
ME01345B (me) 2012-10-31
CN102349923A (zh) 2012-02-15
HRP20120178T1 (hr) 2012-05-31
JP5230195B2 (ja) 2013-07-10
BRPI0513303A (pt) 2008-05-06
KR20070039541A (ko) 2007-04-12
WO2006005415A2 (en) 2006-01-19
ES2380913T3 (es) 2012-05-21
CA2569888C (en) 2013-08-13
CN102349923B (zh) 2016-04-27
US20070207970A1 (en) 2007-09-06
US8394854B2 (en) 2013-03-12
KR101296479B1 (ko) 2013-08-13
ATE542529T1 (de) 2012-02-15
PT1773314E (pt) 2012-03-29
AU2005262050B2 (en) 2011-02-24
DK1773314T3 (da) 2012-05-07
PL1773314T3 (pl) 2012-06-29
HK1113542A1 (en) 2008-10-10
AU2005262050A1 (en) 2006-01-19
EP1773314A2 (en) 2007-04-18
US7879908B2 (en) 2011-02-01
US20110086917A1 (en) 2011-04-14
CY1112686T1 (el) 2016-02-10
WO2006005415A3 (en) 2006-05-26
EP1773314B1 (en) 2012-01-25
CA2569888A1 (en) 2006-01-19
SI1773314T1 (sl) 2012-04-30
BRPI0513303A8 (pt) 2017-12-26
CN101087602A (zh) 2007-12-12
JP2008517872A (ja) 2008-05-29

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Granted publication date: 20110914