CA2569888C - Use of l-carnitine for the treatment of cardiovascular diseases - Google Patents

Use of l-carnitine for the treatment of cardiovascular diseases Download PDF

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Publication number
CA2569888C
CA2569888C CA2569888A CA2569888A CA2569888C CA 2569888 C CA2569888 C CA 2569888C CA 2569888 A CA2569888 A CA 2569888A CA 2569888 A CA2569888 A CA 2569888A CA 2569888 C CA2569888 C CA 2569888C
Authority
CA
Canada
Prior art keywords
carnitine
acid
infarction
glucose
day
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
CA2569888A
Other languages
English (en)
French (fr)
Other versions
CA2569888A1 (en
Inventor
Aleardo Koverech
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Alfasigma SpA
Original Assignee
Sigma Tau Industrie Farmaceutiche Riunite SpA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sigma Tau Industrie Farmaceutiche Riunite SpA filed Critical Sigma Tau Industrie Farmaceutiche Riunite SpA
Publication of CA2569888A1 publication Critical patent/CA2569888A1/en
Application granted granted Critical
Publication of CA2569888C publication Critical patent/CA2569888C/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/205—Amine addition salts of organic acids; Inner quaternary ammonium salts, e.g. betaine, carnitine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
    • A61K31/221—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin with compounds having an amino group, e.g. acetylcholine, acetylcarnitine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7004—Monosaccharides having only carbon, hydrogen and oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Cardiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Emergency Medicine (AREA)
  • Molecular Biology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Hospice & Palliative Care (AREA)
  • Urology & Nephrology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CA2569888A 2004-07-13 2005-06-21 Use of l-carnitine for the treatment of cardiovascular diseases Expired - Lifetime CA2569888C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
IT000346A ITRM20040346A1 (it) 2004-07-13 2004-07-13 Uso della l-carnitina per il trattamento di patologie cardiovascolari.
ITRM2004A000346 2004-07-13
PCT/EP2005/006657 WO2006005415A2 (en) 2004-07-13 2005-06-21 Use of l-carnitine and glucose for the treatment of cardiovascular diseases

Publications (2)

Publication Number Publication Date
CA2569888A1 CA2569888A1 (en) 2006-01-19
CA2569888C true CA2569888C (en) 2013-08-13

Family

ID=34971575

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2569888A Expired - Lifetime CA2569888C (en) 2004-07-13 2005-06-21 Use of l-carnitine for the treatment of cardiovascular diseases

Country Status (21)

Country Link
US (2) US7879908B2 (enExample)
EP (1) EP1773314B1 (enExample)
JP (1) JP5230195B2 (enExample)
KR (1) KR101296479B1 (enExample)
CN (2) CN102349923B (enExample)
AT (1) ATE542529T1 (enExample)
AU (1) AU2005262050B2 (enExample)
BR (1) BRPI0513303A8 (enExample)
CA (1) CA2569888C (enExample)
CY (1) CY1112686T1 (enExample)
DK (1) DK1773314T3 (enExample)
ES (1) ES2380913T3 (enExample)
HR (1) HRP20120178T1 (enExample)
IT (1) ITRM20040346A1 (enExample)
ME (1) ME01345B (enExample)
MX (1) MXPA06014665A (enExample)
PL (1) PL1773314T3 (enExample)
PT (1) PT1773314E (enExample)
RS (1) RS52253B (enExample)
SI (1) SI1773314T1 (enExample)
WO (1) WO2006005415A2 (enExample)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR086543A1 (es) * 2011-05-25 2014-01-08 Bg Medicine Inc Inhibidores de galectina-3 y metodos de uso de los mismos, composicion farmaceutica

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1120033B (it) * 1979-10-05 1986-03-19 Sigma Tau Ind Farmaceuti Composizione farmaceutica comprendente-carnitina adatta per l'alimentazione parenterale
JPS6415220A (en) 1987-07-06 1989-01-19 Mitsubishi Electric Corp Tension control device for utilizing maximum torque and maximum electric current of winding motor
JPH06102624B2 (ja) * 1990-08-10 1994-12-14 アース製薬株式会社 非心臓由来の不整脈防止薬
IT1261695B (it) * 1993-06-02 1996-05-29 Sigma Tau Ind Farmaceuti Impiego di l-carnitina e alcanoil l-carnitine nella conservazione del sangue per trasfusioni e soluzioni stabilizzatrici che le contengono.
US5998386A (en) * 1997-09-19 1999-12-07 Feldman; Arthur M. Pharmaceutical compositions and method of using same for the treatment of failing myocardial tissue
AU1295700A (en) * 1998-11-26 2000-06-13 Sigma-Tau Industrie Farmaceutiche Riunite S.P.A. Use of fumarate salt of l-carnitine or its alkanoyl derivatives in ischaemia
MXPA02003635A (es) * 1999-10-11 2002-10-23 Sigma Tau Ind Farmaceuti Uso de l-carnitina y sus derivados de alcanoilo como agentes osmoticos en soluciones para uso medico.
JP4674046B2 (ja) * 2002-04-01 2011-04-20 ザ ガバナーズ オブ ザ ユニバーシティ オブ アルバータ グルコース利用を刺激する化合物および使用方法
ITRM20030178A1 (it) 2003-04-17 2004-10-18 Sigma Tau Ind Farmaceuti Uso della l-carnitina per il trattamento di patologie cardiovascolari.

Also Published As

Publication number Publication date
US8394854B2 (en) 2013-03-12
CN101087602B (zh) 2011-09-14
CN102349923A (zh) 2012-02-15
ITRM20040346A1 (it) 2004-10-13
JP5230195B2 (ja) 2013-07-10
PT1773314E (pt) 2012-03-29
KR20070039541A (ko) 2007-04-12
ME01345B (me) 2012-10-31
PL1773314T3 (pl) 2012-06-29
DK1773314T3 (da) 2012-05-07
US20110086917A1 (en) 2011-04-14
WO2006005415A2 (en) 2006-01-19
HK1113542A1 (en) 2008-10-10
ATE542529T1 (de) 2012-02-15
EP1773314A2 (en) 2007-04-18
HRP20120178T1 (hr) 2012-05-31
US7879908B2 (en) 2011-02-01
RS52253B (sr) 2012-10-31
AU2005262050A1 (en) 2006-01-19
WO2006005415A3 (en) 2006-05-26
HK1166003A1 (zh) 2012-10-19
US20070207970A1 (en) 2007-09-06
EP1773314B1 (en) 2012-01-25
KR101296479B1 (ko) 2013-08-13
AU2005262050B2 (en) 2011-02-24
BRPI0513303A (pt) 2008-05-06
BRPI0513303A8 (pt) 2017-12-26
CA2569888A1 (en) 2006-01-19
CN101087602A (zh) 2007-12-12
CN102349923B (zh) 2016-04-27
CY1112686T1 (el) 2016-02-10
MXPA06014665A (es) 2007-03-12
SI1773314T1 (sl) 2012-04-30
JP2008517872A (ja) 2008-05-29
ES2380913T3 (es) 2012-05-21

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Legal Events

Date Code Title Description
EEER Examination request
H11 Ip right ceased following rejected request for revival

Free format text: ST27 STATUS EVENT CODE: T-6-6-H10-H11-H101 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: TIME LIMIT FOR REVERSAL EXPIRED

Effective date: 20241223