BRPI0513303A - uso de l-carnitina para o tratamento de doenças cardiovasculares - Google Patents
uso de l-carnitina para o tratamento de doenças cardiovascularesInfo
- Publication number
- BRPI0513303A BRPI0513303A BRPI0513303-3A BRPI0513303A BRPI0513303A BR PI0513303 A BRPI0513303 A BR PI0513303A BR PI0513303 A BRPI0513303 A BR PI0513303A BR PI0513303 A BRPI0513303 A BR PI0513303A
- Authority
- BR
- Brazil
- Prior art keywords
- carnitine
- infarction
- treatment
- grams
- days
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/205—Amine addition salts of organic acids; Inner quaternary ammonium salts, e.g. betaine, carnitine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
- A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
- A61K31/221—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin with compounds having an amino group, e.g. acetylcholine, acetylcarnitine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7004—Monosaccharides having only carbon, hydrogen and oxygen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Cardiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Molecular Biology (AREA)
- Emergency Medicine (AREA)
- Heart & Thoracic Surgery (AREA)
- Vascular Medicine (AREA)
- Hospice & Palliative Care (AREA)
- Urology & Nephrology (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
USO DE L-CARNITINA PARA O TRATAMENTO DE DOENçAS CARDIOVASCULARES. A presente invenção refere-se ao uso de L-carnitina, ou um de seus sais farmaceuticamente aceitáveis, é descrito em combinação com glicose para a preparação de um medicamento útil para diminuir o número de mortes causadas por infarto do miocárdio agudo, para reduzir o número de dias gasto por pacientes de infarto em cuidados intensivos em hospital, e para reduzir o número de episódios de insuficiência cardíaca pós-infarto, em que a L-carnitina é administrada intravenosamente dentro apenas de algumas horas do início de sintomas de infarto do miocárdio agudo em uma dose inicial de 9 gramas ao dia em combinação com 1000 a 1500 mL de uma solução de glicose a 5% durante 5 dias, após o que o tratamento com L-carnitina é continuado em uma dose de 4 gramas ao dia administrados oralmente.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT000346A ITRM20040346A1 (it) | 2004-07-13 | 2004-07-13 | Uso della l-carnitina per il trattamento di patologie cardiovascolari. |
| PCT/EP2005/006657 WO2006005415A2 (en) | 2004-07-13 | 2005-06-21 | Use of l-carnitine and glucose for the treatment of cardiovascular diseases |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| BRPI0513303A true BRPI0513303A (pt) | 2008-05-06 |
| BRPI0513303A8 BRPI0513303A8 (pt) | 2017-12-26 |
Family
ID=34971575
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BRPI0513303A BRPI0513303A8 (pt) | 2004-07-13 | 2005-06-21 | Uso de l-carnitina para o tratamento de doenças cardiovasculares |
Country Status (22)
| Country | Link |
|---|---|
| US (2) | US7879908B2 (pt) |
| EP (1) | EP1773314B1 (pt) |
| JP (1) | JP5230195B2 (pt) |
| KR (1) | KR101296479B1 (pt) |
| CN (2) | CN102349923B (pt) |
| AT (1) | ATE542529T1 (pt) |
| AU (1) | AU2005262050B2 (pt) |
| BR (1) | BRPI0513303A8 (pt) |
| CA (1) | CA2569888C (pt) |
| CY (1) | CY1112686T1 (pt) |
| DK (1) | DK1773314T3 (pt) |
| ES (1) | ES2380913T3 (pt) |
| HK (2) | HK1113542A1 (pt) |
| HR (1) | HRP20120178T1 (pt) |
| IT (1) | ITRM20040346A1 (pt) |
| ME (1) | ME01345B (pt) |
| MX (1) | MXPA06014665A (pt) |
| PL (1) | PL1773314T3 (pt) |
| PT (1) | PT1773314E (pt) |
| RS (1) | RS52253B (pt) |
| SI (1) | SI1773314T1 (pt) |
| WO (1) | WO2006005415A2 (pt) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AR086543A1 (es) * | 2011-05-25 | 2014-01-08 | Bg Medicine Inc | Inhibidores de galectina-3 y metodos de uso de los mismos, composicion farmaceutica |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IT1120033B (it) * | 1979-10-05 | 1986-03-19 | Sigma Tau Ind Farmaceuti | Composizione farmaceutica comprendente-carnitina adatta per l'alimentazione parenterale |
| JPS6415220A (en) | 1987-07-06 | 1989-01-19 | Mitsubishi Electric Corp | Tension control device for utilizing maximum torque and maximum electric current of winding motor |
| JPH06102624B2 (ja) * | 1990-08-10 | 1994-12-14 | アース製薬株式会社 | 非心臓由来の不整脈防止薬 |
| IT1261695B (it) | 1993-06-02 | 1996-05-29 | Sigma Tau Ind Farmaceuti | Impiego di l-carnitina e alcanoil l-carnitine nella conservazione del sangue per trasfusioni e soluzioni stabilizzatrici che le contengono. |
| US5998386A (en) * | 1997-09-19 | 1999-12-07 | Feldman; Arthur M. | Pharmaceutical compositions and method of using same for the treatment of failing myocardial tissue |
| WO2000030637A1 (en) * | 1998-11-26 | 2000-06-02 | Sigma-Tau Industrie Farmaceutiche Riunite S.P.A. | Use of fumarate salt of l-carnitine or its alkanoyl derivatives in ischaemia |
| DK1220670T3 (da) * | 1999-10-11 | 2006-12-18 | Sigma Tau Ind Farmaceuti | Anvendelse af L-carnitin og dets alkanoylderivater som osmotiske stoffer i oplösninger til medicinsk anvendelse |
| CA2480557C (en) * | 2002-04-01 | 2013-02-19 | Gary David Lopaschuk | Cycloalkylcarboxyl derivatives that stimulate glucose utilization and methods of use |
| ITRM20030178A1 (it) | 2003-04-17 | 2004-10-18 | Sigma Tau Ind Farmaceuti | Uso della l-carnitina per il trattamento di patologie cardiovascolari. |
-
2004
- 2004-07-13 IT IT000346A patent/ITRM20040346A1/it unknown
-
2005
- 2005-06-21 BR BRPI0513303A patent/BRPI0513303A8/pt not_active Application Discontinuation
- 2005-06-21 EP EP05755616A patent/EP1773314B1/en active Active
- 2005-06-21 AT AT05755616T patent/ATE542529T1/de active
- 2005-06-21 RS RS20120095A patent/RS52253B/en unknown
- 2005-06-21 ME MEP-2012-32A patent/ME01345B/me unknown
- 2005-06-21 US US11/629,202 patent/US7879908B2/en active Active
- 2005-06-21 KR KR1020077000711A patent/KR101296479B1/ko active IP Right Grant
- 2005-06-21 DK DK05755616.9T patent/DK1773314T3/da active
- 2005-06-21 CA CA2569888A patent/CA2569888C/en active Active
- 2005-06-21 MX MXPA06014665A patent/MXPA06014665A/es not_active Application Discontinuation
- 2005-06-21 ES ES05755616T patent/ES2380913T3/es active Active
- 2005-06-21 CN CN201110226409.1A patent/CN102349923B/zh not_active Expired - Fee Related
- 2005-06-21 SI SI200531481T patent/SI1773314T1/sl unknown
- 2005-06-21 JP JP2007520688A patent/JP5230195B2/ja not_active Expired - Fee Related
- 2005-06-21 AU AU2005262050A patent/AU2005262050B2/en not_active Ceased
- 2005-06-21 WO PCT/EP2005/006657 patent/WO2006005415A2/en active Application Filing
- 2005-06-21 PL PL05755616T patent/PL1773314T3/pl unknown
- 2005-06-21 PT PT05755616T patent/PT1773314E/pt unknown
- 2005-06-21 CN CN2005800234751A patent/CN101087602B/zh not_active Expired - Fee Related
-
2008
- 2008-03-13 HK HK08102916.9A patent/HK1113542A1/xx not_active IP Right Cessation
-
2010
- 2010-12-20 US US12/972,617 patent/US8394854B2/en active Active
-
2012
- 2012-02-22 HR HRP20120178TT patent/HRP20120178T1/hr unknown
- 2012-04-05 CY CY20121100341T patent/CY1112686T1/el unknown
- 2012-07-10 HK HK12106717.5A patent/HK1166003A1/zh not_active IP Right Cessation
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B07D | Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette] | ||
| B25A | Requested transfer of rights approved |
Owner name: ALFASIGMA S.P.A. (IT) |
|
| B07E | Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette] | ||
| B07A | Application suspended after technical examination (opinion) [chapter 7.1 patent gazette] | ||
| B09B | Patent application refused [chapter 9.2 patent gazette] | ||
| B09B | Patent application refused [chapter 9.2 patent gazette] |
Free format text: MANTIDO O INDEFERIMENTO UMA VEZ QUE NAO FOI APRESENTADO RECURSO DENTRO DO PRAZO LEGAL |