CN102349923B - L-肉碱和葡萄糖治疗心血管疾病的应用 - Google Patents

L-肉碱和葡萄糖治疗心血管疾病的应用 Download PDF

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Publication number
CN102349923B
CN102349923B CN201110226409.1A CN201110226409A CN102349923B CN 102349923 B CN102349923 B CN 102349923B CN 201110226409 A CN201110226409 A CN 201110226409A CN 102349923 B CN102349923 B CN 102349923B
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China
Prior art keywords
vbt
glucose
carnitine
acid
day
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Expired - Fee Related
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CN201110226409.1A
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English (en)
Chinese (zh)
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CN102349923A (zh
Inventor
A·科沃里奇
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Alpha Sigma Co ltd
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Sigma Tau Industrie Farmaceutiche Riunite SpA
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/205—Amine addition salts of organic acids; Inner quaternary ammonium salts, e.g. betaine, carnitine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
    • A61K31/221—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin with compounds having an amino group, e.g. acetylcholine, acetylcarnitine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7004—Monosaccharides having only carbon, hydrogen and oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Cardiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Emergency Medicine (AREA)
  • Molecular Biology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Hospice & Palliative Care (AREA)
  • Urology & Nephrology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CN201110226409.1A 2004-07-13 2005-06-21 L-肉碱和葡萄糖治疗心血管疾病的应用 Expired - Fee Related CN102349923B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
IT000346A ITRM20040346A1 (it) 2004-07-13 2004-07-13 Uso della l-carnitina per il trattamento di patologie cardiovascolari.
ITRM2004A000346 2004-07-13
CN2005800234751A CN101087602B (zh) 2004-07-13 2005-06-21 L-肉碱和葡萄糖治疗心血管疾病的应用

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
CN2005800234751A Division CN101087602B (zh) 2004-07-13 2005-06-21 L-肉碱和葡萄糖治疗心血管疾病的应用

Publications (2)

Publication Number Publication Date
CN102349923A CN102349923A (zh) 2012-02-15
CN102349923B true CN102349923B (zh) 2016-04-27

Family

ID=34971575

Family Applications (2)

Application Number Title Priority Date Filing Date
CN201110226409.1A Expired - Fee Related CN102349923B (zh) 2004-07-13 2005-06-21 L-肉碱和葡萄糖治疗心血管疾病的应用
CN2005800234751A Expired - Fee Related CN101087602B (zh) 2004-07-13 2005-06-21 L-肉碱和葡萄糖治疗心血管疾病的应用

Family Applications After (1)

Application Number Title Priority Date Filing Date
CN2005800234751A Expired - Fee Related CN101087602B (zh) 2004-07-13 2005-06-21 L-肉碱和葡萄糖治疗心血管疾病的应用

Country Status (21)

Country Link
US (2) US7879908B2 (enExample)
EP (1) EP1773314B1 (enExample)
JP (1) JP5230195B2 (enExample)
KR (1) KR101296479B1 (enExample)
CN (2) CN102349923B (enExample)
AT (1) ATE542529T1 (enExample)
AU (1) AU2005262050B2 (enExample)
BR (1) BRPI0513303A8 (enExample)
CA (1) CA2569888C (enExample)
CY (1) CY1112686T1 (enExample)
DK (1) DK1773314T3 (enExample)
ES (1) ES2380913T3 (enExample)
HR (1) HRP20120178T1 (enExample)
IT (1) ITRM20040346A1 (enExample)
ME (1) ME01345B (enExample)
MX (1) MXPA06014665A (enExample)
PL (1) PL1773314T3 (enExample)
PT (1) PT1773314E (enExample)
RS (1) RS52253B (enExample)
SI (1) SI1773314T1 (enExample)
WO (1) WO2006005415A2 (enExample)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR086543A1 (es) * 2011-05-25 2014-01-08 Bg Medicine Inc Inhibidores de galectina-3 y metodos de uso de los mismos, composicion farmaceutica

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4320145A (en) * 1979-10-05 1982-03-16 Claudio Cavazza Pharmaceutical composition for parenteral nutrition comprising L-carnitine or acyl L-carnitines
EP0627161A1 (en) * 1993-06-02 1994-12-07 Sigma-Tau Industrie Farmaceutiche Riunite S.p.A. Use of L-carnitine and alkanoyl L-carnitines in the storage of blood for transfusions and stabilizing solutions containing them

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6415220A (en) 1987-07-06 1989-01-19 Mitsubishi Electric Corp Tension control device for utilizing maximum torque and maximum electric current of winding motor
JPH06102624B2 (ja) * 1990-08-10 1994-12-14 アース製薬株式会社 非心臓由来の不整脈防止薬
US5998386A (en) * 1997-09-19 1999-12-07 Feldman; Arthur M. Pharmaceutical compositions and method of using same for the treatment of failing myocardial tissue
AU1295700A (en) * 1998-11-26 2000-06-13 Sigma-Tau Industrie Farmaceutiche Riunite S.P.A. Use of fumarate salt of l-carnitine or its alkanoyl derivatives in ischaemia
MXPA02003635A (es) * 1999-10-11 2002-10-23 Sigma Tau Ind Farmaceuti Uso de l-carnitina y sus derivados de alcanoilo como agentes osmoticos en soluciones para uso medico.
JP4674046B2 (ja) * 2002-04-01 2011-04-20 ザ ガバナーズ オブ ザ ユニバーシティ オブ アルバータ グルコース利用を刺激する化合物および使用方法
ITRM20030178A1 (it) 2003-04-17 2004-10-18 Sigma Tau Ind Farmaceuti Uso della l-carnitina per il trattamento di patologie cardiovascolari.

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4320145A (en) * 1979-10-05 1982-03-16 Claudio Cavazza Pharmaceutical composition for parenteral nutrition comprising L-carnitine or acyl L-carnitines
EP0627161A1 (en) * 1993-06-02 1994-12-07 Sigma-Tau Industrie Farmaceutiche Riunite S.p.A. Use of L-carnitine and alkanoyl L-carnitines in the storage of blood for transfusions and stabilizing solutions containing them

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
急性心肌梗塞早期应用L-肉碱临床疗效观察;催俊友等;《江苏临床医学杂志》;19991231;第3卷(第4期);第331-332页 *
肉碱与心血管疾病;马宏星等;《心血管病学进展》;20001231;第21卷(第5期);第309-312页 *

Also Published As

Publication number Publication date
CA2569888C (en) 2013-08-13
US8394854B2 (en) 2013-03-12
CN101087602B (zh) 2011-09-14
CN102349923A (zh) 2012-02-15
ITRM20040346A1 (it) 2004-10-13
JP5230195B2 (ja) 2013-07-10
PT1773314E (pt) 2012-03-29
KR20070039541A (ko) 2007-04-12
ME01345B (me) 2012-10-31
PL1773314T3 (pl) 2012-06-29
DK1773314T3 (da) 2012-05-07
US20110086917A1 (en) 2011-04-14
WO2006005415A2 (en) 2006-01-19
HK1113542A1 (en) 2008-10-10
ATE542529T1 (de) 2012-02-15
EP1773314A2 (en) 2007-04-18
HRP20120178T1 (hr) 2012-05-31
US7879908B2 (en) 2011-02-01
RS52253B (sr) 2012-10-31
AU2005262050A1 (en) 2006-01-19
WO2006005415A3 (en) 2006-05-26
HK1166003A1 (zh) 2012-10-19
US20070207970A1 (en) 2007-09-06
EP1773314B1 (en) 2012-01-25
KR101296479B1 (ko) 2013-08-13
AU2005262050B2 (en) 2011-02-24
BRPI0513303A (pt) 2008-05-06
BRPI0513303A8 (pt) 2017-12-26
CA2569888A1 (en) 2006-01-19
CN101087602A (zh) 2007-12-12
CY1112686T1 (el) 2016-02-10
MXPA06014665A (es) 2007-03-12
SI1773314T1 (sl) 2012-04-30
JP2008517872A (ja) 2008-05-29
ES2380913T3 (es) 2012-05-21

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Granted publication date: 20160427