CN101085337A - Traditional Chinese medicine preparation for curing nephrotic syndrome - Google Patents

Abstract

The invention relates to a Chinese medicinal composition for treating nephrotic syndrome, which is prepared from more than ten kinds of Chinese medicinal herbs including fresh ginger peel, cassia twig, barren wort and root of bidentate achyranthes.

Description

The Chinese medicine preparation of treatment nephrotic syndrome

Technical field

The present invention relates to treat the Chinese medicine preparation of nephrotic syndrome, is that a kind of nephrotic syndrome for the treatment of is the Chinese medicine preparation of raw material with the Chinese herbal medicine.Belong to the field of Chinese medicines.

Background technology

(Nephrotic Syndrome NS) is proposed in 1932 by foreign scholar Hriction nephrotic syndrome.In order to summarize one group of card Hou Qun in the renal glomerular disease, it accounts for 70%～90% in child's renal glomerular disease, also account for 20%～30% in the adult.All have clinically a large amount of albuminuria (every day＞3.5g), hypoproteinemia (albumin＜30g/L), obviously edema, hyperlipemia (characteristic person such as serum cholesterol＞6.5mmol/L) can examine and is nephrotic syndrome.Nephrotic syndrome is at the clinical branch that constitutional and Secondary cases are arranged.Primary nephrotic syndrome (PNS) refers to by the sick causer of primary glomerular, adult's the most nephrotic syndrome of 2/3 and child is constitutional, pathological change is mainly the minute lesion type, and part is changes such as film, proliferative, film proliferative and focal nephrosclerosis.The patient of morbidity more than 45 years old, may be except must noting with malignant tumor, with Hodgkin, membranous nephropathy accompanies by solid tumors such as lung, breast, gastrointestinal etc. as minimal change nephropathy.The Secondary cases nephrotic syndrome is meant and is secondary to the whole body other diseases or by specificity cause of disease causer, as medicine mediation property nephrotic syndrome, the nephrotic syndrome that causes by allergy, poisoning, immunoreation, the nephrotic syndrome that causes by infection such as antibacterial, virus, parasites, nephrotic syndrome due to tumor and the heredity, nephrotic syndrome that metabolic disease caused such as systemic disease such as connective tissue, anaphylactoid purpura and diabetes, amyloidosis etc.Nephrotic syndrome 1/3 and the child 10% who is grown up can be by above-mentioned cause of disease secondary.Disease categories such as " edema " of nephrotic syndrome ownership Chinese medicine, " asthenia ".The clinical manifestation of primary disease is: a large amount of albuminuria (＞3.5g/24h), hypoproteinemia (albumin＜30g/L), obviously edema, hyperlipemia.The nephrotic syndrome course of disease is long, the relapse rate height, and simple western medicine treatment often can not obtain ideal effect, some intractable nephrotic syndromes especially, clinical treatment is often more thorny.And adopt the comprehensive method treatment nephrotic syndrome of Chinese and western medicine, and not only enlarged the treatment approach, and clinical confirmation obtained gratifying curative effect, be considered to comparatively ideal therapeutic scheme.The traditional Chinese medical science is divided disease type Coryza Treated by Syndrome Differentiation such as retention of damp-heat in the interior, the wet dipping of water, edema due to YANG-insufficiency, stagnation of dampness due to deficiency of the spleen, edema due to wind pathogen Xiang Bo clinically, obtains very good effect.Therefore invent a kind of not only safety but also effective Chinese medicine preparation, be significant.

Summary of the invention

The present invention develops in conjunction with the latest modern technological scientific achievement on the basis of traditional tcm syndrome differentiation and treatment.The purpose of this invention is to provide a kind of Chinese medicine preparation for the treatment of nephrotic syndrome.Have determined curative effect, safe ready, have no side effect, cheap characteristics.

The present invention is made by the following weight proportion raw material:

1.5～6 parts of 1.5～6 portions of Semen Phaseolis of 1.5～6 parts of Rhizoma Atractylodis Macrocephalae (parched)s of Radix Astragali

1.0～4 parts of 1.0～4 portions of Rhizoma Alismatis of 1.0～4 parts of Herba Epimedii of CORTEX ZINGIBERIS RHIZOMAE

0.1～2 part of 1.0～4 parts of Ramulus Cinnamomi of 1.0～4 parts of Radix Achyranthis Bidentataes of Rhizoma Dioscoreae

0.1～1 part of 0.1～2 part of Radix Aconiti Lateralis Preparata of 0.1～2 part of Cortex Moutan of Semen Plantaginis.

The weight proportion of each raw material of optimization formula of the present invention is:

2.5～3.5 parts of 2.5～3.5 portions of Semen Phaseolis of 2.5～3.5 parts of Rhizoma Atractylodis Macrocephalae (parched)s of Radix Astragali

1.5～2.5 parts of 1.5～2.5 portions of Rhizoma Alismatis of 1.5～2.5 parts of Herba Epimedii of CORTEX ZINGIBERIS RHIZOMAE

0.5～1.5 part of 1.5～2.5 parts of Ramulus Cinnamomi of 1.5～2.5 parts of Radix Achyranthis Bidentataes of Rhizoma Dioscoreae

0.3～0.7 part of 0.5～1.5 part of Radix Aconiti Lateralis Preparata of 0.5～1.5 part of Cortex Moutan of Semen Plantaginis.

The weight proportion of each raw material of optimum formula of the present invention is:

3 parts of 3 portions of Semen Phaseolis of 3 parts of Rhizoma Atractylodis Macrocephalae (parched)s of Radix Astragali

2 parts of 2 portions of Rhizoma Alismatis of 2 parts of Herba Epimedii of CORTEX ZINGIBERIS RHIZOMAE

1 part of 2 parts of Ramulus Cinnamomi of 2 parts of Radix Achyranthis Bidentataes of Rhizoma Dioscoreae

0.5 part of 1 part of Radix Aconiti Lateralis Preparata of 1 part of Cortex Moutan of Semen Plantaginis.

Drug action mechanism among the present invention is as follows:

The Radix Astragali property of medicine is sweet, warm.Return lung, spleen channel.Has benefiting qi and raising yang, strengthening superficial resistance to stop perspiration, inducing diuresis to remove edema, the effect of promoting pus discharge and tissue regeneration strengthening.Can treat the card of all Qi and blood deficiencies, as diarrhea due to hypofunction of the spleen, the cough due to deficiency of the lung, proctoptosis, uterine prolapse, spontaneous perspiration, night sweat, edema, arthralgia due to stagnation of blood, carbuncle is difficult bursts or bursts for a long time and do not hold back etc.(the 2813rd page of Shanghai science tech publishing house second edition write by " Chinese medicine voluminous dictionary " Nanjing University of Traditional Chinese Medicine).

Rhizoma Atractylodis Macrocephalae (parched) hardship, sweet, temperature.Return spleen, stomach warp.Has invigorating the spleen and benefiting QI, dampness diuretic, hidroschesis, antiabortive effect.Can treat the weak of deficiency-weakness of spleen-QI, lack of appetite abdominal distention is had loose bowels, constipation, the dysuria of fluid-retention stagnating in the interior, edema, dizziness due to fluid-retention, cold-damp numbness, general pain, spontaneous sweating due to deficiency of QI, frequent fetal movement etc.(the 945th page of Shanghai science tech publishing house second edition write by " Chinese medicine voluminous dictionary " Nanjing University of Traditional Chinese Medicine).

The Semen Phaseoli property of medicine is sweet, sour, is slightly cold.GUIXIN, small intestinal, spleen channel.Has the inducing diuresis to remove edema jaundice eliminating, the effect of heat-clearing and toxic substances removing eliminating carbuncle.Can treat edema, beriberi, jaundice, gonorrhea is had blood in stool, toxic swelling skin infection, scall etc.(the 1443rd page of Shanghai science tech publishing house second edition write by " Chinese medicine voluminous dictionary " Nanjing University of Traditional Chinese Medicine).

CORTEX ZINGIBERIS RHIZOMAE property of medicine suffering, cold.Return spleen, lung meridian.Effect with line water detumescence.Can treat edema from the beginning of, dysuria etc.(the 927th page of Shanghai science tech publishing house second edition write by " Chinese medicine voluminous dictionary " Nanjing University of Traditional Chinese Medicine).

Herba Epimedii property of medicine suffering, sweet, temperature.Return kidney, Liver Channel.Has kidney invigorating and YANG supporting, strengthening the tendons and bones, the effect of expelling wind and removing dampness.Can treat impotence and seminal emission, cold caused by deficiency is sterile, the frequent micturition incontinence, and dyspnea and cough due to deficiency of the kidney, soreness of the waist and knees, rheumatic arthralgia, hemiplegia, extremity are meciless etc.(the 3152nd page of Shanghai science tech publishing house second edition write by " Chinese medicine voluminous dictionary " Nanjing University of Traditional Chinese Medicine).

The Rhizoma Alismatis property of medicine is sweet, light, and is cold.Return kidney, urinary bladder channel.Have promoting diuresis to eliminate damp pathogen, treating stranguria effect expels the heat-evil.Can treat dysuria, the puckery pain of pyretic stranguria, the edema distension is had loose bowels, dizziness due to fluid-retention, seminal emission etc.(the 2067th page of Shanghai science tech publishing house second edition write by " Chinese medicine voluminous dictionary " Nanjing University of Traditional Chinese Medicine).

The Rhizoma Dioscoreae property of medicine is sweet, flat.Return spleen, lung, kidney channel.Have spleen reinforcing, support lung, reinforce the kidney, the effect that benefit is smart.Can treat diarrhea due to hypofunction of the spleen, the lack of appetite edema, cough and asthma due to lung deficiency is quenched one's thirst, seminal emission, leukorrhagia, the frequent micturition of suffering from a deficiency of the kidney.Carbuncle is controlled in external, scrofula etc.(the 218th page of Shanghai science tech publishing house second edition write by " Chinese medicine voluminous dictionary " Nanjing University of Traditional Chinese Medicine).

Radix Achyranthis Bidentatae bitter in the mouth, acid, property is flat.Has invigorating the liver and kidney, bone and muscle strengthening, dissipating blood stasis blood, the effect of subduing inflammation.Can treat soreness of waist and knee joint, muscles and bones is unable, amenorrhea, hematuria, difficult labour etc.(the 177th page of chief editor such as the firm Xiao Ying of party " Chinese medicine and health food development and exploitation " People's Health Publisher).

Ramulus Cinnamomi property of medicine suffering, sweet, temperature.Return bladder, the heart, lung meridian.Has expelling cold and relieving exterior syndrome, warming the meridian, the effect of activating yang.Can treat exterior syndrome due to wind-cold, arthralgia due to cold-dampnes, extreme cold of the limbs, amenorrhea dysmenorrhea ， mass in the abdomen caking, the thoracic obstruction, cardiopalmus, phlegm retention, dysuria etc.(the 2522nd page of Shanghai science tech publishing house second edition write by " Chinese medicine voluminous dictionary " Nanjing University of Traditional Chinese Medicine).

The Semen Plantaginis property of medicine is sweet, light, is slightly cold.Return lung, liver, kidney, urinary bladder channel.Have heat clearing away, diuresis makes eye bright, the expectorant effect.Can treat urinary obstruction, stranguria with turbid discharge, leukorrhagia, edema, the heat-damp in summer dysentery, conjunctival congestion is hidden from view, and the expectorant heat syndrome cough is breathed heavily etc.(the 539th page of Shanghai science tech publishing house second edition write by " Chinese medicine voluminous dictionary " Nanjing University of Traditional Chinese Medicine).

Cortex Moutan property of medicine hardship, suffering are slightly cold.GUIXIN, liver, kidney channel.Has clearing away heat and cooling blood, the effect of promoting blood circulation to remove blood stasis.Can treat the epidemic febrile disease pathogenic heat attacking blood system in febrile diseases, send out speckle, tell nosebleed, the calentura later stage, hot Fu Yin divided heating, osteopyrexia and fever, and amenorrhea due to stagnation of blood, dysmenorrhea, mass in the abdomen, carbuncle sore tumefacting virus falls and pounces on the pain of injury, rheumatic arthralgia etc.(the 1578th page of Shanghai science tech publishing house second edition write by " Chinese medicine voluminous dictionary " Nanjing University of Traditional Chinese Medicine).

Radix Aconiti Lateralis Preparata property of medicine suffering, sweet, heat, poisonous.GUIXIN, kidney, spleen channel.Has recuperating depleted YANG and rescuing the patient from collapse, the effect of dispelling cold and removing dampness.Can treat excessive YIN keeping YANG externally, loss of YANG due to profuse perspiration, vomiting and diarrhoea is fainted contrary, trusted subordinate's cold type of pain, cold-dysentery, beriberi edema, anemofrigid-damp arthralgia, the disease of the leakage of carbuncle of yin nature skin ulcer and all chronic diseaseses etc.(the 1672nd page of Shanghai science tech publishing house second edition write by " Chinese medicine voluminous dictionary " Nanjing University of Traditional Chinese Medicine).

The present invention follows the principles of formulating prescriptions of the traditional Chinese medical science " monarch ", is monarch drug with Radix Aconiti Lateralis Preparata, Ramulus Cinnamomi, Radix Astragali, Rhizoma Atractylodis Macrocephalae (parched) and Semen Phaseoli; With CORTEX ZINGIBERIS RHIZOMAE, Herba Epimedii, Rhizoma Alismatis, Rhizoma Dioscoreae and Radix Achyranthis Bidentatae is ministerial drug; With Semen Plantaginis and Cortex Moutan is adjuvant.All medicines are harmonious, and are total to the tool warming YANG to promote diuresis, the effect of replenishing QI to invigorate the spleen.The treatment nephrotic syndrome has determined curative effect, has no side effect taking convenience, cheap characteristics.

Clinical drug of the present invention uses the result to show that following advantage is arranged:

1, the Chinese herbal medicine each component selected for use of the present invention meets the regulation of Pharmacopoeia of People's Republic of China, utilizes the comprehensive function treatment nephrotic syndrome of the Chinese medicine of respectively distinguishing the flavor of, and is nontoxic to human body.Show that through the acute and chronic toxicity test of animal the animal of being tested does not see any toxic reaction, its main organs does not have tangible change yet, and safety of medicine is reliable.

2, rich in proteins in the medicine of the present invention, glucose, glucuronic acid, volatile oil, pectin, fructose, organic acid, lecithin, vitamin, aminoacid also contains various trace elements such as Saponin, plant sterol and calcium, is beneficial to absorption of human body, health invigorating.

3, the present invention not only can effectively treat nephrotic syndrome, and the prevention of nephrotic syndrome is also had good effect, and the treatment nephrotic syndrome has determined curative effect, has no side effect taking convenience, cheap characteristics.

For showing medicine of the present invention, as follows through clinical test results to treatment management of Idiopathic Nephrotic Syndrome in Children effect; Treatment nephrotic syndrome patient 20 examples.Take the embodiment decoction, each 1 bag, two to three times on the one, take half an hour ante cibum.Three months is a course of treatment, take continuously three the course of treatment observe the curative effect.8 examples of fully recovering account for 40%, and 9 examples that take a turn for the better account for 45%, and invalid 3 examples account for 15%, and total effective rate reaches 85%.After three course of therapy, patient does not have any untoward reaction, and three big routine tests and hepatic and renal function detect no abnormal.

The specific embodiment

The embodiment decoction takes by weighing raw material by following weight:

3 parts of 3 portions of Semen Phaseolis of 3 parts of Rhizoma Atractylodis Macrocephalae (parched)s of Radix Astragali

2 parts of 2 portions of Rhizoma Alismatis of 2 parts of Herba Epimedii of CORTEX ZINGIBERIS RHIZOMAE

1 part of 2 parts of Ramulus Cinnamomi of 2 parts of Radix Achyranthis Bidentataes of Rhizoma Dioscoreae

0.5 part of 1 part of Radix Aconiti Lateralis Preparata of 1 part of Cortex Moutan of Semen Plantaginis.

Preparation method is to get above-mentioned raw materials to clean roguing, dries, and is ground into granule, soaks 1 hour, puts and decocts with water secondary in the multi-function extractor, adds up the water of 10 times of amounts of medical material for the first time, decocts 1.5～2 hours, gets decocting liquid, filters.Add up for the second time the water of 7 times of amounts of medical material, decocted 1～1.2 hour, get decocting liquid twice, filter, in the heat-sealing bag, 105 ℃ of high temperature sterilizes, packing is promptly.The decoction of the treatment nephrotic syndrome that the present invention makes is that plastic packaging is packed, and every bag of 210ml is oral, one time one bag, every day two to three times.Three months is a course of treatment.

Claims (3)

1, the Chinese medicine preparation of treatment nephrotic syndrome is characterized in that it is made by the following weight proportion raw material:

1.5～6 parts of 1.5～6 portions of Semen Phaseolis of 1.5～6 parts of Rhizoma Atractylodis Macrocephalae (parched)s of Radix Astragali

1.0～4 parts of 1.0～4 portions of Rhizoma Alismatis of 1.0～4 parts of Herba Epimedii of CORTEX ZINGIBERIS RHIZOMAE

0.1～2 part of 1.0～4 parts of Ramulus Cinnamomi of 1.0～4 parts of Radix Achyranthis Bidentataes of Rhizoma Dioscoreae

0.1～1 part of 0.1～2 part of Radix Aconiti Lateralis Preparata of 0.1～2 part of Cortex Moutan of Semen Plantaginis.

2, the Chinese medicine preparation of treatment nephrotic syndrome according to claim 1, wherein the weight proportion of each raw material is:

2.5～3.5 parts of 2.5～3.5 portions of Semen Phaseolis of 2.5～3.5 parts of Rhizoma Atractylodis Macrocephalae (parched)s of Radix Astragali

1.5～2.5 parts of 1.5～2.5 portions of Rhizoma Alismatis of 1.5～2.5 parts of Herba Epimedii of CORTEX ZINGIBERIS RHIZOMAE

0.5～1.5 part of 1.5～2.5 parts of Ramulus Cinnamomi of 1.5～2.5 parts of Radix Achyranthis Bidentataes of Rhizoma Dioscoreae

0.3～0.7 part of 0.5～1.5 part of Radix Aconiti Lateralis Preparata of 0.5～1.5 part of Cortex Moutan of Semen Plantaginis.

3, the Chinese medicine preparation of treatment nephrotic syndrome according to claim 1, wherein the weight proportion of each raw material is:

3 parts of 3 portions of Semen Phaseolis of 3 parts of Rhizoma Atractylodis Macrocephalae (parched)s of Radix Astragali

2 parts of 2 portions of Rhizoma Alismatis of 2 parts of Herba Epimedii of CORTEX ZINGIBERIS RHIZOMAE

1 part of 2 parts of Ramulus Cinnamomi of 2 parts of Radix Achyranthis Bidentataes of Rhizoma Dioscoreae

0.5 part of 1 part of Radix Aconiti Lateralis Preparata of 1 part of Cortex Moutan of Semen Plantaginis.