CN101085252A - Traditional Chinese medicine preparation for treating nephrotic syndrome - Google Patents

Traditional Chinese medicine preparation for treating nephrotic syndrome Download PDF

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Publication number
CN101085252A
CN101085252A CN 200710117892 CN200710117892A CN101085252A CN 101085252 A CN101085252 A CN 101085252A CN 200710117892 CN200710117892 CN 200710117892 CN 200710117892 A CN200710117892 A CN 200710117892A CN 101085252 A CN101085252 A CN 101085252A
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China
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parts
chinese medicine
nephrotic syndrome
rhizoma
parched
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CN 200710117892
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Chinese (zh)
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王信锁
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Beijing Yixintang Medicine Institute
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Beijing Yixintang Medicine Institute
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Priority to CN 200710117892 priority Critical patent/CN101085252A/en
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Abstract

The invention relates to a Chinese medicinal composition for treating nephrotic syndrome, which is prepared from more than ten kinds of Chinese medicinal herbs including corktree bark, anemarrhena rhizome, Japanese felt fern leaf. and cogongrass rhizome.

Description

A kind of Chinese medicine preparation for the treatment of nephrotic syndrome
Technical field
The present invention relates to a kind of Chinese medicine preparation for the treatment of nephrotic syndrome, is that a kind of nephrotic syndrome for the treatment of is the Chinese medicine preparation of raw material with the Chinese herbal medicine.Belong to the field of Chinese medicines.
Background technology
(Nephrotic Syndrome NS) is proposed in 1932 by foreign scholar Hriction nephrotic syndrome.In order to summarize one group of card Hou Qun in the renal glomerular disease, it accounts for 70%~90% in child's renal glomerular disease, also account for 20%~30% in the adult.All have clinically a large amount of albuminuria (every day>3.5g), hypoproteinemia (albumin<30g/L), obviously edema, hyperlipemia (characteristic person such as serum cholesterol>6.5mmol/L) can examine and is nephrotic syndrome.Nephrotic syndrome is at the clinical branch that constitutional and Secondary cases are arranged.Primary nephrotic syndrome (PNS) refers to by the sick causer of primary glomerular, adult's the most nephrotic syndrome of 2/3 and child is constitutional, pathological change is mainly the minute lesion type, and part is changes such as film, proliferative, film proliferative and focal nephrosclerosis.The patient of morbidity more than 45 years old, may be except must noting with malignant tumor, with Hodgkin, membranous nephropathy accompanies by solid tumors such as lung, breast, gastrointestinal etc. as minimal change nephropathy.The Secondary cases nephrotic syndrome is meant and is secondary to the whole body other diseases or by specificity cause of disease causer, as medicine mediation property nephrotic syndrome, the nephrotic syndrome that causes by allergy, poisoning, immunoreation, the nephrotic syndrome that causes by infection such as antibacterial, virus, parasites, nephrotic syndrome due to tumor and the heredity, nephrotic syndrome that metabolic disease caused such as systemic disease such as connective tissue, anaphylactoid purpura and diabetes, amyloidosis etc.Nephrotic syndrome 1/3 and the child 10% who is grown up can be by above-mentioned cause of disease secondary.Disease categories such as " edema " of nephrotic syndrome ownership Chinese medicine, " asthenia ".The clinical manifestation of primary disease is: a large amount of albuminuria (>3.5g/24h), hypoproteinemia (albumin<30g/L), obviously edema, hyperlipemia.The nephrotic syndrome course of disease is long, the relapse rate height, and simple western medicine treatment often can not obtain ideal effect, some intractable nephrotic syndromes especially, clinical treatment is often more thorny.And adopt the comprehensive method treatment nephrotic syndrome of Chinese and western medicine, and not only enlarged the treatment approach, and clinical confirmation obtained gratifying curative effect, be considered to comparatively ideal therapeutic scheme.
The traditional Chinese medical science is divided disease type Coryza Treated by Syndrome Differentiation such as retention of damp-heat in the interior, the wet dipping of water, edema due to YANG-insufficiency, stagnation of dampness due to deficiency of the spleen, edema due to wind pathogen Xiang Bo clinically, obtains very good effect.Therefore invent a kind of not only safety but also effective Chinese medicine preparation, be significant.
Summary of the invention
The present invention develops in conjunction with the latest modern technological scientific achievement on the basis of traditional tcm syndrome differentiation and treatment.The purpose of this invention is to provide a kind of Chinese medicine preparation for the treatment of nephrotic syndrome.Have determined curative effect, safe ready, have no side effect, cheap characteristics.
The present invention is made by the following weight proportion raw material:
1.0~4 parts of 1.0~4 parts of Rhizoma Imperataes of 1.5~6 parts of Folium Pyrrosiaes of Cortex Phellodendri
1.0~4 parts of 1.0~4 parts of Rhizoma Atractylodis Macrocephalae (parched)s of 1.5~6 parts of Fructus Gardeniae (parched) of the Rhizoma Anemarrhenae
0.1~2 part of 1.0~4 parts of Fructus Forsythiae of 1.5~6 parts of Radix Rehmanniae of Rhizoma Alismatis
0.1~2 part of 1.0~4 portions of Herba Artemisiae Scopariae of 1.0~4 portions of Herba Plantaginiss of Polyporus.
The weight proportion of each raw material of optimization formula of the present invention is:
1.5~2.5 parts of 1.5~2.5 parts of Rhizoma Imperataes of 2.5~3.5 parts of Folium Pyrrosiaes of Cortex Phellodendri
1.5~2.5 parts of 1.5~2.5 parts of Rhizoma Atractylodis Macrocephalae (parched)s of 2.5~3.5 parts of Fructus Gardeniae (parched) of the Rhizoma Anemarrhenae
0.5~1.5 part of 1.5~2.5 parts of Fructus Forsythiae of 2.5~3.5 parts of Radix Rehmanniae of Rhizoma Alismatis
0.5~1.5 part of 1.5~2.5 portions of Herba Artemisiae Scopariae of 1.5~2.5 portions of Herba Plantaginiss of Polyporus.
The weight proportion of each raw material of optimum formula of the present invention is:
2 parts of 2 parts of Rhizoma Imperataes of 3 parts of Folium Pyrrosiaes of Cortex Phellodendri
2 parts of 2 parts of Rhizoma Atractylodis Macrocephalae (parched)s of 3 parts of Fructus Gardeniae (parched) of the Rhizoma Anemarrhenae
1 part of 2 parts of Fructus Forsythiae of 3 parts of Radix Rehmanniae of Rhizoma Alismatis
1 part of 2 portions of Herba Artemisiae Scopariae of 2 portions of Herba Plantaginiss of Polyporus.
Drug action mechanism among the present invention is as follows:
Cortex Phellodendri property of medicine hardship, cold.Return kidney, bladder, large intestine channel.Has heat clearing and damp drying, the effect of eliminating fire and detoxication.Can treat hygropyretic dysentery, have loose bowels, jaundice, nocturnal emission, stranguria with turbid discharge, leukorrhagia, hectic fever due to YIN-deficiency consumptive fever , Wei Bi, and aphtha of the mouth and tongue, conjunctival congestion and swelling pain, skin sore, skin eczema etc.(the 2823rd page of Shanghai science tech publishing house second edition write by " Chinese medicine voluminous dictionary " Nanjing University of Traditional Chinese Medicine).
Rhizoma Anemarrhenae property of medicine hardship, cold.Return lung, stomach, kidney channel.Has clearing away heat-fire, nourishing yin and moistening dryness.Can treat epidemic febrile disease hyperpyrexia excessive thirst, the cough due to lung-heat, osteopyrexia and fever, seminal emission, night sweat, restlessness of asrhenia type and insomnia is quenched one's thirst etc.(the 1924th page of Shanghai science tech publishing house second edition write by " Chinese medicine voluminous dictionary " Nanjing University of Traditional Chinese Medicine).
The Rhizoma Alismatis property of medicine is sweet, light, and is cold.Return kidney, urinary bladder channel.Have promoting diuresis to eliminate damp pathogen, treating stranguria effect expels the heat-evil.Can treat dysuria, the puckery pain of pyretic stranguria, the edema distension is had loose bowels, dizziness due to fluid-retention, seminal emission etc.(the 2067th page of Shanghai science tech publishing house second edition write by " Chinese medicine voluminous dictionary " Nanjing University of Traditional Chinese Medicine).
The Polyporus property of medicine is sweet, light, and is flat.Return spleen, kidney, urinary bladder channel.Effect with promoting diuresis to eliminate damp pathogen.Can treat dysuria, the edema distension is had loose bowels, stranguria with turbid discharge, leukorrhagia, beriberi edema etc.(the 3060th page of Shanghai science tech publishing house second edition write by " Chinese medicine voluminous dictionary " Nanjing University of Traditional Chinese Medicine).
Folium Pyrrosiae property of medicine hardship, sweet, cold.Return lung, kidney, urinary bladder channel.Has relieving stranguria by diuresis, removing heat from the lung and dissipating phlegm, the effect of cooling blood for hemostasis.Can treat stranguria, edema, dysuria, the expectorant heat syndrome cough is breathed heavily, and spitting of blood is spitted blood epistaxis, metrorrhagia and traumatic hemorrhage etc.(the 811st page of Shanghai science tech publishing house second edition write by " Chinese medicine voluminous dictionary " Nanjing University of Traditional Chinese Medicine).
Fructus Gardeniae (parched) property of medicine hardship, cold.GUIXIN, liver, lung, stomach, tri-jiao channel.Has the pathogenic fire purging relieving restlessness, clearing away heat-damp and promoting diuresis, the effect of removing pathogenic heat from blood and toxic substance from the body.It is vexed to treat calentura, the liver-fire conjunctival congestion, and headache, jaundice due to damp-heat, stranguria is spitted blood, epistaxis, dysentery, hematuria, aphtha of the mouth and tongue, sore swollen toxin is sprained and is swollen and ache etc.(the 2242nd page of Shanghai science tech publishing house second edition write by " Chinese medicine voluminous dictionary " Nanjing University of Traditional Chinese Medicine).
The Radix Rehmanniae nature and flavor are sweet, cold.GUIXIN, liver, kidney channel.Has clearing away heat and cooling blood, yin nourishing, the effect of promoting the production of body fluid.Can treat that calentura crimson tongue excessive thirst, interior-heat caused by deficiency of YIN, hectic fever due to YIN-deficiency consumptive fever, interior-heat are quenched one's thirst, haematemesis, epistaxis, send out speckle dermexanthesis etc.(Ji Yubin chief editor " Chinese medicine medicine for preventing pharmacology and application " Heilungkiang science tech publishing house 1999 version the 514th page).
The Herba Plantaginis property of medicine is sweet, and is cold.Return liver, small intestinal, urinary bladder channel.Have clearing away heat and promoting diuresis, make eye bright, the antidotal effect.Can treat pyretic stranguria, stranguria caused by urinary stone, stranguria with blood, hematuria, nebulousurine, leukorrhagia, heat-damp in summer dysentery, epistaxis, liver-heat conjunctival congestion, laryngopharynx swelling and pain, carbuncle sore tumefacting virus etc.(the 541st page of Shanghai science tech publishing house second edition write by " Chinese medicine voluminous dictionary " Nanjing University of Traditional Chinese Medicine).
The Rhizoma Imperatae property of medicine is sweet, and is cold.GUIXIN, lung, stomach, urinary bladder channel.Has clearing away heat and promoting production of body fluid, cooling blood for hemostasis, the effect of inducing diuresis for treating stranguria syndrome.Can treat the calentura excessive thirst, dyspnea and cough due to lung-heat, the gastric heat vomiting, heat in blood is hemorrhage, the puckery pain of dribbling urination, edema, jaundice etc.(the 992nd page of Shanghai science tech publishing house second edition write by " Chinese medicine voluminous dictionary " Nanjing University of Traditional Chinese Medicine).
Rhizoma Atractylodis Macrocephalae (parched) hardship, sweet, temperature.Return spleen, stomach warp.Has invigorating the spleen and benefiting QI, dampness diuretic, hidroschesis, antiabortive effect.Can treat the weak of deficiency-weakness of spleen-QI, lack of appetite abdominal distention is had loose bowels, constipation, the dysuria of fluid-retention stagnating in the interior, edema, dizziness due to fluid-retention, cold-damp numbness, general pain, spontaneous sweating due to deficiency of QI, frequent fetal movement etc.(the 945th page of Shanghai science tech publishing house second edition write by " Chinese medicine voluminous dictionary " Nanjing University of Traditional Chinese Medicine).
Fructus Forsythiae property of medicine hardship is slightly cold.Return lung, the heart, gallbladder meridian.Has heat-clearing and toxic substances removing, the effect of dispersing swelling and dissipating binds.Can treat anemopyretic cold, epidemic febrile disease, pyretic stranguria urine retention, carbuncle, toxic swelling, scrofula, goiter, sore throat etc.(the 1554th page of Shanghai science tech publishing house second edition write by " Chinese medicine voluminous dictionary " Nanjing University of Traditional Chinese Medicine).
The little hardship of the Herba Artemisiae Scopariae property of medicine, little suffering are slightly cold.Return spleen, stomach, urinary bladder channel.Has clearing away heat-damp and promoting diuresis, the effect of jaundice eliminating.Can treat jaundice, dysuria, eczema pruritus etc.(the 2146th page of Shanghai science tech publishing house second edition write by " Chinese medicine voluminous dictionary " Nanjing University of Traditional Chinese Medicine).
The present invention follows the principles of formulating prescriptions of the traditional Chinese medical science " monarch ", is monarch drug with Cortex Phellodendri, the Rhizoma Anemarrhenae, Rhizoma Alismatis and Radix Rehmanniae; With Polyporus, Folium Pyrrosiae, Fructus Gardeniae (parched), Herba Plantaginis, Rhizoma Imperatae and Rhizoma Atractylodis Macrocephalae (parched) is ministerial drug; With Fructus Forsythiae and Herba Artemisiae Scopariae is adjuvant.All medicines are harmonious, and are total to the tool nourishing YIN and clearing away heat, inducing diuresis and reducing edema effect.The treatment nephrotic syndrome has determined curative effect, has no side effect taking convenience, cheap characteristics.
Clinical drug of the present invention uses the result to show that following advantage is arranged:
1, the Chinese herbal medicine each component selected for use of the present invention meets the regulation of Pharmacopoeia of People's Republic of China, utilizes the comprehensive function treatment nephrotic syndrome of the Chinese medicine of respectively distinguishing the flavor of, and is nontoxic to human body.Show that through the acute and chronic toxicity test of animal the animal of being tested does not see any toxic reaction, its main organs does not have tangible change yet, and safety of medicine is reliable.
2, rich in proteins in the medicine of the present invention, glucose, glucuronic acid, volatile oil, pectin, fructose, organic acid, lecithin, vitamin, aminoacid also contains various trace elements such as Saponin, plant sterol and calcium, is beneficial to absorption of human body, health invigorating.
3, the present invention not only can effectively treat nephrotic syndrome, and the prevention of nephrotic syndrome is also had good effect, and the treatment nephrotic syndrome has determined curative effect, has no side effect taking convenience, cheap characteristics.
For showing medicine of the present invention, as follows through clinical test results to treatment management of Idiopathic Nephrotic Syndrome in Children effect; Treatment nephrotic syndrome patient 12 examples.Take the embodiment decoction, each 1 bag, two to three times on the one, take half an hour ante cibum.Three months is a course of treatment, take continuously three the course of treatment observe the curative effect.6 examples of fully recovering account for 50%, and 4 examples that take a turn for the better account for 33.33%, and invalid 2 examples account for 16.67%, and total effective rate reaches 83.33%.After three course of therapy, patient does not have any untoward reaction, and three big routine tests and hepatic and renal function detect no abnormal.
The specific embodiment
The embodiment decoction takes by weighing raw material by following weight:
2 parts of 2 parts of Rhizoma Imperataes of 3 parts of Folium Pyrrosiaes of Cortex Phellodendri
2 parts of 2 parts of Rhizoma Atractylodis Macrocephalae (parched)s of 3 parts of Fructus Gardeniae (parched) of the Rhizoma Anemarrhenae
1 part of 2 parts of Fructus Forsythiae of 3 parts of Radix Rehmanniae of Rhizoma Alismatis
1 part of 2 portions of Herba Artemisiae Scopariae of 2 portions of Herba Plantaginiss of Polyporus.
Preparation method is to get above-mentioned raw materials to clean roguing, dries, and is ground into granule, soaks 1 hour, puts and decocts with water secondary in the multi-function extractor, adds up the water of 10 times of amounts of medical material for the first time, decocts 1.5~2 hours, gets decocting liquid, filters.Add up for the second time the water of 7 times of amounts of medical material, decocted 1~1.2 hour, get decocting liquid twice, filter, in the heat-sealing bag, 105 ℃ of high temperature sterilizes, packing is promptly.The decoction of the treatment nephrotic syndrome that the present invention makes is that plastic packaging is packed, and every bag of 210ml is oral, one time one bag, every day two to three times.Three months is a course of treatment.

Claims (3)

1, a kind of Chinese medicine preparation for the treatment of nephrotic syndrome is characterized in that it is made by the following weight proportion raw material:
1.0~4 parts of 1.0~4 parts of Rhizoma Imperataes of 1.5~6 parts of Folium Pyrrosiaes of Cortex Phellodendri
1.0~4 parts of 1.0~4 parts of Rhizoma Atractylodis Macrocephalae (parched)s of 1.5~6 parts of Fructus Gardeniae (parched) of the Rhizoma Anemarrhenae
0.1~2 part of 1.0~4 parts of Fructus Forsythiae of 1.5~6 parts of Radix Rehmanniae of Rhizoma Alismatis
0.1~2 part of 1.0~4 portions of Herba Artemisiae Scopariae of 1.0~4 portions of Herba Plantaginiss of Polyporus.
2, a kind of Chinese medicine preparation for the treatment of nephrotic syndrome according to claim 1, wherein the weight proportion of each raw material is:
1.5~2.5 parts of 1.5~2.5 parts of Rhizoma Imperataes of 2.5~3.5 parts of Folium Pyrrosiaes of Cortex Phellodendri
1.5~2.5 parts of 1.5~2.5 parts of Rhizoma Atractylodis Macrocephalae (parched)s of 2.5~3.5 parts of Fructus Gardeniae (parched) of the Rhizoma Anemarrhenae
0.5~1.5 part of 1.5~2.5 parts of Fructus Forsythiae of 2.5~3.5 parts of Radix Rehmanniae of Rhizoma Alismatis
0.5~1.5 part of 1.5~2.5 portions of Herba Artemisiae Scopariae of 1.5~2.5 portions of Herba Plantaginiss of Polyporus.
3, a kind of Chinese medicine preparation for the treatment of nephrotic syndrome according to claim 1, wherein the weight proportion of each raw material is:
2 parts of 2 parts of Rhizoma Imperataes of 3 parts of Folium Pyrrosiaes of Cortex Phellodendri
2 parts of 2 parts of Rhizoma Atractylodis Macrocephalae (parched)s of 3 parts of Fructus Gardeniae (parched) of the Rhizoma Anemarrhenae
1 part of 2 parts of Fructus Forsythiae of 3 parts of Radix Rehmanniae of Rhizoma Alismatis
1 part of 2 portions of Herba Artemisiae Scopariae of 2 portions of Herba Plantaginiss of Polyporus.
CN 200710117892 2007-06-26 2007-06-26 Traditional Chinese medicine preparation for treating nephrotic syndrome Pending CN101085252A (en)

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Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102293857A (en) * 2011-07-07 2011-12-28 中国中医科学院中药研究所 Invention of effective component in glutinous rehmannia and plantain prescription for treating chronic glomerulonephritis
CN104306789A (en) * 2014-11-13 2015-01-28 向金环 Traditional Chinese medicine for treating nephritis
CN104771641A (en) * 2015-04-26 2015-07-15 黄萍 Traditional Chinese medicine composition for treating nephrotic syndromes with stagnant and jamming dampness heat

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102293857A (en) * 2011-07-07 2011-12-28 中国中医科学院中药研究所 Invention of effective component in glutinous rehmannia and plantain prescription for treating chronic glomerulonephritis
CN104306789A (en) * 2014-11-13 2015-01-28 向金环 Traditional Chinese medicine for treating nephritis
CN104771641A (en) * 2015-04-26 2015-07-15 黄萍 Traditional Chinese medicine composition for treating nephrotic syndromes with stagnant and jamming dampness heat

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WD01 Invention patent application deemed withdrawn after publication

Open date: 20071212

C02 Deemed withdrawal of patent application after publication (patent law 2001)