CN101080384B - N-取代的水杨酰胺的制备方法 - Google Patents
N-取代的水杨酰胺的制备方法 Download PDFInfo
- Publication number
- CN101080384B CN101080384B CN2005800431247A CN200580043124A CN101080384B CN 101080384 B CN101080384 B CN 101080384B CN 2005800431247 A CN2005800431247 A CN 2005800431247A CN 200580043124 A CN200580043124 A CN 200580043124A CN 101080384 B CN101080384 B CN 101080384B
- Authority
- CN
- China
- Prior art keywords
- formula
- compound
- alkyl
- ethyl
- water
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 0 CC(C)(CNC(C(C(O)=C1)=CC=C*1N)=O)C(*)(*)C(C)(C(O*)=O)N Chemical compound CC(C)(CNC(C(C(O)=C1)=CC=C*1N)=O)C(*)(*)C(C)(C(O*)=O)N 0.000 description 2
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C233/00—Carboxylic acid amides
- C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
- C07C235/42—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton
- C07C235/44—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton with carbon atoms of carboxamide groups and singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring
- C07C235/58—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton with carbon atoms of carboxamide groups and singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring with carbon atoms of carboxamide groups and singly-bound oxygen atoms, bound in ortho-position to carbon atoms of the same non-condensed six-membered aromatic ring
- C07C235/60—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton with carbon atoms of carboxamide groups and singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring with carbon atoms of carboxamide groups and singly-bound oxygen atoms, bound in ortho-position to carbon atoms of the same non-condensed six-membered aromatic ring having the nitrogen atoms of the carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C233/00—Carboxylic acid amides
- C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C233/16—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms
- C07C233/24—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a six-membered aromatic ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
- C07C235/42—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton
- C07C235/44—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton with carbon atoms of carboxamide groups and singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring
- C07C235/58—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton with carbon atoms of carboxamide groups and singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring with carbon atoms of carboxamide groups and singly-bound oxygen atoms, bound in ortho-position to carbon atoms of the same non-condensed six-membered aromatic ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
- C07D265/04—1,3-Oxazines; Hydrogenated 1,3-oxazines
- C07D265/12—1,3-Oxazines; Hydrogenated 1,3-oxazines condensed with carbocyclic rings or ring systems
- C07D265/14—1,3-Oxazines; Hydrogenated 1,3-oxazines condensed with carbocyclic rings or ring systems condensed with one six-membered ring
- C07D265/24—1,3-Oxazines; Hydrogenated 1,3-oxazines condensed with carbocyclic rings or ring systems condensed with one six-membered ring with hetero atoms directly attached in positions 2 and 4
- C07D265/26—Two oxygen atoms, e.g. isatoic anhydride
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB0427603.6 | 2004-12-16 | ||
| GBGB0427603.6A GB0427603D0 (en) | 2004-12-16 | 2004-12-16 | Organic compounds |
| PCT/EP2005/013454 WO2006063821A1 (en) | 2004-12-16 | 2005-12-14 | Manufacture process of n-substituted salicylamides |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN101080384A CN101080384A (zh) | 2007-11-28 |
| CN101080384B true CN101080384B (zh) | 2011-06-15 |
Family
ID=34090175
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN2005800431247A Expired - Fee Related CN101080384B (zh) | 2004-12-16 | 2005-12-14 | N-取代的水杨酰胺的制备方法 |
Country Status (24)
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2006292337B8 (en) | 2005-09-19 | 2013-02-07 | Emisphere Technologies, Inc. | Crystalline forms of the di-sodium salt of N-(5-chlorosalicyloyl)-8-aminocaprylic acid |
| MX2010004716A (es) | 2007-11-02 | 2010-12-17 | Emisphere Tech Inc | Metodo para tratar la deficiencia de vitamina b12. |
| CN109473182B (zh) * | 2018-11-12 | 2021-10-19 | 北京北排科技有限公司 | 一种基于深度信念网络的mbr膜透水率智能检测方法 |
| BR112021023195A2 (pt) * | 2019-05-20 | 2022-02-15 | Lonza Guangzhou Pharmaceutical Ltd | Método para preparação de carsalam |
| CN115260116B (zh) * | 2022-08-19 | 2024-04-12 | 株洲壹诺生物技术有限公司 | 8-(2-羟基苯甲酰胺基)辛酸钠及苯并噁嗪-2,4-二酮和8-溴辛酸乙酯的制法 |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SU382610A1 (ru) * | 1968-07-08 | 1973-05-25 | Способ получения амидов карбоновых кислот | |
| ES2235854T3 (es) * | 1999-04-05 | 2005-07-16 | Emisphere Technologies, Inc. | Sales disodicas, monohidratos y solvatos etanolicos para aportar agentes activos. |
| OA11972A (en) * | 1999-06-25 | 2006-04-18 | Inst For Pharmaceutical | Substituted phenoxyacetic acids. |
| US6900344B2 (en) * | 2000-03-21 | 2005-05-31 | Emisphere Technologies, Inc. | Method of preparing alkylated salicylamides via a dicarboxylate intermediate |
| WO2001092206A1 (en) | 2000-06-02 | 2001-12-06 | Emisphere Technologies, Inc. | Method of preparing salicylamides |
| CA2411754C (en) * | 2000-06-29 | 2009-05-26 | Emisphere Technologies, Inc. | 4-[(4-chloro-2-hydroxybenzoyl)amino]butanoic acid and compositions for delivering active agents |
| AU2001296865A1 (en) * | 2000-09-06 | 2002-03-22 | Emisphere Technologies, Inc. | (5-(2-hydroxy-4-chlorobenzoyl) aminovaleric acid and salts thereof and compositions containing the same for delivering active agents |
| US7049283B2 (en) * | 2000-12-06 | 2006-05-23 | Novartis Ag | Pharmaceutical compositions for the oral delivery of pharmacologically active agents |
| AU2003223158B2 (en) * | 2002-01-09 | 2008-01-17 | Emisphere Technologies, Inc. | Polymorphs of sodium 4-[(4-chloro-2-hydroxybenzoyl)amino]butanoate |
| JP4417113B2 (ja) | 2002-02-20 | 2010-02-17 | エミスフェアー・テクノロジーズ・インク | Ｇｌｐ−１分子の投与方法 |
| US20050054557A1 (en) * | 2002-05-09 | 2005-03-10 | Goldberg Michael M. | Compositions for delivering parathyroid hormone and calcitonin |
-
2004
- 2004-12-16 GB GBGB0427603.6A patent/GB0427603D0/en not_active Ceased
-
2005
- 2005-12-02 GT GT200500353A patent/GT200500353A/es unknown
- 2005-12-14 EP EP15170908.6A patent/EP2955171A1/en not_active Withdrawn
- 2005-12-14 CA CA2587213A patent/CA2587213C/en not_active Expired - Fee Related
- 2005-12-14 RU RU2007126972/04A patent/RU2404158C2/ru not_active IP Right Cessation
- 2005-12-14 MX MX2007007211A patent/MX2007007211A/es active IP Right Grant
- 2005-12-14 JP JP2007545942A patent/JP5224816B2/ja not_active Expired - Fee Related
- 2005-12-14 KR KR1020077013580A patent/KR101287233B1/ko not_active Expired - Fee Related
- 2005-12-14 EP EP05818421.9A patent/EP1838664B1/en not_active Expired - Lifetime
- 2005-12-14 PT PT58184219T patent/PT1838664E/pt unknown
- 2005-12-14 CN CN2005800431247A patent/CN101080384B/zh not_active Expired - Fee Related
- 2005-12-14 PL PL05818421T patent/PL1838664T3/pl unknown
- 2005-12-14 BR BRPI0519327-3A patent/BRPI0519327A2/pt not_active Application Discontinuation
- 2005-12-14 AR ARP050105245A patent/AR055007A1/es not_active Application Discontinuation
- 2005-12-14 ES ES05818421.9T patent/ES2547349T3/es not_active Expired - Lifetime
- 2005-12-14 WO PCT/EP2005/013454 patent/WO2006063821A1/en not_active Ceased
- 2005-12-14 US US11/721,817 patent/US8461385B2/en not_active Expired - Fee Related
- 2005-12-14 AU AU2005315850A patent/AU2005315850B2/en not_active Ceased
- 2005-12-14 PE PE2005001448A patent/PE20060740A1/es not_active Application Discontinuation
- 2005-12-15 TW TW094144576A patent/TW200635880A/zh unknown
-
2007
- 2007-05-11 ZA ZA200703826A patent/ZA200703826B/xx unknown
- 2007-05-21 IL IL183366A patent/IL183366A0/en unknown
- 2007-06-11 MA MA29983A patent/MA29092B1/fr unknown
- 2007-06-15 TN TNP2007000229A patent/TNSN07229A1/fr unknown
- 2007-07-09 NO NO20073548A patent/NO338969B1/no not_active IP Right Cessation
Non-Patent Citations (3)
| Title |
|---|
| 实施例2. |
| 邢其毅 等.基础有机化学 第2版.高等教育出版社,1993,145页. |
| 邢其毅等.基础有机化学 第2版.高等教育出版社,1993,145页. * |
Also Published As
| Publication number | Publication date |
|---|---|
| ZA200703826B (en) | 2008-08-27 |
| TW200635880A (en) | 2006-10-16 |
| AR055007A1 (es) | 2007-08-01 |
| ES2547349T3 (es) | 2015-10-05 |
| AU2005315850B2 (en) | 2009-11-05 |
| JP2008524142A (ja) | 2008-07-10 |
| IL183366A0 (en) | 2007-09-20 |
| RU2007126972A (ru) | 2009-01-27 |
| PL1838664T3 (pl) | 2016-04-29 |
| GB0427603D0 (en) | 2005-01-19 |
| MA29092B1 (fr) | 2007-12-03 |
| US20090253811A1 (en) | 2009-10-08 |
| US8461385B2 (en) | 2013-06-11 |
| EP1838664B1 (en) | 2015-07-15 |
| TNSN07229A1 (en) | 2008-11-21 |
| WO2006063821A1 (en) | 2006-06-22 |
| RU2404158C2 (ru) | 2010-11-20 |
| KR101287233B1 (ko) | 2013-07-17 |
| BRPI0519327A2 (pt) | 2009-01-13 |
| KR20070086276A (ko) | 2007-08-27 |
| EP1838664A1 (en) | 2007-10-03 |
| MX2007007211A (es) | 2007-08-15 |
| PE20060740A1 (es) | 2006-09-04 |
| NO338969B1 (no) | 2016-11-07 |
| PT1838664E (pt) | 2015-10-16 |
| NO20073548L (no) | 2007-09-17 |
| CA2587213A1 (en) | 2006-06-22 |
| AU2005315850A1 (en) | 2006-06-22 |
| GT200500353A (es) | 2006-07-17 |
| JP5224816B2 (ja) | 2013-07-03 |
| CA2587213C (en) | 2015-05-19 |
| EP2955171A1 (en) | 2015-12-16 |
| CN101080384A (zh) | 2007-11-28 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| C56 | Change in the name or address of the patentee |
Owner name: NOVARTIS CO., LTD. Free format text: FORMER NAME: NOVARTIS AG |
|
| CP01 | Change in the name or title of a patent holder |
Address after: Basel Patentee after: Novartis Ag Address before: Basel Patentee before: Novartis AG |
|
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20110615 Termination date: 20171214 |
|
| CF01 | Termination of patent right due to non-payment of annual fee |