BRPI0519327A2 - processo de preparaÇço de salicilamida n-substituÍda, composto, uso do mesmo e composiÇço farmacÊutica - Google Patents

processo de preparaÇço de salicilamida n-substituÍda, composto, uso do mesmo e composiÇço farmacÊutica

Info

Publication number
BRPI0519327A2
BRPI0519327A2 BRPI0519327-3A BRPI0519327A BRPI0519327A2 BR PI0519327 A2 BRPI0519327 A2 BR PI0519327A2 BR PI0519327 A BRPI0519327 A BR PI0519327A BR PI0519327 A2 BRPI0519327 A2 BR PI0519327A2
Authority
BR
Brazil
Prior art keywords
salicylamide
unsubstituted
compound
pharmaceutical composition
preparation process
Prior art date
Application number
BRPI0519327-3A
Other languages
English (en)
Inventor
Bernhard Riss
Ulrich Meier
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=34090175&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=BRPI0519327(A2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of BRPI0519327A2 publication Critical patent/BRPI0519327A2/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
    • C07C235/42—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton
    • C07C235/44—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton with carbon atoms of carboxamide groups and singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring
    • C07C235/58—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton with carbon atoms of carboxamide groups and singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring with carbon atoms of carboxamide groups and singly-bound oxygen atoms, bound in ortho-position to carbon atoms of the same non-condensed six-membered aromatic ring
    • C07C235/60—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton with carbon atoms of carboxamide groups and singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring with carbon atoms of carboxamide groups and singly-bound oxygen atoms, bound in ortho-position to carbon atoms of the same non-condensed six-membered aromatic ring having the nitrogen atoms of the carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C233/16—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms
    • C07C233/24—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
    • C07C235/42—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton
    • C07C235/44—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton with carbon atoms of carboxamide groups and singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring
    • C07C235/58—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton with carbon atoms of carboxamide groups and singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring with carbon atoms of carboxamide groups and singly-bound oxygen atoms, bound in ortho-position to carbon atoms of the same non-condensed six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
    • C07D265/04—1,3-Oxazines; Hydrogenated 1,3-oxazines
    • C07D265/12—1,3-Oxazines; Hydrogenated 1,3-oxazines condensed with carbocyclic rings or ring systems
    • C07D265/14—1,3-Oxazines; Hydrogenated 1,3-oxazines condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C07D265/24—1,3-Oxazines; Hydrogenated 1,3-oxazines condensed with carbocyclic rings or ring systems condensed with one six-membered ring with hetero atoms directly attached in positions 2 and 4
    • C07D265/26—Two oxygen atoms, e.g. isatoic anhydride

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

PROCESSO DE FABRICAÇçO DE N-SALICILAMIDAS SUBSTITUÍDAS. A presente invenção refere-se a um método de preparação de salicilamidas N-substituídas e derivados das mesmas, e seus sais, hidratos e solvatos. Em particular, a presente invenção refere-se a um método de preparação de ácido N-(5-clorossaliciloil)-8-aminocaprílico (5-CNAC) e seu monoidrato de d issódio correspondente.
BRPI0519327-3A 2004-12-16 2005-12-14 processo de preparaÇço de salicilamida n-substituÍda, composto, uso do mesmo e composiÇço farmacÊutica BRPI0519327A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB0427603.6A GB0427603D0 (en) 2004-12-16 2004-12-16 Organic compounds
PCT/EP2005/013454 WO2006063821A1 (en) 2004-12-16 2005-12-14 Manufacture process of n-substituted salicylamides

Publications (1)

Publication Number Publication Date
BRPI0519327A2 true BRPI0519327A2 (pt) 2009-01-13

Family

ID=34090175

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0519327-3A BRPI0519327A2 (pt) 2004-12-16 2005-12-14 processo de preparaÇço de salicilamida n-substituÍda, composto, uso do mesmo e composiÇço farmacÊutica

Country Status (24)

Country Link
US (1) US8461385B2 (pt)
EP (2) EP2955171A1 (pt)
JP (1) JP5224816B2 (pt)
KR (1) KR101287233B1 (pt)
CN (1) CN101080384B (pt)
AR (1) AR055007A1 (pt)
AU (1) AU2005315850B2 (pt)
BR (1) BRPI0519327A2 (pt)
CA (1) CA2587213C (pt)
ES (1) ES2547349T3 (pt)
GB (1) GB0427603D0 (pt)
GT (1) GT200500353A (pt)
IL (1) IL183366A0 (pt)
MA (1) MA29092B1 (pt)
MX (1) MX2007007211A (pt)
NO (1) NO338969B1 (pt)
PE (1) PE20060740A1 (pt)
PL (1) PL1838664T3 (pt)
PT (1) PT1838664E (pt)
RU (1) RU2404158C2 (pt)
TN (1) TNSN07229A1 (pt)
TW (1) TW200635880A (pt)
WO (1) WO2006063821A1 (pt)
ZA (1) ZA200703826B (pt)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PE20070548A1 (es) * 2005-09-19 2007-07-12 Emisphere Tech Inc Formas cristalinas de la sal de di-sodio del acido n-(5-clorosaliciloil)-8-aminocaprilico
WO2009059188A1 (en) 2007-11-02 2009-05-07 Emisphere Technologies, Inc. Method of treating vitamin b12 deficiency
CN109473182B (zh) * 2018-11-12 2021-10-19 北京北排科技有限公司 一种基于深度信念网络的mbr膜透水率智能检测方法
CA3141383A1 (en) * 2019-05-20 2020-11-26 Lonza Guangzhou Pharmaceutical Ltd. Method for preparation of carsalam
CN115260116B (zh) * 2022-08-19 2024-04-12 株洲壹诺生物技术有限公司 8-(2-羟基苯甲酰胺基)辛酸钠及苯并噁嗪-2,4-二酮和8-溴辛酸乙酯的制法

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2369591C (en) 1999-04-05 2011-06-14 Emisphere Technologies, Inc. Disodium salts, monohydrate, and ethanol solvates
BR0011928A (pt) * 1999-06-25 2002-04-09 Inst For Pharm Discovery Inc Composto, composição farmacêutica, uso de, um composto e métodos para o tratamento de complicações diabéticas, para o tratamento ou a prevenção do desenvolvimento de condições de doença associadas com velocidade de condução neuronial prejudicada e de neuropatia diabética
ES2386263T3 (es) 2000-03-21 2012-08-14 Emisphere Technologies, Inc. Método de preparación de salicilamidas alquiladas mediante un producto intermedio de dicarboxilato
WO2001092206A1 (en) 2000-06-02 2001-12-06 Emisphere Technologies, Inc. Method of preparing salicylamides
CN100482637C (zh) * 2000-06-29 2009-04-29 艾米斯菲尔技术有限公司 用于投递活性剂的化合物和组合物
US7495030B2 (en) * 2000-09-06 2009-02-24 Emisphere Technologies, Inc. (5-(2-hydroxy-4-chlorobenzoyl) aminovaleric acid and salts thereof and compositions containing the same for delivering active agents
US7049283B2 (en) * 2000-12-06 2006-05-23 Novartis Ag Pharmaceutical compositions for the oral delivery of pharmacologically active agents
ES2412306T3 (es) * 2002-01-09 2013-07-11 Emisphere Technologies, Inc. Polimorfos de 4-((4-cloro-2-hidroxibenzoil)amino)butanoato de sodio
NZ534125A (en) 2002-02-20 2006-11-30 Emisphere Tech Inc A formulation comprising a GLP-1 compound and a delivery agent
US20050054557A1 (en) * 2002-05-09 2005-03-10 Goldberg Michael M. Compositions for delivering parathyroid hormone and calcitonin

Also Published As

Publication number Publication date
US8461385B2 (en) 2013-06-11
RU2007126972A (ru) 2009-01-27
GT200500353A (es) 2006-07-17
CA2587213C (en) 2015-05-19
RU2404158C2 (ru) 2010-11-20
CA2587213A1 (en) 2006-06-22
AU2005315850B2 (en) 2009-11-05
ZA200703826B (en) 2008-08-27
JP2008524142A (ja) 2008-07-10
IL183366A0 (en) 2007-09-20
AU2005315850A1 (en) 2006-06-22
KR20070086276A (ko) 2007-08-27
GB0427603D0 (en) 2005-01-19
MX2007007211A (es) 2007-08-15
EP1838664B1 (en) 2015-07-15
EP1838664A1 (en) 2007-10-03
PE20060740A1 (es) 2006-09-04
AR055007A1 (es) 2007-08-01
NO20073548L (no) 2007-09-17
PT1838664E (pt) 2015-10-16
JP5224816B2 (ja) 2013-07-03
TW200635880A (en) 2006-10-16
EP2955171A1 (en) 2015-12-16
WO2006063821A1 (en) 2006-06-22
CN101080384A (zh) 2007-11-28
KR101287233B1 (ko) 2013-07-17
PL1838664T3 (pl) 2016-04-29
MA29092B1 (fr) 2007-12-03
NO338969B1 (no) 2016-11-07
US20090253811A1 (en) 2009-10-08
TNSN07229A1 (en) 2008-11-21
ES2547349T3 (es) 2015-10-05
CN101080384B (zh) 2011-06-15

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Legal Events

Date Code Title Description
B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]
B07E Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette]
B06A Patent application procedure suspended [chapter 6.1 patent gazette]
B11B Dismissal acc. art. 36, par 1 of ipl - no reply within 90 days to fullfil the necessary requirements