UY27619A1 - Ésteres hidroxamato del ácido n-(4-fenil sustituido)- antranílico - Google Patents
Ésteres hidroxamato del ácido n-(4-fenil sustituido)- antranílicoInfo
- Publication number
- UY27619A1 UY27619A1 UY27619A UY27619A UY27619A1 UY 27619 A1 UY27619 A1 UY 27619A1 UY 27619 A UY27619 A UY 27619A UY 27619 A UY27619 A UY 27619A UY 27619 A1 UY27619 A1 UY 27619A1
- Authority
- UY
- Uruguay
- Prior art keywords
- substituted
- esters
- antranílico
- hydroxamate
- phenyl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C317/00—Sulfones; Sulfoxides
- C07C317/26—Sulfones; Sulfoxides having sulfone or sulfoxide groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton
- C07C317/32—Sulfones; Sulfoxides having sulfone or sulfoxide groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton with sulfone or sulfoxide groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton
- C07C317/34—Sulfones; Sulfoxides having sulfone or sulfoxide groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton with sulfone or sulfoxide groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton having sulfone or sulfoxide groups and amino groups bound to carbon atoms of six-membered aromatic rings being part of the same non-condensed ring or of a condensed ring system containing that ring
- C07C317/36—Sulfones; Sulfoxides having sulfone or sulfoxide groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton with sulfone or sulfoxide groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton having sulfone or sulfoxide groups and amino groups bound to carbon atoms of six-membered aromatic rings being part of the same non-condensed ring or of a condensed ring system containing that ring with the nitrogen atoms of the amino groups bound to hydrogen atoms or to carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C259/00—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups
- C07C259/04—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups without replacement of the other oxygen atom of the carboxyl group, e.g. hydroxamic acids
- C07C259/10—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups without replacement of the other oxygen atom of the carboxyl group, e.g. hydroxamic acids having carbon atoms of hydroxamic groups bound to carbon atoms of six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
- C07C323/23—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton
- C07C323/31—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton having the sulfur atom of at least one of the thio groups bound to a carbon atom of a six-membered aromatic ring of the carbon skeleton
- C07C323/33—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton having the sulfur atom of at least one of the thio groups bound to a carbon atom of a six-membered aromatic ring of the carbon skeleton having at least one of the nitrogen atoms bound to a carbon atom of the same non-condensed six-membered aromatic ring
- C07C323/35—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton having the sulfur atom of at least one of the thio groups bound to a carbon atom of a six-membered aromatic ring of the carbon skeleton having at least one of the nitrogen atoms bound to a carbon atom of the same non-condensed six-membered aromatic ring the thio group being a sulfide group
- C07C323/36—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton having the sulfur atom of at least one of the thio groups bound to a carbon atom of a six-membered aromatic ring of the carbon skeleton having at least one of the nitrogen atoms bound to a carbon atom of the same non-condensed six-membered aromatic ring the thio group being a sulfide group the sulfur atom of the sulfide group being further bound to an acyclic carbon atom
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Rheumatology (AREA)
- Dermatology (AREA)
- Immunology (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pain & Pain Management (AREA)
- Vascular Medicine (AREA)
- Urology & Nephrology (AREA)
- Hospice & Palliative Care (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
La presente invención se refiere a ésteres oxigenados de derivados del ácido 4-sustituido-fenilamino-benzhidroxámico, a comoposiciones farmacéuticas y a métodos para su uso.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US35120102P | 2002-01-23 | 2002-01-23 |
Publications (1)
Publication Number | Publication Date |
---|---|
UY27619A1 true UY27619A1 (es) | 2003-08-29 |
Family
ID=27613472
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
UY27619A UY27619A1 (es) | 2002-01-23 | 2003-01-22 | Ésteres hidroxamato del ácido n-(4-fenil sustituido)- antranílico |
Country Status (15)
Country | Link |
---|---|
US (2) | US6891066B2 (es) |
EP (1) | EP1467968A1 (es) |
JP (1) | JP2005515253A (es) |
AR (1) | AR038213A1 (es) |
BR (1) | BR0307060A (es) |
CA (1) | CA2473545A1 (es) |
DO (1) | DOP2003000565A (es) |
GT (1) | GT200300010A (es) |
HN (1) | HN2003000044A (es) |
MX (1) | MXPA04005527A (es) |
PA (1) | PA8563801A1 (es) |
PE (1) | PE20030856A1 (es) |
TW (1) | TW592692B (es) |
UY (1) | UY27619A1 (es) |
WO (1) | WO2003062191A1 (es) |
Families Citing this family (27)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP3000810B1 (en) | 2002-03-13 | 2017-07-19 | Array Biopharma, Inc. | N3 alkylated benzimidazole derivative as mek inhibitor |
EP1500643A4 (en) * | 2002-04-03 | 2007-03-28 | Dainippon Sumitomo Pharma Co | BENZAMIDE DERIVATIVES |
RU2352558C2 (ru) | 2003-10-21 | 2009-04-20 | Уорнер-Ламберт Компани Ллс | Полиморфная форма n-[(r)-2,3-дигидроксипропокси]-3,4-дифтор-2-(2-фтор-4 йодфениламино)бензамида |
US7598383B2 (en) | 2003-11-19 | 2009-10-06 | Array Biopharma Inc. | Heterocyclic inhibitors of MEK and methods of use thereof |
UA89035C2 (ru) | 2003-12-03 | 2009-12-25 | Лео Фарма А/С | Эфиры гидроксамовых кислот и их фармацевтическое применение |
US20050171182A1 (en) * | 2003-12-11 | 2005-08-04 | Roger Briesewitz | Methods and compositions for use in the treatment of mutant receptor tyrosine kinase driven cellular proliferative diseases |
US8101799B2 (en) * | 2005-07-21 | 2012-01-24 | Ardea Biosciences | Derivatives of N-(arylamino) sulfonamides as inhibitors of MEK |
NZ567140A (en) | 2005-10-07 | 2011-09-30 | Exelixis Inc | Azetidines as MEK inhibitors for the treatment of proliferative diseases |
AU2007334402B2 (en) | 2006-12-14 | 2014-02-13 | Exelixis, Inc. | Methods of using MEK inhibitors |
EP2346818B1 (en) | 2008-11-10 | 2012-12-05 | Bayer Intellectual Property GmbH | Substituted sulphonamido phenoxybenzamides |
US9084781B2 (en) | 2008-12-10 | 2015-07-21 | Novartis Ag | MEK mutations conferring resistance to MEK inhibitors |
BR112012008599A2 (pt) * | 2009-10-13 | 2019-09-24 | Allostem Therapeutics Llc | composto da formula (i), composto da fórmula (ia), composto da fórmula (ic), composto da fórmula (ii), composto da fórmula (iia), composto, método para tratamento de um transtorno hiperproliferativo em um mamífero, que inclui um humano, método para tratamento de uma doença, condição ou transtorno inflamatório em um mamífero, que inclui um humano, método para tratamento de um transtorno ou condição que é modulada pela cascata de meik em um mamífero, que inclui um himano, método para tratar ou prevenir câncer, composição farmacêutica e método para inibir uma enzima mek |
CN102656142A (zh) | 2009-10-21 | 2012-09-05 | 拜耳制药股份公司 | 取代的苯磺酰胺 |
US20120263714A1 (en) | 2009-10-21 | 2012-10-18 | Bayer Intellectual Property Gmbh | Substituted halophenoxybenzamide derivatives |
WO2011047795A1 (en) | 2009-10-21 | 2011-04-28 | Bayer Schering Pharma Aktiengesellschaft | Substituted benzosulphonamides |
EP3028699B1 (en) | 2010-02-25 | 2018-03-21 | Dana-Farber Cancer Institute, Inc. | Braf mutations conferring resistance to braf inhibitors |
ES2714875T3 (es) | 2010-03-09 | 2019-05-30 | Dana Farber Cancer Inst Inc | Métodos de diagnóstico y tratamiento del cáncer en pacientes que presentan o desarrollan resistencia a una primera terapia del cáncer |
CA2816188A1 (en) | 2010-10-29 | 2012-05-03 | Marion Hitchcock | Substituted phenoxypyridines |
US20150141470A1 (en) | 2012-05-08 | 2015-05-21 | The Broad Institute, Inc. | Diagnostic and treatment methods in patients having or at risk of developing resistance to cancer therapy |
CN104394855A (zh) | 2012-05-31 | 2015-03-04 | 拜耳医药股份有限公司 | 用于测定肝细胞癌(hcc)患者的治疗的有效响应的生物标记 |
MY186549A (en) | 2012-10-12 | 2021-07-26 | Exelixis Inc | Novel process for making compounds for use in the treatment of cancer |
US9556112B2 (en) * | 2012-11-15 | 2017-01-31 | Duquesne University Of The Holy Ghost | Carboxylic acid ester prodrug inhibitors of MEK |
JP6863742B2 (ja) * | 2013-09-11 | 2021-04-21 | ジ・アドミニストレーターズ・オブ・ザ・チューレーン・エデュケーショナル・ファンド | 新規アントラニルアミドとその使用 |
CN105646438A (zh) * | 2015-12-22 | 2016-06-08 | 天津大学 | 一种缩酮类糖醇基小分子凝胶因子及其制备方法和应用 |
US10214322B2 (en) * | 2016-02-16 | 2019-02-26 | Pan Pacific Plastics Mfg., Inc. | Child resistant plastic bag assembly |
HUE055738T2 (hu) | 2017-10-17 | 2021-12-28 | Atriva Therapeutics Gmbh | Új MEK-inhibitor vírus- és baktérium-fertõzések kezelésére |
TW202342018A (zh) | 2022-03-04 | 2023-11-01 | 美商奇奈特生物製藥公司 | Mek激酶抑制劑 |
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US2082171A (en) * | 1933-05-24 | 1937-06-01 | Winthrop Chem Co Inc | Basically substituted amino acridine derivatives |
NL62219C (es) * | 1945-05-07 | |||
US2553914A (en) * | 1948-03-22 | 1951-05-22 | Ward Blenkinsop & Co Ltd | Substituted diphenylamine 2-monocarboxylic acids and the production thereof |
US3781358A (en) * | 1968-05-29 | 1973-12-25 | E Anderson | Intermediates for preparing acridines |
CH541608A (de) | 1970-11-06 | 1973-09-15 | Ciba Geigy Ag | Verfahren zur Herstellung von Nitrodiphenylaminen und deren Verwendung |
DE2636669A1 (de) * | 1976-08-14 | 1978-02-23 | Basf Ag | Verfahren zur herstellung von glykolestern |
US4121039A (en) * | 1977-09-26 | 1978-10-17 | Gaf Corporation | Process for producing an unsaturated glycol diester using a catalyst comprising palladium containing thorium as a promotor |
US4263448A (en) * | 1979-03-30 | 1981-04-21 | Halcon Research And Development Corp. | Process for oxidation of hydrocarbons |
US4510139A (en) * | 1984-01-06 | 1985-04-09 | Sterling Drug Inc. | Substituted aminobenzamides and their use as agents which inhibit lipoxygenase activity |
DE3608726A1 (de) * | 1986-03-15 | 1987-09-17 | Hoechst Ag | Verwendung aminosubstituierter benzoesaeuren als heilmittel gegen diarrhoe und arzneimittel auf basis dieser verbindungen |
US5155110A (en) | 1987-10-27 | 1992-10-13 | Warner-Lambert Company | Fenamic acid hydroxamate derivatives having cyclooxygenase and 5-lipoxygenase inhibition |
US5068250A (en) * | 1988-09-29 | 1991-11-26 | Trustees Of University Of Pennsylvania | Irreversible ligands for nonsteroidal antiinflammatory drug and prostaglandin binding sites |
WO1993024442A1 (en) | 1992-05-29 | 1993-12-09 | Yamanouchi Pharmaceutical Co., Ltd. | Medicine containing benzoic acid derivative and novel benzoic acid derivative |
US5525625A (en) * | 1995-01-24 | 1996-06-11 | Warner-Lambert Company | 2-(2-Amino-3-methoxyphenyl)-4-oxo-4H-[1]benzopyran for treating proliferative disorders |
AU6858996A (en) | 1995-08-28 | 1997-03-19 | Interlab Corporation | Pharmaceutical compositions for the treatment of infectious diseases |
IL118657A0 (en) | 1996-06-14 | 1996-10-16 | Arad Dorit | Inhibitors for picornavirus proteases |
US6251943B1 (en) * | 1997-02-28 | 2001-06-26 | Warner-Lambert Company | Method of treating or preventing septic shock by administering a MEK inhibitor |
WO1999001426A1 (en) * | 1997-07-01 | 1999-01-14 | Warner-Lambert Company | 4-bromo or 4-iodo phenylamino benzhydroxamic acid derivatives and their use as mek inhibitors |
US6310060B1 (en) * | 1998-06-24 | 2001-10-30 | Warner-Lambert Company | 2-(4-bromo or 4-iodo phenylamino) benzoic acid derivatives and their use as MEK inhibitors |
CA2290509A1 (en) | 1997-07-01 | 1999-01-14 | Warner-Lambert Company | 2-(4-bromo or 4-iodo phenylamino) benzoic acid derivatives and their use as mek inhibitors |
DK1028950T3 (da) | 1997-10-28 | 2003-09-01 | Warner Lambert Co | 7-substituerede quinazolin-2,4-dioner nyttige som antibakterielle midler |
EP1150950A2 (en) | 1999-01-13 | 2001-11-07 | Warner-Lambert Company | Anthranilic acid derivatives |
EP1301472B1 (en) | 2000-07-19 | 2014-03-26 | Warner-Lambert Company LLC | Oxygenated esters of 4-iodo phenylamino benzhydroxamic acids |
-
2003
- 2003-01-13 WO PCT/IB2003/000211 patent/WO2003062191A1/en active Application Filing
- 2003-01-13 BR BR0307060-3A patent/BR0307060A/pt not_active IP Right Cessation
- 2003-01-13 MX MXPA04005527A patent/MXPA04005527A/es unknown
- 2003-01-13 EP EP03731797A patent/EP1467968A1/en not_active Withdrawn
- 2003-01-13 CA CA002473545A patent/CA2473545A1/en not_active Abandoned
- 2003-01-13 JP JP2003562075A patent/JP2005515253A/ja not_active Withdrawn
- 2003-01-17 PE PE2003000059A patent/PE20030856A1/es not_active Application Discontinuation
- 2003-01-22 GT GT200300010A patent/GT200300010A/es unknown
- 2003-01-22 AR ARP030100185A patent/AR038213A1/es unknown
- 2003-01-22 TW TW092101396A patent/TW592692B/zh not_active IP Right Cessation
- 2003-01-22 UY UY27619A patent/UY27619A1/es not_active Application Discontinuation
- 2003-01-23 US US10/349,801 patent/US6891066B2/en not_active Expired - Fee Related
- 2003-01-23 DO DO2003000565A patent/DOP2003000565A/es unknown
- 2003-01-23 PA PA20038563801A patent/PA8563801A1/es unknown
- 2003-01-27 HN HN2003000044A patent/HN2003000044A/es unknown
-
2005
- 2005-02-04 US US11/051,142 patent/US7078438B2/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
US7078438B2 (en) | 2006-07-18 |
CA2473545A1 (en) | 2003-07-31 |
WO2003062191A8 (en) | 2004-01-15 |
PE20030856A1 (es) | 2003-10-11 |
US6891066B2 (en) | 2005-05-10 |
DOP2003000565A (es) | 2003-08-15 |
AR038213A1 (es) | 2005-01-05 |
HN2003000044A (es) | 2003-08-01 |
JP2005515253A (ja) | 2005-05-26 |
PA8563801A1 (es) | 2003-09-17 |
US20040006245A1 (en) | 2004-01-08 |
US20050137263A1 (en) | 2005-06-23 |
TW592692B (en) | 2004-06-21 |
EP1467968A1 (en) | 2004-10-20 |
GT200300010A (es) | 2003-08-22 |
TW200302083A (en) | 2003-08-01 |
WO2003062191A1 (en) | 2003-07-31 |
MXPA04005527A (es) | 2005-03-23 |
BR0307060A (pt) | 2004-10-26 |
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