CN101058564B - 芳基烷基氨基甲酸酯衍生物的生产及其在治疗中的用途 - Google Patents

芳基烷基氨基甲酸酯衍生物的生产及其在治疗中的用途 Download PDF

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CN101058564B
CN101058564B CN2007100840856A CN200710084085A CN101058564B CN 101058564 B CN101058564 B CN 101058564B CN 2007100840856 A CN2007100840856 A CN 2007100840856A CN 200710084085 A CN200710084085 A CN 200710084085A CN 101058564 B CN101058564 B CN 101058564B
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CN101058564A (zh
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A·阿布阿卜杜拉
A·阿尔马里奥加西亚
C·霍恩阿尔特
A·拉韦
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Sanofi Aventis France
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CN2007100840856A 2003-01-23 2004-01-22 芳基烷基氨基甲酸酯衍生物的生产及其在治疗中的用途 Expired - Fee Related CN101058564B (zh)

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FR0300704A FR2850377B1 (fr) 2003-01-23 2003-01-23 Derives d'arylalkylcarbamates, leur preparation et leur application en therapeutique
FR03/00704 2003-01-23

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Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2864080B1 (fr) * 2003-12-23 2006-02-03 Sanofi Synthelabo Derives de 1-piperazine-et-1-homopiperazine-carboxylates, leur preparation et leur application en therapeutique
FR2865205B1 (fr) 2004-01-16 2006-02-24 Sanofi Synthelabo Derives de type aryloxyalkylcarbamates, leur preparation et leur application en therapeutique
FR2866884B1 (fr) * 2004-02-26 2007-08-31 Sanofi Synthelabo Derives d'aryl-et d'heteroaryl-piperidinecarboxylates, leur preparation et leur application en therapeutique
FR2866885B1 (fr) * 2004-02-26 2007-08-31 Sanofi Synthelabo Derives de piperidinylalkylcarbamates, leur prepation et leur application en therapeutique
FR2866886B1 (fr) * 2004-02-26 2007-08-31 Sanofi Synthelabo Derives d'aryl-et d'heteroaryl-akylcarbamates, leur preparation et leur application en therapeutique
DE102004039326A1 (de) * 2004-08-12 2006-02-16 Abbott Gmbh & Co. Kg Neue medizinische Verwendungen und Verfahren
WO2006074025A1 (en) * 2004-12-30 2006-07-13 Janssen Pharmaceutica N.V. Piperazinyl and piperidinyl ureas as modulators of fatty acid amide hydrolase
US20070155707A1 (en) * 2005-12-29 2007-07-05 Kadmus Pharmaceuticals, Inc. Ionizable inhibitors of fatty acid amide hydrolase
US20080089845A1 (en) * 2006-09-07 2008-04-17 N.V. Organon Methods for determining effective doses of fatty acid amide hydrolase inhibitors in vivo
US20090099240A1 (en) * 2006-10-02 2009-04-16 N.V. Organon Methods for treating energy metabolism disorders by inhibiting fatty acid amide hydrolase activity
EP2096915A1 (en) * 2006-11-20 2009-09-09 N.V. Organon Metabolically-stabilized inhibitors of fatty acid amide hydrolase
WO2009009041A2 (en) * 2007-07-06 2009-01-15 Kinex Pharmaceuticals, Llc Compositions and methods for modulating a kinase cascade
TW200948805A (en) * 2008-03-07 2009-12-01 Sigma Tau Ind Farmaceuti Enol carbamate derivatives as modulators of fatty acid amide hydrolase
CN101538245B (zh) * 2008-03-18 2011-02-16 中国科学院上海药物研究所 一类哒嗪酮类化合物及其制备方法和制备药物的用途
UA108233C2 (uk) 2010-05-03 2015-04-10 Модулятори активності гідролази амідів жирних кислот
EP2598477B1 (en) * 2010-07-28 2016-03-02 The Regents of The University of California Peripherally restricted faah inhibitors
JP6092870B2 (ja) 2011-08-19 2017-03-08 ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア メタ置換ビフェニル末梢に限局されたｆａａｈ阻害剤
US9926273B2 (en) 2012-08-30 2018-03-27 Athenex, Inc. Composition and methods for modulating a kinase cascade
ES2908240T3 (es) 2014-04-07 2022-04-28 Univ California Inhibidores de la enzima amida hidrolasa de ácidos grasos (FAAH) con biodisponibilidad oral mejorada y su uso como medicamentos
BR112021007830A2 (pt) * 2018-11-20 2021-08-03 Bayer Aktiengesellschaft antagonistas do adrenoceptor-alfa2 do subtipo c (al-fa-2c) para o tratamento da apneia do sono
CN118515624B (zh) * 2024-04-29 2025-01-24 聊城金歌合成材料有限公司 一种含三氟甲基多取代恶唑烷-4-酮的合成方法及应用

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2909467A (en) * 1958-07-09 1959-10-20 Us Vitamin Pharm Corp 3-(d-alpha-methylphenethyl)-5-methyl-1, 3-oxazolidine-2, 4-dione
US3311655A (en) * 1960-05-24 1967-03-28 France Etat Process for the preparation of urethanes
DE3003653A1 (de) * 1980-02-01 1981-08-06 Hoechst Ag, 6000 Frankfurt Verfahren zur herstellung von n-substituierten oxazolindionen-(2,4)

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3742022A (en) * 1967-05-08 1973-06-26 A Verbiscar Carbamate esters of physiologically active ph enenthylamines
JP2616989B2 (ja) * 1989-04-03 1997-06-04 株式会社トクヤマ ２，４―オキサゾリジンジオン化合物
EP0545478A1 (en) * 1991-12-03 1993-06-09 MERCK SHARP & DOHME LTD. Heterocyclic compounds as tachykinin antagonists
GB9210744D0 (en) * 1992-05-20 1992-07-08 Pfizer Ltd Antiviral peptides
US6462054B1 (en) * 2000-03-27 2002-10-08 The Scripps Research Institute Inhibitors of fatty acid amide hydrolase
MXPA03009850A (es) * 2001-04-27 2004-02-12 Bristol Myers Squibb Co Inhibidores de bisarilimidazolil de hidrolasa de amida del acido graso.
PL373970A1 (en) * 2002-02-08 2005-09-19 Bristol-Myers Squibb Company (oxime)carbamoyl fatty acid amide hydrolase inhibitors

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2909467A (en) * 1958-07-09 1959-10-20 Us Vitamin Pharm Corp 3-(d-alpha-methylphenethyl)-5-methyl-1, 3-oxazolidine-2, 4-dione
US3311655A (en) * 1960-05-24 1967-03-28 France Etat Process for the preparation of urethanes
DE3003653A1 (de) * 1980-02-01 1981-08-06 Hoechst Ag, 6000 Frankfurt Verfahren zur herstellung von n-substituierten oxazolindionen-(2,4)

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
Seymour L. Shapiro, Ira M. Rose, Frank C. Testa,等.N-Substituted Oxaolidiones.J. Of American Chemistry Society81 24.1959,81(24),6498-6504. *
Seymour L.Shapiro, Ira M. Rose, Frank C.Testa,等.N-Substituted Oxaolidiones.J.Of American Chemistry Society81 24.1959,81(24),6498-6504. *
Stefania Cesa, Vittoria Mucciante, Leucio Rossi.Tetraethyllmmonium Hydrogen Carbonate organicSynthisis:Synthesis of Oxaolidine-2,4-diones.Tetrahedron55 1.1999,55(1),193-200. *
Stefania Cesa,Vittoria Mucciante,Leucio Rossi.Tetraethyllmmonium Hydrogen Carbonate organicSynthisis:Synthesis of Oxaolidine-2,4-diones.Tetrahedron55 1.1999,55(1),193-200. *

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