CN101052622A - 阿片中间体及其合成方法 - Google Patents

阿片中间体及其合成方法 Download PDF

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Publication number
CN101052622A
CN101052622A CNA2005800376856A CN200580037685A CN101052622A CN 101052622 A CN101052622 A CN 101052622A CN A2005800376856 A CNA2005800376856 A CN A2005800376856A CN 200580037685 A CN200580037685 A CN 200580037685A CN 101052622 A CN101052622 A CN 101052622A
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CN
China
Prior art keywords
formula
compounds
alkyl
aryl
acyl group
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CNA2005800376856A
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English (en)
Chinese (zh)
Inventor
王先棋
法兰克.W.莫泽
加里.L.坎特雷尔
丹尼尔.P.马格帕兰加兰
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Mallinckrodt Inc
Original Assignee
Mallinckrodt Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mallinckrodt Inc filed Critical Mallinckrodt Inc
Publication of CN101052622A publication Critical patent/CN101052622A/zh
Pending legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
    • C07C235/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton
    • C07C235/32—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton containing six-membered aromatic rings
    • C07C235/34—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton containing six-membered aromatic rings having the nitrogen atoms of the carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/12—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring
    • C07D217/18—Aralkyl radicals
    • C07D217/20—Aralkyl radicals with oxygen atoms directly attached to the aromatic ring of said aralkyl radical, e.g. papaverine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
    • C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
    • C07D221/22—Bridged ring systems
    • C07D221/28—Morphinans

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Vacuum Packaging (AREA)
  • Saccharide Compounds (AREA)
CNA2005800376856A 2004-11-04 2005-10-21 阿片中间体及其合成方法 Pending CN101052622A (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US62539704P 2004-11-04 2004-11-04
US60/625,397 2004-11-04

Publications (1)

Publication Number Publication Date
CN101052622A true CN101052622A (zh) 2007-10-10

Family

ID=35695757

Family Applications (1)

Application Number Title Priority Date Filing Date
CNA2005800376856A Pending CN101052622A (zh) 2004-11-04 2005-10-21 阿片中间体及其合成方法

Country Status (13)

Country Link
US (1) US7834184B2 (enExample)
EP (1) EP1812399B1 (enExample)
JP (1) JP2008518910A (enExample)
CN (1) CN101052622A (enExample)
AT (1) ATE450513T1 (enExample)
AU (1) AU2005305210B2 (enExample)
CA (1) CA2585698A1 (enExample)
DE (1) DE602005018092D1 (enExample)
ES (1) ES2336131T3 (enExample)
MX (1) MX2007005194A (enExample)
PL (1) PL1812399T3 (enExample)
PT (1) PT1812399E (enExample)
WO (1) WO2006052430A2 (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108383788A (zh) * 2018-03-27 2018-08-10 合肥医工医药有限公司 一种二甲啡烷异构体的制备方法

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MX2009006008A (es) * 2006-12-12 2009-06-16 Mallinckrodt Inc Preparacion de hexahidroisoquinolinas a partir de dihidroisoquinolinas.
US8829020B2 (en) 2009-07-16 2014-09-09 Mallinckrodt Llc Compounds and compositions for use in phototherapy and in treatment of ocular neovascular disease and cancers
WO2011038169A2 (en) 2009-09-24 2011-03-31 Mallinckrodt Inc. One-pot preparation of hexahydroisoquinolines from amides

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GB9127306D0 (en) 1991-12-23 1992-02-19 Boots Co Plc Therapeutic agents
JPH06247935A (ja) 1993-02-25 1994-09-06 Banyu Pharmaceut Co Ltd ６，７−ジアルコキシ−３，４−ジヒドロイソキノリン−８−オール類、その製造法及び該化合物を用いた６，７−ジアルコキシ−１，２，３，４−テトラヒドロイソキノリン−８−オール類の製造法
US5445164A (en) 1993-05-11 1995-08-29 Gynetech, Inc. Cervical tissue sampling device
BR9406897A (pt) 1993-06-22 1996-03-26 Knoll Ag Compostos de tetraidroisoquinolina composiçoes farmaceuticas processo de analgesia ou de tratamento de psicoses doença de parkinson sindrome de leschnyan distúrbio da falta de atençao ou danos cognitivos ou na supressao da dependencia de drogas ou discinesia tardia e uso de um composto
US5869697A (en) 1994-05-02 1999-02-09 Council Of Scientific & Industrial Research Process for preparing diltiazem
US6043253A (en) 1998-03-03 2000-03-28 Merck & Co., Inc. Fused piperidine substituted arylsulfonamides as β3-agonists
KR100295740B1 (ko) 1998-09-17 2001-11-05 박영구 N-치환된-하이드록시고리화알킬아민유도체의제조방법
EP1130022B1 (en) 2000-02-29 2009-07-22 Universita Degli Studi di Firenze 3-Aza-6,8-dioxabicyclo[3.2.1]octanes and analogues and combinatorial libraries containing them
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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108383788A (zh) * 2018-03-27 2018-08-10 合肥医工医药有限公司 一种二甲啡烷异构体的制备方法

Also Published As

Publication number Publication date
CA2585698A1 (en) 2006-05-18
DE602005018092D1 (de) 2010-01-14
WO2006052430A3 (en) 2006-08-24
MX2007005194A (es) 2007-06-20
EP1812399A2 (en) 2007-08-01
US7834184B2 (en) 2010-11-16
EP1812399B1 (en) 2009-12-02
JP2008518910A (ja) 2008-06-05
AU2005305210B2 (en) 2012-01-19
AU2005305210A1 (en) 2006-05-18
PT1812399E (pt) 2010-02-03
WO2006052430A2 (en) 2006-05-18
PL1812399T3 (pl) 2010-05-31
US20080097100A1 (en) 2008-04-24
ATE450513T1 (de) 2009-12-15
ES2336131T3 (es) 2010-04-08

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SE01 Entry into force of request for substantive examination
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Open date: 20071010