ATE450513T1 - Opiatzwischenprodukte und syntheseverfahren - Google Patents
Opiatzwischenprodukte und syntheseverfahrenInfo
- Publication number
- ATE450513T1 ATE450513T1 AT05812329T AT05812329T ATE450513T1 AT E450513 T1 ATE450513 T1 AT E450513T1 AT 05812329 T AT05812329 T AT 05812329T AT 05812329 T AT05812329 T AT 05812329T AT E450513 T1 ATE450513 T1 AT E450513T1
- Authority
- AT
- Austria
- Prior art keywords
- opiato
- intermediate products
- synthesis processes
- alkyl
- synthesis
- Prior art date
Links
- 230000015572 biosynthetic process Effects 0.000 title abstract 2
- 238000000034 method Methods 0.000 title abstract 2
- 238000003786 synthesis reaction Methods 0.000 title abstract 2
- 239000013067 intermediate product Substances 0.000 title 1
- 239000000543 intermediate Substances 0.000 abstract 3
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- 125000003118 aryl group Chemical group 0.000 abstract 2
- 125000002252 acyl group Chemical group 0.000 abstract 1
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 1
- 125000002485 formyl group Chemical group [H]C(*)=O 0.000 abstract 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 150000003809 morphinane derivatives Chemical class 0.000 abstract 1
- 229940127240 opiate Drugs 0.000 abstract 1
- 238000006467 substitution reaction Methods 0.000 abstract 1
- 229940124530 sulfonamide Drugs 0.000 abstract 1
- 150000003456 sulfonamides Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
- C07C235/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton
- C07C235/32—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton containing six-membered aromatic rings
- C07C235/34—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton containing six-membered aromatic rings having the nitrogen atoms of the carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/12—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring
- C07D217/18—Aralkyl radicals
- C07D217/20—Aralkyl radicals with oxygen atoms directly attached to the aromatic ring of said aralkyl radical, e.g. papaverine
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
- C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
- C07D221/22—Bridged ring systems
- C07D221/28—Morphinans
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
- Vacuum Packaging (AREA)
- Saccharide Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US62539704P | 2004-11-04 | 2004-11-04 | |
| PCT/US2005/038140 WO2006052430A2 (en) | 2004-11-04 | 2005-10-21 | Opiate intermediates and methods of synthesis |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE450513T1 true ATE450513T1 (de) | 2009-12-15 |
Family
ID=35695757
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT05812329T ATE450513T1 (de) | 2004-11-04 | 2005-10-21 | Opiatzwischenprodukte und syntheseverfahren |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US7834184B2 (enExample) |
| EP (1) | EP1812399B1 (enExample) |
| JP (1) | JP2008518910A (enExample) |
| CN (1) | CN101052622A (enExample) |
| AT (1) | ATE450513T1 (enExample) |
| AU (1) | AU2005305210B2 (enExample) |
| CA (1) | CA2585698A1 (enExample) |
| DE (1) | DE602005018092D1 (enExample) |
| ES (1) | ES2336131T3 (enExample) |
| MX (1) | MX2007005194A (enExample) |
| PL (1) | PL1812399T3 (enExample) |
| PT (1) | PT1812399E (enExample) |
| WO (1) | WO2006052430A2 (enExample) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MX2009006008A (es) * | 2006-12-12 | 2009-06-16 | Mallinckrodt Inc | Preparacion de hexahidroisoquinolinas a partir de dihidroisoquinolinas. |
| US8829020B2 (en) | 2009-07-16 | 2014-09-09 | Mallinckrodt Llc | Compounds and compositions for use in phototherapy and in treatment of ocular neovascular disease and cancers |
| WO2011038169A2 (en) | 2009-09-24 | 2011-03-31 | Mallinckrodt Inc. | One-pot preparation of hexahydroisoquinolines from amides |
| CN108383788A (zh) * | 2018-03-27 | 2018-08-10 | 合肥医工医药有限公司 | 一种二甲啡烷异构体的制备方法 |
Family Cites Families (32)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB685748A (en) | 1949-10-14 | 1953-01-07 | Hoffmann La Roche | Improvements in or relating to isoquinoline derivatives |
| DE1138765B (de) | 1954-12-28 | 1962-10-31 | Farmaceutici Italia | Verfahren zur Herstellung der Kaffeesaeureester der Chinasaeure |
| DE1154268B (de) | 1960-01-07 | 1963-09-12 | Bayer Ag | Die Verhuetung der elektrostatischen Aufladung bei synthetischen Hochpolymeren |
| US3438989A (en) | 1967-03-10 | 1969-04-15 | Warner Lambert Pharmaceutical | Process for the production of ( ) dihydrothebainone |
| US3862327A (en) | 1967-11-01 | 1975-01-21 | Uniroyal Inc | Substituted phenylethyl sulfites useful for controlling mites |
| FR2015566A1 (enExample) | 1968-08-13 | 1970-04-30 | Basf Ag | |
| US3922285A (en) | 1971-03-26 | 1975-11-25 | Hoffmann La Roche | Process for the methylenation of catechols |
| US3914233A (en) | 1972-10-20 | 1975-10-21 | Hoffmann La Roche | 4-Hydroxy-N-substituted morphinan derivatives |
| HU182087B (en) | 1980-01-15 | 1983-12-28 | Mta Kiserleti Orvostudomanyi K | Process for preparing an active substance for the selective inhibition of the multiplication of normal cells and of cells in myeloide leukemia |
| US4727146A (en) | 1980-07-03 | 1988-02-23 | The United States Of America As Represented By The Department Of Health And Human Services | Synthesis of chiral 1-benzyl-1,2,3,4-tetra-hydroisoquinolines by asymmetric reduction |
| US4410700A (en) * | 1980-07-03 | 1983-10-18 | The United States Of America As Represented By The Department Of Health And Human Services | Preparation of chiral 1-benzyl-1,2,3,4-tetrahydroisoquinolines by optical resolution |
| US4368326A (en) * | 1980-07-03 | 1983-01-11 | Rice Kenner C | Short total synthesis of dihydrothebainone, dihydrocodeinone, and nordihydroccodeinone |
| US4521601A (en) | 1981-05-20 | 1985-06-04 | The United States Of America As Represented By The Department Of Health & Human Services | Practical total synthesis unnatural enantiomers of opium-derived morphinans |
| US4514569A (en) | 1982-01-28 | 1985-04-30 | Hendrickson James B | Synthesis of 1-substituted isoquinolines |
| US4452601A (en) | 1982-03-19 | 1984-06-05 | Celanese Corporation | Process for the thermal stabilization of acrylic fibers and films |
| US4613668A (en) * | 1983-12-22 | 1986-09-23 | The United States Of America As Represented By The Department Of Health And Human Services | Short total synthesis or morphinan compounds which uses cyclization of a cycloalkylcarbonyl compound selected from cyclopropylcarbonyl and cyclobutylcarbonyl |
| US4727504A (en) * | 1984-07-05 | 1988-02-23 | The Charles Stark Draper Laboratory, Inc. | Interference canceller and signal quantizer |
| US4737504A (en) | 1986-07-25 | 1988-04-12 | Ohio State University Research Foundation | 5-fluoro-and 8-fluoro-trimetoquinol compounds and the processes for their preparation |
| US5668285A (en) | 1986-10-31 | 1997-09-16 | The United States Of America As Represented By The Department Of Health And Human Services | Total synthesis of northebaine, normophine, noroxymorphone enantiomers and derivatives via N-Nor intermediates |
| US5023342A (en) | 1988-05-26 | 1991-06-11 | Massachusetts Institute Of Technology | Cyclic sulfate compounds |
| US5189200A (en) | 1990-12-21 | 1993-02-23 | Sepracor, Inc. | Process for the stereoselective transformation of a diol to an alcohol |
| GB9127306D0 (en) | 1991-12-23 | 1992-02-19 | Boots Co Plc | Therapeutic agents |
| JPH06247935A (ja) | 1993-02-25 | 1994-09-06 | Banyu Pharmaceut Co Ltd | ６，７−ジアルコキシ−３，４−ジヒドロイソキノリン−８−オール類、その製造法及び該化合物を用いた６，７−ジアルコキシ−１，２，３，４−テトラヒドロイソキノリン−８−オール類の製造法 |
| US5445164A (en) | 1993-05-11 | 1995-08-29 | Gynetech, Inc. | Cervical tissue sampling device |
| BR9406897A (pt) | 1993-06-22 | 1996-03-26 | Knoll Ag | Compostos de tetraidroisoquinolina composiçoes farmaceuticas processo de analgesia ou de tratamento de psicoses doença de parkinson sindrome de leschnyan distúrbio da falta de atençao ou danos cognitivos ou na supressao da dependencia de drogas ou discinesia tardia e uso de um composto |
| US5869697A (en) | 1994-05-02 | 1999-02-09 | Council Of Scientific & Industrial Research | Process for preparing diltiazem |
| US6043253A (en) | 1998-03-03 | 2000-03-28 | Merck & Co., Inc. | Fused piperidine substituted arylsulfonamides as β3-agonists |
| KR100295740B1 (ko) | 1998-09-17 | 2001-11-05 | 박영구 | N-치환된-하이드록시고리화알킬아민유도체의제조방법 |
| EP1130022B1 (en) | 2000-02-29 | 2009-07-22 | Universita Degli Studi di Firenze | 3-Aza-6,8-dioxabicyclo[3.2.1]octanes and analogues and combinatorial libraries containing them |
| US6593341B2 (en) | 2001-03-29 | 2003-07-15 | Molecular Design International, Inc. | β3-adrenoreceptor agonists, agonist compositions and methods of making and using the same |
| US6818766B2 (en) | 2002-10-02 | 2004-11-16 | Synthon Bv | Process for making bicalutamide and intermediates thereof |
| US6596734B1 (en) | 2002-10-11 | 2003-07-22 | Molecular Design International, Inc. | Tetrahydroisoquinoline compounds for use as β3-adrenoreceptor agonists |
-
2005
- 2005-10-21 CA CA002585698A patent/CA2585698A1/en not_active Abandoned
- 2005-10-21 AT AT05812329T patent/ATE450513T1/de active
- 2005-10-21 MX MX2007005194A patent/MX2007005194A/es active IP Right Grant
- 2005-10-21 PL PL05812329T patent/PL1812399T3/pl unknown
- 2005-10-21 WO PCT/US2005/038140 patent/WO2006052430A2/en not_active Ceased
- 2005-10-21 CN CNA2005800376856A patent/CN101052622A/zh active Pending
- 2005-10-21 EP EP05812329A patent/EP1812399B1/en not_active Expired - Lifetime
- 2005-10-21 DE DE602005018092T patent/DE602005018092D1/de not_active Expired - Lifetime
- 2005-10-21 US US11/718,263 patent/US7834184B2/en active Active
- 2005-10-21 ES ES05812329T patent/ES2336131T3/es not_active Expired - Lifetime
- 2005-10-21 PT PT05812329T patent/PT1812399E/pt unknown
- 2005-10-21 JP JP2007539018A patent/JP2008518910A/ja not_active Withdrawn
- 2005-10-21 AU AU2005305210A patent/AU2005305210B2/en not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| CA2585698A1 (en) | 2006-05-18 |
| DE602005018092D1 (de) | 2010-01-14 |
| WO2006052430A3 (en) | 2006-08-24 |
| MX2007005194A (es) | 2007-06-20 |
| EP1812399A2 (en) | 2007-08-01 |
| US7834184B2 (en) | 2010-11-16 |
| EP1812399B1 (en) | 2009-12-02 |
| JP2008518910A (ja) | 2008-06-05 |
| AU2005305210B2 (en) | 2012-01-19 |
| AU2005305210A1 (en) | 2006-05-18 |
| CN101052622A (zh) | 2007-10-10 |
| PT1812399E (pt) | 2010-02-03 |
| WO2006052430A2 (en) | 2006-05-18 |
| PL1812399T3 (pl) | 2010-05-31 |
| US20080097100A1 (en) | 2008-04-24 |
| ES2336131T3 (es) | 2010-04-08 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification |
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