CN1008816B - 含高丙炔基胺的杀真菌组合物 - Google Patents
含高丙炔基胺的杀真菌组合物Info
- Publication number
- CN1008816B CN1008816B CN85109165A CN85109165A CN1008816B CN 1008816 B CN1008816 B CN 1008816B CN 85109165 A CN85109165 A CN 85109165A CN 85109165 A CN85109165 A CN 85109165A CN 1008816 B CN1008816 B CN 1008816B
- Authority
- CN
- China
- Prior art keywords
- alkyl
- formula
- compound
- parts
- hydrogen
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 238000002360 preparation method Methods 0.000 title claims description 8
- 238000000034 method Methods 0.000 title description 12
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- 239000002253 acid Substances 0.000 claims abstract description 12
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- 239000012458 free base Substances 0.000 claims abstract 3
- 201000010099 disease Diseases 0.000 claims abstract 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims abstract 2
- 150000001875 compounds Chemical class 0.000 claims description 49
- 125000000217 alkyl group Chemical group 0.000 claims description 36
- 229910052739 hydrogen Inorganic materials 0.000 claims description 23
- 239000001257 hydrogen Substances 0.000 claims description 23
- 229910052799 carbon Inorganic materials 0.000 claims description 12
- 150000002431 hydrogen Chemical class 0.000 claims description 12
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims description 11
- 238000006243 chemical reaction Methods 0.000 claims description 11
- 150000001721 carbon Chemical group 0.000 claims description 10
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 9
- -1 dialkylphenylsilyl Chemical group 0.000 claims description 8
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- 125000003884 phenylalkyl group Chemical group 0.000 claims description 5
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- WYURNTSHIVDZCO-UHFFFAOYSA-N Tetrahydrofuran Chemical compound C1CCOC1 WYURNTSHIVDZCO-UHFFFAOYSA-N 0.000 description 8
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- 125000004390 alkyl sulfonyl group Chemical group 0.000 description 5
- 239000012442 inert solvent Substances 0.000 description 5
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 5
- 230000003647 oxidation Effects 0.000 description 5
- 238000007254 oxidation reaction Methods 0.000 description 5
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- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 description 4
- 241000221785 Erysiphales Species 0.000 description 4
- 241000221535 Pucciniales Species 0.000 description 4
- GDTBXPJZTBHREO-UHFFFAOYSA-N bromine Substances BrBr GDTBXPJZTBHREO-UHFFFAOYSA-N 0.000 description 4
- 229910052794 bromium Inorganic materials 0.000 description 4
- 235000013339 cereals Nutrition 0.000 description 4
- 229910052801 chlorine Inorganic materials 0.000 description 4
- 239000000460 chlorine Substances 0.000 description 4
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- YMWUJEATGCHHMB-UHFFFAOYSA-N Dichloromethane Chemical compound ClCCl YMWUJEATGCHHMB-UHFFFAOYSA-N 0.000 description 3
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- WSFSSNUMVMOOMR-UHFFFAOYSA-N Formaldehyde Chemical compound O=C WSFSSNUMVMOOMR-UHFFFAOYSA-N 0.000 description 3
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- 125000005037 alkyl phenyl group Chemical group 0.000 description 2
- FPIPGXGPPPQFEQ-OVSJKPMPSA-N all-trans-retinol Chemical compound OC\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-OVSJKPMPSA-N 0.000 description 2
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- QBWKPGNFQQJGFY-QLFBSQMISA-N 3-[(1r)-1-[(2r,6s)-2,6-dimethylmorpholin-4-yl]ethyl]-n-[6-methyl-3-(1h-pyrazol-4-yl)imidazo[1,2-a]pyrazin-8-yl]-1,2-thiazol-5-amine Chemical compound N1([C@H](C)C2=NSC(NC=3C4=NC=C(N4C=C(C)N=3)C3=CNN=C3)=C2)C[C@H](C)O[C@H](C)C1 QBWKPGNFQQJGFY-QLFBSQMISA-N 0.000 description 1
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- 229920002379 silicone rubber Polymers 0.000 description 1
- 235000017550 sodium carbonate Nutrition 0.000 description 1
- 229910000029 sodium carbonate Inorganic materials 0.000 description 1
- APSBXTVYXVQYAB-UHFFFAOYSA-M sodium docusate Chemical compound [Na+].CCCCC(CC)COC(=O)CC(S([O-])(=O)=O)C(=O)OCC(CC)CCCC APSBXTVYXVQYAB-UHFFFAOYSA-M 0.000 description 1
- DAJSVUQLFFJUSX-UHFFFAOYSA-M sodium;dodecane-1-sulfonate Chemical class [Na+].CCCCCCCCCCCCS([O-])(=O)=O DAJSVUQLFFJUSX-UHFFFAOYSA-M 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 239000011343 solid material Substances 0.000 description 1
- 230000001954 sterilising effect Effects 0.000 description 1
- 238000004659 sterilization and disinfection Methods 0.000 description 1
- 239000004575 stone Substances 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 125000001424 substituent group Chemical group 0.000 description 1
- CZDYPVPMEAXLPK-UHFFFAOYSA-N tetramethylsilane Chemical compound C[Si](C)(C)C CZDYPVPMEAXLPK-UHFFFAOYSA-N 0.000 description 1
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 description 1
- 238000007738 vacuum evaporation Methods 0.000 description 1
- 239000000080 wetting agent Substances 0.000 description 1
- CHNQZRKUZPNOOH-UHFFFAOYSA-J zinc;manganese(2+);n-[2-(sulfidocarbothioylamino)ethyl]carbamodithioate Chemical compound [Mn+2].[Zn+2].[S-]C(=S)NCCNC([S-])=S.[S-]C(=S)NCCNC([S-])=S CHNQZRKUZPNOOH-UHFFFAOYSA-J 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N33/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic nitrogen compounds
- A01N33/02—Amines; Quaternary ammonium compounds
- A01N33/04—Nitrogen directly attached to aliphatic or cycloaliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/695—Silicon compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Plant Pathology (AREA)
- Zoology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Agronomy & Crop Science (AREA)
- Pest Control & Pesticides (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Environmental Sciences (AREA)
- Dentistry (AREA)
- Wood Science & Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Dermatology (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Plural Heterocyclic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Furan Compounds (AREA)
- Pyrane Compounds (AREA)
- Pyrrole Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Compounds Containing Sulfur Atoms (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DEP3442529.2 | 1984-11-22 | ||
| DE19843442529 DE3442529A1 (de) | 1984-11-22 | 1984-11-22 | Neue homopropargylaminderivate, verfahren zu ihrer herstellung und ihre verwendung |
| DE19853528736 DE3528736A1 (de) | 1985-08-10 | 1985-08-10 | Neue homopropargylaminderivate, verfahren zu ihrer herstellung und ihre verwendung |
| DEP3528736.5 | 1985-08-10 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN85109165A CN85109165A (zh) | 1986-07-16 |
| CN1008816B true CN1008816B (zh) | 1990-07-18 |
Family
ID=25826721
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN85109165A Expired CN1008816B (zh) | 1984-11-22 | 1985-11-21 | 含高丙炔基胺的杀真菌组合物 |
Country Status (16)
| Country | Link |
|---|---|
| US (1) | US4684661A (enExample) |
| EP (1) | EP0191269B1 (enExample) |
| JP (1) | JPH0660133B2 (enExample) |
| CN (1) | CN1008816B (enExample) |
| AU (1) | AU590229B2 (enExample) |
| BR (1) | BR8505876A (enExample) |
| CA (1) | CA1276027C (enExample) |
| DE (1) | DE3582060D1 (enExample) |
| DK (1) | DK536085A (enExample) |
| ES (1) | ES8705360A1 (enExample) |
| GR (1) | GR852800B (enExample) |
| HU (1) | HU203073B (enExample) |
| IE (1) | IE58623B1 (enExample) |
| IL (1) | IL77106A (enExample) |
| NZ (1) | NZ214259A (enExample) |
| PT (1) | PT81526B (enExample) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS6145A (ja) * | 1984-06-09 | 1986-01-06 | Kaken Pharmaceut Co Ltd | Ｎ‐（４‐ｔｅｒｔ‐ブチルベンジル）‐Ｎ‐メチル‐１‐ナフチルメチルアミンおよびそれを有効成分とする抗真菌剤 |
| US5334628A (en) * | 1984-06-09 | 1994-08-02 | Kaken Pharmaceutical Co., Ltd. | Amine derivatives, processes for preparing the same and fungicides containing the same |
| US5030625A (en) * | 1984-11-22 | 1991-07-09 | Sandoz Ltd. | Anti-fungal homopropargylamine compounds |
| JPS63230610A (ja) * | 1987-03-19 | 1988-09-27 | Kaken Pharmaceut Co Ltd | 農園芸用殺菌剤 |
| EP0363326A3 (en) * | 1988-10-07 | 1991-10-09 | Sandoz Ag | Fungicidal amines |
| US5045551A (en) * | 1989-09-19 | 1991-09-03 | Allergan, Inc. | Acetylenes disubstituted with a heteroaromatic group and a 2-substituted chromanyl, thiochromanyl or 1,2,3,4-tetrahydroquinolinyl group having retinoid-like activity |
| US6743940B2 (en) | 2000-12-15 | 2004-06-01 | Ciba Specialty Chemicals Corporation | 4-aminobut-2-ynecarboxylic acid derivatives |
| EP1215198A1 (en) * | 2000-12-15 | 2002-06-19 | Ciba SC Holding AG | 4-Aminobut-2-yne carboxylic acid derivatives and their use as antimicrobial agents |
| US20060078580A1 (en) | 2004-10-08 | 2006-04-13 | Mediquest Therapeutics, Inc. | Organo-gel formulations for therapeutic applications |
| US7740875B2 (en) * | 2004-10-08 | 2010-06-22 | Mediquest Therapeutics, Inc. | Organo-gel formulations for therapeutic applications |
| CN108084125B (zh) * | 2016-11-23 | 2020-08-18 | 华东理工大学 | 苯并杂环烷基胺类化合物及其用途 |
| CN106905165B (zh) * | 2017-03-14 | 2019-07-26 | 广东药科大学 | 一种抗真菌类药物及其中间体的合成和应用 |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR1468761A (fr) * | 1965-08-05 | 1967-02-10 | Amines et esters carbamiques acétyléniques | |
| JPS5941966B2 (ja) * | 1975-10-21 | 1984-10-11 | 住友化学工業株式会社 | ガイチユウボウジヨソセイブツ オヨビ ソノセイゾウホウ |
| JPS5919549B2 (ja) * | 1976-01-01 | 1984-05-07 | 武田薬品工業株式会社 | 異節環状化合物 |
| DE2609280A1 (de) * | 1976-03-04 | 1977-09-15 | Schering Ag | Schaedlingsbekaempfungsmittel |
| DE2716943C2 (de) * | 1976-04-28 | 1986-08-14 | Sandoz-Patent-GmbH, 7850 Lörrach | N-(3-Phenyl-2-propenyl)-N-(1-naphthylmethyl)-amine, ihre Verwendung und Herstellung |
| DE19975055I1 (de) * | 1979-08-22 | 2000-01-27 | Novartis Ag | Propenylamine Verfahren zu ihrer Herstellung sie enthaltende pharmazeutische Zusammensetzungen und ihre Verwending als Arzneimittel |
| DE3218176A1 (de) * | 1982-05-14 | 1983-11-17 | Bayer Ag, 5090 Leverkusen | Jodpropargylammoniumsalze, verfahren zu ihrer herstellung und ihre verwendung als schaedlingsbekaempfungsmittel |
| DE3405332A1 (de) * | 1984-02-15 | 1985-08-22 | Sandoz-Patent-GmbH, 7850 Lörrach | Neue allylamine, verfahren zu ihrer herstellung und ihre verwendung |
| HU207282B (en) * | 1984-05-31 | 1993-03-29 | Chinoin Gyogyszer Es Vegyeszet | Process for producing phenyl-alkyl-amine derivatives and pharmaceutical compositions containing them |
-
1985
- 1985-11-13 EP EP85810537A patent/EP0191269B1/en not_active Expired - Lifetime
- 1985-11-13 DE DE8585810537T patent/DE3582060D1/de not_active Expired - Lifetime
- 1985-11-20 GR GR852800A patent/GR852800B/el unknown
- 1985-11-20 NZ NZ214259A patent/NZ214259A/xx unknown
- 1985-11-20 AU AU50085/85A patent/AU590229B2/en not_active Ceased
- 1985-11-20 DK DK536085A patent/DK536085A/da not_active Application Discontinuation
- 1985-11-20 HU HU854428A patent/HU203073B/hu not_active IP Right Cessation
- 1985-11-20 PT PT81526A patent/PT81526B/pt not_active IP Right Cessation
- 1985-11-20 US US06/799,807 patent/US4684661A/en not_active Expired - Fee Related
- 1985-11-20 IL IL77106A patent/IL77106A/xx not_active IP Right Cessation
- 1985-11-21 CN CN85109165A patent/CN1008816B/zh not_active Expired
- 1985-11-21 CA CA000495876A patent/CA1276027C/en not_active Expired - Lifetime
- 1985-11-21 IE IE292285A patent/IE58623B1/en not_active IP Right Cessation
- 1985-11-21 JP JP60263634A patent/JPH0660133B2/ja not_active Expired - Lifetime
- 1985-11-21 ES ES549152A patent/ES8705360A1/es not_active Expired
- 1985-11-22 BR BR8505876A patent/BR8505876A/pt unknown
Also Published As
| Publication number | Publication date |
|---|---|
| IE58623B1 (en) | 1993-10-20 |
| JPS61137843A (ja) | 1986-06-25 |
| EP0191269B1 (en) | 1991-03-06 |
| EP0191269A2 (en) | 1986-08-20 |
| DK536085D0 (da) | 1985-11-20 |
| IE852922L (en) | 1986-05-22 |
| IL77106A0 (en) | 1986-04-29 |
| ES549152A0 (es) | 1987-05-01 |
| EP0191269A3 (en) | 1987-08-05 |
| CA1276027C (en) | 1990-11-06 |
| IL77106A (en) | 1988-12-30 |
| ES8705360A1 (es) | 1987-05-01 |
| AU5008585A (en) | 1986-05-29 |
| CN85109165A (zh) | 1986-07-16 |
| PT81526B (pt) | 1988-03-03 |
| PT81526A (en) | 1985-12-01 |
| US4684661A (en) | 1987-08-04 |
| BR8505876A (pt) | 1986-08-12 |
| DE3582060D1 (de) | 1991-04-11 |
| AU590229B2 (en) | 1989-11-02 |
| NZ214259A (en) | 1989-10-27 |
| JPH0660133B2 (ja) | 1994-08-10 |
| HUT39712A (en) | 1986-10-29 |
| DK536085A (da) | 1986-05-23 |
| GR852800B (enExample) | 1986-03-19 |
| HU203073B (en) | 1991-05-28 |
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