CN100573152C - 评估患消化性溃疡的危险度的方法,包括定量测定血清样品中胃蛋白酶原i(pgi)和胃泌素-17的浓度的步骤 - Google Patents

评估患消化性溃疡的危险度的方法,包括定量测定血清样品中胃蛋白酶原i(pgi)和胃泌素-17的浓度的步骤 Download PDF

Info

Publication number
CN100573152C
CN100573152C CN00808720.2A CN00808720A CN100573152C CN 100573152 C CN100573152 C CN 100573152C CN 00808720 A CN00808720 A CN 00808720A CN 100573152 C CN100573152 C CN 100573152C
Authority
CN
China
Prior art keywords
gastrin
determination
pepsinogen
use according
monoclonal
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
CN00808720.2A
Other languages
English (en)
Chinese (zh)
Other versions
CN1355888A (zh
Inventor
彭蒂·西波南
马蒂·哈科南
奥斯莫·斯沃瓦尼米
埃里克·福斯布洛姆
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Biohit Oy
Original Assignee
Biohit Oy
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Biohit Oy filed Critical Biohit Oy
Publication of CN1355888A publication Critical patent/CN1355888A/zh
Application granted granted Critical
Publication of CN100573152C publication Critical patent/CN100573152C/zh
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Images

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/195—Assays involving biological materials from specific organisms or of a specific nature from bacteria
    • G01N2333/205—Assays involving biological materials from specific organisms or of a specific nature from bacteria from Campylobacter (G)
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/575—Hormones
    • G01N2333/595—Gastrins; Cholecystokinins [CCK]
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/90—Enzymes; Proenzymes
    • G01N2333/914—Hydrolases (3)
    • G01N2333/948—Hydrolases (3) acting on peptide bonds (3.4)
    • G01N2333/95—Proteinases, i.e. endopeptidases (3.4.21-3.4.99)
    • G01N2333/964—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue
    • G01N2333/96425—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue from mammals
    • G01N2333/96427—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue from mammals in general
    • G01N2333/9643—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue from mammals in general with EC number
    • G01N2333/96472—Aspartic endopeptidases (3.4.23)
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/06—Gastro-intestinal diseases
    • G01N2800/062—Gastritis or peptic ulcer disease

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Cell Biology (AREA)
  • Biotechnology (AREA)
  • Food Science & Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Measuring Pulse, Heart Rate, Blood Pressure Or Blood Flow (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Seal Device For Vehicle (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)
  • Crystals, And After-Treatments Of Crystals (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
CN00808720.2A 1999-04-30 2000-04-28 评估患消化性溃疡的危险度的方法,包括定量测定血清样品中胃蛋白酶原i(pgi)和胃泌素-17的浓度的步骤 Expired - Lifetime CN100573152C (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FI990992A FI118653B (fi) 1999-04-30 1999-04-30 Menetelmä peptisen haavan riskin määrittämiseksi
FI990992 1999-04-30

Publications (2)

Publication Number Publication Date
CN1355888A CN1355888A (zh) 2002-06-26
CN100573152C true CN100573152C (zh) 2009-12-23

Family

ID=8554567

Family Applications (1)

Application Number Title Priority Date Filing Date
CN00808720.2A Expired - Lifetime CN100573152C (zh) 1999-04-30 2000-04-28 评估患消化性溃疡的危险度的方法,包括定量测定血清样品中胃蛋白酶原i(pgi)和胃泌素-17的浓度的步骤

Country Status (13)

Country Link
US (1) US6872543B1 (enExample)
EP (1) EP1173770B1 (enExample)
JP (1) JP4598959B2 (enExample)
CN (1) CN100573152C (enExample)
AT (1) ATE300053T1 (enExample)
AU (1) AU4299800A (enExample)
DE (1) DE60021369T2 (enExample)
DK (1) DK1173770T3 (enExample)
ES (1) ES2241597T3 (enExample)
FI (1) FI118653B (enExample)
PT (1) PT1173770E (enExample)
RU (1) RU2225615C2 (enExample)
WO (1) WO2000067035A1 (enExample)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FI20010019A7 (fi) 2001-01-05 2002-07-06 Biohit Oyj Menetelmä atrofisen gastriitin diagnostisoimiseksi
AU2002252456A1 (en) * 2001-03-23 2002-10-08 Aphton Corporation Combination treatment of pancreatic cancer
US20090191232A1 (en) * 2001-05-04 2009-07-30 Gevas Philip C Combination therapy for the treatment of tumors
EP1416964A4 (en) * 2001-07-09 2005-10-12 Aphton Corp TREATMENT AND PREVENTION OF CANCER AND PRECANCEROUS DISEASES OF THE LIVER, LUNG AND ESOPHAGUS
SE0200974D0 (sv) * 2002-03-27 2002-03-27 Phagen Ab Screening method for gastritis
FI119571B (fi) * 2002-09-06 2008-12-31 Biohit Oyj Menetelmä esofagiitin tai Barrettin ruokatorven riskin osoittamiseksi yksilöllä
EP1608984A2 (en) * 2003-03-28 2005-12-28 Aphton Corporation Gastrin hormone immunoassays
US20060020119A1 (en) * 2004-03-29 2006-01-26 Stephen Grimes Monoclonal antibodies to gastrin hormone
FI119572B (fi) * 2004-03-05 2008-12-31 Biohit Oyj Menetelmä vatsan limakalvon tilan ennustamiseksi
US8158128B2 (en) 2004-09-22 2012-04-17 Cancer Advances, Inc. Monoclonal antibodies to progastrin
US8272265B2 (en) * 2005-07-12 2012-09-25 Technion Research And Development Foundation Ltd. System and method for active detection of asymmetry in rotating structures
EP2203745A4 (en) * 2007-10-26 2010-12-08 Biohit Oyj METHODS AND PRODUCTS FOR DIAGNOSING AUTOIMMUNE DISEASES AND GASTRIC CANCER RELATED TO ATROPHIC GASTRITIS
RU2465597C1 (ru) * 2011-04-08 2012-10-27 Сергей Михайлович Котелевец Способ определения вероятности развития рака желудка
RU2582565C1 (ru) * 2015-03-06 2016-04-27 Государственное бюджетное образовательное учреждение высшего профессионального образования "Оренбургский государственный медицинский университет" Министерства здравоохранения Российской Федерации /ГБОУ ВПО ОрГМУ Минздрава России/ Способ дифференциальной диагностики язвы желудка и двенадцатиперстной кишки
CN104820096B (zh) * 2015-04-30 2017-04-19 必欧瀚生物技术（合肥）有限公司 一种判断早期胃癌风险检测用标志物的量的联合标准量及在筛查早期胃癌方面的应用
CN107271669A (zh) * 2016-09-23 2017-10-20 清华大学深圳研究生院 胃蛋白酶原、抗幽门螺杆菌抗体和胃泌素17检测方法及其试剂盒
CN107328938A (zh) * 2016-09-23 2017-11-07 清华大学深圳研究生院 胃蛋白酶原和抗幽门螺杆菌抗体检测方法及其试剂盒
JP6885581B2 (ja) * 2017-02-06 2021-06-16 学校法人東京歯科大学 ガストリン測定におけるカットオフ値の推定方法
CA3066756A1 (en) 2017-06-15 2018-12-20 Cancer Advances Inc. Compositions and methods for inducing humoral and cellular immunities against tumors and cancer
US12150978B2 (en) 2017-06-15 2024-11-26 Cancer Advances Inc. Compositions and methods for preventing tumors and cancer
RU2677228C1 (ru) * 2017-12-08 2019-01-16 Федеральное государственное бюджетное образовательное учреждение высшего образования "Национальный исследовательский Мордовский государственный университет им. Н.П. Огарёва" Способ иммунодиагностики заболеваний гастродуоденальной зоны

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH07304800A (ja) * 1994-05-06 1995-11-21 Nippon Igaku Rinshiyou Kensa Kenkyusho:Kk ヒトペプシノゲンに対するモノクローナル抗体
FI97304C (fi) * 1994-11-16 1996-11-25 Locus Genex Oy Menetelmä mahasyövän riskin seulonnaksi
JP2949474B2 (ja) * 1995-08-28 1999-09-13 隆久 古田 ペプシノーゲンｉ／ｉｉ比の変化率を基礎としたヘリコバクター・ピロリ除菌判定方法
JPH10148636A (ja) * 1996-11-15 1998-06-02 Takahisa Furuta ペプシノーゲン ｉ／ｉｉ 比の変化率を基礎としたヘリコバクター・ピロリ除菌判定方法

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
Effect of eradiction of helicobacter pylori on serumepsinogenI,gastrin and insulin in duodenal ulcer patients:A12-monthfollow-up study. TSENG-SHING CHEN, M.D. ET AL.THE AMERICAN JOURNAL OF GASTROENTEROLOGY,Vol.89 No.9. 1994 *

Also Published As

Publication number Publication date
RU2225615C2 (ru) 2004-03-10
EP1173770A1 (en) 2002-01-23
DE60021369T2 (de) 2006-05-24
WO2000067035A1 (en) 2000-11-09
EP1173770B1 (en) 2005-07-20
DE60021369D1 (de) 2005-08-25
AU4299800A (en) 2000-11-17
ES2241597T3 (es) 2005-11-01
CN1355888A (zh) 2002-06-26
FI990992A0 (fi) 1999-04-30
JP2002543433A (ja) 2002-12-17
FI990992L (fi) 2000-10-31
PT1173770E (pt) 2005-09-30
DK1173770T3 (da) 2005-08-08
US6872543B1 (en) 2005-03-29
FI118653B (fi) 2008-01-31
JP4598959B2 (ja) 2010-12-15
ATE300053T1 (de) 2005-08-15

Similar Documents

Publication Publication Date Title
CN100573152C (zh) 评估患消化性溃疡的危险度的方法,包括定量测定血清样品中胃蛋白酶原i(pgi)和胃泌素-17的浓度的步骤
US7358062B2 (en) Method for diagnosing atrophic gastritis
Sheu et al. Serum and urine levels of interleukin-6 and interleukin-8 in children with acute pyelonephritis
Ebule et al. Helicobacter pylori infection and atrophic gastritis
Sitas et al. Serum anti-Helicobacter pylori IgG antibodies and pepsinogens A and C as serological markers of chronic atrophic gastritis.
EP1552311B1 (en) Method for detecting a risk of acid related disease in an individual
WO2019143891A1 (en) Mycobacterium avium subspecies paratuberculosis immunodiagnostic antigens, methods, and kits comprising same
JP2009145220A (ja) 歯周病の診断方法及び歯周病診断キット
FI119572B (fi) Menetelmä vatsan limakalvon tilan ennustamiseksi
CN101680899A (zh) 通过粪便中幽门螺杆菌抗原的定量测定来判断胃粘膜状态的方法
JP2021520493A (ja) 胃腸洗浄液試料における免疫グロブリンのグリカン結合パターンを評価するがん検出方法
WO2023281160A1 (en) Unified gastropanel in one microplate
US20040038329A1 (en) Methods for monitoring treatment of helicobacter infection and for predicting the likelihood of successful eradication
EP2728358B1 (en) Haptoglobin alpha-r as marker for diagnosing lung cancer
WO2009062022A1 (en) Methods and compositions for the diagnosis of crohn's disease
IFTIMI et al. Polyacrylamide Gel Electrophoresis of Proteins Method versus Enzyme-Linked Immunosorbent Assay and Immunochromatography with Monoclonal Antibodies in Pediatric Infection with Helicobacter Pylori
US20160349257A1 (en) Methods and compositions for the diagnosis of crohn's disease
WO2000019208A1 (en) Egfr 37 kda fragment as cancer marker
Przyklenk et al. Evaluation of an IgG-ELISA-kit for diagnosing Helicobacter pylori associated gastroduodenal disease
RU2370774C2 (ru) Способ контроля эффективности специфической иммунотерапии поллиноза
Rustemovic et al. M1113 Pancreatic Insufficiency in Inflammatory Bowel Disease; Assesment By Fecal Elastase-1
Koike et al. Effect of lafutidine on 13C-urea breath test (UBT): intragastric acidification reduces the frequency of false negative UBT results
Ellis et al. Markers of malabsorption: coeliac disease
HK1142404A (en) Method for evaluating gastric mucosal state by quantifying helicobacter pylori antigen in feces
HK1149956A1 (en) Method of assessing colorectal cancer from a stool sample by use of the marker combination calprotectin and hemoglobin/haptoglobin complex

Legal Events

Date Code Title Description
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
C06 Publication
PB01 Publication
C14 Grant of patent or utility model
GR01 Patent grant
ASS Succession or assignment of patent right

Owner name: BIOHIT BIOECH (HEFEI) CO., LTD.

Free format text: FORMER OWNER: BIOHIT OY

Effective date: 20141202

C41 Transfer of patent application or patent right or utility model
COR Change of bibliographic data

Free format text: CORRECT: ADDRESS; TO: 230000 HEFEI, ANHUI PROVINCE

TR01 Transfer of patent right

Effective date of registration: 20141202

Address after: 230000 Anhui Province, Hefei high tech Zone Wangjiang Road, No. 800 Hefei Innovation Industrial Park D9 building a layer to five

Patentee after: Will Europe Han Biotechnology (Hefei) Co., Ltd.

Address before: Helsinki

Patentee before: Biohit OY

C41 Transfer of patent application or patent right or utility model
TR01 Transfer of patent right

Effective date of registration: 20161124

Address after: Helsinki

Patentee after: Biohit OY

Address before: 230000 Anhui Province, Hefei high tech Zone Wangjiang Road, No. 800 Hefei Innovation Industrial Park D9 building a layer to five

Patentee before: Will Europe Han Biotechnology (Hefei) Co., Ltd.

EE01 Entry into force of recordation of patent licensing contract

Application publication date: 20020626

Assignee: Will Europe Han Biotechnology (Hefei) Co., Ltd.

Assignor: Biohit OY

Contract record no.: 2017990000359

Denomination of invention: Method for assessing risk of peptic ulcer, comprising steps of determining quantitatively concentrations of pepsinogen I(PGI) and gastrin-17 in a serum sample

Granted publication date: 20091223

License type: Exclusive License

Record date: 20170908

EE01 Entry into force of recordation of patent licensing contract
CX01 Expiry of patent term
CX01 Expiry of patent term

Granted publication date: 20091223