CN100448863C - 抗生素化合物 - Google Patents
抗生素化合物 Download PDFInfo
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- CN100448863C CN100448863C CNB2004800210818A CN200480021081A CN100448863C CN 100448863 C CN100448863 C CN 100448863C CN B2004800210818 A CNB2004800210818 A CN B2004800210818A CN 200480021081 A CN200480021081 A CN 200480021081A CN 100448863 C CN100448863 C CN 100448863C
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Images
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
- C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
- C07D493/08—Bridged systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
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- C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
- C12N1/20—Bacteria; Culture media therefor
- C12N1/205—Bacterial isolates
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- C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
- C12P17/02—Oxygen as only ring hetero atoms
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- C12R2001/00—Microorganisms ; Processes using microorganisms
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- C12R2001/465—Streptomyces
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
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Abstract
Description
培养基 | 生长量 | 气生菌丝体 | 可溶性色素 | 底物菌丝体 |
酵母提取物麦芽提取物(ISP2) | 丰富 | 带褐色斑点(5F4)的桦树灰色(5D2:)扩生的气生菌丝带有极少量短孢子螺旋 | 无 | 橙黄色(5C6) |
燕麦(ISP3) | 丰富 | 灰色的(5D2)与扩生的褐色(5F4)的聚结;短小子实体在高度分支的气生菌丝体上排列为致密短小的螺旋状(4-5环) | 无 | 棕黄色(5E8) |
无机盐淀粉(ISP4) | 丰富 | 灰色的(5D2)与扩生的褐色的孢子团聚结(5F4);扩生的聚结削弱了对孢子螺旋的观测。 | 无 | 边缘淡黄色(4A2),中央灰褐色(4E2) |
甘油天冬素(ISP5) | 稀少 | 无 | 无 | 橙灰色(5B2)不育的营养菌丝体 |
酯氨酸琼脂(ISP7) | 丰富 | 边缘为棕黄色,中心为灰色(5B1);在分支的气生菌丝中有大量短孢子螺旋 | 无 | 暗棕色(6F8) |
培养基 | 生长量 | 气生菌丝体 | 可溶性色素 | 底物菌丝体 |
酵母提取物麦芽提取物(ISP2) | 丰富 | 均匀灰色(5E1)密集生长,以短小致密不规则孢子链形成的环和卷扩生的气生菌丝体。子实体产生于主要和次要的气生分支,聚结 | 无 | 棕黄包(5E7) |
燕麦(ISP3) | 丰富 | 灰褐色(5F2),扩生的气生菌丝体,孢子链聚结 | 无 | 橄榄棕色(4E4) |
无机盐淀粉(ISP4) | 丰富 | 灰褐色(5F2),扩生的气生菌丝体,孢子链聚结 | 无 | 橄榄棕色(4D3/E3) |
甘油天冬素(ISP5) | 稀少 | 无 | 无 | 白色(4B2),不育的底物菌丝体 |
酪氨酸琼脂(ISP7) | 丰富 | 灰色(5C1),扩生的气生菌丝体增长,在主要的气生菌丝上生出多达3圈的短小致密螺旋,在聚结中瓦解 | 无 | 浅灰黄色(4B4) |
脂肪酸 | 占总脂肪酸百分比% | 占总脂肪酸百分比% |
MA7327 | MA7331 | |
14:0异 | 11.54 | 2.50 |
15::0 | 2.14 | 4.12 |
15:0异 | 8.95 | 25.02 |
15:0反异 | 14.77 | 11.25 |
15:0反异20H | 8.71 | 3.22 |
16::0 | 1.72 | 4.78 |
16:0异 | 26.19 | 14.23 |
16:1异H | 7.78 | 2.15 |
16:0异20H | 2.07 | 0.00 |
17:0 | 0.00 | 0.81 |
17:0反异 | 3.56 | 5.59 |
17:0环 | 0.97 | 2.32 |
17:0异 | 1.35 | 7.72 |
17:0异20H | 0.00 | 0.73 |
17:1异C | 1.43 | 4.28 |
17:1反异C | 2.67 | 2.01 |
17:1顺9 | 0.00 | 0.73 |
碳源 | MA7327 | MA7331 |
D-葡萄糖 | 3 | 2 |
L-阿拉伯糖 | 1 | 1 |
蔗糖 | 3 | 3 |
D-木糖 | 2 | 3 |
I-肌醇 | 3 | 3 |
D-甘露糖醇 | 3 | 2 |
D型果糖 | 3 | 3 |
鼠李糖 | 0 | 0 |
棉子糖 | 3 | 3 |
纤维素 | 1 | 0 |
代表性菌株的培育条件和接种 |
芽胞杆菌、葡萄球菌、肠球菌:培育条件,35℃;18-22小时读取MIC值;埃希氏菌:阳离子可调的Mueller Hinton肉汤培基(CAMHB;BBL);接种量=10<sup>5</sup>CFU/mL |
肺炎链球菌:培育条件,35℃;22-24小时读取MIC值;阳离子可调的Mueller Hinton肉汤培基+2.5%溶解马血(LHB);接种量=10<sup>5</sup>CFU/mL |
流感嗜血杆菌:培育条件,35℃;18-22小时读取MIC值;嗜血杆菌试验培基(HTM;Remel);接种量=10<sup>5</sup>CFU/mL |
念珠菌:培育条件,35℃;24小时读取MIC值;RPMI 1640培基(Bio Whittaker)接种量=10<sup>3</sup>CFU/mL |
Claims (6)
Applications Claiming Priority (2)
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US48986503P | 2003-07-24 | 2003-07-24 | |
US60/489,865 | 2003-07-24 |
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CN1849313A CN1849313A (zh) | 2006-10-18 |
CN100448863C true CN100448863C (zh) | 2009-01-07 |
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US (1) | US7745644B2 (zh) |
EP (1) | EP1651628B1 (zh) |
JP (1) | JP4538455B2 (zh) |
CN (1) | CN100448863C (zh) |
AT (1) | ATE460405T1 (zh) |
AU (1) | AU2004259014B2 (zh) |
CA (1) | CA2532802C (zh) |
DE (1) | DE602004025946D1 (zh) |
WO (1) | WO2005009391A2 (zh) |
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EP1756034B1 (en) * | 2004-05-24 | 2012-07-04 | Merck Sharp & Dohme Corp. | Antibiotic compound |
WO2008032140A1 (en) * | 2006-09-11 | 2008-03-20 | Yedir Ouhdouch | Antibiotic chemical structure obtained from the strain streptomyces sp. bs46 and its use against methicillin-resistant bacteria |
EP2083831B1 (en) * | 2006-09-22 | 2013-12-25 | Merck Sharp & Dohme Corp. | Method of treatment using fatty acid synthesis inhibitors |
CN101450915B (zh) * | 2007-11-30 | 2013-01-23 | 山东轩竹医药科技有限公司 | 环己烯酮取代的苯甲酸衍生物 |
KR101064112B1 (ko) | 2008-12-12 | 2011-09-08 | 서울대학교산학협력단 | 신규한 플라텐시마이신 유도체와 이의 제조방법 및 플라텐시마이신의 신규한 제조방법 |
US8471043B2 (en) * | 2008-04-08 | 2013-06-25 | Snu R&Db Foundation | Platensimycin derivatives, their intermediates, and process for preparing the same, and new process for preparing platensimycin |
JP2010057390A (ja) * | 2008-09-02 | 2010-03-18 | Nikken Seibutsu Igaku Kenkyusho:Kk | 検査用具 |
US8754054B2 (en) * | 2010-07-09 | 2014-06-17 | Albany Molecular Research, Inc. | Antibacterial compounds, methods of making them, and uses thereof |
MY180383A (en) * | 2013-12-24 | 2020-11-28 | Harvard College | Cortistatin analogues and syntheses and uses thereof |
JP7032732B2 (ja) * | 2018-03-01 | 2022-03-09 | 国立大学法人 東京大学 | プラテンシマイシンの製造方法 |
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US6365610B1 (en) * | 1998-07-29 | 2002-04-02 | Taiho Pharmaceutical Company Ltd. | Ozonide compounds with inhibitory activity for urokinase production and angiogenesis |
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CH456570A (de) * | 1965-11-18 | 1968-07-31 | Geigy Ag J R | Verfahren zur Herstellung von neuen substituierten Harnstoffderivaten |
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2004
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EP1651628A2 (en) | 2006-05-03 |
EP1651628B1 (en) | 2010-03-10 |
WO2005009391A2 (en) | 2005-02-03 |
WO2005009391A3 (en) | 2005-10-20 |
US20080306139A1 (en) | 2008-12-11 |
DE602004025946D1 (de) | 2010-04-22 |
JP2006528639A (ja) | 2006-12-21 |
ATE460405T1 (de) | 2010-03-15 |
AU2004259014A1 (en) | 2005-02-03 |
CN1849313A (zh) | 2006-10-18 |
EP1651628A4 (en) | 2008-07-16 |
JP4538455B2 (ja) | 2010-09-08 |
AU2004259014B2 (en) | 2009-12-17 |
US7745644B2 (en) | 2010-06-29 |
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