CN100422343C - 乙型肝炎病毒的耐药性的识别方法 - Google Patents

乙型肝炎病毒的耐药性的识别方法 Download PDF

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CN100422343C
CN100422343C CNB2003801059163A CN200380105916A CN100422343C CN 100422343 C CN100422343 C CN 100422343C CN B2003801059163 A CNB2003801059163 A CN B2003801059163A CN 200380105916 A CN200380105916 A CN 200380105916A CN 100422343 C CN100422343 C CN 100422343C
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hbv
virus
sequence
hepatitis
nucleic acid
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CN1726287A (zh
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六波羅明紀
松本晶博
田中栄司
清澤研道
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Advanced Life Science Institute Inc
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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/70—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving virus or bacteriophage
    • C12Q1/701—Specific hybridization probes
    • C12Q1/706—Specific hybridization probes for hepatitis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses

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  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Virology (AREA)
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  • Bioinformatics & Cheminformatics (AREA)
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  • Wood Science & Technology (AREA)
  • Gastroenterology & Hepatology (AREA)
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  • Analytical Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CNB2003801059163A 2002-12-11 2003-12-10 乙型肝炎病毒的耐药性的识别方法 Expired - Fee Related CN100422343C (zh)

Applications Claiming Priority (2)

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JP2002359372 2002-12-11
JP359372/2002 2002-12-11

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CN1726287A CN1726287A (zh) 2006-01-25
CN100422343C true CN100422343C (zh) 2008-10-01

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JP (1) JP4398379B2 (ja)
KR (1) KR20050095584A (ja)
CN (1) CN100422343C (ja)
AU (1) AU2003289016A1 (ja)
WO (1) WO2004053162A1 (ja)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101177715B (zh) * 2006-11-09 2010-12-29 中山大学达安基因股份有限公司 检测乙型肝炎病毒前c/bcp区基因突变的方法和试剂盒
US8435764B2 (en) * 2009-05-06 2013-05-07 The Chinese University Of Hongkong Multiplex detection of hepatitis virus variations
CN101812537B (zh) * 2009-10-27 2012-08-08 重庆医科大学 同时检测乙型肝炎病毒三种核苷酸类似物耐药位点的方法及其试剂盒
CN101948834B (zh) * 2010-09-16 2012-07-04 山东大学 用于治疗HBV的siRNA
JP7455336B2 (ja) * 2019-03-26 2024-03-26 富士フイルム株式会社 Ｂ型肝炎ウイルスタンパク質の産生を阻害する医薬組成物およびスクリーニング方法

Non-Patent Citations (8)

* Cited by examiner, † Cited by third party
Title
Effect of multiple mutations in the core promoter andpre-core/core region of hepatitis B virus genome on theresponse to interferon in a antigen-positive chronic hepatitisB,2001,vol.16,no.4,. Zhang X. Et al...J,Gastroenterol.Hepatol.,,Vol.16 No.4. 2001
Effect of multiple mutations in the core promoter andpre-core/core region of hepatitis B virus genome on theresponse to interferon in a antigen-positive chronic hepatitisB,2001,vol.16,no.4,. Zhang X. Et al...J,Gastroenterol.Hepatol.,,Vol.16 No.4. 2001 *
In vivo suppression of precore mRNA synthesisi is assosiatedwith mutations in the hepatitis B virus core promoter. Laras A et al。.Virology,Vol.295 No.1. 2001
In vivo suppression of precore mRNA synthesisi is assosiatedwith mutations in the hepatitis B virus core promoter. Laras A et al。.Virology,Vol.295 No.1. 2001 *
Mutation in HBV RNA-dependent DNA polymerase confersresistances to lamivudine in vivo. Tipples G. A. et al.Hepatology,Vol.24 No.3. 1996
Mutation in HBV RNA-dependent DNA polymerase confersresistances to lamivudine in vivo. Tipples G. A. et al.Hepatology,Vol.24 No.3. 1996 *
Precore and core promoter mutations hepatitis Bvirus DNAlevels and progressive liver injury in chronic hapatitis B. Yotsuyanagi H. et al.J Hepatol,Vol.37 No.3. 2002
Precore and core promoter mutations hepatitis Bvirus DNAlevels and progressive liver injury in chronic hapatitis B. Yotsuyanagi H. et al.J Hepatol,Vol.37 No.3. 2002 *

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Publication number Publication date
AU2003289016A1 (en) 2004-06-30
KR20050095584A (ko) 2005-09-29
CN1726287A (zh) 2006-01-25
JP4398379B2 (ja) 2010-01-13
WO2004053162A1 (ja) 2004-06-24
JPWO2004053162A1 (ja) 2006-04-13

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