CN100410260C - 青霉烷酸化合物的制备方法 - Google Patents

青霉烷酸化合物的制备方法 Download PDF

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Publication number
CN100410260C
CN100410260C CNB2004800253122A CN200480025312A CN100410260C CN 100410260 C CN100410260 C CN 100410260C CN B2004800253122 A CNB2004800253122 A CN B2004800253122A CN 200480025312 A CN200480025312 A CN 200480025312A CN 100410260 C CN100410260 C CN 100410260C
Authority
CN
China
Prior art keywords
bismuth
formula
compound
metal
penicillanic acid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CNB2004800253122A
Other languages
English (en)
Chinese (zh)
Other versions
CN1845929A (zh
Inventor
德丸祥久
斋藤纪雄
秋月诚
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Otsuka Chemical Co Ltd
Original Assignee
Otsuka Chemical Co Ltd
Taiho Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Otsuka Chemical Co Ltd, Taiho Pharmaceutical Co Ltd filed Critical Otsuka Chemical Co Ltd
Publication of CN1845929A publication Critical patent/CN1845929A/zh
Application granted granted Critical
Publication of CN100410260C publication Critical patent/CN100410260C/zh
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D499/04—Preparation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D499/86—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring with only atoms other than nitrogen atoms directly attached in position 6 and a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Catalysts (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
CNB2004800253122A 2003-09-03 2004-09-02 青霉烷酸化合物的制备方法 Expired - Fee Related CN100410260C (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2003311709 2003-09-03
JP311709/2003 2003-09-03
PCT/JP2004/013097 WO2005023821A1 (ja) 2003-09-03 2004-09-02 ペニシラン酸化合物の製造方法

Publications (2)

Publication Number Publication Date
CN1845929A CN1845929A (zh) 2006-10-11
CN100410260C true CN100410260C (zh) 2008-08-13

Family

ID=34269709

Family Applications (1)

Application Number Title Priority Date Filing Date
CNB2004800253122A Expired - Fee Related CN100410260C (zh) 2003-09-03 2004-09-02 青霉烷酸化合物的制备方法

Country Status (13)

Country Link
US (1) US7514553B2 (es)
EP (1) EP1666482B1 (es)
JP (1) JP4346528B2 (es)
KR (1) KR100759640B1 (es)
CN (1) CN100410260C (es)
AR (1) AR045553A1 (es)
AT (1) ATE452897T1 (es)
CA (1) CA2537406C (es)
DE (1) DE602004024802D1 (es)
ES (1) ES2336677T3 (es)
HK (1) HK1096957A1 (es)
TW (1) TWI280963B (es)
WO (1) WO2005023821A1 (es)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103044447B (zh) * 2013-01-16 2014-12-17 江西富祥药业股份有限公司 一种青霉烷亚砜酸二苯甲酯的制备方法
CN103819489B (zh) * 2014-03-18 2015-10-28 齐鲁天和惠世制药有限公司 一种青霉烷酸二苯甲酯亚砜的制备方法

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0129360A1 (en) * 1983-06-06 1984-12-27 Pfizer Inc. Process for debromination of dibromopenicillanic acid and derivatives
EP0262202A1 (en) * 1986-04-10 1988-04-06 Leo Pharm Prod Ltd PROCESS FOR PREPARING PENICILLANIC ACID DERIVATIVES.
EP1041075A1 (en) * 1999-03-03 2000-10-04 Alex-Gyogyszer Kutatási Procedure for the preparation of dioxopenicillanic acid derivatives

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4588527A (en) * 1983-06-06 1986-05-13 Pfizer Inc. Process for preparing penicillanic acid 1,1-dioxide derivatives
EP0139048A1 (en) 1983-10-18 1985-05-02 Gist-Brocades N.V. Process for the dehalogenation of 6,6-dibromopenicillanic acid 1,1-dioxide
US4596677A (en) * 1984-04-06 1986-06-24 Bristol-Myers Company Anhydropenicillin intermediates
JPS6163683A (ja) 1984-09-05 1986-04-01 Kanebo Ltd ペニシラン酸およびその誘導体の製造法
JPH10245386A (ja) 1997-03-05 1998-09-14 Otsuka Chem Co Ltd エキソメチレンペナム化合物の製造方法
GB2343676A (en) * 1998-11-12 2000-05-17 Merck & Co Inc Selective mono-debromination of polybromoalkyl aryl ketones

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0129360A1 (en) * 1983-06-06 1984-12-27 Pfizer Inc. Process for debromination of dibromopenicillanic acid and derivatives
EP0262202A1 (en) * 1986-04-10 1988-04-06 Leo Pharm Prod Ltd PROCESS FOR PREPARING PENICILLANIC ACID DERIVATIVES.
EP1041075A1 (en) * 1999-03-03 2000-10-04 Alex-Gyogyszer Kutatási Procedure for the preparation of dioxopenicillanic acid derivatives

Also Published As

Publication number Publication date
WO2005023821A1 (ja) 2005-03-17
US7514553B2 (en) 2009-04-07
EP1666482A4 (en) 2009-04-01
CA2537406A1 (en) 2005-03-17
CA2537406C (en) 2010-09-14
ES2336677T3 (es) 2010-04-15
AR045553A1 (es) 2005-11-02
TW200510432A (en) 2005-03-16
KR100759640B1 (ko) 2007-09-17
EP1666482B1 (en) 2009-12-23
KR20060058121A (ko) 2006-05-29
TWI280963B (en) 2007-05-11
ATE452897T1 (de) 2010-01-15
HK1096957A1 (en) 2007-06-15
US20060281917A1 (en) 2006-12-14
JP2005097297A (ja) 2005-04-14
DE602004024802D1 (de) 2010-02-04
EP1666482A1 (en) 2006-06-07
CN1845929A (zh) 2006-10-11
JP4346528B2 (ja) 2009-10-21

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Granted publication date: 20080813