AR045553A1 - Un procedimiento para preparar un compuesto de acido penicilanico - Google Patents

Un procedimiento para preparar un compuesto de acido penicilanico

Info

Publication number
AR045553A1
AR045553A1 ARP040103134A ARP040103134A AR045553A1 AR 045553 A1 AR045553 A1 AR 045553A1 AR P040103134 A ARP040103134 A AR P040103134A AR P040103134 A ARP040103134 A AR P040103134A AR 045553 A1 AR045553 A1 AR 045553A1
Authority
AR
Argentina
Prior art keywords
acid compound
bismuth
prepare
procedure
compound
Prior art date
Application number
ARP040103134A
Other languages
English (en)
Inventor
Yoshihisa Tokumaru
Norio Saito
Makoto Akizuki
Original Assignee
Otsuka Chemical Co Ltd
Taiho Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Otsuka Chemical Co Ltd, Taiho Pharmaceutical Co Ltd filed Critical Otsuka Chemical Co Ltd
Publication of AR045553A1 publication Critical patent/AR045553A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D499/04—Preparation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D499/86—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring with only atoms other than nitrogen atoms directly attached in position 6 and a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Catalysts (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

Un procedimiento para preparar un compuesto de ácido penicilánico de fórmula (2) que comprende hacer reaccionar un compuesto de ácido penicilánico halogenado de fórmula (1, (a) en presencia de un compuesto de bismuto o de metal bismuto con un metal que tenga menor potencial estándar de oxidación-reducción que el bismuto para obtener el compuesto (2) (X e Y son un átomo de H o átomo de halógeno, siempre que X e Y no sean átomos de H al mismo tiempo, n es un entero de 0 a 2, R es un gripo protector de ácido carboxílico; n y r son como previamente.
ARP040103134A 2003-09-03 2004-09-02 Un procedimiento para preparar un compuesto de acido penicilanico AR045553A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP2003311709 2003-09-03

Publications (1)

Publication Number Publication Date
AR045553A1 true AR045553A1 (es) 2005-11-02

Family

ID=34269709

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP040103134A AR045553A1 (es) 2003-09-03 2004-09-02 Un procedimiento para preparar un compuesto de acido penicilanico

Country Status (13)

Country Link
US (1) US7514553B2 (es)
EP (1) EP1666482B1 (es)
JP (1) JP4346528B2 (es)
KR (1) KR100759640B1 (es)
CN (1) CN100410260C (es)
AR (1) AR045553A1 (es)
AT (1) ATE452897T1 (es)
CA (1) CA2537406C (es)
DE (1) DE602004024802D1 (es)
ES (1) ES2336677T3 (es)
HK (1) HK1096957A1 (es)
TW (1) TWI280963B (es)
WO (1) WO2005023821A1 (es)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103044447B (zh) * 2013-01-16 2014-12-17 江西富祥药业股份有限公司 一种青霉烷亚砜酸二苯甲酯的制备方法
CN103819489B (zh) * 2014-03-18 2015-10-28 齐鲁天和惠世制药有限公司 一种青霉烷酸二苯甲酯亚砜的制备方法

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4468351A (en) 1983-06-06 1984-08-28 Pfizer Inc. Process for debromination of dibromopenicillanic acid and derivatives
US4588527A (en) * 1983-06-06 1986-05-13 Pfizer Inc. Process for preparing penicillanic acid 1,1-dioxide derivatives
EP0139048A1 (en) 1983-10-18 1985-05-02 Gist-Brocades N.V. Process for the dehalogenation of 6,6-dibromopenicillanic acid 1,1-dioxide
US4596677A (en) * 1984-04-06 1986-06-24 Bristol-Myers Company Anhydropenicillin intermediates
JPS6163683A (ja) 1984-09-05 1986-04-01 Kanebo Ltd ペニシラン酸およびその誘導体の製造法
EP0262202B1 (en) 1986-04-10 1992-07-01 Leo Pharmaceutical Products Ltd. A/S (Lovens Kemiske Fabrik Produktionsaktieselskab) Method for preparing penicillanic acid derivatives
JPH10245386A (ja) 1997-03-05 1998-09-14 Otsuka Chem Co Ltd エキソメチレンペナム化合物の製造方法
GB2343676A (en) * 1998-11-12 2000-05-17 Merck & Co Inc Selective mono-debromination of polybromoalkyl aryl ketones
EP1041075B1 (en) 1999-03-03 2005-02-02 Astur Pharma S.A. Procedure for the preparation of dioxopenicillanic acid derivatives

Also Published As

Publication number Publication date
CN100410260C (zh) 2008-08-13
DE602004024802D1 (de) 2010-02-04
JP2005097297A (ja) 2005-04-14
JP4346528B2 (ja) 2009-10-21
KR100759640B1 (ko) 2007-09-17
HK1096957A1 (en) 2007-06-15
ATE452897T1 (de) 2010-01-15
EP1666482A4 (en) 2009-04-01
CA2537406A1 (en) 2005-03-17
US7514553B2 (en) 2009-04-07
CN1845929A (zh) 2006-10-11
ES2336677T3 (es) 2010-04-15
US20060281917A1 (en) 2006-12-14
WO2005023821A1 (ja) 2005-03-17
KR20060058121A (ko) 2006-05-29
TWI280963B (en) 2007-05-11
TW200510432A (en) 2005-03-16
EP1666482B1 (en) 2009-12-23
CA2537406C (en) 2010-09-14
EP1666482A1 (en) 2006-06-07

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Legal Events

Date Code Title Description
FG Grant, registration
FD Application declared void or lapsed, e.g., due to non-payment of fee