CN100409844C - 神经氨酸苷酶抑制剂 - Google Patents

神经氨酸苷酶抑制剂 Download PDF

Info

Publication number
CN100409844C
CN100409844C CNB011247142A CN01124714A CN100409844C CN 100409844 C CN100409844 C CN 100409844C CN B011247142 A CNB011247142 A CN B011247142A CN 01124714 A CN01124714 A CN 01124714A CN 100409844 C CN100409844 C CN 100409844C
Authority
CN
China
Prior art keywords
chemical compound
group
independently
alkyl
groups
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
CNB011247142A
Other languages
English (en)
Chinese (zh)
Other versions
CN1347693A (zh
Inventor
诺伯特·毕乔夫伯格
金正恩
威勒德·雷
刘洪涛
马修·威廉斯
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Gilead Sciences Inc
Original Assignee
Gilead Sciences Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27410155&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CN100409844(C) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from US08/476,946 external-priority patent/US5866601A/en
Application filed by Gilead Sciences Inc filed Critical Gilead Sciences Inc
Publication of CN1347693A publication Critical patent/CN1347693A/zh
Application granted granted Critical
Publication of CN100409844C publication Critical patent/CN100409844C/zh
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Images

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
    • C07D309/16—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D309/28—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Virology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Pulmonology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Saccharide Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Epoxy Compounds (AREA)
  • Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)
  • Pyrane Compounds (AREA)
  • Polyesters Or Polycarbonates (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Pyrrole Compounds (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
CNB011247142A 1995-02-27 1996-02-26 神经氨酸苷酶抑制剂 Expired - Lifetime CN100409844C (zh)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US39524595A 1995-02-27 1995-02-27
US08/395,245 1995-02-27
US08/476,946 US5866601A (en) 1995-02-27 1995-06-06 Carbocyclic compounds
US08/476,946 1995-06-06
US58056795A 1995-12-29 1995-12-29
US08/580,567 1995-12-29

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
CNB961901330A Division CN1185223C (zh) 1995-02-27 1996-02-26 新颖化合物,其合成方法及治疗用途

Related Child Applications (1)

Application Number Title Priority Date Filing Date
CNB2005100876596A Division CN100338031C (zh) 1995-02-27 1996-02-26 新颖化合物，其合成方法及治疗用途

Publications (2)

Publication Number Publication Date
CN1347693A CN1347693A (zh) 2002-05-08
CN100409844C true CN100409844C (zh) 2008-08-13

Family

ID=27410155

Family Applications (2)

Application Number Title Priority Date Filing Date
CNB011247142A Expired - Lifetime CN100409844C (zh) 1995-02-27 1996-02-26 神经氨酸苷酶抑制剂
CNB961901330A Expired - Lifetime CN1185223C (zh) 1995-02-27 1996-02-26 新颖化合物,其合成方法及治疗用途

Family Applications After (1)

Application Number Title Priority Date Filing Date
CNB961901330A Expired - Lifetime CN1185223C (zh) 1995-02-27 1996-02-26 新颖化合物,其合成方法及治疗用途

Country Status (26)

Country Link
US (3) US5952375A (https=)
EP (1) EP0759917B1 (https=)
JP (3) JP3300365B2 (https=)
KR (1) KR100447096B1 (https=)
CN (2) CN100409844C (https=)
AT (2) ATE191711T1 (https=)
AU (1) AU720933B2 (https=)
BR (2) BR9607098A (https=)
CZ (1) CZ297945B6 (https=)
DE (4) DE759917T1 (https=)
DK (1) DK0759917T3 (https=)
ES (2) ES2249863T3 (https=)
GR (1) GR3033914T3 (https=)
HU (1) HU228450B1 (https=)
LU (1) LU90991I2 (https=)
MX (1) MX9706496A (https=)
NL (1) NL300105I2 (https=)
NO (1) NO318455B1 (https=)
NZ (1) NZ306625A (https=)
PL (1) PL194173B1 (https=)
PT (1) PT759917E (https=)
RU (1) RU2181357C2 (https=)
SG (1) SG45864A1 (https=)
SI (1) SI9620042A (https=)
UA (1) UA56128C2 (https=)
WO (1) WO1996026933A1 (https=)

Families Citing this family (87)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN100409844C (zh) 1995-02-27 2008-08-13 吉里德科学公司 神经氨酸苷酶抑制剂
US5714509A (en) * 1995-05-03 1998-02-03 The University Of Alabama Inhibitors of bacterial sialidase and methods of making and using the same
US5763483A (en) * 1995-12-29 1998-06-09 Gilead Sciences, Inc. Carbocyclic compounds
US6093816A (en) 1996-06-27 2000-07-25 Isis Pharmaceuticals, Inc. Cationic lipids
US6518438B2 (en) 1996-08-23 2003-02-11 Gilead Sciences, Inc. Preparation of cyclohexene carboxylate derivatives
US5859284A (en) * 1996-08-23 1999-01-12 Gilead Sciences, Inc. Preparation of carbocyclic compounds
MXPA99001697A (es) * 1996-08-23 2004-04-05 Gilead Sciences Inc Preparacion de derivados de carboxilato de ciclohexeno.
WO1998017647A1 (en) * 1996-10-21 1998-04-30 Gilead Sciences, Inc. Piperidine compounds
US5994377A (en) * 1996-10-21 1999-11-30 Gilead Sciences, Inc. Piperidine compounds
AU732916C (en) * 1996-11-14 2002-06-06 Biota Scientific Management Pty Ltd Method and novel compounds for use therein
WO1999006369A1 (en) * 1997-08-01 1999-02-11 University Of Florida Neuraminidase inhibitors
US5886213A (en) * 1997-08-22 1999-03-23 Gilead Sciences, Inc. Preparation of carbocyclic compounds
US20040053999A1 (en) * 1997-09-17 2004-03-18 Bischofberger Norbert W. Novel compounds and methods for synthesis and therapy
JP2001516739A (ja) * 1997-09-17 2001-10-02 ギリアード サイエンシーズ， インコーポレイテッド ６員環を含む化合物、それらの調製プロセス、および医薬としてのそれらの使用
TW477783B (en) * 1997-12-12 2002-03-01 Gilead Sciences Inc Novel compounds useful as neuraminidase inhibitors and pharmaceutical compositions containing same
DK1040094T3 (da) * 1997-12-17 2009-06-02 Biocryst Pharm Inc Substitueret cyklopentan og cyklopenten-forbindelser anvendelige som neuraminidase-inhibitorer
US6518305B1 (en) 1998-04-23 2003-02-11 Abbott Laboratories Five-membered carbocyclic and heterocyclic inhibitors of neuraminidases
US6455571B1 (en) 1998-04-23 2002-09-24 Abbott Laboratories Inhibitors of neuraminidases
CN1328546A (zh) * 1998-04-23 2001-12-26 艾博特公司 作为神经氨酸酶抑制剂的吡咯烷
ES2167975T3 (es) * 1998-05-13 2002-05-16 Hoffmann La Roche Procedimiento para la preparacion de acido shikimico y sus derivados.
AU1476900A (en) * 1998-11-13 2000-06-05 Gilead Sciences, Inc. 1,4,5,6-tetrahydro-pyridazine derivatives, their preparation and their use as neuraminidase inhibitors
AUPP913999A0 (en) * 1999-03-12 1999-04-01 Biota Scientific Management Pty Ltd Novel chemical compounds and their use
DE60002949T2 (de) 1999-06-11 2004-05-19 F. Hoffmann-La Roche Ag Verfahren zur Herstellung des Neuraminidase-Inhibitoren ro-64-0796
DE19930177B4 (de) 1999-06-30 2007-02-08 Nikolai Vladimirovich Bovin Intermolekular assoziierende Verbindungen und deren Verwendung
WO2001028981A1 (en) * 1999-10-19 2001-04-26 Abbott Laboratories 1-cyclohexene-1-carboxylic acid and 1-cyclohexene-1-carboxylates as neuraminidase inhibitors
US6593314B1 (en) * 1999-10-19 2003-07-15 Abbott Laboratories Neuraminidase inhibitors
US6627396B1 (en) * 1999-10-28 2003-09-30 The Regents Of The University Of California Influenza sensor
JP2001131144A (ja) * 1999-11-02 2001-05-15 Sagami Chem Res Center ７−アザビシクロ［４．１．０］ヘプト−３−エン−３−カルボン酸エステル類の製造方法
US6462226B1 (en) 1999-12-03 2002-10-08 Hoffmann-La Roche Inc. Process for the preparation of 4,5-diamino shikimic acid derivatives
EP1245569A1 (en) 1999-12-27 2002-10-02 Sagami Chemical Research Center Process for the production of 5-oxy-7-oxabicyclo- 4.1.0]hept-3-e ne-3-carboxylic acid esters
US8642051B2 (en) * 2000-03-21 2014-02-04 Suzanne Jaffe Stillman Method of hydration; infusion packet system(s), support member(s), delivery system(s), and method(s); with business model(s) and Method(s)
AU2001252578A1 (en) * 2000-04-25 2001-11-07 Sankyo Company Limited Preventives for influenza
GB0015324D0 (en) * 2000-06-22 2000-08-16 Biota Scient Management Medicaments
PL203804B1 (pl) 2000-06-27 2009-11-30 Hoffmann La Roche Sposób wytwarzania kompozycji farmaceutycznej w postaci spoistej, płytkowej, piankowej, gąbczastej lub ciastowatej struktury i kompozycja farmaceutyczna otrzymana tym sposobem
AUPR001000A0 (en) 2000-09-08 2000-10-05 Biota Scientific Management Pty Ltd Novel chemical compounds and their use
WO2002092555A1 (en) * 2001-05-11 2002-11-21 Sankyo Company, Limited Sialic acid derivatives
US6964784B2 (en) 2002-03-07 2005-11-15 Optigenex, Inc. Method of preparation and composition of a water soluble extract of the bioactive component of the plant species uncaria for enhancing immune, anti-inflammatory, anti-tumor and dna repair processes of warm blooded animals
RU2220739C1 (ru) * 2002-08-30 2004-01-10 Гапонюк Петр Яковлевич Интраназальное средство
US7807174B2 (en) * 2002-11-22 2010-10-05 Nexbio, Inc. Class of therapeutic protein based molecules
US7122684B2 (en) 2003-03-13 2006-10-17 Roche Colorado Corporation Process for preparing 1,2-diamino compounds
NZ543864A (en) 2003-06-16 2009-10-30 Leuven K U Res & Dev Pyrimidine compounds having phosphonate groups as antiviral nucleotide analogs
WO2007053792A2 (en) * 2005-11-05 2007-05-10 Amplyx Pharmaceuticals, Inc. Improving the pharmacokinetics of protease inhibitors and other drugs
US7687658B2 (en) * 2005-11-25 2010-03-30 Hetero Drugs Limited Process for oseltamivir phosphate
KR100819759B1 (ko) 2005-12-01 2008-04-07 (주)파인켐 아자이드 화합물의 폭발성을 제거한 공정을 이용한 1,2-다이아미노 화합물 또는 이의 부가염 제조 방법
EP2178819A2 (en) 2005-12-28 2010-04-28 F.Hoffmann-La Roche Ag Epoxide intermediate in the tamiflu synthesis
EP1987825B1 (en) 2006-02-20 2018-09-05 Chugai Seiyaku Kabushiki Kaisha Pharmaceutical composition comprising oseltamivir phosphate
US20080063722A1 (en) * 2006-09-08 2008-03-13 Advanced Inhalation Research, Inc. Composition of a Spray-Dried Powder for Pulmonary Delivery of a Long Acting Neuraminidase Inhibitor (LANI)
US20080306098A1 (en) * 2006-11-06 2008-12-11 Mutz Mitchell W Pharmacokinetics of protease inhibitors and other drugs
WO2008090151A1 (en) 2007-01-23 2008-07-31 Therapicon Srl Antiviral compounds
US20080194801A1 (en) * 2007-02-14 2008-08-14 Swanson Basil I Robust multidentate ligands for diagnosis and anti-viral drugs for influenza and related viruses
US8435769B2 (en) 2007-04-13 2013-05-07 Monsanto Technology Llc Use of glyphosate to produce shikimic acid in microorganisms
US20090054334A1 (en) * 2007-05-23 2009-02-26 Mutz Mitchell W Combinatorial improvement of bifunctional drug properties
EP2190439B1 (en) * 2007-08-31 2016-03-09 Academia Sinica Oseltamivir phosphonate derivatives with anti-influenza activity and synthesis thereof
BRPI0818236B1 (pt) 2007-10-16 2020-07-21 Monsanto Technology Llc processo para recuperação do ácido chiquímico de um fluxo de processo aquoso compreendendo ainda glifosato
US20100284993A1 (en) * 2007-10-24 2010-11-11 Mutz Mitchell W Enhancing the Efficacy of Anti-Infective Therapeutics
WO2009078813A1 (en) * 2007-12-19 2009-06-25 Nanyang Technological University Method of forming oseltamivir and derivatives thereof
US8334319B2 (en) * 2008-01-04 2012-12-18 Roche Palo Alto Llc Polymorphic forms of oseltamivir phosphate
US20100081713A1 (en) * 2008-03-19 2010-04-01 CombinatoRx, (Singapore) Pte. Ltd. Compositions and methods for treating viral infections
EP2276479B1 (en) 2008-04-15 2014-07-02 SineVir Therapeutics LLC Prodrugs of neuraminidase inhibitors
TWI491416B (zh) 2008-12-24 2015-07-11 Daiichi Sankyo Co Ltd 吸入用乾燥粉末醫藥組成物
CN101486664B (zh) * 2008-12-31 2013-09-04 北京大学深圳研究生院 用作流感病毒神经氨酸酶抑制剂的多取代五元环小分子化合物
NZ610978A (en) 2009-05-15 2014-11-28 Redx Pharma Ltd Redox drug derivatives
WO2011021223A2 (en) * 2009-08-19 2011-02-24 Msn Laboratories Limited Novel salts of ethyl (3r, 4s, 5r)-4,5-imino-3-(l-ethylpropoxy)-1- cvclohexene-1-carboxylate and its use
KR20120115262A (ko) * 2009-11-11 2012-10-17 쓰리엠 이노베이티브 프로퍼티즈 캄파니 중합체 조성물 및 그의 제조 방법 및 물품
IT1396620B1 (it) 2009-11-25 2012-12-14 Therapicon Srl Analoghi chimerici
CN103189354A (zh) 2010-07-16 2013-07-03 格林代克斯联合股份公司 具有抗病毒功效的1,4-二氢吡啶衍生物
AT510585B1 (de) 2010-11-18 2012-05-15 Apeptico Forschung & Entwicklung Gmbh Zusammensetzung umfassend ein peptid und ein hemmstoff der viralen neuraminidase
KR101369584B1 (ko) 2011-04-19 2014-03-06 일양약품주식회사 페닐-이속사졸 유도체 및 그의 제조방법
EP2578218A1 (en) 2011-10-06 2013-04-10 Grindeks, A Joint Stock Company Antiviral efficacy of disodium 2,6-dimethyl-1,4-dihydropyridine-3,5-bis(carbonyloxyacetate) and its derivatives
DE102011117128A1 (de) 2011-10-28 2013-05-02 Christian-Albrechts-Universität Zu Kiel Verbindungen zur Therapie der Influenza
RU2469020C1 (ru) * 2011-11-08 2012-12-10 Александр Васильевич Иващенко (3r,4r,5s)-5-амино-4-ациламино-3-(1-этил-пропокси)-циклогекс-1-ен-карбоновые кислоты, их эфиры и способ применения
RU2489422C1 (ru) * 2012-05-12 2013-08-10 Александр Васильевич Иващенко Фторзамещенные (3r,4r,5s)-5-гуанидино-4-ациламино-3-(пентан-3-илокси)циклогексен-1-карбоновые кислоты, их эфиры и способ применения
RU2521593C1 (ru) * 2013-02-27 2014-06-27 Общество с ограниченной ответственностью "Интеллектуальный Диалог" Моно и дифторзамещенные этил (3r,4r,5s)-5-азидо-4-ацетиламино-3-(1-этилпропокси)-циклогексен-1-карбоксилаты, способ получения и применения
JP6453050B2 (ja) * 2013-11-15 2019-01-16 国立大学法人富山大学 ２−デオキシ−２，３−ジデヒドロシアル酸誘導体およびその製造法
CN103819357B (zh) * 2014-01-28 2016-03-16 浙江大学 (-)-有效霉醇叠氮四乙酸酯的制备方法
US9950989B2 (en) 2014-02-14 2018-04-24 Toa Eiyo Ltd. Cyclic hydrocarbon compound
US20170100385A1 (en) 2014-05-12 2017-04-13 Glaxosmithkline Intellectual Property (No. 2) Limited Pharmaceutical compositions comprising danirixin for treating infectious diseases
US9392814B2 (en) 2014-06-06 2016-07-19 Nicholas J. Singer Delivery system for drinks
GB2532178A (en) * 2014-06-09 2016-05-18 Redx Pharma Plc Antiviral compounds
JP7381190B2 (ja) 2014-12-26 2023-11-15 エモリー・ユニバーシテイ Ｎ４－ヒドロキシシチジン及び誘導体並びにそれに関連する抗ウイルス用途
USD773313S1 (en) 2015-06-23 2016-12-06 Nicholas J. Singer Package
WO2017106820A1 (en) 2015-12-17 2017-06-22 Thomas Jefferson University Antiviral agents for drug-resistant influenza a
KR102339817B1 (ko) 2016-06-30 2021-12-16 한미약품 주식회사 오셀타미비어 함유 경구용 고형제제 및 그 제조방법
KR20190018469A (ko) * 2016-08-10 2019-02-22 시오노기세야쿠 가부시키가이샤 치환된 다환성 피리돈 유도체 및 그의 프로드러그를 함유하는 의약 조성물
PT3706762T (pt) 2017-12-07 2024-12-05 Univ Emory N4-hidroxicitidina e derivados e utilizações antivirais relacionadas com os mesmos
KR20200106607A (ko) 2019-03-05 2020-09-15 주식회사 코아팜바이오 오셀타미비르 함유 의약 조성물
WO2025221915A1 (en) * 2024-04-16 2025-10-23 University Of Utah Research Foundation Synthesis of gadusol and related compounds

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1992006691A1 (en) * 1990-10-19 1992-04-30 Biota Scientific Management Pty. Ltd. Anti-viral compounds that bind the active site of influenza neuramidase and display in vivo activity against orthomyxovirus and paramyxovirus
EP0539204A1 (en) * 1991-10-23 1993-04-28 Biota Scientific Management Pty. Ltd. Antiviral 4-substituted-2-deoxy-2,3-didehydro derivatives of alpha D-neuraminic acid
WO1993012105A1 (en) * 1991-12-17 1993-06-24 Glaxo Group Limited Preparation of n-acetyl neuraminic derivatives
US5360817A (en) * 1990-04-24 1994-11-01 Biota Scientific Management Pty Ltd Derivatives and analogues of 2-deoxy-2,3-didehydro-N-acetyl neuraminic acid and their use as antiviral agents

Family Cites Families (41)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4968788A (en) * 1986-04-04 1990-11-06 Board Of Regents, The University Of Texas System Biologically reversible phosphate and phosphonate protective gruops
US5206400A (en) * 1986-07-07 1993-04-27 Ohio State University Diastereomeric mono- and di-substituted diamino cyclohexane compounds and the method of preparation thereof
EP0398924B1 (en) * 1988-01-12 1996-06-26 Board Of Regents, The University Of Texas System Histamine release inhibitory factor and preparations therefore
US5175273A (en) * 1988-07-01 1992-12-29 Genentech, Inc. Nucleic acid intercalating agents
US5270340A (en) * 1988-12-27 1993-12-14 Bayer Aktiengesellschaft Substituted 2-cyclohexen-1-yl-amine fungicidal and herbicidal agents
GB2238049A (en) * 1989-11-22 1991-05-22 Ki Nii Epidemiologii I Infekts Method for preparing inhibitor for influenza virus neuraminidase
DE4033415A1 (de) * 1990-10-20 1992-04-23 Bayer Ag Antimikrobielle mittel sowie substituierte 2-cyclohexan-1-yl-amin-derivate und deren herstellung
DE4131311A1 (de) * 1991-09-20 1993-04-01 Basf Ag Dihydropyranderivate und diese enthaltende pflanzenschutzmittel
FR2687674B1 (fr) * 1992-02-07 1995-05-19 Roussel Uclaf Nouveaux derives de la pyridone, leur procede de preparation, les nouveaux intermediaires obtenus, leur application a titre de medicaments et les compositions pharmaceutiques les renfermant.
US5292938A (en) * 1992-04-13 1994-03-08 Associated Universities, Inc. Synthesis of 4-substituted-trans-1, 2-diaminocyclohexyl polyaminocarboxylate metal chelating agents for the preparation of stable radiometal antibody immunoconjugates for therapy and spect and pet imaging
US5633360A (en) 1992-04-14 1997-05-27 Gilead Sciences, Inc. Oligonucleotide analogs capable of passive cell membrane permeation
GB9220327D0 (en) * 1992-09-25 1992-11-11 Glaxo Group Ltd Process
GB9220241D0 (en) * 1992-09-25 1992-11-11 Glaxo Group Ltd Process
US5639786A (en) * 1992-12-04 1997-06-17 Biota Scientific Management, Pty., Ltd. Antiviral 4-substituted-2-deoxy-2,3-didehydro-derivatives of α-D-neuraninic acid
US5514798A (en) * 1993-06-02 1996-05-07 Gilead Sciences, Inc. Method and cyclic carbonates for nucleotide analogues
GB9311873D0 (en) * 1993-06-09 1993-07-28 Glaxo Group Ltd Process
GB9311892D0 (en) * 1993-06-09 1993-07-28 Glaxo Wellcome Australia Ltd Device
GB9312531D0 (en) * 1993-06-17 1993-08-04 Glaxo Group Ltd Process
GB9325841D0 (en) * 1993-12-17 1994-02-23 Glaxo Group Ltd Chemical compounds
GB9400206D0 (en) * 1994-01-07 1994-03-02 Glaxo Group Ltd Chemical compound
AUPM354694A0 (en) * 1994-01-27 1994-02-17 Biota Scientific Management Pty Ltd Chemical compounds
US5985859A (en) * 1994-04-14 1999-11-16 The University Of Alabama Methods of inhibiting bacterial sialidase
GB9410817D0 (en) * 1994-05-28 1994-07-20 Glaxo Group Ltd Medicaments
AUPM725794A0 (en) * 1994-08-03 1994-08-25 Biota Scientific Management Pty Ltd Chemical compounds
US5556963A (en) * 1994-08-05 1996-09-17 Oklahoma Medical Research Foundation Synthesis of 4-alkoxy-N-acetylneuraminic acid
GB9416365D0 (en) * 1994-08-12 1994-10-05 Glaxo Group Ltd Medicaments
US5512596A (en) * 1994-09-02 1996-04-30 Gilead Sciences, Inc. Aromatic compounds
EP0789695A2 (en) 1994-11-04 1997-08-20 Gilead Sciences, Inc. Thiepane compounds inhibiting and detecting hiv protease
US5866601A (en) * 1995-02-27 1999-02-02 Gilead Sciences, Inc. Carbocyclic compounds
CN100409844C (zh) * 1995-02-27 2008-08-13 吉里德科学公司 神经氨酸苷酶抑制剂
US5602277A (en) 1995-03-30 1997-02-11 Biocryst Pharmaceuticals, Inc. Substituted benzene derivatives useful as neuraminidase inhibitors
US5714509A (en) * 1995-05-03 1998-02-03 The University Of Alabama Inhibitors of bacterial sialidase and methods of making and using the same
GB9525389D0 (en) 1995-12-12 1996-02-14 Biota Scient Management Ltd Chemical compounds
GB9510141D0 (en) 1995-05-19 1995-07-12 Biota Scient Management Chemical compounds
HUP9801766A3 (en) * 1995-05-19 2000-09-28 Biota Scient Managemant Pty Lt 6-carboxamido dihydropyran derivatives, process for producing them and medicaments containing the same
GB9516276D0 (en) 1995-08-08 1995-10-11 Biota Scient Management Chemical compounds
US5763483A (en) * 1995-12-29 1998-06-09 Gilead Sciences, Inc. Carbocyclic compounds
MXPA99001697A (es) 1996-08-23 2004-04-05 Gilead Sciences Inc Preparacion de derivados de carboxilato de ciclohexeno.
US5859284A (en) 1996-08-23 1999-01-12 Gilead Sciences, Inc. Preparation of carbocyclic compounds
EP0882721A4 (en) * 1996-09-10 1999-12-22 Daikin Ind Ltd SIALIC ACIDS 2,7-DIDEOXY-7-FLUORO- 2, 3-DIDEHYDRO A QUADRUPLE SUBSTITUTION
US5886213A (en) 1997-08-22 1999-03-23 Gilead Sciences, Inc. Preparation of carbocyclic compounds

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5360817A (en) * 1990-04-24 1994-11-01 Biota Scientific Management Pty Ltd Derivatives and analogues of 2-deoxy-2,3-didehydro-N-acetyl neuraminic acid and their use as antiviral agents
WO1992006691A1 (en) * 1990-10-19 1992-04-30 Biota Scientific Management Pty. Ltd. Anti-viral compounds that bind the active site of influenza neuramidase and display in vivo activity against orthomyxovirus and paramyxovirus
EP0539204A1 (en) * 1991-10-23 1993-04-28 Biota Scientific Management Pty. Ltd. Antiviral 4-substituted-2-deoxy-2,3-didehydro derivatives of alpha D-neuraminic acid
WO1993012105A1 (en) * 1991-12-17 1993-06-24 Glaxo Group Limited Preparation of n-acetyl neuraminic derivatives

Also Published As

Publication number Publication date
US6225341B1 (en) 2001-05-01
US20050176758A1 (en) 2005-08-11
DK0759917T3 (da) 2000-07-31
WO1996026933A1 (en) 1996-09-06
BR9607098A (pt) 1997-11-04
NZ306625A (en) 2001-04-27
CZ297945B6 (cs) 2007-05-02
ES2118674T3 (es) 2000-08-16
JP3300365B2 (ja) 2002-07-08
SI9620042A (sl) 1998-12-31
EP0759917A1 (en) 1997-03-05
JP2002161074A (ja) 2002-06-04
KR19980703600A (ko) 1998-12-05
ES2249863T3 (es) 2006-04-01
HU228450B1 (en) 2013-03-28
DE69607704D1 (de) 2000-05-18
BR9607098B8 (pt) 2014-11-18
PL194173B1 (pl) 2007-05-31
CZ269097A3 (en) 1997-11-12
ES2118674T1 (es) 1998-10-01
US5952375A (en) 1999-09-14
JP2006036770A (ja) 2006-02-09
LU90991I2 (fr) 2003-02-11
DE69607704T2 (de) 2000-12-28
HK1026893A1 (en) 2000-12-29
DE69635231T2 (de) 2006-07-13
RU2181357C2 (ru) 2002-04-20
PT759917E (pt) 2000-10-31
MX9706496A (es) 1997-11-29
NO973908L (no) 1997-10-27
CN1147813A (zh) 1997-04-16
NL300105I2 (nl) 2003-02-03
ATE191711T1 (de) 2000-04-15
GR3033914T3 (en) 2000-11-30
ATE305453T1 (de) 2005-10-15
UA56128C2 (uk) 2003-05-15
SG45864A1 (en) 1999-04-27
KR100447096B1 (ko) 2005-10-11
DE10299052I1 (de) 2003-05-22
NO318455B1 (no) 2005-03-21
CN1185223C (zh) 2005-01-19
NL300105I1 (nl) 2003-01-06
EP0759917B1 (en) 2000-04-12
HUP9800026A2 (hu) 1999-09-28
AU720933B2 (en) 2000-06-15
PL322000A1 (en) 1998-01-05
HUP9800026A3 (en) 2002-04-29
DE759917T1 (de) 1998-10-22
JPH11501908A (ja) 1999-02-16
CN1347693A (zh) 2002-05-08
AU5357196A (en) 1996-09-18
NO973908D0 (no) 1997-08-26
DE69635231D1 (de) 2006-02-09
JP4234917B2 (ja) 2009-03-04

Similar Documents

Publication Publication Date Title
CN100409844C (zh) 神经氨酸苷酶抑制剂
US5763483A (en) Carbocyclic compounds
KR20010024123A (ko) 6-원 고리를 갖는 화합물, 그의 제조 방법 및의약물로서의 용도
WO1996026933A9 (en) Novel selective inhibitors of viral or bacterial neuraminidases
JP2008273948A (ja) ウイルスまたは細菌ノイラミニダーゼの新規な選択的インヒビター
US20040053999A1 (en) Novel compounds and methods for synthesis and therapy
HK1120494B (en) Novel compounds and methods for synthesis and therapy
HK1115749A (en) Novel compounds and methods for synthesis and therapy
AU2003204079B2 (en) Novel compounds and methods for synthesis and therapy
CN101143859A (zh) 新颖化合物,其合成方法及治疗用途

Legal Events

Date Code Title Description
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
C06 Publication
PB01 Publication
C14 Grant of patent or utility model
GR01 Patent grant
REG Reference to a national code

Ref country code: HK

Ref legal event code: GR

Ref document number: 1046359

Country of ref document: HK

EE01 Entry into force of recordation of patent licensing contract

Application publication date: 20020508

Assignee: Dongyangguang Industry Development Co., Ltd., Shenzhen

Assignor: HOFFMANN LA ROCHE

Contract record no.: 2013990000525

Denomination of invention: Method for preparing neuraminidase inhibitor RO-64-0796

Granted publication date: 20080813

License type: Common License

Record date: 20130827

LICC Enforcement, change and cancellation of record of contracts on the licence for exploitation of a patent or utility model
CX01 Expiry of patent term

Granted publication date: 20080813

EXPY Termination of patent right or utility model