CN100402026C - 取代的氰基吡咯烷和含有它们的组合制剂用于治疗高脂血症和相关疾病的用途 - Google Patents

取代的氰基吡咯烷和含有它们的组合制剂用于治疗高脂血症和相关疾病的用途 Download PDF

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Publication number
CN100402026C
CN100402026C CNB038128446A CN03812844A CN100402026C CN 100402026 C CN100402026 C CN 100402026C CN B038128446 A CNB038128446 A CN B038128446A CN 03812844 A CN03812844 A CN 03812844A CN 100402026 C CN100402026 C CN 100402026C
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China
Prior art keywords
formula
compound
hyperlipidemia
pharmaceutically acceptable
cholesterol
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Expired - Fee Related
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CNB038128446A
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English (en)
Chinese (zh)
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CN1658867A (zh
Inventor
D·G·霍姆斯
T·E·休斯
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Novartis AG
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Novartis AG
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/401—Proline; Derivatives thereof, e.g. captopril
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A61P39/06—Free radical scavengers or antioxidants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Biochemistry (AREA)
  • Toxicology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CNB038128446A 2002-06-03 2003-06-02 取代的氰基吡咯烷和含有它们的组合制剂用于治疗高脂血症和相关疾病的用途 Expired - Fee Related CN100402026C (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US38522002P 2002-06-03 2002-06-03
US60/385,220 2002-06-03

Related Child Applications (1)

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CNA2008100965659A Division CN101273987A (zh) 2002-06-03 2003-06-02 取代的氰基吡咯烷和含有它们的组合制剂用于治疗高脂血症和相关疾病的用途

Publications (2)

Publication Number Publication Date
CN1658867A CN1658867A (zh) 2005-08-24
CN100402026C true CN100402026C (zh) 2008-07-16

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ID=29712145

Family Applications (2)

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CNB038128446A Expired - Fee Related CN100402026C (zh) 2002-06-03 2003-06-02 取代的氰基吡咯烷和含有它们的组合制剂用于治疗高脂血症和相关疾病的用途
CNA2008100965659A Pending CN101273987A (zh) 2002-06-03 2003-06-02 取代的氰基吡咯烷和含有它们的组合制剂用于治疗高脂血症和相关疾病的用途

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Country Status (25)

Country Link
US (2) US20050176806A1 (https=)
EP (1) EP1513519B1 (https=)
JP (2) JP2005532338A (https=)
KR (1) KR20050012771A (https=)
CN (2) CN100402026C (https=)
AT (1) ATE422884T1 (https=)
AU (2) AU2003245903B2 (https=)
BR (1) BR0311535A (https=)
CA (1) CA2487297C (https=)
CY (1) CY1112800T1 (https=)
DE (1) DE60326232D1 (https=)
DK (1) DK1513519T3 (https=)
EC (1) ECSP045469A (https=)
ES (1) ES2321600T3 (https=)
IL (1) IL165181A (https=)
MX (1) MXPA04012149A (https=)
NO (1) NO333585B1 (https=)
NZ (1) NZ536832A (https=)
PL (1) PL210408B1 (https=)
PT (1) PT1513519E (https=)
RU (1) RU2362555C2 (https=)
SG (1) SG154333A1 (https=)
SI (1) SI1513519T1 (https=)
WO (1) WO2003101448A1 (https=)
ZA (1) ZA200409136B (https=)

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CN100402026C (zh) * 2002-06-03 2008-07-16 诺瓦提斯公司 取代的氰基吡咯烷和含有它们的组合制剂用于治疗高脂血症和相关疾病的用途
AR041089A1 (es) * 2003-05-15 2005-05-04 Merck & Co Inc Procedimiento y composiciones farmaceutiicas para tratar aterosclerosis, dislipidemias y afecciones relacionadas
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WO2006083214A1 (en) * 2005-02-02 2006-08-10 Astrazeneca Ab Pharmaceutical composition comprising a p2x7 receptor antagonist and a hmg-coa reductase inhibitor
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PE20071221A1 (es) 2006-04-11 2007-12-14 Arena Pharm Inc Agonistas del receptor gpr119 en metodos para aumentar la masa osea y para tratar la osteoporosis y otras afecciones caracterizadas por masa osea baja, y la terapia combinada relacionada a estos agonistas
US20100260841A1 (en) * 2007-02-08 2010-10-14 Paolini John F Method of Treating Atherosclerosis, Dyslipidemias and Related Conditions
EP2108960A1 (en) 2008-04-07 2009-10-14 Arena Pharmaceuticals, Inc. Methods of using A G protein-coupled receptor to identify peptide YY (PYY) secretagogues and compounds useful in the treatment of conditons modulated by PYY
AR077642A1 (es) 2009-07-09 2011-09-14 Arena Pharm Inc Moduladores del metabolismo y el tratamiento de trastornos relacionados con el mismo
AU2011237775A1 (en) 2010-04-06 2012-11-22 Arena Pharmaceuticals, Inc. Modulators of the GPR119 receptor and the treatment of disorders related thereto
PH12013500547A1 (en) 2010-09-22 2013-06-10 Arena Pharm Inc Modulators of the gpr119 receptor and the treatment of disorders related thereto
KR101298788B1 (ko) * 2011-03-15 2013-08-22 보령제약 주식회사 안정성이 개선된 복합제제
US20140018371A1 (en) 2011-04-01 2014-01-16 Arena Pharmaceuticals, Inc. Modulators Of The GPR119 Receptor And The Treatment Of Disorders Related Thereto
US20140066369A1 (en) 2011-04-19 2014-03-06 Arena Pharmaceuticals, Inc. Modulators Of The GPR119 Receptor And The Treatment Of Disorders Related Thereto
US20140038889A1 (en) 2011-04-22 2014-02-06 Arena Pharmaceuticals, Inc. Modulators Of The GPR119 Receptor And The Treatment Of Disorders Related Thereto
WO2012145604A1 (en) 2011-04-22 2012-10-26 Arena Pharmaceuticals, Inc. Modulators of the gpr119 receptor and the treatment of disorders related thereto
WO2012170702A1 (en) 2011-06-08 2012-12-13 Arena Pharmaceuticals, Inc. Modulators of the gpr119 receptor and the treatment of disorders related thereto
WO2013055910A1 (en) 2011-10-12 2013-04-18 Arena Pharmaceuticals, Inc. Modulators of the gpr119 receptor and the treatment of disorders related thereto
EA021236B1 (ru) * 2012-10-03 2015-05-29 Дафот Энтерпраизес Лимитед Nα-АЦИЛЬНЫЕ ПРОИЗВОДНЫЕ АМИНОАЦИЛ-2-ЦИАНОПИРРОЛИДИНА - ИНГИБИТОРЫ ПРОЛИЛЭНДОПЕПТИДАЗЫ И ДИПЕПТИДИЛПЕПТИДАЗЫ-IV, ОБЛАДАЮЩИЕ ГИПОГЛИКЕМИЧЕСКИМ, ПРОТИВОГИПОКСИЧЕСКИМ, НЕЙРОПРОТЕКТОРНЫМ И УЛУЧШАЮЩИМ КОГНИТИВНЫЕ ФУНКЦИИ ДЕЙСТВИЕМ
WO2014074668A1 (en) 2012-11-08 2014-05-15 Arena Pharmaceuticals, Inc. Modulators of gpr119 and the treatment of disorders related thereto
EA201791982A1 (ru) 2015-03-09 2020-02-17 Интекрин Терапьютикс, Инк. Способы лечения неалкогольной жировой болезни печени и/или липодистрофии
AU2018249822A1 (en) 2017-04-03 2019-10-31 Coherus Biosciences Inc. PPArgamma agonist for treatment of progressive supranuclear palsy
KR20210143848A (ko) * 2019-03-22 2021-11-29 러쉬 유니버시티 메디컬 센터 리소좀 축적 장애를 위한 비강 유전자 전달 및 경구 신남산, 올레아미드 또는 젬피브로질의 병용

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Also Published As

Publication number Publication date
AU2003245903B2 (en) 2006-11-30
ES2321600T3 (es) 2009-06-09
CN1658867A (zh) 2005-08-24
ZA200409136B (en) 2005-07-27
PL374016A1 (en) 2005-09-19
DE60326232D1 (de) 2009-04-02
MXPA04012149A (es) 2005-04-19
PL210408B1 (pl) 2012-01-31
JP2005532338A (ja) 2005-10-27
EP1513519A1 (en) 2005-03-16
CN101273987A (zh) 2008-10-01
RU2004139029A (ru) 2005-08-27
SI1513519T1 (sl) 2009-06-30
ECSP045469A (es) 2005-01-28
KR20050012771A (ko) 2005-02-02
RU2362555C2 (ru) 2009-07-27
IL165181A0 (en) 2005-12-18
SG154333A1 (en) 2009-08-28
IL165181A (en) 2010-06-16
US20120014907A1 (en) 2012-01-19
ATE422884T1 (de) 2009-03-15
CA2487297C (en) 2011-08-09
AU2006246483B9 (en) 2010-08-12
AU2003245903A1 (en) 2003-12-19
NO333585B1 (no) 2013-07-15
CA2487297A1 (en) 2003-12-11
PT1513519E (pt) 2009-05-06
EP1513519B1 (en) 2009-02-18
NZ536832A (en) 2006-11-30
NO20045452L (no) 2005-03-01
CY1112800T1 (el) 2016-02-10
BR0311535A (pt) 2005-02-22
JP2010155866A (ja) 2010-07-15
AU2006246483A1 (en) 2006-12-21
AU2006246483B2 (en) 2010-06-24
HK1074794A1 (en) 2005-11-25
WO2003101448A1 (en) 2003-12-11
DK1513519T3 (da) 2009-06-02
US20050176806A1 (en) 2005-08-11

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