CN100400101C - 包含病毒唑的疫苗及其使用方法 - Google Patents

包含病毒唑的疫苗及其使用方法 Download PDF

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CN100400101C
CN100400101C CNB018150713A CN01815071A CN100400101C CN 100400101 C CN100400101 C CN 100400101C CN B018150713 A CNB018150713 A CN B018150713A CN 01815071 A CN01815071 A CN 01815071A CN 100400101 C CN100400101 C CN 100400101C
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CN1469755A (zh
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M·萨比尔格
C·胡尔特格伦
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Tripep AB
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    • A61K48/00Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
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    • A61K48/0058Nucleic acids adapted for tissue specific expression, e.g. having tissue specific promoters as part of a contruct
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    • C12N2730/10011Hepadnaviridae
    • C12N2730/10111Orthohepadnavirus, e.g. hepatitis B virus
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    • C12N2770/24011Flaviviridae
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    • C12N2770/00011Details
    • C12N2770/24011Flaviviridae
    • C12N2770/24211Hepacivirus, e.g. hepatitis C virus, hepatitis G virus
    • C12N2770/24234Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
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    • Y02A50/00TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
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  • Medicinal Chemistry (AREA)
  • Virology (AREA)
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  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
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  • Communicable Diseases (AREA)
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  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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  • Gastroenterology & Hepatology (AREA)
  • General Engineering & Computer Science (AREA)
  • Oncology (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
CNB018150713A 2000-08-17 2001-08-15 包含病毒唑的疫苗及其使用方法 Expired - Fee Related CN100400101C (zh)

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Application Number Priority Date Filing Date Title
US22576700P 2000-08-17 2000-08-17
US09/705547 2000-08-17
US60/225,767 2000-08-17
US22917500P 2000-08-29 2000-08-29
US60/229,175 2000-08-29
US70554700A 2000-11-03 2000-11-03
US09/705,547 2000-11-03

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CN1469755A CN1469755A (zh) 2004-01-21
CN100400101C true CN100400101C (zh) 2008-07-09

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US (1) US6960569B2 (cg-RX-API-DMAC7.html)
EP (3) EP1947185B1 (cg-RX-API-DMAC7.html)
JP (1) JP5175417B2 (cg-RX-API-DMAC7.html)
KR (2) KR100801123B1 (cg-RX-API-DMAC7.html)
CN (1) CN100400101C (cg-RX-API-DMAC7.html)
AT (2) ATE375804T1 (cg-RX-API-DMAC7.html)
AU (4) AU9215101A (cg-RX-API-DMAC7.html)
CA (1) CA2419418A1 (cg-RX-API-DMAC7.html)
DE (1) DE60130998T2 (cg-RX-API-DMAC7.html)
ES (1) ES2296803T3 (cg-RX-API-DMAC7.html)
PL (1) PL360990A1 (cg-RX-API-DMAC7.html)
WO (2) WO2002014362A2 (cg-RX-API-DMAC7.html)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE375804T1 (de) * 2000-08-17 2007-11-15 Tripep Ab Ribavirin-enthaltende vakzine
RU2286172C2 (ru) 2000-08-17 2006-10-27 Трипеп Аб Вакцины, содержащие рибавирин, и способы их использования
US7022830B2 (en) 2000-08-17 2006-04-04 Tripep Ab Hepatitis C virus codon optimized non-structural NS3/4A fusion gene
US6680059B2 (en) 2000-08-29 2004-01-20 Tripep Ab Vaccines containing ribavirin and methods of use thereof
WO2002102307A2 (en) * 2001-06-15 2002-12-27 Ribapharm Nucleoside vaccine adjuvants
WO2004019878A2 (en) * 2002-08-27 2004-03-11 Compound Therapeutics, Inc. Adzymes and uses thereof
KR20050086843A (ko) * 2002-11-26 2005-08-30 트리펩 아베 증강인자 성분으로서의 c형 간염 바이러스 비구조 단백질4a(ns4a)
US7419912B2 (en) 2004-04-01 2008-09-02 Cree, Inc. Laser patterning of light emitting devices
DE602005002673T2 (de) * 2004-04-29 2008-07-24 F. Hoffmann-La Roche Ag Nukleotidsequenzvariation im Gen NS5A als Marker
AU2012200012B8 (en) * 2004-09-29 2014-05-01 The Administrators Of The Tulane Educational Fund Inhibitors of hepatitis C virus
ES2349153T3 (es) * 2004-09-29 2010-12-28 The Administrators Of The Tulane Educational Fund Inhibidores del virus de la hepatitis c.
WO2008004992A2 (en) * 2005-05-25 2008-01-10 Tripep Ab Transdermal formulations containing hepatitis c virus immunogens and an ethoxylated oil
US7968697B2 (en) * 2005-05-25 2011-06-28 Chrontech Pharma Ab Hepatitis C virus non-structural NS3/4A fusion gene
CN101330928B (zh) * 2005-10-07 2012-11-14 西马生物医学计划公司 用于预防和治疗丙型肝炎的免疫刺激剂组合
ES2334472B1 (es) * 2006-06-09 2011-01-21 Proyecto De Biomedicina Cima, S.L. Combinacion inmunoestimuladora para profilaxis y tratamiento de hepatitis c.
US20090214593A1 (en) * 2007-08-16 2009-08-27 Tripep Ab Immunogen platform
WO2009022236A2 (en) * 2007-08-16 2009-02-19 Tripep Ab Immunogen platform
US20100310605A1 (en) * 2007-12-18 2010-12-09 Peking University People's Hospital anti-hcv vaccine and preparation methods and uses thereof
CN108148121B (zh) * 2018-03-06 2021-07-09 中美赛尔生物科技(广东)有限公司 丙型肝炎病毒抗原多肽组合物以及丙型肝炎病毒疫苗

Family Cites Families (85)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2933693A (en) 1957-05-03 1960-04-19 Lyle R Battersby Sensitivity control circuit
US4215051A (en) 1979-08-29 1980-07-29 Standard Oil Company (Indiana) Formation, purification and recovery of phthalic anhydride
US4486530A (en) 1980-08-04 1984-12-04 Hybritech Incorporated Immunometric assays using monoclonal antibodies
US4376110A (en) 1980-08-04 1983-03-08 Hybritech, Incorporated Immunometric assays using monoclonal antibodies
US4873191A (en) 1981-06-12 1989-10-10 Ohio University Genetic transformation of zygotes
US4818540A (en) 1985-02-25 1989-04-04 Rutgers, The State University Of New Jersey Transdermal fertility control system and process
US4683202A (en) 1985-03-28 1987-07-28 Cetus Corporation Process for amplifying nucleic acid sequences
US4683195A (en) 1986-01-30 1987-07-28 Cetus Corporation Process for amplifying, detecting, and/or-cloning nucleic acid sequences
US4965188A (en) 1986-08-22 1990-10-23 Cetus Corporation Process for amplifying, detecting, and/or cloning nucleic acid sequences using a thermostable enzyme
US5643565A (en) 1985-09-20 1997-07-01 Chiron Corporation Human IL-2 as a vaccine adjuvant
US5322770A (en) 1989-12-22 1994-06-21 Hoffman-Laroche Inc. Reverse transcription with thermostable DNA polymerases - high temperature reverse transcription
US4946778A (en) 1987-09-21 1990-08-07 Genex Corporation Single polypeptide chain binding molecules
US6171782B1 (en) 1987-11-18 2001-01-09 Chiron Corporation Antibody compositions to HCV and uses thereof
EP0318216B2 (en) * 1987-11-18 2001-08-29 Chiron Corporation NANBV diagnostics
US5714596A (en) 1987-11-18 1998-02-03 Chiron Corporation NANBV diagnostics: polynucleotides useful for screening for hepatitis C virus
US5350671A (en) 1987-11-18 1994-09-27 Chiron Corporation HCV immunoassays employing C domain antigens
US5698390A (en) 1987-11-18 1997-12-16 Chiron Corporation Hepatitis C immunoassays
US5968775A (en) 1987-11-18 1999-10-19 Chiron Corporation Hepatitis C virus infected cell systems
US5683864A (en) 1987-11-18 1997-11-04 Chiron Corporation Combinations of hepatitis C virus (HCV) antigens for use in immunoassays for anti-HCV antibodies
US5712088A (en) 1987-11-18 1998-01-27 Chiron Corporation Methods for detecting Hepatitis C virus using polynucleotides specific for same
US5679342A (en) 1987-11-18 1997-10-21 Chiron Corporation Hepatitis C virus infected cell systems
US4950647A (en) 1988-10-04 1990-08-21 Nucleic Acid Research Institute T cell immunopotentiator
KR0185373B1 (ko) 1989-03-17 1999-05-01 로버트 피. 블랙버언 Hcv 폴리단백질에서 유래되는 hcv 아미노산 서열 부분을 포함하는 폴리펩티드 및 그 사용
US5703055A (en) 1989-03-21 1997-12-30 Wisconsin Alumni Research Foundation Generation of antibodies through lipid mediated DNA delivery
US6027729A (en) 1989-04-20 2000-02-22 Chiron Corporation NANBV Diagnostics and vaccines
AU638719B2 (en) 1989-05-18 1993-07-08 Novartis Vaccines And Diagnostics, Inc. Nanbv diagnostics: polynucleotides useful for screening for hepatitis c virus
US5143854A (en) 1989-06-07 1992-09-01 Affymax Technologies N.V. Large scale photolithographic solid phase synthesis of polypeptides and receptor binding screening thereof
ATE161041T1 (de) 1989-08-25 1997-12-15 Chiron Corp Verfahren zur hcv-züchtung in zell-linien aus b- oder t-lymphozyten
CA2065287C (en) * 1989-09-15 1999-12-21 Tatsuo Miyamura New hcv isolates
US5372928A (en) 1989-09-15 1994-12-13 Chiron Corporation Hepatitis C virus isolates
US6194140B1 (en) 1990-04-04 2001-02-27 Chiron Corporation HCV NS3 protein fragments having helicase activity and improved solubility
RO109916B1 (ro) 1990-04-04 1995-07-28 Chiron Corp Compozitie de antigeni ai hepatitei virale c
DE69133402T2 (de) 1990-04-04 2004-11-11 Chiron Corp. (N.D.Ges.D. Staates Delaware), Emeryville Protease von hepatitis-c-virus
US5712087A (en) 1990-04-04 1998-01-27 Chiron Corporation Immunoassays for anti-HCV antibodies employing combinations of hepatitis C virus (HCV) antigens
JP2714255B2 (ja) 1990-08-10 1998-02-16 カイロン コーポレイション Nanbv診断法:c型肝炎ウイルスのスクリーニングに有用なポリヌクレオチド
US5604105B1 (en) 1990-10-12 1999-08-24 Spectral Diagnostics Inc Method and device for diagnosingand distinguishing chest pain in early onset thereof
US5710008B1 (en) 1990-10-12 1999-09-07 Spectral Diagnostics Inc Method and device for diagnosing and distinguishing chest pain in early onset thereof
CA2027434C (en) 1990-10-12 1999-01-05 George Jackowski Diagnostic kit for diagnosing and distinguishing chest pain in early onset thereof
CA2203443C (en) 1990-11-08 2001-08-28 Robert O. Ralston Hepatitis c virus asialoglycoproteins
US6274148B1 (en) 1990-11-08 2001-08-14 Chiron Corporation Hepatitis C virus asialoglycoproteins
EP1046421B8 (en) 1990-12-06 2006-01-11 Affymetrix, Inc. (a Delaware Corporation) Methods and reagents for very large scale immobilized polymer synthesis
KR100193801B1 (ko) 1991-05-08 1999-06-15 케네스 엠. 골드만 진단 및 치료용 c형 간염 바이러스(hcv) 게놈서열
US6190864B1 (en) 1991-05-08 2001-02-20 Chiron Corporation HCV genomic sequences for diagnostics and therapeutics
FR2677372B1 (fr) * 1991-06-06 1994-11-10 Pasteur Institut Sequences nucleotidiques et peptidiques d'un isolat de virus de l'hepatite c, applications diagnostiques et therapeutiques.
HU227547B1 (en) 1991-06-24 2011-08-29 Novartis Vaccines & Diagnostic Hepatitis c virus (hcv) polypeptides
RO116199B1 (ro) 1991-09-13 2000-11-30 Chiron Corp Compozitie polipeptidica hcv imunogena
US5412087A (en) 1992-04-24 1995-05-02 Affymax Technologies N.V. Spatially-addressable immobilization of oligonucleotides and other biological polymers on surfaces
US5795714A (en) 1992-11-06 1998-08-18 Trustees Of Boston University Method for replicating an array of nucleic acid probes
DE4239311C2 (de) 1992-11-23 1996-04-18 Guehring Joerg Dr Bohrer, insbesondere Spitzbohrwerkzeug mit austauschbarem Schneideinsatz
DE69434469T2 (de) 1993-01-26 2006-06-14 Univ Pennsylvania Zusammensetzungen und verfahren zur verabreichung von genetischem material
BR9405334A (pt) 1993-04-27 1999-05-25 Innogenetics Nv Novas sequências de genótipos de vírus da hepatite c e seu uso como agentes terapêuticos e diagnóstico
JPH09507121A (ja) 1993-10-26 1997-07-22 アフィマックス テクノロジーズ ナームロゼ ベノートスハップ 生物学的チップ上の核酸プローブアレー
DE69528074T2 (de) 1994-09-23 2003-04-30 Zonagen, Inc. Chitosan induzierte verstärkung
US6235888B1 (en) 1994-10-05 2001-05-22 The General Hospital Corporation Hepatitis C virus vaccine
BR9509421A (pt) 1994-10-21 1997-09-30 Innogenetics Nv Novas sequências de genotipos de vírus de hepatite C e uso como agentes profiláticos terapêuticos e diagnósticos
FR2730935A1 (fr) 1994-12-21 1996-08-30 Vacsyn Sa Vaccin presentant une immunogenicite accrue
US5932556A (en) 1995-09-17 1999-08-03 Tam; Robert C Methods and compositions for regulation of CD28 expression
WO1996028162A1 (en) 1995-03-14 1996-09-19 University Of Medicine & Dentistry Of New Jersey New drug combination for the treatment of viral diseases
PT879056E (pt) 1996-01-23 2002-10-31 Ribapharm Inc Modulacao da expressao das citocinas th1/th2 atraves de ribavirina em linfocitos t activados
US6150337A (en) 1996-01-23 2000-11-21 Icn Pharmaceuticals, Inc. Specific modulation of Th1/Th2 cytokine expression by Ribavirin in activated T-lymphocytes
US5767097A (en) 1996-01-23 1998-06-16 Icn Pharmaceuticals, Inc. Specific modulation of Th1/Th2 cytokine expression by ribavirin in activated T-lymphocytes
US6228575B1 (en) 1996-02-08 2001-05-08 Affymetrix, Inc. Chip-based species identification and phenotypic characterization of microorganisms
CA2244891C (en) 1996-02-09 2008-12-30 Cornell Research Foundation, Inc. Detection of nucleic acid sequence differences using the ligase detection reaction with addressable arrays
US6514731B1 (en) 1996-05-24 2003-02-04 Chiron Corporation Methods for the preparation of hepatitis C virus multiple copy epitope fusion antigens
JP2002500502A (ja) 1996-06-11 2002-01-08 メルク エンド カンパニー インコーポレーテッド 合成c型肝炎遺伝子
EP2298900A1 (en) 1996-09-17 2011-03-23 Novartis Vaccines and Diagnostics, Inc. Compositions and methods for treating intracellular diseases
CZ126799A3 (cs) 1996-10-16 1999-07-14 Icn Pharmaceuticals Purinové L-nukleosidy a jejich analogy a farmaceutické prostředky, které je obsahují
HUP0001107A3 (en) 1996-10-16 2003-01-28 Icn Pharmaceuticals Inc Costa Monocyclic l-nucleosides, analogs and pharmaceutical compositions thereof
IL119833A (en) 1996-12-15 2001-01-11 Lavie David Hypericum perforatum extracts for the preparation of pharmaceutical compositions for the treatment of hepatitis
KR20000070167A (ko) 1997-01-14 2000-11-25 와트 씨 데이빗, 해리 에이 루스제 질병의 시토킨 관련 치료 방법
EP0969862B1 (en) 1997-02-07 2006-10-18 Merck & Co., Inc. Synthetic hiv gag genes
WO1998037180A2 (en) * 1997-02-22 1998-08-27 Abbott Laboratories Hcv fusion protease and polynucleotide encoding same
US6153421A (en) * 1997-07-18 2000-11-28 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Cloned genomes of infectious hepatitis C viruses and uses thereof
WO1999028482A2 (en) * 1997-11-28 1999-06-10 Schering Corporation Single-chain recombinant complexes of hepatitis c virus ns3 protease and ns4a cofactor peptide
US6541011B2 (en) 1998-02-11 2003-04-01 Maxygen, Inc. Antigen library immunization
WO1999054735A1 (en) * 1998-04-17 1999-10-28 Innogenetics N.V. Improved immunodiagnostic assays using reducing agents
GB9820525D0 (en) 1998-09-21 1998-11-11 Allergy Therapeutics Ltd Formulation
US20020187945A1 (en) 1999-01-29 2002-12-12 Robert Tam Modulation of immune response by ribavirin
CA2357735A1 (en) 1999-01-29 2000-08-03 Icn Pharmaceuticals, Inc. Modulation of immune response by ribavirin
AU2574601A (en) * 1999-11-24 2001-06-04 Chiron Corporation Novel hcv non-structural polypeptide
JP4837229B2 (ja) 2000-06-15 2011-12-14 ノバルティス バクシンズ アンド ダイアグノスティックス,インコーポレーテッド 抗hcv抗体についてのイムノアッセイ
ATE375804T1 (de) 2000-08-17 2007-11-15 Tripep Ab Ribavirin-enthaltende vakzine
AU2002337840B2 (en) 2001-10-11 2007-08-09 Msd Italia S.R.L. Hepatitis C virus vaccine
KR20140137679A (ko) 2013-05-23 2014-12-03 삼성전자주식회사 카드 소켓 장치
US12501293B2 (en) 2019-08-14 2025-12-16 Samsung Electronics Co., Ltd. Method and terminal for performing RRM measurement in wireless communication system

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
Enhancement of hepatitis C virus core antigen-specific type 1T helper cell response by ribavirin correlates with theincreased level of IL-2. CHIANG B L ET AL.Joint annual meting of the american association of immunologists and the clinical immunology society. 2000 *
Interferon-alpha treatment induces delayedd CD4 proliferativeresponses to the hepatitis C virus nonstructural protein 3regardledd of the outcome of therapy. ZHANG ZHU-XU ET AL.JOURNAL OF INFECTIOUS DISEASES,Vol.175 No.6. 1997 *
persprctives for a vaccine against hepatiais c virus. abrignani asrgio et al.journal of hepatology,Vol.31 No.1. 1999 *

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