CN100338049C - 制备14β－羟基－浆果赤霉素Ⅲ－1,14－碳酸酯的方法 - Google Patents

制备14β－羟基－浆果赤霉素Ⅲ－1,14－碳酸酯的方法 Download PDF

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Publication number
CN100338049C
CN100338049C CNB028205235A CN02820523A CN100338049C CN 100338049 C CN100338049 C CN 100338049C CN B028205235 A CNB028205235 A CN B028205235A CN 02820523 A CN02820523 A CN 02820523A CN 100338049 C CN100338049 C CN 100338049C
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CN
China
Prior art keywords
baccatine iii
ketone group
boc
described method
beta
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Chinese (zh)
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CN1688563A (zh
Inventor
E·邦巴尔代利
G·丰塔纳
A·巴塔格利亚
A·圭里尼
E·巴尔代利
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/08—Bridged systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D305/00—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms
    • C07D305/14—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms condensed with carbocyclic rings or ring systems
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Epoxy Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
CNB028205235A 2001-10-19 2002-07-18 制备14β－羟基－浆果赤霉素Ⅲ－1,14－碳酸酯的方法 Expired - Fee Related CN100338049C (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IT2001MI002185A ITMI20012185A1 (it) 2001-10-19 2001-10-19 Procedimento per la preparazione della 14beta-idrossi-baccatina iii-1,14-carbonato
ITMI2001A002185 2001-10-19

Publications (2)

Publication Number Publication Date
CN1688563A CN1688563A (zh) 2005-10-26
CN100338049C true CN100338049C (zh) 2007-09-19

Family

ID=11448528

Family Applications (1)

Application Number Title Priority Date Filing Date
CNB028205235A Expired - Fee Related CN100338049C (zh) 2001-10-19 2002-07-18 制备14β－羟基－浆果赤霉素Ⅲ－1,14－碳酸酯的方法

Country Status (23)

Country Link
US (1) US7317113B2 (hu)
EP (1) EP1436278B1 (hu)
JP (2) JP4467976B2 (hu)
KR (1) KR100896543B1 (hu)
CN (1) CN100338049C (hu)
AT (1) ATE466847T1 (hu)
AU (1) AU2002363080B2 (hu)
BR (1) BR0213329A (hu)
CA (1) CA2464336C (hu)
DE (1) DE60236303D1 (hu)
DK (1) DK1436278T3 (hu)
ES (1) ES2341611T3 (hu)
HK (1) HK1080475A1 (hu)
HU (1) HU229256B1 (hu)
IL (4) IL161444A0 (hu)
IT (1) ITMI20012185A1 (hu)
MX (1) MXPA04003517A (hu)
NO (1) NO328534B1 (hu)
PL (1) PL207878B1 (hu)
PT (1) PT1436278E (hu)
RU (1) RU2285000C2 (hu)
SI (1) SI1436278T1 (hu)
WO (1) WO2003035634A1 (hu)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ITMI20012186A1 (it) * 2001-10-19 2003-04-19 Indena Spa Procedimento per la preparazione della 14-beta-idrossi-baccatina iii-1,14-carbonato
ITMI20012185A1 (it) * 2001-10-19 2003-04-19 Indena Spa Procedimento per la preparazione della 14beta-idrossi-baccatina iii-1,14-carbonato
AU2002324091A1 (en) * 2002-09-16 2004-04-30 Nokia Corporation Direct conversion receiver and receiving method
EP2080764B1 (en) 2008-01-18 2012-08-22 INDENA S.p.A. Solid forms of ortataxel

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1123547A (zh) * 1993-03-26 1996-05-29 纽约州州立大学研究基金会 抗肿瘤化合物、药物组合物、其制备方法以及其用于治疗的方法
CN1177961A (zh) * 1995-05-19 1998-04-01 因迪纳有限公司 10－脱乙酰基－14β－羟基浆果赤霉素Ⅲ衍生物,其制备方法及含有它们的制剂
CN1178528A (zh) * 1995-03-17 1998-04-08 因迪纳有限公司 10－脱乙酰浆果赤霉素Ⅲ和10－脱乙酰－14β－羟基浆果赤霉素Ⅲ衍生物、其制备方法以及含有它们的药物组合物
US5811452A (en) * 1997-01-08 1998-09-22 The Research Foundation Of State University Of New York Taxoid reversal agents for drug-resistance in cancer chemotherapy and pharmaceutical compositions thereof
CN1218475A (zh) * 1996-05-10 1999-06-02 因迪纳有限公司 紫杉烷衍生物,其制备方法以及含有它们的制剂

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0620877A (ja) * 1992-03-02 1994-01-28 Du Pont Japan Ltd タンタル固体電解コンデンサ
IT1254517B (it) 1992-03-06 1995-09-25 Indena Spa 14-beta idrossi-10-deacetil-baccatina iii, suoi derivati, loro prepazione ed impiego terapeutico
FR2732341A1 (fr) 1995-03-27 1996-10-04 Rhone Poulenc Rorer Sa Nouveaux taxoides, leur preparation et les compositions pharmaceutiques qui les contiennent
US5917062A (en) * 1997-11-21 1999-06-29 Indena S.P.A Intermediates and methods useful in the semisynthesis of paclitaxel and analogs
IT1318678B1 (it) * 2000-08-10 2003-08-27 Indena Spa Procedimento per la preparazione di derivati della baccatina iii.
IT1320107B1 (it) * 2000-11-28 2003-11-18 Indena Spa Procedimento per la preparazione di derivati tassanici.
IT1319682B1 (it) * 2000-12-06 2003-10-23 Indena Spa Procedimento di sintesi del paclitaxel.
ITMI20012185A1 (it) * 2001-10-19 2003-04-19 Indena Spa Procedimento per la preparazione della 14beta-idrossi-baccatina iii-1,14-carbonato
ITMI20012186A1 (it) * 2001-10-19 2003-04-19 Indena Spa Procedimento per la preparazione della 14-beta-idrossi-baccatina iii-1,14-carbonato
ITMI20021921A1 (it) * 2002-09-10 2004-03-11 Indena Spa Funzionalizzazione della posizione 14 dei nuclei tassanici e sintesi di nuovi derivati antitumorali.

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1123547A (zh) * 1993-03-26 1996-05-29 纽约州州立大学研究基金会 抗肿瘤化合物、药物组合物、其制备方法以及其用于治疗的方法
CN1178528A (zh) * 1995-03-17 1998-04-08 因迪纳有限公司 10－脱乙酰浆果赤霉素Ⅲ和10－脱乙酰－14β－羟基浆果赤霉素Ⅲ衍生物、其制备方法以及含有它们的药物组合物
CN1177961A (zh) * 1995-05-19 1998-04-01 因迪纳有限公司 10－脱乙酰基－14β－羟基浆果赤霉素Ⅲ衍生物,其制备方法及含有它们的制剂
CN1218475A (zh) * 1996-05-10 1999-06-02 因迪纳有限公司 紫杉烷衍生物,其制备方法以及含有它们的制剂
US5811452A (en) * 1997-01-08 1998-09-22 The Research Foundation Of State University Of New York Taxoid reversal agents for drug-resistance in cancer chemotherapy and pharmaceutical compositions thereof

Also Published As

Publication number Publication date
WO2003035634A1 (en) 2003-05-01
US7317113B2 (en) 2008-01-08
CA2464336A1 (en) 2003-05-01
US20050020669A1 (en) 2005-01-27
IL161444A (en) 2008-12-29
IL185920A (en) 2011-02-28
IL185920A0 (en) 2008-01-06
HUP0402020A3 (en) 2007-05-29
PT1436278E (pt) 2010-05-31
DE60236303D1 (de) 2010-06-17
RU2004111670A (ru) 2005-04-20
AU2002363080B2 (en) 2007-11-29
PL207878B1 (pl) 2011-02-28
HK1080475A1 (en) 2006-04-28
ATE466847T1 (de) 2010-05-15
NO328534B1 (no) 2010-03-15
KR100896543B1 (ko) 2009-05-07
BR0213329A (pt) 2004-10-13
PL367981A1 (en) 2005-03-21
HUP0402020A2 (hu) 2005-01-28
MXPA04003517A (es) 2004-07-23
HU229256B1 (hu) 2013-10-28
EP1436278A1 (en) 2004-07-14
ES2341611T3 (es) 2010-06-23
EP1436278B1 (en) 2010-05-05
CN1688563A (zh) 2005-10-26
DK1436278T3 (da) 2010-08-02
KR20040045024A (ko) 2004-05-31
WO2003035634A8 (en) 2004-05-21
CA2464336C (en) 2009-12-22
SI1436278T1 (sl) 2010-08-31
ITMI20012185A1 (it) 2003-04-19
JP2005509638A (ja) 2005-04-14
NO20041542L (no) 2004-04-15
IL185921A (en) 2011-06-30
RU2285000C2 (ru) 2006-10-10
IL185921A0 (en) 2008-01-06
JP2010047600A (ja) 2010-03-04
JP4467976B2 (ja) 2010-05-26
IL161444A0 (en) 2004-09-27

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