CL2021002104A1 - Compuestos, composiciones y métodos. - Google Patents
Compuestos, composiciones y métodos.Info
- Publication number
- CL2021002104A1 CL2021002104A1 CL2021002104A CL2021002104A CL2021002104A1 CL 2021002104 A1 CL2021002104 A1 CL 2021002104A1 CL 2021002104 A CL2021002104 A CL 2021002104A CL 2021002104 A CL2021002104 A CL 2021002104A CL 2021002104 A1 CL2021002104 A1 CL 2021002104A1
- Authority
- CL
- Chile
- Prior art keywords
- methods
- compositions
- compounds
- stereoisomer
- stereoisomers
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
- A61K31/351—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom not condensed with another ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/433—Thidiazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/498—Pyrazines or piperazines ortho- and peri-condensed with carbocyclic ring systems, e.g. quinoxaline, phenazine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D271/00—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms
- C07D271/02—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms not condensed with other rings
- C07D271/10—1,3,4-Oxadiazoles; Hydrogenated 1,3,4-oxadiazoles
- C07D271/113—1,3,4-Oxadiazoles; Hydrogenated 1,3,4-oxadiazoles with oxygen, sulfur or nitrogen atoms, directly attached to ring carbon atoms, the nitrogen atoms not forming part of a nitro radical
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
- C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
- C07D493/08—Bridged systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Plural Heterocyclic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Abstract
La presente descripción hace referencia en términos generales a moduladores del factor de iniciación eucariota 2B o una sal farmacéuticamente aceptable, un estereoisómero, una mezcla de estereoisómeros o un profármaco de estos y a métodos para realizarlos y utilizarlos.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201962805263P | 2019-02-13 | 2019-02-13 | |
US201962877232P | 2019-07-22 | 2019-07-22 |
Publications (1)
Publication Number | Publication Date |
---|---|
CL2021002104A1 true CL2021002104A1 (es) | 2022-04-08 |
Family
ID=72043948
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CL2021002104A CL2021002104A1 (es) | 2019-02-13 | 2021-08-10 | Compuestos, composiciones y métodos. |
Country Status (18)
Country | Link |
---|---|
US (2) | US11306077B2 (es) |
EP (1) | EP3923935A4 (es) |
JP (1) | JP2022520236A (es) |
KR (1) | KR20210126036A (es) |
CN (1) | CN113518618A (es) |
AU (1) | AU2020223228A1 (es) |
BR (1) | BR112021015639A2 (es) |
CA (1) | CA3129609A1 (es) |
CL (1) | CL2021002104A1 (es) |
CO (1) | CO2021010490A2 (es) |
CR (1) | CR20210426A (es) |
IL (1) | IL285302A (es) |
MA (1) | MA54953A (es) |
MX (1) | MX2021009669A (es) |
PE (1) | PE20212023A1 (es) |
SG (1) | SG11202108552QA (es) |
TW (1) | TW202045164A (es) |
WO (1) | WO2020168011A1 (es) |
Families Citing this family (11)
Publication number | Priority date | Publication date | Assignee | Title |
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SG11202000532SA (en) | 2017-08-09 | 2020-02-27 | Denali Therapeutics Inc | Compounds, compositions and methods |
EP3723762A4 (en) | 2017-12-13 | 2021-12-08 | Praxis Biotech LLC | STRESS INTEGRATED RESPONSE PATH INHIBITORS |
CA3100715A1 (en) | 2018-06-05 | 2019-12-12 | Praxis Biotech LLC | Inhibitors of integrated stress response pathway |
PE20212023A1 (es) | 2019-02-13 | 2021-10-18 | Denali Therapeutics Inc | Compuestos, composiciones y metodos |
CN114466654A (zh) | 2019-06-12 | 2022-05-10 | 普拉西斯生物技术有限责任公司 | 整合应激反应通路调节剂 |
AU2021236284A1 (en) | 2020-03-11 | 2022-08-18 | Evotec International Gmbh | Modulators of the integrated stress response pathway |
JP2023546224A (ja) | 2020-10-22 | 2023-11-01 | エヴォテック・インターナショナル・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング | 統合ストレス応答経路のモジュレーター |
US20230391763A1 (en) | 2020-10-22 | 2023-12-07 | Evotec International Gmbh | Modulators of the integrated stress response pathway |
MX2023004623A (es) | 2020-10-22 | 2023-05-12 | Evotec Int Gmbh | Moduladores de la via integrada de respuesta al estres. |
CN116710427A (zh) * | 2020-12-18 | 2023-09-05 | 戴纳立制药公司 | 化合物的固体形式 |
WO2024032501A1 (zh) * | 2022-08-08 | 2024-02-15 | 深圳众格生物科技有限公司 | 一种化合物、包含其的药物组合物及其用途 |
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2020
- 2020-02-12 PE PE2021001317A patent/PE20212023A1/es unknown
- 2020-02-12 TW TW109104414A patent/TW202045164A/zh unknown
- 2020-02-12 JP JP2021547076A patent/JP2022520236A/ja active Pending
- 2020-02-12 KR KR1020217027796A patent/KR20210126036A/ko active Search and Examination
- 2020-02-12 AU AU2020223228A patent/AU2020223228A1/en active Pending
- 2020-02-12 CR CR20210426A patent/CR20210426A/es unknown
- 2020-02-12 SG SG11202108552QA patent/SG11202108552QA/en unknown
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- 2020-02-12 CN CN202080017506.7A patent/CN113518618A/zh active Pending
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MA54953A (fr) | 2021-12-22 |
JP2022520236A (ja) | 2022-03-29 |
KR20210126036A (ko) | 2021-10-19 |
CO2021010490A2 (es) | 2021-08-30 |
WO2020168011A1 (en) | 2020-08-20 |
CN113518618A (zh) | 2021-10-19 |
US11958840B2 (en) | 2024-04-16 |
SG11202108552QA (en) | 2021-09-29 |
EP3923935A1 (en) | 2021-12-22 |
US20210292311A1 (en) | 2021-09-23 |
IL285302A (en) | 2021-09-30 |
BR112021015639A2 (pt) | 2021-10-05 |
MX2021009669A (es) | 2021-10-13 |
PE20212023A1 (es) | 2021-10-18 |
AU2020223228A1 (en) | 2021-08-26 |
EP3923935A4 (en) | 2022-10-26 |
TW202045164A (zh) | 2020-12-16 |
US11306077B2 (en) | 2022-04-19 |
CR20210426A (es) | 2021-09-30 |
US20230114472A1 (en) | 2023-04-13 |
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