CL2017002729A1 - Proteína de unión a rgma y su uso - Google Patents
Proteína de unión a rgma y su usoInfo
- Publication number
- CL2017002729A1 CL2017002729A1 CL2017002729A CL2017002729A CL2017002729A1 CL 2017002729 A1 CL2017002729 A1 CL 2017002729A1 CL 2017002729 A CL2017002729 A CL 2017002729A CL 2017002729 A CL2017002729 A CL 2017002729A CL 2017002729 A1 CL2017002729 A1 CL 2017002729A1
- Authority
- CL
- Chile
- Prior art keywords
- rgma
- union
- seq
- prevent
- providing
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/06—Antiglaucoma agents or miotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/22—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against growth factors ; against growth regulators
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/46—Hybrid immunoglobulins
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/10—Cells modified by introduction of foreign genetic material
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biomedical Technology (AREA)
- Immunology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Ophthalmology & Optometry (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- General Engineering & Computer Science (AREA)
- Pulmonology (AREA)
- Dermatology (AREA)
- Psychiatry (AREA)
- Psychology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Diabetes (AREA)
- Hospice & Palliative Care (AREA)
- Hematology (AREA)
- Rheumatology (AREA)
Abstract
<p>LA PRESENTE INVENCIÓN TIENE POR OBJETO OBTENER UNA MOLÉCULA GUÍA ANTI-REPELENTE A (RGMA) QUE TENGA UNA ALTA ACTIVIDAD DE UNIÓN Y POCOS EFECTOS SECUNDARIOS QUE SE PUEDAN USAR COMO MEDICAMENTO PARA PREVENIR, TRATAR O PREVENIR LA RECAÍDA DE ENFERMEDADES NEUROLÓGICAS O INMUNOLÓGICAS. EL PROBLEMA SE RESUELVE PROPORCIONANDO UNA PROTEÍNA DE UNIÓN A RGMA AISLADA QUE NO INHIBE LA UNIÓN ENTRE RGMA Y NEOGENINA SINO QUE NEUTRALIZA LA ACTIVIDAD INHIBIDORA DE LA PROLIFERACIÓN DE NEURITAS DE RGMA, PREFERIBLEMENTE PROPORCIONANDO UN ANTICUERPO ANTI-RGMA QUE TIENE REGIONES DETERMINANTES DE COMPLEMENTARIEDAD QUE TIENEN SECUENCIAS DE AMINOÁCIDOS DE SEQ ID NOS: 30-35 O SEQ ID NO: 36-40 EN EL LISTADO DE SECUENCIAS, Y SFG.</p>
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2015091095 | 2015-04-28 |
Publications (1)
Publication Number | Publication Date |
---|---|
CL2017002729A1 true CL2017002729A1 (es) | 2018-06-08 |
Family
ID=57198582
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CL2017002729A CL2017002729A1 (es) | 2015-04-28 | 2017-10-26 | Proteína de unión a rgma y su uso |
Country Status (34)
Country | Link |
---|---|
US (3) | US10287346B2 (es) |
EP (2) | EP3584260A1 (es) |
JP (6) | JP6497760B2 (es) |
KR (4) | KR20230173734A (es) |
CN (2) | CN113801225A (es) |
AU (2) | AU2016253886B2 (es) |
BR (1) | BR112017022994A2 (es) |
CA (1) | CA2983898A1 (es) |
CL (1) | CL2017002729A1 (es) |
CO (1) | CO2017011975A2 (es) |
CR (2) | CR20200517A (es) |
CY (1) | CY1122569T1 (es) |
DK (1) | DK3290441T3 (es) |
DO (1) | DOP2017000248A (es) |
ES (1) | ES2758480T3 (es) |
GT (1) | GT201700224A (es) |
HK (1) | HK1245808A1 (es) |
HR (1) | HRP20192099T1 (es) |
HU (1) | HUE047146T2 (es) |
IL (2) | IL287291B (es) |
LT (1) | LT3290441T (es) |
MX (2) | MX2017013894A (es) |
PE (2) | PE20180251A1 (es) |
PH (1) | PH12017501941A1 (es) |
PL (1) | PL3290441T3 (es) |
PT (1) | PT3290441T (es) |
RS (1) | RS59847B1 (es) |
RU (1) | RU2705304C2 (es) |
SA (1) | SA517390230B1 (es) |
SG (1) | SG11201708848TA (es) |
SI (1) | SI3290441T1 (es) |
TW (3) | TW202138389A (es) |
WO (1) | WO2016175236A1 (es) |
ZA (2) | ZA201708047B (es) |
Families Citing this family (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU2016253886B2 (en) * | 2015-04-28 | 2019-05-16 | Mitsubishi Tanabe Pharma Corporation | RGMa binding protein and use thereof |
US11035534B2 (en) | 2017-05-25 | 2021-06-15 | Signify Holding B.V. | Luminaire |
MX2021000324A (es) | 2018-07-10 | 2021-03-25 | Mitsubishi Tanabe Pharma Corp | Metodo de prevencion o tratamiento para neuropatia periferica o enfermedad acompa?ada por dolor en la que se reconoce la neuropatia periferica o trastorno de astrocitos. |
US20210269535A1 (en) * | 2018-07-19 | 2021-09-02 | The University Of Tokyo | Therapeutic or prophylactic agent for htlv-1-associated myelopathy (ham), and method for treating ham |
AR120898A1 (es) * | 2019-12-26 | 2022-03-30 | Univ Osaka | Agente para tratar o prevenir neuromielitis óptica en fase aguda |
CN114945385A (zh) * | 2020-01-15 | 2022-08-26 | 国立大学法人大阪大学 | 痴呆症的预防或治疗剂 |
US20230055626A1 (en) * | 2020-01-15 | 2023-02-23 | Osaka University | Agent for prevention or treatment of diabetic autonomic neuropathy |
CN112138146B (zh) * | 2020-09-25 | 2022-08-09 | 安徽医科大学 | Manf蛋白的应用 |
AR124914A1 (es) | 2021-02-18 | 2023-05-17 | Mitsubishi Tanabe Pharma Corp | Nuevo anticuerpo anti-pad4 |
WO2024101345A1 (ja) * | 2022-11-07 | 2024-05-16 | 国立大学法人大阪大学 | 異常タンパク質の凝集体蓄積が関与する疾患の予防又は治療剤 |
Family Cites Families (53)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4737456A (en) | 1985-05-09 | 1988-04-12 | Syntex (U.S.A.) Inc. | Reducing interference in ligand-receptor binding assays |
GB8607679D0 (en) | 1986-03-27 | 1986-04-30 | Winter G P | Recombinant dna product |
GB8928874D0 (en) | 1989-12-21 | 1990-02-28 | Celltech Ltd | Humanised antibodies |
SG48759A1 (en) | 1990-01-12 | 2002-07-23 | Abgenix Inc | Generation of xenogenic antibodies |
DE69133476T2 (de) | 1990-08-29 | 2006-01-05 | GenPharm International, Inc., Palo Alto | Transgene Mäuse fähig zur Produktion heterologer Antikörper |
NZ255101A (en) | 1992-07-24 | 1997-08-22 | Cell Genesys Inc | A yeast artificial chromosome (yac) vector containing an hprt minigene expressible in murine stem cells and genetically modified rodent therefor |
EP0754225A4 (en) | 1993-04-26 | 2001-01-31 | Genpharm Int | HETEROLOGIC ANTIBODY-PRODUCING TRANSGENIC NON-HUMAN ANIMALS |
US5565331A (en) | 1993-11-12 | 1996-10-15 | The Regents Of The University Of California | Nucleic acids encoding neural axon outgrowth modulators |
US5747262A (en) | 1995-10-16 | 1998-05-05 | The Regents Of The University Of California | Neurological drug screens |
US5824775A (en) | 1996-04-19 | 1998-10-20 | The Regents Of The University Of California | Human netrin-1 |
US5939271A (en) | 1997-02-19 | 1999-08-17 | The Regents Of The University Of California | Netrin receptor |
WO1999008533A1 (en) | 1997-08-13 | 1999-02-25 | Yale University | Central nervous system axon regeneration |
US6528624B1 (en) | 1998-04-02 | 2003-03-04 | Genentech, Inc. | Polypeptide variants |
WO2000032746A2 (en) | 1998-11-30 | 2000-06-08 | Millennium Pharmaceuticals, Inc. | Netrin-like and ependymin-like nucleic acids and polypeptides and uses thereof |
US6737056B1 (en) | 1999-01-15 | 2004-05-18 | Genentech, Inc. | Polypeptide variants with altered effector function |
DK2270149T3 (en) | 1999-04-09 | 2016-05-09 | Kyowa Hakko Kirin Co Ltd | PROCEDURE TO CONTROL THE ACTIVITY OF IMMUNOLOGICAL FUNCTIONAL MOLECULE. |
US7166573B1 (en) | 1999-05-28 | 2007-01-23 | Ludwig Institute For Cancer Research | Breast, gastric and prostate cancer associated antigens and uses therefor |
CN102311986B (zh) | 2000-10-06 | 2015-08-19 | 协和发酵麒麟株式会社 | 产生抗体组合物的细胞 |
EP1355666B1 (en) | 2000-12-22 | 2012-06-13 | Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. | Use of repulsive guidance molecule (RGM) and its modulators |
US20030103945A1 (en) | 2001-02-09 | 2003-06-05 | Chen Dong Feng | Methods and compositions for stimulating axon regeneration and preventing neuronal cell degeneration |
US7317091B2 (en) | 2002-03-01 | 2008-01-08 | Xencor, Inc. | Optimized Fc variants |
WO2003089608A2 (en) | 2002-04-18 | 2003-10-30 | The General Hospital Corporation | Drg11-responsive (dragon) gene family |
WO2004003150A2 (en) * | 2002-06-26 | 2004-01-08 | Yale University | Modulators and modulation of the interacton between rgm and neogenin |
US20040199186A1 (en) | 2003-04-04 | 2004-10-07 | Kuffler Suzanne Elizabeth | Implant to promote axon regeneration across spinal cord and peripheral nerve gaps |
JPWO2005035586A1 (ja) | 2003-10-08 | 2007-11-22 | 協和醗酵工業株式会社 | 融合蛋白質組成物 |
AU2005221471A1 (en) | 2004-03-11 | 2005-09-22 | Bioclues, Inc | Axon regeneration promoter |
CN1950108A (zh) * | 2004-03-11 | 2007-04-18 | 生物线索株式会社 | 轴突再生促进剂 |
WO2006019904A1 (en) | 2004-07-14 | 2006-02-23 | University Of Utha Research Foundation | Netrin-related compositions and uses |
US20060063208A1 (en) * | 2004-08-02 | 2006-03-23 | Woolf Clifford J | DRG11-responsive (DRAGON) gene and uses thereof |
US7449442B2 (en) | 2005-07-12 | 2008-11-11 | Children's Medical Center Corporation | EGFR inhibitors promote axon regeneration |
EP1928905B1 (de) * | 2005-09-30 | 2015-04-15 | AbbVie Deutschland GmbH & Co KG | Bindungsdomänen von proteinen der repulsive guidance molecule (rgm) proteinfamilie und funktionale fragmente davon sowie deren verwendung |
US20080051319A1 (en) | 2006-08-22 | 2008-02-28 | Children's Medical Center Corporation | Inhibiting JNK Signaling Promotes CNS Axon Regeneration |
JPWO2008038599A1 (ja) * | 2006-09-25 | 2010-01-28 | 国立大学法人 千葉大学 | 軸索再生促進剤 |
EP1906185A1 (en) | 2006-09-26 | 2008-04-02 | ProteoSys AG | Use of at least one isoform of progesterone receptor membrane component 1 (PGRMC1) |
EP2033971A1 (de) * | 2007-09-06 | 2009-03-11 | Abbott GmbH & Co. KG | Bone Morphogenetic Protein (BMP)-bindende Domänen von Proteinen der Repulsive Guidance Molecule (RGM) Proteinfamilie und funktionale Fragmente davon sowie deren Verwendung |
US8962803B2 (en) | 2008-02-29 | 2015-02-24 | AbbVie Deutschland GmbH & Co. KG | Antibodies against the RGM A protein and uses thereof |
DE102008014880A1 (de) | 2008-03-12 | 2009-09-17 | Eberhard-Karls-Universität Tübingen | Antientzündliches Polypeptid |
US8470977B2 (en) * | 2008-03-14 | 2013-06-25 | Transgene S.A. | Antibody against the CSF-1R |
CN101306193A (zh) | 2008-05-15 | 2008-11-19 | 复旦大学 | 人神经突起生长素在制备创伤愈合药物中的应用 |
CA2724199C (en) | 2008-06-06 | 2016-07-26 | Children's Medical Center Corporation | Promoting axon regeneration in the adult cns through control of protein translation |
JP2010146801A (ja) | 2008-12-17 | 2010-07-01 | Kurita Water Ind Ltd | 微生物発電方法及び微生物発電装置 |
DK2510001T3 (en) * | 2009-12-08 | 2016-02-29 | Abbvie Deutschland | MONOCLONAL ANTIBODIES AGAINST RGM A PROTEIN USED TO TREAT DEGENERATION OF THE RETINAL NERVE FIBER LAYER |
EP2510948B1 (en) * | 2009-12-09 | 2015-09-09 | Mitsubishi Tanabe Pharma Corporation | T cell activation inhibitor, pharmaceutical composition containing same, and screening method for t cell activation inhibiting substance |
JP6342812B2 (ja) * | 2011-12-14 | 2018-06-13 | アッヴィ・ドイチュラント・ゲー・エム・ベー・ハー・ウント・コー・カー・ゲー | 鉄関連障害を診断および治療するための組成物および方法 |
UA118083C2 (uk) * | 2012-01-27 | 2018-11-26 | Еббві Дойчланд Гмбх Унд Ко. Кг | ВИДІЛЕНЕ МОНОКЛОНАЛЬНЕ АНТИТІЛО ПРОТИ МОЛЕКУЛИ ВІДШТОВХУВАЛЬНОГО НАПРЯМНОГО СИГНАЛУ (RGMa) ТА ЙОГО ЗАСТОСУВАННЯ В ЛІКУВАННІ РОЗЛАДУ, АСОЦІЙОВАНОГО З ДЕГЕНЕРАЦІЄЮ НЕЙРИТІВ |
WO2013113107A1 (en) | 2012-02-03 | 2013-08-08 | University Health Network | Methods for promoting neuron survival, axonal growth and/or regeneration |
GB201203180D0 (en) * | 2012-02-24 | 2012-04-11 | Okapi Sciences Nv | Compounds for treating parvovirus infection |
US20140242043A1 (en) | 2013-02-23 | 2014-08-28 | Stemnion, Inc. | Methods for preventing or treating optic neuritis |
PE20160690A1 (es) * | 2013-03-18 | 2016-08-14 | Biocerox Prod Bv | Anticuerpos anti-cd134 (ox40) humanizados y usos de los mismos |
JP2016533318A (ja) | 2013-09-17 | 2016-10-27 | ユニバーシティ ヘルス ネットワーク (ユーエイチエヌ): テクノロジー ディベロップメント アンド コマーシャリゼーション | Rgma/ネオジェニンのシス相互作用又は脂質ラフトを標的とする剤及び治療方法における該剤の使用 |
WO2015120138A2 (en) | 2014-02-05 | 2015-08-13 | Dana-Farber Cancer Institute, Inc. | AGENTS THAT MODULATE RGMb-NEOGENIN-BMP SIGNALING AND METHODS OF USE THEREOF |
AU2016253886B2 (en) * | 2015-04-28 | 2019-05-16 | Mitsubishi Tanabe Pharma Corporation | RGMa binding protein and use thereof |
CN105925578A (zh) | 2016-05-30 | 2016-09-07 | 东北师范大学 | 靶向沉默Neogenin的shRNA |
-
2016
- 2016-04-27 AU AU2016253886A patent/AU2016253886B2/en active Active
- 2016-04-27 PE PE2017002320A patent/PE20180251A1/es unknown
- 2016-04-27 CR CR20200517A patent/CR20200517A/es unknown
- 2016-04-27 SI SI201630515T patent/SI3290441T1/sl unknown
- 2016-04-27 RS RS20191502A patent/RS59847B1/sr unknown
- 2016-04-27 KR KR1020237042670A patent/KR20230173734A/ko active Search and Examination
- 2016-04-27 LT LTEP16786512.0T patent/LT3290441T/lt unknown
- 2016-04-27 ES ES16786512T patent/ES2758480T3/es active Active
- 2016-04-27 CN CN202110957449.7A patent/CN113801225A/zh active Pending
- 2016-04-27 CA CA2983898A patent/CA2983898A1/en active Pending
- 2016-04-27 HU HUE16786512A patent/HUE047146T2/hu unknown
- 2016-04-27 SG SG11201708848TA patent/SG11201708848TA/en unknown
- 2016-04-27 PT PT167865120T patent/PT3290441T/pt unknown
- 2016-04-27 EP EP19179190.4A patent/EP3584260A1/en active Pending
- 2016-04-27 KR KR1020197032016A patent/KR102451786B1/ko active IP Right Grant
- 2016-04-27 EP EP16786512.0A patent/EP3290441B1/en active Active
- 2016-04-27 RU RU2017135353A patent/RU2705304C2/ru active
- 2016-04-27 CN CN201680023980.4A patent/CN107531791B/zh active Active
- 2016-04-27 CR CR20170539A patent/CR20170539A/es unknown
- 2016-04-27 MX MX2017013894A patent/MX2017013894A/es unknown
- 2016-04-27 KR KR1020177034449A patent/KR102040235B1/ko active IP Right Grant
- 2016-04-27 BR BR112017022994-3A patent/BR112017022994A2/pt active Search and Examination
- 2016-04-27 PE PE2022001997A patent/PE20230381A1/es unknown
- 2016-04-27 DK DK16786512.0T patent/DK3290441T3/da active
- 2016-04-27 KR KR1020227034319A patent/KR102613528B1/ko active IP Right Grant
- 2016-04-27 PL PL16786512T patent/PL3290441T3/pl unknown
- 2016-04-27 WO PCT/JP2016/063166 patent/WO2016175236A1/ja active Application Filing
- 2016-04-27 US US15/569,382 patent/US10287346B2/en active Active
- 2016-04-27 JP JP2017515573A patent/JP6497760B2/ja active Active
- 2016-04-27 IL IL287291A patent/IL287291B/en unknown
- 2016-04-28 TW TW110120801A patent/TW202138389A/zh unknown
- 2016-04-28 TW TW105113270A patent/TWI732757B/zh active
- 2016-04-28 TW TW112111250A patent/TW202328205A/zh unknown
-
2017
- 2017-10-25 GT GT201700224A patent/GT201700224A/es unknown
- 2017-10-25 DO DO2017000248A patent/DOP2017000248A/es unknown
- 2017-10-25 PH PH12017501941A patent/PH12017501941A1/en unknown
- 2017-10-25 SA SA517390230A patent/SA517390230B1/ar unknown
- 2017-10-26 CL CL2017002729A patent/CL2017002729A1/es unknown
- 2017-10-26 IL IL255293A patent/IL255293B/en unknown
- 2017-10-27 MX MX2022005565A patent/MX2022005565A/es unknown
- 2017-11-24 CO CONC2017/0011975A patent/CO2017011975A2/es unknown
- 2017-11-27 ZA ZA2017/08047A patent/ZA201708047B/en unknown
-
2018
- 2018-04-19 HK HK18105139.1A patent/HK1245808A1/zh unknown
-
2019
- 2019-03-07 JP JP2019041550A patent/JP6955721B2/ja active Active
- 2019-03-19 US US16/358,657 patent/US11008388B2/en active Active
- 2019-08-02 AU AU2019210655A patent/AU2019210655A1/en not_active Abandoned
- 2019-11-15 CY CY20191101205T patent/CY1122569T1/el unknown
- 2019-11-22 HR HRP20192099TT patent/HRP20192099T1/hr unknown
- 2019-11-25 ZA ZA2019/07773A patent/ZA201907773B/en unknown
-
2021
- 2021-03-22 JP JP2021047826A patent/JP2021106587A/ja active Pending
- 2021-05-17 US US17/322,482 patent/US20210277098A1/en active Pending
-
2022
- 2022-12-16 JP JP2022201082A patent/JP7306660B2/ja active Active
- 2022-12-16 JP JP2022201081A patent/JP7307446B2/ja active Active
-
2023
- 2023-06-22 JP JP2023102631A patent/JP2023120374A/ja active Pending
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CL2017002729A1 (es) | Proteína de unión a rgma y su uso | |
BR112017003582A2 (pt) | anticorpos, composições e usos | |
CO2017000507A2 (es) | Receptor quimérico de antígeno bcma | |
CR20200290A (es) | PÉPTIDOS Y COMPOSICIONES PARA EL TRATAMIENTO DE DAÑO ARTICULAR (Divisional 2015-0466) | |
PE20170140A1 (es) | Metodos para tratar el cancer con inhibidores de tigit y agentes contra el cancer | |
BR112018007017A2 (pt) | polipeptídeos | |
EA201500802A1 (ru) | Способы профилактики и/или лечения кардиомиопатии и устранения симптомов кардиомиопатии, фармацевтическая композиция, векторы | |
AR090973A1 (es) | Anticuerpos utiles para el diagnostico del cancer | |
UY35462A (es) | Formulación de un polipéptido del factor viii. | |
BR112017008157A2 (pt) | polipeptídeos de fgf-21 modificados e usos dos mesmos | |
MY194175A (en) | Variant rnai | |
ES2693321T3 (es) | Péptidos antiinflamatorios y composición que comprende los mismos | |
PE20171142A1 (es) | Vectores para expresion de antigenos asociados a prostata | |
ES2691070T3 (es) | Péptidos antiinflamatorios y composición que comprende los mismos | |
ES2722773T3 (es) | Polipéptidos de fHbp meningocócicos modificados | |
ES2627330T3 (es) | Uso de JAZ5a para mejorar la resistencia a la sequía en una planta | |
MX2015011860A (es) | Materiales y metodos para mejorar la funcion pulmonar y para la prevencion y/o tratamiento de complicaciones pulmonares inducidas por radiacion. | |
MX2017000083A (es) | Compuestos de platino, composiciones y usos de estos. | |
ES2694667T3 (es) | Método para producir oxalato oxidasas que tienen actividad óptica cerca de pH fisiológico y uso de tales oxalato oxidasas recombinantes en el tratamiento de enfermedades relacionadas con oxalato | |
BR112014027239A2 (pt) | peptídeo, método de identificação de peptídeos, método para o tratamento de câncer, nucleotídeo, vetor, uso de um peptídeo e invenção | |
AR120721A2 (es) | Péptidos y composiciones para el tratamiento de daño articular | |
MX2017006748A (es) | Composiciones de aminoácidos para el tratamiento de síntomas de enfermedades. | |
BR112016015678B1 (pt) | Polipeptídeo compreendendo um fragmento de ospa de c-terminal híbrido, seu processo de produção, seu uso, ácido nucleico, vetor, célula hospedeira, composição farmacêutica | |
BR112017006969A2 (pt) | peptídeo derivado de hsp70, composição farmacêutica para o tratamento ou a prevenção de câncer usando o mesmo, indutor de imunidade e método de produção de célula apresentadora de antígeno | |
MX2016000448A (es) | Péptidos y análogos peptídicos protectores de tejido para prevenir y tratar enfermedades y trastornos asociados con daño del tejido. |