CL2015000544A1 - Una composicion farmaceutica que comprende regorafenib y al menos un excipiente farmaceuticamente aceptable, en el que la composicion esta recubierta por un recubrimiento que comprende un polimero basado en alcohol polivinilico; y su procedimiento de preparacion. - Google Patents

Una composicion farmaceutica que comprende regorafenib y al menos un excipiente farmaceuticamente aceptable, en el que la composicion esta recubierta por un recubrimiento que comprende un polimero basado en alcohol polivinilico; y su procedimiento de preparacion.

Info

Publication number
CL2015000544A1
CL2015000544A1 CL2015000544A CL2015000544A CL2015000544A1 CL 2015000544 A1 CL2015000544 A1 CL 2015000544A1 CL 2015000544 A CL2015000544 A CL 2015000544A CL 2015000544 A CL2015000544 A CL 2015000544A CL 2015000544 A1 CL2015000544 A1 CL 2015000544A1
Authority
CL
Chile
Prior art keywords
composition
regorafenib
coated
coating
pharmaceutically acceptable
Prior art date
Application number
CL2015000544A
Other languages
English (en)
Spanish (es)
Inventor
Dr Susanne Skrabs
Dr Adrian Funke
Dr Mayk Kresse
Dr Ulrich Oberdieck
Original Assignee
Bayer Healthcare Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=46963450&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CL2015000544(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Bayer Healthcare Llc filed Critical Bayer Healthcare Llc
Publication of CL2015000544A1 publication Critical patent/CL2015000544A1/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/2027—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A61K9/2806—Coating materials
    • A61K9/2833—Organic macromolecular compounds
    • A61K9/286—Polysaccharides, e.g. gums; Cyclodextrin
    • A61K9/2866—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A61K9/2893—Tablet coating processes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
CL2015000544A 2012-09-06 2015-03-05 Una composicion farmaceutica que comprende regorafenib y al menos un excipiente farmaceuticamente aceptable, en el que la composicion esta recubierta por un recubrimiento que comprende un polimero basado en alcohol polivinilico; y su procedimiento de preparacion. CL2015000544A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP12183331 2012-09-06

Publications (1)

Publication Number Publication Date
CL2015000544A1 true CL2015000544A1 (es) 2015-08-21

Family

ID=46963450

Family Applications (1)

Application Number Title Priority Date Filing Date
CL2015000544A CL2015000544A1 (es) 2012-09-06 2015-03-05 Una composicion farmaceutica que comprende regorafenib y al menos un excipiente farmaceuticamente aceptable, en el que la composicion esta recubierta por un recubrimiento que comprende un polimero basado en alcohol polivinilico; y su procedimiento de preparacion.

Country Status (43)

Country Link
US (1) US20140065212A1 (enExample)
EP (2) EP2892507B1 (enExample)
JP (1) JP6445436B2 (enExample)
KR (1) KR102162036B1 (enExample)
CN (5) CN116392598A (enExample)
AP (1) AP2015008292A0 (enExample)
AR (1) AR092439A1 (enExample)
AU (1) AU2013312531B2 (enExample)
BR (1) BR112015004936B1 (enExample)
CA (1) CA2883767C (enExample)
CL (1) CL2015000544A1 (enExample)
CO (1) CO7310528A2 (enExample)
CR (1) CR20150114A (enExample)
CU (1) CU24244B1 (enExample)
CY (1) CY1118839T1 (enExample)
DK (1) DK2892507T3 (enExample)
EA (1) EA027685B1 (enExample)
ES (1) ES2623205T3 (enExample)
GT (1) GT201500053A (enExample)
HK (1) HK1214170A1 (enExample)
HR (1) HRP20170620T1 (enExample)
HU (1) HUE032758T2 (enExample)
IL (1) IL237350B (enExample)
IN (1) IN2015DN01673A (enExample)
JO (1) JO3479B1 (enExample)
LT (1) LT2892507T (enExample)
MA (1) MA37888B1 (enExample)
MX (1) MX359922B (enExample)
MY (1) MY176135A (enExample)
NZ (1) NZ705578A (enExample)
PE (1) PE20151005A1 (enExample)
PH (1) PH12015500460A1 (enExample)
PL (1) PL2892507T3 (enExample)
PT (1) PT2892507T (enExample)
RS (1) RS56019B1 (enExample)
SA (1) SA515360113B1 (enExample)
SG (1) SG11201501683WA (enExample)
SI (1) SI2892507T1 (enExample)
TW (1) TWI640329B (enExample)
UA (1) UA115994C2 (enExample)
UY (1) UY35006A (enExample)
WO (1) WO2014039677A1 (enExample)
ZA (1) ZA201501394B (enExample)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR081060A1 (es) 2010-04-15 2012-06-06 Bayer Schering Pharma Ag Procedimiento para preparar 4-{4-[({[4-cloro-3-(trifluorometil)fenil]amino}carbonil)amino]-3-fluorofenoxi}-n-metilpiridin-2-carboxamida
DK3043778T3 (da) * 2013-09-13 2017-11-27 Bayer Pharma AG Farmaceutiske sammensætninger, der indeholder refametinib
CN104586808B (zh) * 2014-12-27 2017-08-18 北京元延医药科技股份有限公司 抗肿瘤药物组合物
CN105136956A (zh) * 2015-09-11 2015-12-09 江苏嘉逸医药有限公司 一种快速测定瑞戈非尼含量的方法
CN105267167A (zh) * 2015-09-11 2016-01-27 江苏嘉逸医药有限公司 一种瑞戈非尼口服固体药物组合物的制备方法
CN106880615A (zh) * 2015-12-15 2017-06-23 北大方正集团有限公司 一种瑞戈非尼的口服固体制剂及其制备方法
CN106880607A (zh) * 2015-12-15 2017-06-23 北大方正集团有限公司 一种含有瑞戈非尼的口腔崩解片及其制备方法
CN105496975B (zh) * 2015-12-17 2019-01-04 河南润弘制药股份有限公司 一种瑞戈非尼片剂及其制备方法
CN106913527A (zh) * 2015-12-28 2017-07-04 江苏先声药业有限公司 一种瑞戈非尼速释微丸及其制备方法
CN105879049B (zh) * 2016-05-13 2019-03-26 浙江大学 一种瑞戈非尼与β-环糊精的包合物及其制备方法
CN107661296A (zh) * 2016-07-27 2018-02-06 江苏先声药业有限公司 一种瑞戈非尼固体分散体及其制备方法
KR102843438B1 (ko) 2017-06-02 2025-08-06 바이엘 헬쓰케어 엘엘씨 암을 치료하기 위한 레고라페닙 및 pd-1/pd-l1(2) 억제제의 조합
CA3103498A1 (en) * 2018-07-06 2020-01-09 Agios Pharmaceuticals, Inc. Ivosidenib forms and pharmaceutical compositions
CN111053751A (zh) * 2018-10-16 2020-04-24 正大天晴药业集团股份有限公司 瑞戈非尼的缓释片剂及其制备方法
TWI799599B (zh) * 2019-06-06 2023-04-21 華納國際生物科技股份有限公司 醫藥或保健品自乳化固體分散組成物
EP3861989A1 (en) 2020-02-07 2021-08-11 Bayer Aktiengesellschaft Pharmaceutical composition containing regorafenib and a stabilizing agent
CN112587485A (zh) * 2021-01-08 2021-04-02 湖南南新制药股份有限公司 一种药物固体分散体及其制备方法
CN113018274A (zh) * 2021-03-10 2021-06-25 药源生物科技（启东）有限公司 一种含羟丙甲纤维素的药物组合物及其制备方法
WO2024191389A1 (en) * 2023-03-10 2024-09-19 Abdi Ibrahim Ilac Sanayi Ve Ticaret Anonim Sirketi A pharmaceutical composition of regorafenib
WO2025242583A1 (en) 2024-05-24 2025-11-27 Bayer Consumer Care Ag Novel formulation comprising elinzanetant in a solid dispersion

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20100137023A (ko) * 2002-09-20 2010-12-29 안드렉스 랩스 엘엘씨 약제학적 정제
CN1265793C (zh) * 2002-11-18 2006-07-26 杭州容立医药科技有限公司 左西替利嗪伪麻黄碱复方口服制剂及制备方法
HRP20060073B1 (hr) 2003-07-23 2014-03-14 Bayer Healthcare Llc Fluoro supstituirana omega-karboksiaril difenil urea za lijeäśenje i prevenciju bolesti i stanja
MY191349A (en) * 2004-08-27 2022-06-17 Bayer Pharmaceuticals Corp New pharmaceutical compositions for the treatment of hyper-proliferative disorders
JP2009519266A (ja) * 2005-12-15 2009-05-14 バイエル・ヘルスケア・アクチェンゲゼルシャフト 炎症性の皮膚、眼および／または耳疾患を処置するためのジアリールウレア類
AR062927A1 (es) 2006-10-11 2008-12-17 Bayer Healthcare Ag 4- [4-( [ [ 4- cloro-3-( trifluorometil) fenil) carbamoil] amino] -3- fluorofenoxi) -n- metilpiridin-2- carboxamida monohidratada
WO2008044111A1 (en) * 2006-10-13 2008-04-17 Pfizer Products Inc. Pharmaceutical formulation tablet
CN101568339A (zh) * 2006-12-07 2009-10-28 伊莱利利公司 普拉格雷的制品
CA2703365A1 (en) * 2007-10-25 2009-04-30 Yuka Yamanouchi Nifedipine-containing press coated tablet and method of preparing the same
AR081060A1 (es) * 2010-04-15 2012-06-06 Bayer Schering Pharma Ag Procedimiento para preparar 4-{4-[({[4-cloro-3-(trifluorometil)fenil]amino}carbonil)amino]-3-fluorofenoxi}-n-metilpiridin-2-carboxamida
EP2709592B1 (en) * 2011-05-20 2017-08-16 AstraZeneca UK Limited Pharmaceutical composition of rosuvastatin calcium

Also Published As

Publication number Publication date
CA2883767A1 (en) 2014-03-13
PE20151005A1 (es) 2015-06-27
HK1214170A1 (zh) 2016-07-22
GT201500053A (es) 2015-10-12
KR102162036B1 (ko) 2020-10-07
CN111249247A (zh) 2020-06-09
IN2015DN01673A (enExample) 2015-07-03
LT2892507T (lt) 2017-06-12
SG11201501683WA (en) 2015-04-29
HUE032758T2 (en) 2017-10-30
UY35006A (es) 2014-03-31
MA37888A1 (fr) 2018-07-31
BR112015004936A2 (pt) 2017-07-04
UA115994C2 (uk) 2018-01-25
TW201414510A (zh) 2014-04-16
TWI640329B (zh) 2018-11-11
PT2892507T (pt) 2017-05-02
SI2892507T1 (sl) 2017-08-31
CR20150114A (es) 2015-05-11
CU24244B1 (es) 2017-02-02
ES2623205T3 (es) 2017-07-10
SA515360113B1 (ar) 2016-08-10
MX359922B (es) 2018-10-16
RS56019B1 (sr) 2017-09-29
EA201590520A1 (ru) 2015-10-30
NZ705578A (en) 2017-10-27
MX2015002815A (es) 2015-05-15
AP2015008292A0 (en) 2015-02-28
IL237350A0 (en) 2015-04-30
CU20150020A7 (es) 2015-05-28
AU2013312531A1 (en) 2015-03-12
EA027685B1 (ru) 2017-08-31
WO2014039677A1 (en) 2014-03-13
EP3243508A1 (en) 2017-11-15
CN116392598A (zh) 2023-07-07
AU2013312531B2 (en) 2017-10-19
JP6445436B2 (ja) 2018-12-26
EP2892507A1 (en) 2015-07-15
EP2892507B1 (en) 2017-02-01
CN116392484A (zh) 2023-07-07
KR20150048872A (ko) 2015-05-07
AR092439A1 (es) 2015-04-22
MA37888B1 (fr) 2019-08-30
DK2892507T3 (en) 2017-05-01
CA2883767C (en) 2018-11-13
CO7310528A2 (es) 2015-06-30
BR112015004936B1 (pt) 2022-12-06
PH12015500460B1 (en) 2015-04-20
HRP20170620T1 (hr) 2017-06-30
US20140065212A1 (en) 2014-03-06
JO3479B1 (ar) 2020-07-05
CY1118839T1 (el) 2018-01-10
JP2015527395A (ja) 2015-09-17
CN104902878A (zh) 2015-09-09
PH12015500460A1 (en) 2015-04-20
CN116392485A (zh) 2023-07-07
ZA201501394B (en) 2016-07-27
PL2892507T3 (pl) 2017-09-29
MY176135A (en) 2020-07-24
IL237350B (en) 2020-11-30

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