CL2012001396A1 - Compuestos derivados de pirrolopirazina o pirrolopiridina, condensadas cada una con un anillo de triazol, imidazol, pirazol, oxazol, pirrol o imidazolona y sus sales, utiles como inhibidores de syk para tratar condiciones inmunologicas, inflamatorias y oncologicas. - Google Patents

Compuestos derivados de pirrolopirazina o pirrolopiridina, condensadas cada una con un anillo de triazol, imidazol, pirazol, oxazol, pirrol o imidazolona y sus sales, utiles como inhibidores de syk para tratar condiciones inmunologicas, inflamatorias y oncologicas.

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Publication number
CL2012001396A1
CL2012001396A1 CL2012001396A CL2012001396A CL2012001396A1 CL 2012001396 A1 CL2012001396 A1 CL 2012001396A1 CL 2012001396 A CL2012001396 A CL 2012001396A CL 2012001396 A CL2012001396 A CL 2012001396A CL 2012001396 A1 CL2012001396 A1 CL 2012001396A1
Authority
CL
Chile
Prior art keywords
salts
useful
pyrrolopyrazine
pyrrolopyridine
syk
Prior art date
Application number
CL2012001396A
Other languages
English (en)
Inventor
Neil Wishart
Maria A Argiriadi
Eric C Breinlinger
David J Ericsson Anna M Calderwood
Bryan A Fiamengo
Kristi Frank
Michael Z Hoemann
Original Assignee
Abbvie Inc
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Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=44115273&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CL2012001396(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Abbvie Inc filed Critical Abbvie Inc
Publication of CL2012001396A1 publication Critical patent/CL2012001396A1/es

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/06—Phosphorus compounds without P—C bonds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/14—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
    • C07D487/14—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D498/14—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains three hetero rings
    • C07D513/14—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Pulmonology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Rheumatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Compuestos derivados tricíclicos condensados y sus sales, útiles para tratar condiciones inmunológicas y oncológicas.
CL2012001396A 2009-12-01 2012-05-30 Compuestos derivados de pirrolopirazina o pirrolopiridina, condensadas cada una con un anillo de triazol, imidazol, pirazol, oxazol, pirrol o imidazolona y sus sales, utiles como inhibidores de syk para tratar condiciones inmunologicas, inflamatorias y oncologicas. CL2012001396A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US26559109P 2009-12-01 2009-12-01

Publications (1)

Publication Number Publication Date
CL2012001396A1 true CL2012001396A1 (es) 2012-09-14

Family

ID=44115273

Family Applications (1)

Application Number Title Priority Date Filing Date
CL2012001396A CL2012001396A1 (es) 2009-12-01 2012-05-30 Compuestos derivados de pirrolopirazina o pirrolopiridina, condensadas cada una con un anillo de triazol, imidazol, pirazol, oxazol, pirrol o imidazolona y sus sales, utiles como inhibidores de syk para tratar condiciones inmunologicas, inflamatorias y oncologicas.

Country Status (20)

Country Link
US (2) US8785639B2 (es)
EP (1) EP2506713A4 (es)
JP (1) JP2013512282A (es)
KR (1) KR20120102724A (es)
CN (1) CN102711470A (es)
AU (1) AU2010326030A1 (es)
CA (1) CA2781010A1 (es)
CL (1) CL2012001396A1 (es)
CR (1) CR20120294A (es)
DO (1) DOP2012000149A (es)
EC (1) ECSP12011968A (es)
GT (1) GT201200167A (es)
IL (1) IL220053A0 (es)
MX (1) MX2012006381A (es)
NZ (1) NZ599938A (es)
PE (1) PE20130005A1 (es)
RU (1) RU2012127368A (es)
SG (1) SG181147A1 (es)
WO (1) WO2011068899A1 (es)
ZA (1) ZA201203588B (es)

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US10981911B2 (en) 2016-12-16 2021-04-20 Janssen Pharmaceutica Nv Imidazopyrrolopyridine as inhibitors of the JAK family of kinases
US11059823B2 (en) 2016-12-16 2021-07-13 Janssen Pharmaceutica Nv Small molecule inhibitors of the JAK family of kinases
US11066406B2 (en) 2018-06-15 2021-07-20 Janssen Pharmaceutica Nv Small molecule inhibitors of the JAK family of kinases

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WO2012088266A2 (en) 2010-12-22 2012-06-28 Incyte Corporation Substituted imidazopyridazines and benzimidazoles as inhibitors of fgfr3
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US9216999B2 (en) 2011-08-12 2015-12-22 Nissan Chemical Industries, Ltd. Substituted pyrrolo[2,3-h][1,6]naphthyridines and compositions thereof as JAK inhibitors
CN102603743B (zh) * 2012-02-24 2014-05-28 南京天易生物科技有限公司 抗肿瘤的氮杂苯并[f]薁衍生物其制备方法及其用途
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US11059823B2 (en) 2016-12-16 2021-07-13 Janssen Pharmaceutica Nv Small molecule inhibitors of the JAK family of kinases
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EP2506713A4 (en) 2014-09-03
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US20140349970A1 (en) 2014-11-27
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US20110190489A1 (en) 2011-08-04
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CA2781010A1 (en) 2011-06-09
AU2010326030A1 (en) 2012-06-07
CR20120294A (es) 2012-09-03
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NZ599938A (en) 2014-08-29

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