CL2009000023A1 - Compuestos derivados de heterociclos de nitrogeno y azufre, moduladores de beta-amiloide; procedimiento de preparacion; composicion farmaceutica que comprende a dicho compuesto; y uso del compuesto para el tratamiento de alzheimer, angiopatia amiloide cerebral, hemorragia cerebral, demencia multiinfarto, demencia pugilistica o sindrome de down. - Google Patents
Compuestos derivados de heterociclos de nitrogeno y azufre, moduladores de beta-amiloide; procedimiento de preparacion; composicion farmaceutica que comprende a dicho compuesto; y uso del compuesto para el tratamiento de alzheimer, angiopatia amiloide cerebral, hemorragia cerebral, demencia multiinfarto, demencia pugilistica o sindrome de down.Info
- Publication number
- CL2009000023A1 CL2009000023A1 CL2009000023A CL2009000023A CL2009000023A1 CL 2009000023 A1 CL2009000023 A1 CL 2009000023A1 CL 2009000023 A CL2009000023 A CL 2009000023A CL 2009000023 A CL2009000023 A CL 2009000023A CL 2009000023 A1 CL2009000023 A1 CL 2009000023A1
- Authority
- CL
- Chile
- Prior art keywords
- compound
- dementia
- cerebral
- amyloid
- alzheimer
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 6
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 title abstract 4
- 102000013455 Amyloid beta-Peptides Human genes 0.000 title abstract 2
- 108010090849 Amyloid beta-Peptides Proteins 0.000 title abstract 2
- 208000005145 Cerebral amyloid angiopathy Diseases 0.000 title abstract 2
- 206010008111 Cerebral haemorrhage Diseases 0.000 title abstract 2
- 206010012289 Dementia Diseases 0.000 title abstract 2
- 201000010374 Down Syndrome Diseases 0.000 title abstract 2
- 208000005314 Multi-Infarct Dementia Diseases 0.000 title abstract 2
- 201000004810 Vascular dementia Diseases 0.000 title abstract 2
- 238000000034 method Methods 0.000 title abstract 2
- 229910052757 nitrogen Inorganic materials 0.000 title abstract 2
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 2
- 229910052717 sulfur Inorganic materials 0.000 title abstract 2
- 239000011593 sulfur Substances 0.000 title abstract 2
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/60—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
- C07D277/62—Benzothiazoles
- C07D277/68—Benzothiazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
- C07D277/82—Nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
- C07D491/044—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
- C07D491/052—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring the oxygen-containing ring being six-membered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/10—Spiro-condensed systems
- C07D491/113—Spiro-condensed systems with two or more oxygen atoms as ring hetero atoms in the oxygen-containing ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
- C07F7/02—Silicon compounds
- C07F7/08—Compounds having one or more C—Si linkages
- C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
- C07F7/1804—Compounds having Si-O-C linkages
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Abstract
Compuestos derivados de heterociclos de nitrógeno y azufre, moduladores de beta-amiloide; procedimiento de preparación; composición farmacéutica que comprende a dicho compuesto; y uso del compuesto para el tratamiento de Alzheimer, angiopatía amiloide cerebral, hemorragia cerebral, demencia multiinfarto, demencia pugilística o Síndrome de Down.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP08150173 | 2008-01-11 |
Publications (1)
Publication Number | Publication Date |
---|---|
CL2009000023A1 true CL2009000023A1 (es) | 2010-05-07 |
Family
ID=40429771
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CL2009000023A CL2009000023A1 (es) | 2008-01-11 | 2009-01-08 | Compuestos derivados de heterociclos de nitrogeno y azufre, moduladores de beta-amiloide; procedimiento de preparacion; composicion farmaceutica que comprende a dicho compuesto; y uso del compuesto para el tratamiento de alzheimer, angiopatia amiloide cerebral, hemorragia cerebral, demencia multiinfarto, demencia pugilistica o sindrome de down. |
Country Status (18)
Country | Link |
---|---|
US (1) | US7923450B2 (es) |
EP (1) | EP2231629B1 (es) |
JP (1) | JP5306373B2 (es) |
KR (1) | KR101244517B1 (es) |
CN (1) | CN101910142B (es) |
AR (1) | AR070130A1 (es) |
AT (1) | ATE535515T1 (es) |
AU (1) | AU2009203773B2 (es) |
BR (1) | BRPI0906799A2 (es) |
CA (1) | CA2703824C (es) |
CL (1) | CL2009000023A1 (es) |
ES (1) | ES2375919T3 (es) |
IL (1) | IL205023A (es) |
PE (1) | PE20091376A1 (es) |
RU (1) | RU2010132728A (es) |
TW (1) | TW200934489A (es) |
WO (1) | WO2009087127A1 (es) |
ZA (1) | ZA201003814B (es) |
Families Citing this family (26)
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JP5395808B2 (ja) * | 2007-12-21 | 2014-01-22 | エフ.ホフマン−ラ ロシュ アーゲー | オレキシン受容体アンタゴニストとしてのヘテロアリール誘導体 |
US7923450B2 (en) | 2008-01-11 | 2011-04-12 | Hoffmann-La Roche Inc. | Modulators for amyloid beta |
WO2009103652A1 (en) | 2008-02-22 | 2009-08-27 | F. Hoffmann-La Roche Ag | Modulators for amyloid beta |
KR101324414B1 (ko) * | 2008-10-09 | 2013-11-01 | 에프. 호프만-라 로슈 아게 | 아밀로이드 베타의 조절자 |
RU2011116447A (ru) | 2008-11-06 | 2012-12-20 | Астразенека Аб | Модуляторы амилоида бета |
CN102209537A (zh) * | 2008-11-10 | 2011-10-05 | 弗·哈夫曼-拉罗切有限公司 | 杂环γ分泌酶调节剂 |
TW201030002A (en) | 2009-01-16 | 2010-08-16 | Bristol Myers Squibb Co | Bicyclic compounds for the reduction of beta-amyloid production |
TWI468402B (zh) * | 2009-07-31 | 2015-01-11 | 必治妥美雅史谷比公司 | 降低β-類澱粉生成之化合物 |
US8637525B2 (en) | 2009-07-31 | 2014-01-28 | Bristol-Myers Squibb Company | Compounds for the reduction of beta-amyloid production |
US20110190269A1 (en) * | 2010-02-01 | 2011-08-04 | Karlheinz Baumann | Gamma secretase modulators |
US8486967B2 (en) * | 2010-02-17 | 2013-07-16 | Hoffmann-La Roche Inc. | Heteroaryl substituted piperidines |
CN102939282B (zh) | 2010-04-16 | 2015-12-02 | Ac免疫有限公司 | 用于治疗与淀粉状蛋白或淀粉状蛋白样蛋白有关的疾病的化合物 |
TW201206946A (en) | 2010-07-15 | 2012-02-16 | Bristol Myers Squibb Co | Compounds for the reduction of beta-amyloid production |
US20120122843A1 (en) * | 2010-11-11 | 2012-05-17 | Astrazeneca Ab | Compounds and Their Use for Treatment of Amyloid Beta-Related Diseases |
WO2012085166A1 (en) * | 2010-12-22 | 2012-06-28 | Merz Pharma Gmbh & Co. Kgaa | Metabotropic glutamate receptor modulators |
WO2012131539A1 (en) | 2011-03-31 | 2012-10-04 | Pfizer Inc. | Novel bicyclic pyridinones |
US9206195B2 (en) | 2011-08-09 | 2015-12-08 | Boehringer Ingelheim International Gmbh | Dihydrothienopyrimidines |
UA110688C2 (uk) | 2012-09-21 | 2016-01-25 | Пфайзер Інк. | Біциклічні піридинони |
US9718805B2 (en) | 2013-06-04 | 2017-08-01 | Acturum Life Science AB | Triazole compounds and their use as gamma secretase modulators |
JP6368776B2 (ja) | 2013-06-04 | 2018-08-01 | アクチュラム・ライフ・サイエンス・アクチエボラーグ | トリアゾール化合物およびガンマセクレターゼモジュレーターとしてのその使用 |
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WO2017158151A1 (en) | 2016-03-18 | 2017-09-21 | Savira Pharmaceuticals Gmbh | Pyrimidone derivatives and their use in the treatment, amelioration or prevention of a viral disease |
CN109311878B (zh) | 2016-06-27 | 2022-05-24 | 豪夫迈·罗氏有限公司 | 作为γ-分泌酶调节剂的三唑并吡啶类化合物 |
GB201916561D0 (en) | 2019-11-14 | 2020-01-01 | Vib Vzw | Gamma-secretase inhibitor screening assay |
WO2023146880A1 (en) * | 2022-01-25 | 2023-08-03 | Board Of Regents Of The University Of Nebraska | Functionalized allopurinol derivatives for treatment of alzheimer's disease |
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WO2009103652A1 (en) | 2008-02-22 | 2009-08-27 | F. Hoffmann-La Roche Ag | Modulators for amyloid beta |
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2009
- 2009-01-05 US US12/348,370 patent/US7923450B2/en not_active Expired - Fee Related
- 2009-01-05 JP JP2010541760A patent/JP5306373B2/ja not_active Expired - Fee Related
- 2009-01-05 RU RU2010132728/04A patent/RU2010132728A/ru unknown
- 2009-01-05 WO PCT/EP2009/050036 patent/WO2009087127A1/en active Application Filing
- 2009-01-05 AT AT09700149T patent/ATE535515T1/de active
- 2009-01-05 CN CN2009801015980A patent/CN101910142B/zh not_active Expired - Fee Related
- 2009-01-05 CA CA2703824A patent/CA2703824C/en active Active
- 2009-01-05 AU AU2009203773A patent/AU2009203773B2/en not_active Ceased
- 2009-01-05 EP EP09700149A patent/EP2231629B1/en not_active Not-in-force
- 2009-01-05 ES ES09700149T patent/ES2375919T3/es active Active
- 2009-01-05 BR BRPI0906799-0A patent/BRPI0906799A2/pt not_active Application Discontinuation
- 2009-01-05 KR KR1020107015266A patent/KR101244517B1/ko active IP Right Grant
- 2009-01-08 TW TW098100520A patent/TW200934489A/zh unknown
- 2009-01-08 CL CL2009000023A patent/CL2009000023A1/es unknown
- 2009-01-08 PE PE2009000020A patent/PE20091376A1/es not_active Application Discontinuation
- 2009-01-09 AR ARP090100058A patent/AR070130A1/es unknown
-
2010
- 2010-04-12 IL IL205023A patent/IL205023A/en active IP Right Grant
- 2010-05-27 ZA ZA2010/03814A patent/ZA201003814B/en unknown
Also Published As
Publication number | Publication date |
---|---|
KR20100090810A (ko) | 2010-08-17 |
PE20091376A1 (es) | 2009-09-25 |
AR070130A1 (es) | 2010-03-17 |
WO2009087127A1 (en) | 2009-07-16 |
KR101244517B1 (ko) | 2013-03-18 |
TW200934489A (en) | 2009-08-16 |
IL205023A0 (en) | 2010-11-30 |
EP2231629A1 (en) | 2010-09-29 |
US20090181965A1 (en) | 2009-07-16 |
CN101910142B (zh) | 2013-07-10 |
ES2375919T3 (es) | 2012-03-07 |
AU2009203773B2 (en) | 2013-04-18 |
JP2011509272A (ja) | 2011-03-24 |
EP2231629B1 (en) | 2011-11-30 |
ZA201003814B (en) | 2011-02-23 |
ATE535515T1 (de) | 2011-12-15 |
AU2009203773A1 (en) | 2009-07-16 |
CN101910142A (zh) | 2010-12-08 |
RU2010132728A (ru) | 2012-02-20 |
BRPI0906799A2 (pt) | 2015-07-14 |
JP5306373B2 (ja) | 2013-10-02 |
US7923450B2 (en) | 2011-04-12 |
IL205023A (en) | 2013-11-28 |
CA2703824A1 (en) | 2009-07-16 |
CA2703824C (en) | 2016-06-07 |
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