CL2008000825A1 - Compuestos heterociclicos derivados de quinolincarboxamidas utiles como antagonistas de p2x7; su metodo de preparacion; la composicion farmaceutica que lo contiene; el emtodo de preparacion de la composicion; y el uso de los mismos para preparar medicamentos utiles en artritis reumatoide. - Google Patents

Compuestos heterociclicos derivados de quinolincarboxamidas utiles como antagonistas de p2x7; su metodo de preparacion; la composicion farmaceutica que lo contiene; el emtodo de preparacion de la composicion; y el uso de los mismos para preparar medicamentos utiles en artritis reumatoide.

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Publication number
CL2008000825A1
CL2008000825A1 CL2008000825A CL2008000825A CL2008000825A1 CL 2008000825 A1 CL2008000825 A1 CL 2008000825A1 CL 2008000825 A CL2008000825 A CL 2008000825A CL 2008000825 A CL2008000825 A CL 2008000825A CL 2008000825 A1 CL2008000825 A1 CL 2008000825A1
Authority
CL
Chile
Prior art keywords
preparation
useful
composition
rheumatoid arthritis
quinolinecarboxamides
Prior art date
Application number
CL2008000825A
Other languages
English (en)
Spanish (es)
Inventor
Mark Ebden
Simon David Guile
Original Assignee
Astrazeneca Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astrazeneca Ab filed Critical Astrazeneca Ab
Publication of CL2008000825A1 publication Critical patent/CL2008000825A1/es

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4709—Non-condensed quinolines and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond

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CL2008000825A 2007-03-22 2008-03-20 Compuestos heterociclicos derivados de quinolincarboxamidas utiles como antagonistas de p2x7; su metodo de preparacion; la composicion farmaceutica que lo contiene; el emtodo de preparacion de la composicion; y el uso de los mismos para preparar medicamentos utiles en artritis reumatoide. CL2008000825A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US89629807P 2007-03-22 2007-03-22

Publications (1)

Publication Number Publication Date
CL2008000825A1 true CL2008000825A1 (es) 2008-11-03

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ID=39471999

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Application Number Title Priority Date Filing Date
CL2008000825A CL2008000825A1 (es) 2007-03-22 2008-03-20 Compuestos heterociclicos derivados de quinolincarboxamidas utiles como antagonistas de p2x7; su metodo de preparacion; la composicion farmaceutica que lo contiene; el emtodo de preparacion de la composicion; y el uso de los mismos para preparar medicamentos utiles en artritis reumatoide.

Country Status (17)

Country Link
US (1) US7964616B2 (enExample)
EP (1) EP2139879B1 (enExample)
JP (1) JP2010522227A (enExample)
KR (1) KR20090122396A (enExample)
CN (1) CN101679350B (enExample)
AR (1) AR065806A1 (enExample)
AU (1) AU2008228067B2 (enExample)
BR (1) BRPI0809106A2 (enExample)
CA (1) CA2680761A1 (enExample)
CL (1) CL2008000825A1 (enExample)
ES (1) ES2388454T3 (enExample)
MX (1) MX2009010059A (enExample)
PE (1) PE20091225A1 (enExample)
RU (1) RU2460727C2 (enExample)
TW (1) TW200904427A (enExample)
UY (1) UY30976A1 (enExample)
WO (1) WO2008114002A1 (enExample)

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US9556117B2 (en) 2012-12-18 2017-01-31 Actelion Pharmaceuticals Ltd. Indole carboxamide derivatives as P2X7 receptor antagonists
WO2014115078A1 (en) 2013-01-22 2014-07-31 Actelion Pharmaceuticals Ltd Heterocyclic amide derivatives as p2x7 receptor antagonists
KR102222220B1 (ko) 2013-01-22 2021-03-03 이도르시아 파마슈티컬스 리미티드 Ｐ2ｘ7 수용체 길항제로서의 헤테로시클릭 아미드 유도체
TWI624467B (zh) * 2013-10-14 2018-05-21 衛材Ｒ＆Ｄ企管股份有限公司 選擇性經取代之喹啉化合物
AU2015269598B2 (en) * 2014-06-05 2019-11-14 Merck Patent Gmbh Novel quinoline derivatives and their use in neurodegenerative diseases
ES2928164T3 (es) 2015-10-19 2022-11-15 Incyte Corp Compuestos heterocíclicos como inmunomoduladores
MD3377488T2 (ro) 2015-11-19 2023-02-28 Incyte Corp Compuși heterociclici ca imunomodulatori
MA44075A (fr) 2015-12-17 2021-05-19 Incyte Corp Dérivés de n-phényl-pyridine-2-carboxamide et leur utilisation en tant que modulateurs des interactions protéine/protéine pd-1/pd-l1
MY199705A (en) 2015-12-22 2023-11-20 Incyte Corp Heterocyclic compounds as immunomodulators
WO2017192961A1 (en) 2016-05-06 2017-11-09 Incyte Corporation Heterocyclic compounds as immunomodulators
WO2017205464A1 (en) 2016-05-26 2017-11-30 Incyte Corporation Heterocyclic compounds as immunomodulators
KR102685249B1 (ko) 2016-06-20 2024-07-17 인사이트 코포레이션 면역조절제로서의 복소환식 화합물
MA45669A (fr) 2016-07-14 2019-05-22 Incyte Corp Composés hétérocycliques utilisés comme immunomodulateurs
WO2018044783A1 (en) 2016-08-29 2018-03-08 Incyte Corporation Heterocyclic compounds as immunomodulators
EP3558973B1 (en) 2016-12-22 2021-09-15 Incyte Corporation Pyridine derivatives as immunomodulators
PE20191532A1 (es) 2016-12-22 2019-10-23 Incyte Corp Compuestos heterociclicos como inmunomoduladores
EP3558989B1 (en) 2016-12-22 2021-04-14 Incyte Corporation Triazolo[1,5-a]pyridine derivatives as immunomodulators
CA3047991A1 (en) 2016-12-22 2018-06-28 Incyte Corporation Bicyclic heteroaromatic compounds as immunomodulators
RS64055B1 (sr) 2018-03-30 2023-04-28 Incyte Corp Heterociklična jedinjenja kao imunomodulatori
MD3790877T2 (ro) 2018-05-11 2023-08-31 Incyte Corp Derivați de tetrahidro-imidazo[4,5-c]piridină în calitate de imunomodulatori PD-L1
EP3962493A2 (en) 2019-05-03 2022-03-09 Flagship Pioneering Innovations V, Inc. Methods of modulating immune activity/level of irf or sting or of treating cancer, comprising the administration of a sting modulator and/or purinergic receptor modulator or postcellular signaling factor
JP7665593B2 (ja) 2019-08-09 2025-04-21 インサイト・コーポレイション Ｐｄ－１／ｐｄ－ｌ１阻害剤の塩
AR120109A1 (es) 2019-09-30 2022-02-02 Incyte Corp Compuestos de pirido[3,2-d]pirimidina como inmunomoduladores
PE20230407A1 (es) 2019-11-11 2023-03-07 Incyte Corp Sales y formas cristalinas de un inhibidor de pd-1/pd-l1
WO2022099018A1 (en) 2020-11-06 2022-05-12 Incyte Corporation Process of preparing a pd-1/pd-l1 inhibitor
WO2022099075A1 (en) 2020-11-06 2022-05-12 Incyte Corporation Crystalline form of a pd-1/pd-l1 inhibitor
TW202233616A (zh) 2020-11-06 2022-09-01 美商英塞特公司 用於製備ｐｄ－１／ｐｄ－ｌ１抑制劑以及其鹽及結晶形式之方法

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KR20090122396A (ko) 2009-11-27
AR065806A1 (es) 2009-07-01
ES2388454T3 (es) 2012-10-15
US20080234319A1 (en) 2008-09-25
JP2010522227A (ja) 2010-07-01
HK1138850A1 (en) 2010-09-03
UY30976A1 (es) 2008-10-31
RU2009135621A (ru) 2011-04-27
EP2139879A1 (en) 2010-01-06
WO2008114002A1 (en) 2008-09-25
BRPI0809106A2 (pt) 2014-08-26
MX2009010059A (es) 2009-10-12
AU2008228067B2 (en) 2011-12-08
US7964616B2 (en) 2011-06-21
AU2008228067A1 (en) 2008-09-25
EP2139879B1 (en) 2012-07-11
CA2680761A1 (en) 2008-09-25
TW200904427A (en) 2009-02-01
CN101679350B (zh) 2014-03-12
RU2460727C2 (ru) 2012-09-10
PE20091225A1 (es) 2009-09-16

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