CH646948A5 - Chlorhexidinsalze und praeparate enthaltend dieselben. - Google Patents
Chlorhexidinsalze und praeparate enthaltend dieselben. Download PDFInfo
- Publication number
- CH646948A5 CH646948A5 CH322480A CH322480A CH646948A5 CH 646948 A5 CH646948 A5 CH 646948A5 CH 322480 A CH322480 A CH 322480A CH 322480 A CH322480 A CH 322480A CH 646948 A5 CH646948 A5 CH 646948A5
- Authority
- CH
- Switzerland
- Prior art keywords
- preparation
- acid
- compound
- amount
- chlorhexidine
- Prior art date
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- GHXZTYHSJHQHIJ-UHFFFAOYSA-N Chlorhexidine Chemical class C=1C=C(Cl)C=CC=1NC(N)=NC(N)=NCCCCCCN=C(N)N=C(N)NC1=CC=C(Cl)C=C1 GHXZTYHSJHQHIJ-UHFFFAOYSA-N 0.000 title claims description 80
- 238000002360 preparation method Methods 0.000 title claims description 52
- 229960003260 chlorhexidine Drugs 0.000 claims description 74
- MHWLWQUZZRMNGJ-UHFFFAOYSA-N nalidixic acid Chemical group C1=C(C)N=C2N(CC)C=C(C(O)=O)C(=O)C2=C1 MHWLWQUZZRMNGJ-UHFFFAOYSA-N 0.000 claims description 43
- 229960000210 nalidixic acid Drugs 0.000 claims description 36
- 150000001875 compounds Chemical class 0.000 claims description 34
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- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 22
- OAOBMEMWHJWPNA-UHFFFAOYSA-N (4-aminophenyl)phosphonic acid Chemical group NC1=CC=C(P(O)(O)=O)C=C1 OAOBMEMWHJWPNA-UHFFFAOYSA-N 0.000 claims description 19
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- 150000003839 salts Chemical class 0.000 description 28
- 238000002156 mixing Methods 0.000 description 22
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- 239000002585 base Substances 0.000 description 12
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- 229960004927 neomycin Drugs 0.000 description 1
- MGFYIUFZLHCRTH-UHFFFAOYSA-N nitrilotriacetic acid Chemical compound OC(=O)CN(CC(O)=O)CC(O)=O MGFYIUFZLHCRTH-UHFFFAOYSA-N 0.000 description 1
- 229910052757 nitrogen Inorganic materials 0.000 description 1
- QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 description 1
- OQCDKBAXFALNLD-UHFFFAOYSA-N octadecanoic acid Natural products CCCCCCCC(C)CCCCCCCCC(O)=O OQCDKBAXFALNLD-UHFFFAOYSA-N 0.000 description 1
- WWZKQHOCKIZLMA-UHFFFAOYSA-N octanoic acid Chemical compound CCCCCCCC(O)=O WWZKQHOCKIZLMA-UHFFFAOYSA-N 0.000 description 1
- 150000007524 organic acids Chemical class 0.000 description 1
- 235000005985 organic acids Nutrition 0.000 description 1
- COWNFYYYZFRNOY-UHFFFAOYSA-N oxazolidinedione Chemical compound O=C1COC(=O)N1 COWNFYYYZFRNOY-UHFFFAOYSA-N 0.000 description 1
- QPCDCPDFJACHGM-UHFFFAOYSA-K pentetate(3-) Chemical compound OC(=O)CN(CC([O-])=O)CCN(CC([O-])=O)CCN(CC(O)=O)CC([O-])=O QPCDCPDFJACHGM-UHFFFAOYSA-K 0.000 description 1
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 1
- 239000010452 phosphate Substances 0.000 description 1
- 150000003009 phosphonic acids Chemical class 0.000 description 1
- OJMIONKXNSYLSR-UHFFFAOYSA-N phosphorous acid Chemical compound OP(O)O OJMIONKXNSYLSR-UHFFFAOYSA-N 0.000 description 1
- 229940075930 picrate Drugs 0.000 description 1
- OXNIZHLAWKMVMX-UHFFFAOYSA-M picrate anion Chemical compound [O-]C1=C([N+]([O-])=O)C=C([N+]([O-])=O)C=C1[N+]([O-])=O OXNIZHLAWKMVMX-UHFFFAOYSA-M 0.000 description 1
- 230000003389 potentiating effect Effects 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 238000001556 precipitation Methods 0.000 description 1
- 150000003212 purines Chemical class 0.000 description 1
- CVHZOJJKTDOEJC-UHFFFAOYSA-N saccharin Chemical compound C1=CC=C2C(=O)NS(=O)(=O)C2=C1 CVHZOJJKTDOEJC-UHFFFAOYSA-N 0.000 description 1
- 229940081974 saccharin Drugs 0.000 description 1
- 235000019204 saccharin Nutrition 0.000 description 1
- 239000000901 saccharin and its Na,K and Ca salt Substances 0.000 description 1
- 230000035945 sensitivity Effects 0.000 description 1
- 229960003339 sodium phosphate Drugs 0.000 description 1
- 239000001488 sodium phosphate Substances 0.000 description 1
- 229910000162 sodium phosphate Inorganic materials 0.000 description 1
- 241000894007 species Species 0.000 description 1
- 239000008117 stearic acid Substances 0.000 description 1
- 229960005322 streptomycin Drugs 0.000 description 1
- JDVPQXZIJDEHAN-UHFFFAOYSA-M succinamate Chemical compound NC(=O)CCC([O-])=O JDVPQXZIJDEHAN-UHFFFAOYSA-M 0.000 description 1
- 229960002317 succinimide Drugs 0.000 description 1
- BDHFUVZGWQCTTF-UHFFFAOYSA-M sulfonate Chemical compound [O-]S(=O)=O BDHFUVZGWQCTTF-UHFFFAOYSA-M 0.000 description 1
- 239000011593 sulfur Substances 0.000 description 1
- 229910052717 sulfur Inorganic materials 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
- 229940095064 tartrate Drugs 0.000 description 1
- 229940072172 tetracycline antibiotic Drugs 0.000 description 1
- 230000000699 topical effect Effects 0.000 description 1
- VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 description 1
- ILJSQTXMGCGYMG-UHFFFAOYSA-N triacetic acid Chemical compound CC(=O)CC(=O)CC(O)=O ILJSQTXMGCGYMG-UHFFFAOYSA-N 0.000 description 1
- 150000003626 triacylglycerols Chemical class 0.000 description 1
- IEDVJHCEMCRBQM-UHFFFAOYSA-N trimethoprim Chemical compound COC1=C(OC)C(OC)=CC(CC=2C(=NC(N)=NC=2)N)=C1 IEDVJHCEMCRBQM-UHFFFAOYSA-N 0.000 description 1
- 229960001082 trimethoprim Drugs 0.000 description 1
- RYFMWSXOAZQYPI-UHFFFAOYSA-K trisodium phosphate Chemical compound [Na+].[Na+].[Na+].[O-]P([O-])([O-])=O RYFMWSXOAZQYPI-UHFFFAOYSA-K 0.000 description 1
- 239000001993 wax Substances 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C279/00—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
- C07C279/20—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups containing any of the groups, X being a hetero atom, Y being any atom, e.g. acylguanidines
- C07C279/24—Y being a hetero atom
- C07C279/26—X and Y being nitrogen atoms, i.e. biguanides
- C07C279/265—X and Y being nitrogen atoms, i.e. biguanides containing two or more biguanide groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C57/00—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
- C07C57/02—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms with only carbon-to-carbon double bonds as unsaturation
- C07C57/03—Monocarboxylic acids
- C07C57/10—Sorbic acid
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
- C07F9/3804—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)] not used, see subgroups
- C07F9/3834—Aromatic acids (P-C aromatic linkage)
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biochemistry (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Molecular Biology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Cosmetics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US3359379A | 1979-04-26 | 1979-04-26 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CH646948A5 true CH646948A5 (de) | 1984-12-28 |
Family
ID=21871298
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CH322480A CH646948A5 (de) | 1979-04-26 | 1980-04-25 | Chlorhexidinsalze und praeparate enthaltend dieselben. |
| CH3086/84A CH648755A5 (de) | 1979-04-26 | 1980-04-25 | Chlorhexidin enthaltende synergistische praeparate zur verhinderung des wachstums von mikroorganismen. |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CH3086/84A CH648755A5 (de) | 1979-04-26 | 1980-04-25 | Chlorhexidin enthaltende synergistische praeparate zur verhinderung des wachstums von mikroorganismen. |
Country Status (13)
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20050058673A1 (en) | 2003-09-09 | 2005-03-17 | 3M Innovative Properties Company | Antimicrobial compositions and methods |
| ATE511838T1 (de) | 2005-03-10 | 2011-06-15 | 3M Innovative Properties Co | Antimikrobielle zusammensetzungen mit hydroxycarboxylsäureestern |
| EP2497460A1 (en) | 2005-03-10 | 2012-09-12 | 3M Innovative Properties Co. | Methods of reducing microbial contamination |
| WO2006099325A2 (en) | 2005-03-10 | 2006-09-21 | 3M Innovative Properties Company | Methods of treating ear infections |
| US20130065965A1 (en) * | 2009-11-18 | 2013-03-14 | Medichem S.A. | Di(4-chloro-phenyldiguanido) derivative which is free of potential genotoxicity and a process for reducing the residual amount of p-chloroaniline in said di(4-chloro-phenyldiguanido) derivative |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB815800A (en) * | 1956-06-06 | 1959-07-01 | Ici Ltd | New biguanide salts |
| US2684924A (en) * | 1951-02-05 | 1954-07-27 | Ici Ltd | Nu-chlorophenyldiguanidino compounds |
| US2990425A (en) * | 1956-06-06 | 1961-06-27 | Ici Ltd | New biguanide salts |
| US3159537A (en) * | 1960-12-20 | 1964-12-01 | American Cyanamid Co | Potentiation of tetracycline by phosphinic acid |
| NL273482A (enrdf_load_stackoverflow) * | 1961-01-18 | |||
| US3694447A (en) * | 1970-03-10 | 1972-09-26 | Smith Kline French Lab | Complexes of phosphanilic acid and 9-amino-3-nitroacridine |
| US3794723A (en) * | 1970-03-10 | 1974-02-26 | Smithkline Corp | Complexes of phosphanilic acid and 9-amino-3-nitroacridine useful as antifungal or antibacterial agents |
| SE370003B (enrdf_load_stackoverflow) * | 1971-05-18 | 1974-09-30 | Kema Nord Ab | |
| GB1338003A (en) * | 1971-06-18 | 1973-11-21 | Ici Ltd | Cleaning compositions |
| SE374658B (enrdf_load_stackoverflow) * | 1972-07-31 | 1975-03-17 | Hesselgren S G | |
| US3976765A (en) * | 1973-11-01 | 1976-08-24 | Colgate-Palmolive Company | Antibacterial oral preparations |
| US4125610A (en) * | 1977-07-27 | 1978-11-14 | Bristol-Myers Company | Antibacterial compositions |
-
1980
- 1980-04-23 CA CA000350482A patent/CA1159834A/en not_active Expired
- 1980-04-24 IT IT48512/80A patent/IT1188929B/it active
- 1980-04-25 GB GB8013786A patent/GB2053195B/en not_active Expired
- 1980-04-25 CH CH322480A patent/CH646948A5/de not_active IP Right Cessation
- 1980-04-25 DE DE19803016110 patent/DE3016110A1/de active Granted
- 1980-04-25 CY CY1316A patent/CY1316A/en unknown
- 1980-04-25 ES ES490947A patent/ES490947A0/es active Granted
- 1980-04-25 CY CY1324A patent/CY1324A/en unknown
- 1980-04-25 CH CH3086/84A patent/CH648755A5/de not_active IP Right Cessation
- 1980-04-25 JP JP5439280A patent/JPS55149242A/ja active Pending
- 1980-04-25 FR FR8009398A patent/FR2455034A1/fr active Granted
- 1980-04-28 AT AT0227880A patent/AT373235B/de not_active IP Right Cessation
- 1980-04-28 NL NL8002483A patent/NL8002483A/nl not_active Application Discontinuation
-
1982
- 1982-10-13 GB GB08229195A patent/GB2118041B/en not_active Expired
-
1986
- 1986-01-09 HK HK14/86A patent/HK1486A/xx unknown
- 1986-03-27 HK HK212/86A patent/HK21286A/xx unknown
- 1986-12-30 MY MY495/86A patent/MY8600495A/xx unknown
- 1986-12-30 MY MY498/86A patent/MY8600498A/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| GB2118041A (en) | 1983-10-26 |
| HK21286A (en) | 1986-04-04 |
| DE3016110A1 (de) | 1980-11-06 |
| HK1486A (en) | 1986-01-17 |
| IT8048512A1 (it) | 1981-10-24 |
| GB2053195A (en) | 1981-02-04 |
| FR2455034B1 (enrdf_load_stackoverflow) | 1984-08-10 |
| AT373235B (de) | 1983-12-27 |
| DE3016110C2 (enrdf_load_stackoverflow) | 1990-12-13 |
| IT8048512A0 (it) | 1980-04-24 |
| ES8105259A1 (es) | 1981-05-16 |
| MY8600498A (en) | 1986-12-31 |
| GB2053195B (en) | 1983-04-07 |
| IT1188929B (it) | 1988-01-28 |
| FR2455034A1 (fr) | 1980-11-21 |
| CY1324A (en) | 1986-06-27 |
| ES490947A0 (es) | 1981-05-16 |
| GB2118041B (en) | 1984-03-21 |
| NL8002483A (nl) | 1980-10-28 |
| ATA227880A (de) | 1983-05-15 |
| CA1159834A (en) | 1984-01-03 |
| JPS55149242A (en) | 1980-11-20 |
| CH648755A5 (de) | 1985-04-15 |
| MY8600495A (en) | 1986-12-31 |
| CY1316A (en) | 1986-03-28 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PL | Patent ceased |