CH643246A5 - Verfahren zur herstellung von n-cyano-n'-methyl-n''-(2-(((5-methylimidazol-4-yl)-methyl)-thio)-aethyl)-guanidin. - Google Patents

Verfahren zur herstellung von n-cyano-n'-methyl-n''-(2-(((5-methylimidazol-4-yl)-methyl)-thio)-aethyl)-guanidin. Download PDF

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Publication number
CH643246A5
CH643246A5 CH669479A CH669479A CH643246A5 CH 643246 A5 CH643246 A5 CH 643246A5 CH 669479 A CH669479 A CH 669479A CH 669479 A CH669479 A CH 669479A CH 643246 A5 CH643246 A5 CH 643246A5
Authority
CH
Switzerland
Prior art keywords
methyl
cyano
guanidine
mol
thio
Prior art date
Application number
CH669479A
Other languages
German (de)
English (en)
Inventor
Zdravko Dr Ing Crnic
Gordana Dr Ing Karlovic
Gorjana Dipl Ing Radobolja
Slobodan Dr Ing Djokic
Original Assignee
Pliva Pharm & Chem Works
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pliva Pharm & Chem Works filed Critical Pliva Pharm & Chem Works
Publication of CH643246A5 publication Critical patent/CH643246A5/de

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/10—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings
    • C07D317/14—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D317/18—Radicals substituted by singly bound oxygen or sulfur atoms
    • C07D317/22—Radicals substituted by singly bound oxygen or sulfur atoms etherified

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
CH669479A 1978-07-19 1979-07-18 Verfahren zur herstellung von n-cyano-n'-methyl-n''-(2-(((5-methylimidazol-4-yl)-methyl)-thio)-aethyl)-guanidin. CH643246A5 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
YU1725/78A YU40716B (en) 1978-07-19 1978-07-19 Process for obtaining n-cyano-n'-methyl-n'-û2-|5-metylimidazole4-yl)-methyl¨-thioethylù guanidine

Publications (1)

Publication Number Publication Date
CH643246A5 true CH643246A5 (de) 1984-05-30

Family

ID=25555343

Family Applications (1)

Application Number Title Priority Date Filing Date
CH669479A CH643246A5 (de) 1978-07-19 1979-07-18 Verfahren zur herstellung von n-cyano-n'-methyl-n''-(2-(((5-methylimidazol-4-yl)-methyl)-thio)-aethyl)-guanidin.

Country Status (7)

Country Link
AT (1) AT366033B (ja)
CH (1) CH643246A5 (ja)
DE (1) DE2928857C3 (ja)
GB (1) GB2025969B (ja)
IT (1) IT1121013B (ja)
SU (1) SU886744A3 (ja)
YU (1) YU40716B (ja)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HU185298B (en) * 1981-06-26 1984-12-28 Richter Gedeon Vegyeszet Process for producing cimetidine
HU185636B (en) * 1981-06-26 1985-03-28 Richter Gedeon Vegyeszet Process for preparing new cimetidine-hydrate /cimetidine-h/
MY100734A (en) * 1986-09-01 1991-01-31 Mitsui Petrochemical Ind Process for preparation of guanidine derivative.
JPH0629234B2 (ja) * 1986-12-26 1994-04-20 三井石油化学工業株式会社 α−アシロキシケトン誘導体
US5808090A (en) * 1996-02-22 1998-09-15 Endo Pharmaceuticals Inc. Process for preventing precipitation in cimetidine injection solutions

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1397436A (en) 1972-09-05 1975-06-11 Smith Kline French Lab Heterocyclic n-cyanoguinidines
GB1533380A (en) 1974-09-02 1978-11-22 Smith Kline French Lab Process for the preparation of heterocyclic substituted thioureas and h-cyanoguanidines
GB1531221A (en) 1974-09-02 1978-11-08 Smith Kline French Lab Process for preparing guanidine derivatives

Also Published As

Publication number Publication date
DE2928857A1 (de) 1980-02-07
IT1121013B (it) 1986-03-26
YU172578A (en) 1982-10-31
ATA498379A (de) 1981-07-15
AT366033B (de) 1982-03-10
IT7968506A0 (it) 1979-07-19
DE2928857C3 (de) 1988-02-11
GB2025969A (en) 1980-01-30
DE2928857B2 (de) 1981-07-23
GB2025969B (en) 1982-09-02
YU40716B (en) 1986-04-30
SU886744A3 (ru) 1981-11-30

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Legal Events

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PL Patent ceased