CH642066A5 - 3-indolyl-tert.-butylaminopropanole, verfahren zu deren herstellung und sie enthaltende pharmazeutische mittel. - Google Patents

3-indolyl-tert.-butylaminopropanole, verfahren zu deren herstellung und sie enthaltende pharmazeutische mittel. Download PDF

Info

Publication number
CH642066A5
CH642066A5 CH759378A CH759378A CH642066A5 CH 642066 A5 CH642066 A5 CH 642066A5 CH 759378 A CH759378 A CH 759378A CH 759378 A CH759378 A CH 759378A CH 642066 A5 CH642066 A5 CH 642066A5
Authority
CH
Switzerland
Prior art keywords
compound
indolyl
alkyl
phenyl
carbon atoms
Prior art date
Application number
CH759378A
Other languages
German (de)
English (en)
Inventor
William E Kreighbaum
William T Comer
Original Assignee
Bristol Myers Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Co filed Critical Bristol Myers Co
Publication of CH642066A5 publication Critical patent/CH642066A5/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Biomedical Technology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
CH759378A 1977-07-13 1978-07-12 3-indolyl-tert.-butylaminopropanole, verfahren zu deren herstellung und sie enthaltende pharmazeutische mittel. CH642066A5 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US81513877A 1977-07-13 1977-07-13

Publications (1)

Publication Number Publication Date
CH642066A5 true CH642066A5 (de) 1984-03-30

Family

ID=25216976

Family Applications (1)

Application Number Title Priority Date Filing Date
CH759378A CH642066A5 (de) 1977-07-13 1978-07-12 3-indolyl-tert.-butylaminopropanole, verfahren zu deren herstellung und sie enthaltende pharmazeutische mittel.

Country Status (30)

Country Link
JP (1) JPS5419972A (fi)
AR (1) AR225274A1 (fi)
AT (1) AT364821B (fi)
AU (1) AU525064B2 (fi)
BE (1) BE868943A (fi)
CA (1) CA1116598A (fi)
CH (1) CH642066A5 (fi)
CY (1) CY1274A (fi)
DE (1) DE2830884A1 (fi)
DK (1) DK156568C (fi)
ES (1) ES471674A1 (fi)
FI (1) FI69835C (fi)
FR (1) FR2397404A1 (fi)
GB (1) GB2001633B (fi)
GR (1) GR74488B (fi)
HK (1) HK1385A (fi)
HU (1) HU178992B (fi)
IE (1) IE47122B1 (fi)
IL (1) IL55115A (fi)
IT (1) IT1105091B (fi)
KE (1) KE3485A (fi)
LU (1) LU79966A1 (fi)
MY (1) MY8500946A (fi)
NL (1) NL189946C (fi)
NO (1) NO149311C (fi)
NZ (1) NZ187763A (fi)
SE (1) SE429339B (fi)
SG (1) SG82584G (fi)
YU (1) YU40528B (fi)
ZA (1) ZA783744B (fi)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2463765A1 (fr) * 1979-08-17 1981-02-27 Clin Midy Nouveaux derives de l'indole actifs sur le systeme cardiovasculaire
US4321398A (en) * 1981-05-07 1982-03-23 Mead Johnson & Company Thienyl and benzothienyl-tertiary butylaminophenoxypropanols
DE3119796A1 (de) * 1981-05-19 1982-12-23 Hoechst Ag, 6000 Frankfurt Substituierte tryptaminderivate von thienyloxpropanolaminen, verfahren zu ihrer herstellung, pharmazeutische praeparate auf basis dieser verbindungen sowie ihre verwendung
FR2523964B1 (fr) * 1982-03-23 1985-09-27 Sanofi Sa Nouveaux derives de la tryptamine actifs notamment sur le systeme cardiovasculaire et procede pour leur preparation
NZ208337A (en) * 1983-06-10 1988-10-28 Bristol Myers Co 2-(2-hydroxy-3-((2-(ar-hydroxy-1h-aminopropoxy-yl)ethyl benzonitriles and pharmaceutical compositions
FR2601008B1 (fr) * 1986-07-03 1990-03-30 Sanofi Sa Procede de synthese stereospecifique de derives de l'indole
US6825220B2 (en) 2000-11-10 2004-11-30 Eli Lilly And Company 3-Substituted oxindole β 3 agonists
WO2003016307A1 (en) * 2001-08-14 2003-02-27 Eli Lilly And Company β3 ADRENERGIC AGONISTS
EP1444224B1 (en) 2001-08-14 2006-05-03 Eli Lilly And Company 3-substituted oxindole beta-3 agonists
WO2003044016A1 (en) 2001-11-20 2003-05-30 Eli Lilly And Company 3-SUBSTITUTED OXINDOLE β3 AGONISTS
JP2005518357A (ja) 2001-11-20 2005-06-23 イーライ・リリー・アンド・カンパニー ベータ３アドレナリンアゴニスト
US7009060B2 (en) 2002-01-11 2006-03-07 Eli Lilly And Company 2-oxo-benzimidazolyl substituted ethanolamine derivatives and their use as β3 agonists
WO2010014263A1 (en) * 2008-08-01 2010-02-04 Arca Discovery, Inc. Methods and compositions involving (s)-bucindolol

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR1532210A (fr) * 1963-06-21 1968-07-12 Ici Ltd Composés hétérocycliques et leur procédé de préparation
CH495983A (de) * 1968-02-09 1970-09-15 Sandoz Ag Verfahren zur Herstellung von linksdrehendem 4-(2-Hydroxy-3-isopropylaminopropoxy)indol
US3371098A (en) * 1966-11-29 1968-02-27 Philips Corp 5- and 6-methoxy-3-(phenoxyethyl-aminoethyl)-indoles
US3946009A (en) * 1972-05-05 1976-03-23 Merck Sharp & Dohme (I.A.) Corporation 2-(3-Substituted amino-2-hydroxypropoxy)-3-substituted pyrazines

Also Published As

Publication number Publication date
DE2830884C2 (fi) 1990-01-11
DE2830884A1 (de) 1979-02-01
JPS6340784B2 (fi) 1988-08-12
AU3770478A (en) 1980-01-10
SE7807700L (sv) 1979-01-14
IT1105091B (it) 1985-10-28
FI69835B (fi) 1985-12-31
NL189946C (nl) 1993-09-16
NO149311C (no) 1984-03-28
NL7807564A (nl) 1979-01-16
IE47122B1 (en) 1983-12-28
KE3485A (en) 1985-01-25
AU525064B2 (en) 1982-10-21
AR225274A1 (es) 1982-03-15
FR2397404A1 (fr) 1979-02-09
GB2001633A (en) 1979-02-07
DK313878A (da) 1979-01-14
JPS5419972A (en) 1979-02-15
CY1274A (en) 1985-03-08
BE868943A (fr) 1979-01-12
FI69835C (fi) 1986-05-26
FI782205A (fi) 1979-01-14
IE781400L (en) 1979-01-13
NO782407L (no) 1979-01-16
NZ187763A (en) 1984-07-31
DK156568B (da) 1989-09-11
GB2001633B (en) 1982-03-24
YU161178A (en) 1983-02-28
NO149311B (no) 1983-12-19
SE429339B (sv) 1983-08-29
HU178992B (en) 1982-07-28
HK1385A (en) 1985-01-11
NL189946B (nl) 1993-04-16
SG82584G (en) 1985-09-13
DK156568C (da) 1990-02-05
IT7850228A0 (it) 1978-07-10
YU40528B (en) 1986-02-28
ZA783744B (en) 1979-07-25
GR74488B (fi) 1984-06-28
CA1116598A (en) 1982-01-19
IL55115A (en) 1981-09-13
MY8500946A (en) 1985-12-31
ES471674A1 (es) 1979-10-01
FR2397404B1 (fi) 1982-06-11
LU79966A1 (fr) 1979-04-09
AT364821B (de) 1981-11-25
ATA508978A (de) 1981-04-15
IL55115A0 (en) 1978-09-29

Similar Documents

Publication Publication Date Title
EP0005828B1 (de) Neue substituierte Phenylpiperazinderivate, diese enthaltende Arzneimittel und Verfahren zu deren Herstellung
CH642066A5 (de) 3-indolyl-tert.-butylaminopropanole, verfahren zu deren herstellung und sie enthaltende pharmazeutische mittel.
DE2722162A1 (de) Verfahren zur herstellung von phosphonigen saeuren
DD207718A5 (de) Verfahren zur herstellung von 2-guanidino-4-heteroarylthiazolen
DE2702537A1 (de) Neue piperazinderivate, verfahren zu ihrer herstellung und diese enthaltende arzneimittel
DE2938990C2 (fi)
DE3216843C2 (de) 3-Thiomethyl-pyridin-Derivate, Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende Arzneimittel
DD144665A5 (de) Verfahren zur herstellung von 1-phenoxy-3-aminopropan-2-olen
EP0225543B1 (de) Basisch substituierte Phenylacetaldehyde, ihre Herstellung und diese enthaltende Arzneimittel
DE1940566B2 (de) 1- (2-Nitrilophenoxy)-2-hydroxy-3äthylaminopropan, Verfahren zu dessen Herstellung und diese enthaltende Arzneimittel
DE3305495A1 (de) Piperazin- und homopiperazinderivate, verfahren zu ihrer herstellung und sie enthaltende pharmazeutische zubereitungen
DE2824066A1 (de) Neue, zur ulcusbehandlung brauchbare verbindungen, verfahren zu deren herstellung, arzneimittel und zwischenprodukte
EP0007438A1 (de) Neue substituierte 2-Phenylamino-imidazoline-(2), deren Säureadditionssalze, diese enthaltende Arzneimittel und Verfahren zur Herstellung derselben
DE2062055C3 (de) Propanolamin-Derivate, Verfahren zu ihrer Herstellung und sie enthaltende Arzneimittel
EP0000727B1 (de) 3-(4-(1,3-Diazacycloalken-2-yl)-phenyl)-1,2-benzisothiazole, Verfahren zu ihrer Herstellung und diese enthaltende Arzneimittel.
DE1957769C3 (de) 4,6-Diamino-l,2-dihydro-2,2-dimethyl-133-triazin-Derivate, Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende Arzneipräparate
DE2427208A1 (de) Triazole und deren salze, verfahren zu deren herstellung und sie enthaltende arzneimittel
DE2738131A1 (de) Aminoketone, verfahren zu ihrer herstellung und sie enthaltende arzneimittel
DE2628642C2 (de) In 2-Stellung substituierte 1,3-Diaza-fünfringkohlenstoffverbindungen, Verfahren zu ihrer Herstellung und diese enthaltende pharmazeutische Mittel
DE2609574A1 (de) Monosubstituiertes piperazinderivat, verfahren zu seiner herstellung und es enthaltende arzneimittel
EP0035733B1 (de) Neue 1-(Acylamino-aryloxy-)2-hydroxy-3-alkinyl-aminopropane und Verfahren zu ihrer Herstellung
DE2844353C2 (de) p-Isopropylthiophenoxypropanolamin-Derivate, Verfahren zu deren Herstellung und Arzneimittel
DE3220185A1 (de) 4-amino-benzylamin-derivate, verfahren zu ihrer herstellung, sowie ihre verwendung als pharmazeutica
AT295526B (de) Verfahren zur Herstellung von neuen 1,2,5-Thiadiazolderivaten und ihren Salzen
EP0091641B1 (de) N-substituierte Imidazol-Derivate, ihre Herstellung, diese enthaltende Arzneimittel und ihre Verwendung

Legal Events

Date Code Title Description
PL Patent ceased