AT364821B - Verfahren zur herstellung neuer indole, deren saeureadditionssalze und deren isomere - Google Patents

Verfahren zur herstellung neuer indole, deren saeureadditionssalze und deren isomere

Info

Publication number
AT364821B
AT364821B AT0508978A AT508978A AT364821B AT 364821 B AT364821 B AT 364821B AT 0508978 A AT0508978 A AT 0508978A AT 508978 A AT508978 A AT 508978A AT 364821 B AT364821 B AT 364821B
Authority
AT
Austria
Prior art keywords
isomers
acid addition
addition salts
producing new
new indoles
Prior art date
Application number
AT0508978A
Other languages
German (de)
English (en)
Other versions
ATA508978A (de
Original Assignee
Bristol Myers Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Co filed Critical Bristol Myers Co
Publication of ATA508978A publication Critical patent/ATA508978A/de
Application granted granted Critical
Publication of AT364821B publication Critical patent/AT364821B/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Neurology (AREA)
  • Hospice & Palliative Care (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Diabetes (AREA)
  • Neurosurgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
AT0508978A 1977-07-13 1978-07-13 Verfahren zur herstellung neuer indole, deren saeureadditionssalze und deren isomere AT364821B (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US81513877A 1977-07-13 1977-07-13

Publications (2)

Publication Number Publication Date
ATA508978A ATA508978A (de) 1981-04-15
AT364821B true AT364821B (de) 1981-11-25

Family

ID=25216976

Family Applications (1)

Application Number Title Priority Date Filing Date
AT0508978A AT364821B (de) 1977-07-13 1978-07-13 Verfahren zur herstellung neuer indole, deren saeureadditionssalze und deren isomere

Country Status (30)

Country Link
JP (1) JPS5419972A (fi)
AR (1) AR225274A1 (fi)
AT (1) AT364821B (fi)
AU (1) AU525064B2 (fi)
BE (1) BE868943A (fi)
CA (1) CA1116598A (fi)
CH (1) CH642066A5 (fi)
CY (1) CY1274A (fi)
DE (1) DE2830884A1 (fi)
DK (1) DK156568C (fi)
ES (1) ES471674A1 (fi)
FI (1) FI69835C (fi)
FR (1) FR2397404A1 (fi)
GB (1) GB2001633B (fi)
GR (1) GR74488B (fi)
HK (1) HK1385A (fi)
HU (1) HU178992B (fi)
IE (1) IE47122B1 (fi)
IL (1) IL55115A (fi)
IT (1) IT1105091B (fi)
KE (1) KE3485A (fi)
LU (1) LU79966A1 (fi)
MY (1) MY8500946A (fi)
NL (1) NL189946C (fi)
NO (1) NO149311C (fi)
NZ (1) NZ187763A (fi)
SE (1) SE429339B (fi)
SG (1) SG82584G (fi)
YU (1) YU40528B (fi)
ZA (1) ZA783744B (fi)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2463765A1 (fr) * 1979-08-17 1981-02-27 Clin Midy Nouveaux derives de l'indole actifs sur le systeme cardiovasculaire
US4321398A (en) * 1981-05-07 1982-03-23 Mead Johnson & Company Thienyl and benzothienyl-tertiary butylaminophenoxypropanols
DE3119796A1 (de) * 1981-05-19 1982-12-23 Hoechst Ag, 6000 Frankfurt Substituierte tryptaminderivate von thienyloxpropanolaminen, verfahren zu ihrer herstellung, pharmazeutische praeparate auf basis dieser verbindungen sowie ihre verwendung
FR2523964B1 (fr) * 1982-03-23 1985-09-27 Sanofi Sa Nouveaux derives de la tryptamine actifs notamment sur le systeme cardiovasculaire et procede pour leur preparation
NZ208337A (en) * 1983-06-10 1988-10-28 Bristol Myers Co 2-(2-hydroxy-3-((2-(ar-hydroxy-1h-aminopropoxy-yl)ethyl benzonitriles and pharmaceutical compositions
FR2601008B1 (fr) * 1986-07-03 1990-03-30 Sanofi Sa Procede de synthese stereospecifique de derives de l'indole
EP1341759B1 (en) 2000-11-10 2006-06-14 Eli Lilly And Company 3-substituted oxindole beta 3 agonists
EP1444224B1 (en) 2001-08-14 2006-05-03 Eli Lilly And Company 3-substituted oxindole beta-3 agonists
ATE340794T1 (de) 2001-08-14 2006-10-15 Lilly Co Eli Indol derivate als beta-3-adrenerge agonisten zur behandlung von typ 2 diabetes
US7205407B2 (en) 2001-11-20 2007-04-17 Eli Lilly And Company 3-Substituted oxindole β3 agonists
AU2002353844A1 (en) 2001-11-20 2003-06-10 Eli Lilly And Company Beta 3 adrenergic agonists
EP1467733A1 (en) 2002-01-11 2004-10-20 Eli Lilly And Company 2-oxo-benzimidazolyl substituted ethanolamine derivatives and their use as beta3 agonists
CA2960254A1 (en) 2008-08-01 2010-02-04 Arca Biopharma, Inc. Methods and compositions involving (s)-bucindolol

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR1532210A (fr) * 1963-06-21 1968-07-12 Ici Ltd Composés hétérocycliques et leur procédé de préparation
CH495983A (de) * 1968-02-09 1970-09-15 Sandoz Ag Verfahren zur Herstellung von linksdrehendem 4-(2-Hydroxy-3-isopropylaminopropoxy)indol
US3371098A (en) * 1966-11-29 1968-02-27 Philips Corp 5- and 6-methoxy-3-(phenoxyethyl-aminoethyl)-indoles
US3946009A (en) * 1972-05-05 1976-03-23 Merck Sharp & Dohme (I.A.) Corporation 2-(3-Substituted amino-2-hydroxypropoxy)-3-substituted pyrazines

Also Published As

Publication number Publication date
NL189946C (nl) 1993-09-16
IE47122B1 (en) 1983-12-28
FR2397404A1 (fr) 1979-02-09
FI69835C (fi) 1986-05-26
IE781400L (en) 1979-01-13
DK156568C (da) 1990-02-05
FI782205A (fi) 1979-01-14
CH642066A5 (de) 1984-03-30
AR225274A1 (es) 1982-03-15
NZ187763A (en) 1984-07-31
ES471674A1 (es) 1979-10-01
YU40528B (en) 1986-02-28
AU525064B2 (en) 1982-10-21
NO149311C (no) 1984-03-28
NO782407L (no) 1979-01-16
SE7807700L (sv) 1979-01-14
DE2830884C2 (fi) 1990-01-11
KE3485A (en) 1985-01-25
AU3770478A (en) 1980-01-10
IL55115A0 (en) 1978-09-29
DK313878A (da) 1979-01-14
ATA508978A (de) 1981-04-15
DK156568B (da) 1989-09-11
FI69835B (fi) 1985-12-31
ZA783744B (en) 1979-07-25
IT1105091B (it) 1985-10-28
CA1116598A (en) 1982-01-19
NL7807564A (nl) 1979-01-16
LU79966A1 (fr) 1979-04-09
FR2397404B1 (fi) 1982-06-11
IT7850228A0 (it) 1978-07-10
MY8500946A (en) 1985-12-31
GR74488B (fi) 1984-06-28
IL55115A (en) 1981-09-13
HU178992B (en) 1982-07-28
GB2001633A (en) 1979-02-07
NL189946B (nl) 1993-04-16
SG82584G (en) 1985-09-13
YU161178A (en) 1983-02-28
JPS6340784B2 (fi) 1988-08-12
DE2830884A1 (de) 1979-02-01
HK1385A (en) 1985-01-11
SE429339B (sv) 1983-08-29
CY1274A (en) 1985-03-08
JPS5419972A (en) 1979-02-15
BE868943A (fr) 1979-01-12
GB2001633B (en) 1982-03-24
NO149311B (no) 1983-12-19

Similar Documents

Publication Publication Date Title
AT365581B (de) Verfahren zur herstellung neuer 2-benzyl-1,2dihydro-1-oxo-phthalazin-4-ylessigsaeurederivate und deren salze
AT365589B (de) Verfahren zur herstellung neuer 4-hydroxy-2h-1,2benzothiazin-3-carboxamid-1,1-dioxide und deren salze
AT365187B (de) Verfahren zur herstellung neuer 3-(1h-tetrazol-5yl)-hh-pyrido(1,2-a)-pyrimidin-4-one und von derensalzen
ATA936176A (de) Verfahren zur herstellung neuer, basisch substituierter indolderivate und deren saeure- additionssalze
AT364821B (de) Verfahren zur herstellung neuer indole, deren saeureadditionssalze und deren isomere
AT377254B (de) Verfahren zur herstellung neuer substituierter pyrrolidine und deren salzen
AT361929B (de) Verfahren zur herstellung neuer 5,11-dihydro- -6h-pyrido(2,3-b)(1,4) benzodiazepin-6-on- -derivate und ihrer salze
AT380020B (de) Verfahren zur herstellung von d,1-5-methyltetrahydrofols|ureund deren salzen
DD132964A5 (de) Verfahren zur herstellung neuer substituierter 2-phenylamino-imidazoline-(2)und deren saeureadditionssalze
ATA863478A (de) Verfahren zur herstellung neuer 1,4-benzodiazepin-derivate und ihrer salze
AT360028B (de) Verfahren zur herstellung neuer, 5-piperazinyl- substituierter derivate von pyrido-(2.3-b)- -benzothiazepin(1.5) und ihrer salze
AT357517B (de) Verfahren zur herstellung neuer substituierter indole und von deren saeureadditionssalzen
ATA17483A (de) Verfahren zur herstellung neuer 3,3-dialkylund 3,3-alkylen-indolinderivate
AT367022B (de) Verfahren zur herstellung neuer substituierter aethanolamine und deren pharmazeutisch akzeptablen salzen
AT375938B (de) Verfahren zur herstellung von 9-amino-6,7-dihydro-4h-pyrido (1,2-a) pyrimidin-4-on-derivaten, deren physiologisch vertraeglichen salzen, hydraten und isomeren
ATA63479A (de) Verfahren zur herstellung neuer 3,4-dihydro-2h-1,2-benzothiazin-1,1-dioxyde und deren salzen
ATA508376A (de) Verfahren zur herstellung neuer 1-methyl-2- (phenyl-oxymethyl)-5-nitroimidazolderivate
AT369738B (de) Verfahren zur herstellung neuer thiodibenzoxepine und deren saeureadditionssalze
ATA525878A (de) Verfahren zur herstellung neuer indole und von deren salzen
AT357516B (de) Verfahren zur herstellung neuer 2,3-dihydro- benzofuranon-2-derivate
AT351529B (de) Verfahren zur herstellung neuer 1,2,4-triazol- derivate und deren saeureadditionssalzen
ATA39478A (de) Verfahren zur herstellung neuer 3-imino-9,9a- dihydrothiazolo(3,4-a)indolderivate und ihrer salze
AT357519B (de) Verfahren zur herstellung neuer, basisch substituierter indolderivate und deren saeure- additionssalze
AT360040B (de) Verfahren zur herstellung von substituierten orotsaeuren, dihydroorotsaeuren und deren salzen
AT371115B (de) Verfahren zur herstellung neuer 1,2,3,4-tetrahydro-2-piperazinyl-naphthaline und ihrer saeureadditionssalze

Legal Events

Date Code Title Description
ELA Expired due to lapse of time