AT364821B - METHOD FOR PRODUCING NEW INDOLES, THEIR ACID ADDITION SALTS AND THE ISOMERS THEREOF - Google Patents

METHOD FOR PRODUCING NEW INDOLES, THEIR ACID ADDITION SALTS AND THE ISOMERS THEREOF

Info

Publication number
AT364821B
AT364821B AT0508978A AT508978A AT364821B AT 364821 B AT364821 B AT 364821B AT 0508978 A AT0508978 A AT 0508978A AT 508978 A AT508978 A AT 508978A AT 364821 B AT364821 B AT 364821B
Authority
AT
Austria
Prior art keywords
isomers
acid addition
addition salts
producing new
new indoles
Prior art date
Application number
AT0508978A
Other languages
German (de)
Other versions
ATA508978A (en
Original Assignee
Bristol Myers Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Co filed Critical Bristol Myers Co
Publication of ATA508978A publication Critical patent/ATA508978A/en
Application granted granted Critical
Publication of AT364821B publication Critical patent/AT364821B/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Neurology (AREA)
  • Hospice & Palliative Care (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Diabetes (AREA)
  • Neurosurgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
AT0508978A 1977-07-13 1978-07-13 METHOD FOR PRODUCING NEW INDOLES, THEIR ACID ADDITION SALTS AND THE ISOMERS THEREOF AT364821B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US81513877A 1977-07-13 1977-07-13

Publications (2)

Publication Number Publication Date
ATA508978A ATA508978A (en) 1981-04-15
AT364821B true AT364821B (en) 1981-11-25

Family

ID=25216976

Family Applications (1)

Application Number Title Priority Date Filing Date
AT0508978A AT364821B (en) 1977-07-13 1978-07-13 METHOD FOR PRODUCING NEW INDOLES, THEIR ACID ADDITION SALTS AND THE ISOMERS THEREOF

Country Status (30)

Country Link
JP (1) JPS5419972A (en)
AR (1) AR225274A1 (en)
AT (1) AT364821B (en)
AU (1) AU525064B2 (en)
BE (1) BE868943A (en)
CA (1) CA1116598A (en)
CH (1) CH642066A5 (en)
CY (1) CY1274A (en)
DE (1) DE2830884A1 (en)
DK (1) DK156568C (en)
ES (1) ES471674A1 (en)
FI (1) FI69835C (en)
FR (1) FR2397404A1 (en)
GB (1) GB2001633B (en)
GR (1) GR74488B (en)
HK (1) HK1385A (en)
HU (1) HU178992B (en)
IE (1) IE47122B1 (en)
IL (1) IL55115A (en)
IT (1) IT1105091B (en)
KE (1) KE3485A (en)
LU (1) LU79966A1 (en)
MY (1) MY8500946A (en)
NL (1) NL189946C (en)
NO (1) NO149311C (en)
NZ (1) NZ187763A (en)
SE (1) SE429339B (en)
SG (1) SG82584G (en)
YU (1) YU40528B (en)
ZA (1) ZA783744B (en)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2463765A1 (en) * 1979-08-17 1981-02-27 Clin Midy NEW ACTIVE INDOLE DERIVATIVES ON THE CARDIOVASCULAR SYSTEM
US4321398A (en) * 1981-05-07 1982-03-23 Mead Johnson & Company Thienyl and benzothienyl-tertiary butylaminophenoxypropanols
DE3119796A1 (en) * 1981-05-19 1982-12-23 Hoechst Ag, 6000 Frankfurt SUBSTITUTED TRYPTAMINE DERIVATIVES OF THIENYLOX PROPANOLAMINES, METHODS FOR THE PRODUCTION THEREOF, PHARMACEUTICAL PREPARATIONS BASED ON THESE COMPOUNDS AND THEIR USE
FR2523964B1 (en) * 1982-03-23 1985-09-27 Sanofi Sa NOVEL TRYPTAMINE DERIVATIVES ACTIVE IN PARTICULAR ON THE CARDIOVASCULAR SYSTEM AND PROCESS FOR THEIR PREPARATION
NZ208337A (en) * 1983-06-10 1988-10-28 Bristol Myers Co 2-(2-hydroxy-3-((2-(ar-hydroxy-1h-aminopropoxy-yl)ethyl benzonitriles and pharmaceutical compositions
FR2601008B1 (en) * 1986-07-03 1990-03-30 Sanofi Sa PROCESS FOR THE STEREOSPECIFIC SYNTHESIS OF INDOLE DERIVATIVES
JP2004513164A (en) 2000-11-10 2004-04-30 イーライ・リリー・アンド・カンパニー 3-substituted oxindole β3 agonist
WO2003016276A2 (en) 2001-08-14 2003-02-27 Eli Lilly And Company 3-substituted oxindole beta-3 agonists
ATE340794T1 (en) 2001-08-14 2006-10-15 Lilly Co Eli INDOLE DERIVATIVES AS BETA-3 ADRENERGIC AGONISTS FOR THE TREATMENT OF TYPE 2 DIABETES
AU2002353844A1 (en) 2001-11-20 2003-06-10 Eli Lilly And Company Beta 3 adrenergic agonists
US7205407B2 (en) 2001-11-20 2007-04-17 Eli Lilly And Company 3-Substituted oxindole β3 agonists
AU2002357084A1 (en) 2002-01-11 2003-07-30 Eli Lilly And Company 2-oxo-benzimidazolyl substituted ethanolamine derivatives and their use as beta3 agonists
US8946284B2 (en) 2008-08-01 2015-02-03 Arca Biopharma, Inc. Methods and compositions involving (S)-bucindolol

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR1532210A (en) * 1963-06-21 1968-07-12 Ici Ltd Heterocyclic compounds and their preparation process
CH495983A (en) * 1968-02-09 1970-09-15 Sandoz Ag Process for the preparation of levorotatory 4- (2-hydroxy-3-isopropylaminopropoxy) indole
US3371098A (en) * 1966-11-29 1968-02-27 Philips Corp 5- and 6-methoxy-3-(phenoxyethyl-aminoethyl)-indoles
US3946009A (en) * 1972-05-05 1976-03-23 Merck Sharp & Dohme (I.A.) Corporation 2-(3-Substituted amino-2-hydroxypropoxy)-3-substituted pyrazines

Also Published As

Publication number Publication date
YU40528B (en) 1986-02-28
AU3770478A (en) 1980-01-10
NO782407L (en) 1979-01-16
GB2001633B (en) 1982-03-24
FI69835B (en) 1985-12-31
CY1274A (en) 1985-03-08
IT1105091B (en) 1985-10-28
IL55115A (en) 1981-09-13
HU178992B (en) 1982-07-28
AR225274A1 (en) 1982-03-15
DK156568C (en) 1990-02-05
YU161178A (en) 1983-02-28
NZ187763A (en) 1984-07-31
NL7807564A (en) 1979-01-16
FR2397404B1 (en) 1982-06-11
IE781400L (en) 1979-01-13
ZA783744B (en) 1979-07-25
LU79966A1 (en) 1979-04-09
IL55115A0 (en) 1978-09-29
KE3485A (en) 1985-01-25
HK1385A (en) 1985-01-11
SE429339B (en) 1983-08-29
DK156568B (en) 1989-09-11
MY8500946A (en) 1985-12-31
BE868943A (en) 1979-01-12
DE2830884C2 (en) 1990-01-11
DE2830884A1 (en) 1979-02-01
GR74488B (en) 1984-06-28
ATA508978A (en) 1981-04-15
NL189946C (en) 1993-09-16
NO149311C (en) 1984-03-28
NL189946B (en) 1993-04-16
SG82584G (en) 1985-09-13
FI782205A (en) 1979-01-14
DK313878A (en) 1979-01-14
IE47122B1 (en) 1983-12-28
IT7850228A0 (en) 1978-07-10
FI69835C (en) 1986-05-26
CA1116598A (en) 1982-01-19
JPS6340784B2 (en) 1988-08-12
AU525064B2 (en) 1982-10-21
JPS5419972A (en) 1979-02-15
NO149311B (en) 1983-12-19
FR2397404A1 (en) 1979-02-09
GB2001633A (en) 1979-02-07
ES471674A1 (en) 1979-10-01
SE7807700L (en) 1979-01-14
CH642066A5 (en) 1984-03-30

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