FR2397404A1 - NEW 3-INDOLYL-TERTIOBUTYLAMINOPROPANOLS AND MEDICINAL PRODUCTS CONTAINING THEM - Google Patents

NEW 3-INDOLYL-TERTIOBUTYLAMINOPROPANOLS AND MEDICINAL PRODUCTS CONTAINING THEM

Info

Publication number
FR2397404A1
FR2397404A1 FR7820851A FR7820851A FR2397404A1 FR 2397404 A1 FR2397404 A1 FR 2397404A1 FR 7820851 A FR7820851 A FR 7820851A FR 7820851 A FR7820851 A FR 7820851A FR 2397404 A1 FR2397404 A1 FR 2397404A1
Authority
FR
France
Prior art keywords
indolyl
tertiobutylaminopropanols
new
compounds
products containing
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR7820851A
Other languages
French (fr)
Other versions
FR2397404B1 (en
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bristol Myers Co
Original Assignee
Bristol Myers Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Co filed Critical Bristol Myers Co
Publication of FR2397404A1 publication Critical patent/FR2397404A1/en
Application granted granted Critical
Publication of FR2397404B1 publication Critical patent/FR2397404B1/fr
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hospice & Palliative Care (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Indole Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)

Abstract

L'invention a trait à la chimie des médicaments. Elle concerne de nouveaux 3-indolyl-tertiobutyl-aminopropanols, notamment des 1-phénoxy-3-Ø3-indolyl)-tertiobutylõ-amino-2-propanols et les composés 1-aryloxy apparentés. Les composés de l'invention sont des agents antihypertensifs doués d'activité vasodilatatrice et d'activité de bocage des récepteurs B-adrénergiques. On apprécie notamment les compos qui portent un substituant en ortho dans le groupe phénoxy, notamment un substituant méthyle.The invention relates to the chemistry of drugs. It relates to novel 3-indolyl-tertiobutyl-aminopropanols, in particular 1-phenoxy-3-Ø3-indolyl) -tertiobutylõ-amino-2-propanols and related 1-aryloxy compounds. The compounds of the invention are antihypertensive agents endowed with vasodilator activity and B-adrenergic receptor bocage activity. Especially preferred are compounds which bear a substituent in ortho in the phenoxy group, in particular a methyl substituent.

FR7820851A 1977-07-13 1978-07-12 NEW 3-INDOLYL-TERTIOBUTYLAMINOPROPANOLS AND MEDICINAL PRODUCTS CONTAINING THEM Granted FR2397404A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US81513877A 1977-07-13 1977-07-13

Publications (2)

Publication Number Publication Date
FR2397404A1 true FR2397404A1 (en) 1979-02-09
FR2397404B1 FR2397404B1 (en) 1982-06-11

Family

ID=25216976

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7820851A Granted FR2397404A1 (en) 1977-07-13 1978-07-12 NEW 3-INDOLYL-TERTIOBUTYLAMINOPROPANOLS AND MEDICINAL PRODUCTS CONTAINING THEM

Country Status (30)

Country Link
JP (1) JPS5419972A (en)
AR (1) AR225274A1 (en)
AT (1) AT364821B (en)
AU (1) AU525064B2 (en)
BE (1) BE868943A (en)
CA (1) CA1116598A (en)
CH (1) CH642066A5 (en)
CY (1) CY1274A (en)
DE (1) DE2830884A1 (en)
DK (1) DK156568C (en)
ES (1) ES471674A1 (en)
FI (1) FI69835C (en)
FR (1) FR2397404A1 (en)
GB (1) GB2001633B (en)
GR (1) GR74488B (en)
HK (1) HK1385A (en)
HU (1) HU178992B (en)
IE (1) IE47122B1 (en)
IL (1) IL55115A (en)
IT (1) IT1105091B (en)
KE (1) KE3485A (en)
LU (1) LU79966A1 (en)
MY (1) MY8500946A (en)
NL (1) NL189946C (en)
NO (1) NO149311C (en)
NZ (1) NZ187763A (en)
SE (1) SE429339B (en)
SG (1) SG82584G (en)
YU (1) YU40528B (en)
ZA (1) ZA783744B (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2505337A1 (en) * 1981-05-07 1982-11-12 Bristol Myers Co NOVEL THIENYL- AND BENZOTHIENYL-TERT-BUTYLAMINOPHENOXYPROPANOLS USEFUL AS SELECTIVE B-BLOCKING DRUGS

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2463765A1 (en) * 1979-08-17 1981-02-27 Clin Midy NEW ACTIVE INDOLE DERIVATIVES ON THE CARDIOVASCULAR SYSTEM
DE3119796A1 (en) * 1981-05-19 1982-12-23 Hoechst Ag, 6000 Frankfurt SUBSTITUTED TRYPTAMINE DERIVATIVES OF THIENYLOX PROPANOLAMINES, METHODS FOR THE PRODUCTION THEREOF, PHARMACEUTICAL PREPARATIONS BASED ON THESE COMPOUNDS AND THEIR USE
FR2523964B1 (en) * 1982-03-23 1985-09-27 Sanofi Sa NOVEL TRYPTAMINE DERIVATIVES ACTIVE IN PARTICULAR ON THE CARDIOVASCULAR SYSTEM AND PROCESS FOR THEIR PREPARATION
NZ208337A (en) * 1983-06-10 1988-10-28 Bristol Myers Co 2-(2-hydroxy-3-((2-(ar-hydroxy-1h-aminopropoxy-yl)ethyl benzonitriles and pharmaceutical compositions
FR2601008B1 (en) * 1986-07-03 1990-03-30 Sanofi Sa PROCESS FOR THE STEREOSPECIFIC SYNTHESIS OF INDOLE DERIVATIVES
ATE329901T1 (en) 2000-11-10 2006-07-15 Lilly Co Eli 3-SUBSTITUTED OXINDOL DERIVATIVES AS BETA-3 AGONISTS
ATE325119T1 (en) 2001-08-14 2006-06-15 Lilly Co Eli 3-SUBSTITUTED OXINDOLE BETA-3 AGONISTS
ES2272749T3 (en) * 2001-08-14 2007-05-01 Eli Lilly And Company DERIVATIVES OF INDOL AS BETA-3 ADRENERGIC AGONISTS FOR THE TREATMENT OF TYPE 2 DIABETES.
JP2005514366A (en) 2001-11-20 2005-05-19 イーライ・リリー・アンド・カンパニー 3-Substituted oxindole β3 agonist
EP1448561B1 (en) 2001-11-20 2008-02-20 Eli Lilly And Company Beta 3 adrenergic agonists
AU2002357084A1 (en) 2002-01-11 2003-07-30 Eli Lilly And Company 2-oxo-benzimidazolyl substituted ethanolamine derivatives and their use as beta3 agonists
WO2010014263A1 (en) * 2008-08-01 2010-02-04 Arca Discovery, Inc. Methods and compositions involving (s)-bucindolol

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3371098A (en) * 1966-11-29 1968-02-27 Philips Corp 5- and 6-methoxy-3-(phenoxyethyl-aminoethyl)-indoles
FR1532210A (en) * 1963-06-21 1968-07-12 Ici Ltd Heterocyclic compounds and their preparation process

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH495983A (en) * 1968-02-09 1970-09-15 Sandoz Ag Process for the preparation of levorotatory 4- (2-hydroxy-3-isopropylaminopropoxy) indole
US3946009A (en) * 1972-05-05 1976-03-23 Merck Sharp & Dohme (I.A.) Corporation 2-(3-Substituted amino-2-hydroxypropoxy)-3-substituted pyrazines

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR1532210A (en) * 1963-06-21 1968-07-12 Ici Ltd Heterocyclic compounds and their preparation process
US3371098A (en) * 1966-11-29 1968-02-27 Philips Corp 5- and 6-methoxy-3-(phenoxyethyl-aminoethyl)-indoles

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2505337A1 (en) * 1981-05-07 1982-11-12 Bristol Myers Co NOVEL THIENYL- AND BENZOTHIENYL-TERT-BUTYLAMINOPHENOXYPROPANOLS USEFUL AS SELECTIVE B-BLOCKING DRUGS

Also Published As

Publication number Publication date
DK156568C (en) 1990-02-05
AU525064B2 (en) 1982-10-21
CY1274A (en) 1985-03-08
ES471674A1 (en) 1979-10-01
NO782407L (en) 1979-01-16
FI69835C (en) 1986-05-26
GR74488B (en) 1984-06-28
HU178992B (en) 1982-07-28
NL189946C (en) 1993-09-16
JPS6340784B2 (en) 1988-08-12
HK1385A (en) 1985-01-11
IT1105091B (en) 1985-10-28
FI69835B (en) 1985-12-31
SE7807700L (en) 1979-01-14
IL55115A (en) 1981-09-13
DE2830884A1 (en) 1979-02-01
NO149311B (en) 1983-12-19
YU161178A (en) 1983-02-28
ATA508978A (en) 1981-04-15
NL189946B (en) 1993-04-16
SG82584G (en) 1985-09-13
IL55115A0 (en) 1978-09-29
JPS5419972A (en) 1979-02-15
ZA783744B (en) 1979-07-25
DK313878A (en) 1979-01-14
CA1116598A (en) 1982-01-19
BE868943A (en) 1979-01-12
MY8500946A (en) 1985-12-31
NZ187763A (en) 1984-07-31
IT7850228A0 (en) 1978-07-10
GB2001633B (en) 1982-03-24
IE47122B1 (en) 1983-12-28
DE2830884C2 (en) 1990-01-11
KE3485A (en) 1985-01-25
FR2397404B1 (en) 1982-06-11
CH642066A5 (en) 1984-03-30
SE429339B (en) 1983-08-29
AU3770478A (en) 1980-01-10
YU40528B (en) 1986-02-28
FI782205A (en) 1979-01-14
AR225274A1 (en) 1982-03-15
NL7807564A (en) 1979-01-16
IE781400L (en) 1979-01-13
DK156568B (en) 1989-09-11
LU79966A1 (en) 1979-04-09
NO149311C (en) 1984-03-28
GB2001633A (en) 1979-02-07
AT364821B (en) 1981-11-25

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