CH641804A5 - Antibiotische neplanocine. - Google Patents
Antibiotische neplanocine. Download PDFInfo
- Publication number
- CH641804A5 CH641804A5 CH490879A CH490879A CH641804A5 CH 641804 A5 CH641804 A5 CH 641804A5 CH 490879 A CH490879 A CH 490879A CH 490879 A CH490879 A CH 490879A CH 641804 A5 CH641804 A5 CH 641804A5
- Authority
- CH
- Switzerland
- Prior art keywords
- neplanocin
- formula
- water
- group
- liters
- Prior art date
Links
- 230000003115 biocidal effect Effects 0.000 title claims description 10
- ZOGIBYIZRGKFQR-VDAHYXPESA-N 9-[(1r,4r,5s)-4,5-dihydroxy-3-(hydroxymethyl)cyclopent-2-en-1-yl]-3h-purin-6-one Chemical compound O[C@@H]1[C@H](O)C(CO)=C[C@H]1N1C(NC=NC2=O)=C2N=C1 ZOGIBYIZRGKFQR-VDAHYXPESA-N 0.000 claims description 61
- XUGWUUDOWNZAGW-VDAHYXPESA-N (1s,2r,5r)-5-(6-aminopurin-9-yl)-3-(hydroxymethyl)cyclopent-3-ene-1,2-diol Chemical compound C1=NC=2C(N)=NC=NC=2N1[C@@H]1C=C(CO)[C@@H](O)[C@H]1O XUGWUUDOWNZAGW-VDAHYXPESA-N 0.000 claims description 30
- XUGWUUDOWNZAGW-UHFFFAOYSA-N neplanocin A Natural products C1=NC=2C(N)=NC=NC=2N1C1C=C(CO)C(O)C1O XUGWUUDOWNZAGW-UHFFFAOYSA-N 0.000 claims description 30
- ZOGIBYIZRGKFQR-UHFFFAOYSA-N Neplanocin D Natural products OC1C(O)C(CO)=CC1N1C(NC=NC2=O)=C2N=C1 ZOGIBYIZRGKFQR-UHFFFAOYSA-N 0.000 claims description 22
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims description 21
- 239000000126 substance Substances 0.000 claims description 18
- 150000001875 compounds Chemical class 0.000 claims description 17
- KFVDGQIFGNKMLJ-WELJQELGSA-N (1r,2r,3s,4s,5s)-3-(6-aminopurin-9-yl)-1-(hydroxymethyl)-6-oxabicyclo[3.1.0]hexane-2,4-diol Chemical compound NC1=NC=NC2=C1N=CN2[C@@H]1[C@@H](O)[C@@]2(CO)O[C@H]2[C@H]1O KFVDGQIFGNKMLJ-WELJQELGSA-N 0.000 claims description 15
- UTCNWBUUZPUVLH-GBSPZJCNSA-N (1s,2s,3s,4s,5r)-4-(6-aminopurin-9-yl)-1-(hydroxymethyl)-6-oxabicyclo[3.1.0]hexane-2,3-diol Chemical compound NC1=NC=NC2=C1N=CN2[C@H]1[C@H](O)[C@H](O)[C@]2(CO)O[C@@H]21 UTCNWBUUZPUVLH-GBSPZJCNSA-N 0.000 claims description 15
- 229930182507 Neplanocin Natural products 0.000 claims description 15
- KFVDGQIFGNKMLJ-UHFFFAOYSA-N Neplanocin B Natural products NC1=NC=NC2=C1N=CN2C1C(O)C2(CO)OC2C1O KFVDGQIFGNKMLJ-UHFFFAOYSA-N 0.000 claims description 15
- UTCNWBUUZPUVLH-UHFFFAOYSA-N Neplanocin C Natural products NC1=NC=NC2=C1N=CN2C1C(O)C(O)C2(CO)OC21 UTCNWBUUZPUVLH-UHFFFAOYSA-N 0.000 claims description 15
- QTTPSWNJDDVBIP-YEPSODPASA-N (1r,2s,3s)-2-(6-aminopurin-9-yl)-4-(hydroxymethyl)cyclopent-4-ene-1,3-diol Chemical compound C1=NC=2C(N)=NC=NC=2N1[C@H]1[C@H](O)C=C(CO)[C@@H]1O QTTPSWNJDDVBIP-YEPSODPASA-N 0.000 claims description 12
- OLQGNBWDUALSOQ-UHFFFAOYSA-N Neplanocin F Natural products Nc1ncnc2c1ncn2C3CC(=C(CO)C3O)O OLQGNBWDUALSOQ-UHFFFAOYSA-N 0.000 claims description 12
- 244000005700 microbiome Species 0.000 claims description 9
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- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims description 7
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims description 6
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/16—Purine radicals
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
- C12N1/20—Bacteria; Culture media therefor
- C12N1/205—Bacterial isolates
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P19/00—Preparation of compounds containing saccharide radicals
- C12P19/26—Preparation of nitrogen-containing carbohydrates
- C12P19/28—N-glycosides
- C12P19/38—Nucleosides
- C12P19/40—Nucleosides having a condensed ring system containing a six-membered ring having two nitrogen atoms in the same ring, e.g. purine nucleosides
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
- C12R2001/00—Microorganisms ; Processes using microorganisms
- C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Health & Medical Sciences (AREA)
- Wood Science & Technology (AREA)
- Biotechnology (AREA)
- Genetics & Genomics (AREA)
- Zoology (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- General Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Virology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Medicinal Chemistry (AREA)
- Biomedical Technology (AREA)
- General Chemical & Material Sciences (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Compounds Of Unknown Constitution (AREA)
- Saccharide Compounds (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP6289978A JPS54154792A (en) | 1978-05-25 | 1978-05-25 | Novel antibiotic a-11079-b1b and its preparation |
| JP9802778A JPS5524157A (en) | 1978-08-10 | 1978-08-10 | Novel antibiotic substance a-11079-b2 and its preparation |
| JP820579A JPS55100388A (en) | 1979-01-29 | 1979-01-29 | Novel substance neplanocin d and its derivative |
| JP2120179A JPS55113786A (en) | 1979-02-23 | 1979-02-23 | Novel substance, nepranosin b or f and its preparation |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CH641804A5 true CH641804A5 (de) | 1984-03-15 |
Family
ID=27454901
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CH490879A CH641804A5 (de) | 1978-05-25 | 1979-05-25 | Antibiotische neplanocine. |
Country Status (13)
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3148363A1 (de) * | 1980-12-12 | 1982-09-16 | Toyo Jozo K.K., Shizuoka | Neplanocin a-derivate |
| US4742064A (en) * | 1985-09-10 | 1988-05-03 | Regents Of The University Of Minnesota | Antiviral carbocyclic analogs of xylofuranosylpurines |
| ZA894534B (en) * | 1988-06-20 | 1990-03-28 | Merrell Dow Pharma | Novel neplanocin derivatives |
| US5059690A (en) * | 1990-03-01 | 1991-10-22 | E. R. Squibb & Sons, Inc. | Purinyl tetrahydrofurans |
| US5164520A (en) * | 1989-04-24 | 1992-11-17 | E. R. Squibb & Sons, Inc. | Intermediates for purinyl and pyrimidinyl tetrahydrofurans |
| US5145960A (en) * | 1989-04-24 | 1992-09-08 | E. R. Squibb & Sons, Inc. | Pyrimidinyl tetrahydrofurans |
| NZ232993A (en) * | 1989-04-24 | 1992-10-28 | Squibb & Sons Inc | Purinyl and pyrimidinyl tetrahydrofurans |
-
1979
- 1979-04-12 HU HU79TO1102A patent/HU192741B/hu unknown
- 1979-04-26 NL NLAANVRAGE7903318,A patent/NL182231C/xx not_active IP Right Cessation
- 1979-04-26 DE DE2917000A patent/DE2917000C2/de not_active Expired
- 1979-04-26 DE DE2954197A patent/DE2954197C2/de not_active Expired - Lifetime
- 1979-04-26 SE SE7903672A patent/SE443576B/sv not_active IP Right Cessation
- 1979-04-30 DK DK177079A patent/DK149313C/da not_active IP Right Cessation
- 1979-05-08 FR FR7911578A patent/FR2426688A1/fr active Granted
- 1979-05-09 ES ES480384A patent/ES480384A1/es not_active Expired
- 1979-05-17 SU SU792763801A patent/SU906388A3/ru active
- 1979-05-18 GB GB7917481A patent/GB2021582B/en not_active Expired
- 1979-05-23 MX MX797996U patent/MX5788E/es unknown
- 1979-05-23 CA CA328,113A patent/CA1128882A/en not_active Expired
- 1979-05-24 IT IT7922957A patent/IT1115245B/it active
- 1979-05-25 CH CH490879A patent/CH641804A5/de not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| DE2954197C2 (enrdf_load_stackoverflow) | 1990-09-27 |
| SE443576B (sv) | 1986-03-03 |
| DE2917000A1 (de) | 1979-11-29 |
| IT7922957A0 (it) | 1979-05-24 |
| NL7903318A (nl) | 1979-11-27 |
| DK177079A (da) | 1979-11-26 |
| GB2021582A (en) | 1979-12-05 |
| FR2426688A1 (fr) | 1979-12-21 |
| CA1128882A (en) | 1982-08-03 |
| DE2917000C2 (de) | 1985-10-03 |
| GB2021582B (en) | 1982-10-20 |
| DK149313C (da) | 1986-10-20 |
| IT1115245B (it) | 1986-02-03 |
| NL182231C (nl) | 1988-02-01 |
| SE7903672L (sv) | 1979-11-26 |
| ES480384A1 (es) | 1980-04-01 |
| FR2426688B1 (enrdf_load_stackoverflow) | 1982-03-12 |
| DK149313B (da) | 1986-04-28 |
| HU192741B (en) | 1987-07-28 |
| NL182231B (nl) | 1987-09-01 |
| SU906388A3 (ru) | 1982-02-15 |
| MX5788E (es) | 1984-07-11 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PL | Patent ceased | ||
| PL | Patent ceased |