GB2021582A - New antibiotics - Google Patents

New antibiotics

Info

Publication number
GB2021582A
GB2021582A GB7917481A GB7917481A GB2021582A GB 2021582 A GB2021582 A GB 2021582A GB 7917481 A GB7917481 A GB 7917481A GB 7917481 A GB7917481 A GB 7917481A GB 2021582 A GB2021582 A GB 2021582A
Authority
GB
United Kingdom
Prior art keywords
group
image
hydrogen atom
present
new antibiotics
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
GB7917481A
Other versions
GB2021582B (en
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Toyo Jozo KK
Original Assignee
Toyo Jozo KK
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from JP6289978A external-priority patent/JPS54154792A/en
Priority claimed from JP9802778A external-priority patent/JPS5524157A/en
Priority claimed from JP820579A external-priority patent/JPS55100388A/en
Priority claimed from JP2120179A external-priority patent/JPS55113786A/en
Application filed by Toyo Jozo KK filed Critical Toyo Jozo KK
Publication of GB2021582A publication Critical patent/GB2021582A/en
Application granted granted Critical
Publication of GB2021582B publication Critical patent/GB2021582B/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • C12N1/205—Bacterial isolates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/26—Preparation of nitrogen-containing carbohydrates
    • C12P19/28—N-glycosides
    • C12P19/38—Nucleosides
    • C12P19/40—Nucleosides having a condensed ring system containing a six-membered ring having two nitrogen atoms in the same ring, e.g. purine nucleosides
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
    • C12R2001/00—Microorganisms ; Processes using microorganisms
    • C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • General Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Virology (AREA)
  • Biomedical Technology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Compounds Of Unknown Constitution (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Saccharide Compounds (AREA)

Abstract

The present invention provides antibiotic neplanocins of the general formula:- <IMAGE> wherein X is an NH2, -OH, -SH or -SCH3 group or a chlorine atom, R is a hydrogen atom or a protective group for the -OH group, and Z is a <IMAGE> group, in which Y is -O- or a valency bond and R is a hydrogen atom or a protective group for the -OH group, or Z is a group in which Y is -O- or a valency bond, and the physiologically- acceptable salts thereof. The present invention also provides processes for the production of these antibiotics and pharmaceutical compositions containing them.
GB7917481A 1978-05-25 1979-05-18 Antibiotics Expired GB2021582B (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
JP6289978A JPS54154792A (en) 1978-05-25 1978-05-25 Novel antibiotic a-11079-b1b and its preparation
JP9802778A JPS5524157A (en) 1978-08-10 1978-08-10 Novel antibiotic substance a-11079-b2 and its preparation
JP820579A JPS55100388A (en) 1979-01-29 1979-01-29 Novel substance neplanocin d and its derivative
JP2120179A JPS55113786A (en) 1979-02-23 1979-02-23 Novel substance, nepranosin b or f and its preparation

Publications (2)

Publication Number Publication Date
GB2021582A true GB2021582A (en) 1979-12-05
GB2021582B GB2021582B (en) 1982-10-20

Family

ID=27454901

Family Applications (1)

Application Number Title Priority Date Filing Date
GB7917481A Expired GB2021582B (en) 1978-05-25 1979-05-18 Antibiotics

Country Status (13)

Country Link
CA (1) CA1128882A (en)
CH (1) CH641804A5 (en)
DE (2) DE2954197C2 (en)
DK (1) DK149313C (en)
ES (1) ES480384A1 (en)
FR (1) FR2426688A1 (en)
GB (1) GB2021582B (en)
HU (1) HU192741B (en)
IT (1) IT1115245B (en)
MX (1) MX5788E (en)
NL (1) NL182231C (en)
SE (1) SE443576B (en)
SU (1) SU906388A3 (en)

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2500838A1 (en) * 1980-12-12 1982-09-03 Toyo Jozo Kk DERIVATIVES OF NEPLANOCIN A
EP0347852A2 (en) * 1988-06-20 1989-12-27 Merrell Dow Pharmaceuticals Inc. Novel neplanocin derivatives
EP0394893A2 (en) * 1989-04-24 1990-10-31 E.R. SQUIBB &amp; SONS, INC. Purinyl and pyrimidinyl tetrahydrofurans
US5059690A (en) * 1990-03-01 1991-10-22 E. R. Squibb & Sons, Inc. Purinyl tetrahydrofurans
US5145960A (en) * 1989-04-24 1992-09-08 E. R. Squibb & Sons, Inc. Pyrimidinyl tetrahydrofurans
US5164520A (en) * 1989-04-24 1992-11-17 E. R. Squibb & Sons, Inc. Intermediates for purinyl and pyrimidinyl tetrahydrofurans

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4742064A (en) * 1985-09-10 1988-05-03 Regents Of The University Of Minnesota Antiviral carbocyclic analogs of xylofuranosylpurines

Cited By (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2500838A1 (en) * 1980-12-12 1982-09-03 Toyo Jozo Kk DERIVATIVES OF NEPLANOCIN A
EP0347852A2 (en) * 1988-06-20 1989-12-27 Merrell Dow Pharmaceuticals Inc. Novel neplanocin derivatives
EP0347852A3 (en) * 1988-06-20 1991-09-11 Merrell Dow Pharmaceuticals Inc. Novel neplanocin derivatives
EP0394893A2 (en) * 1989-04-24 1990-10-31 E.R. SQUIBB &amp; SONS, INC. Purinyl and pyrimidinyl tetrahydrofurans
EP0394893A3 (en) * 1989-04-24 1991-05-15 E.R. SQUIBB &amp; SONS, INC. Purinyl and pyrimidinyl tetrahydrofurans
US5145960A (en) * 1989-04-24 1992-09-08 E. R. Squibb & Sons, Inc. Pyrimidinyl tetrahydrofurans
US5164520A (en) * 1989-04-24 1992-11-17 E. R. Squibb & Sons, Inc. Intermediates for purinyl and pyrimidinyl tetrahydrofurans
US5059690A (en) * 1990-03-01 1991-10-22 E. R. Squibb & Sons, Inc. Purinyl tetrahydrofurans

Also Published As

Publication number Publication date
SE7903672L (en) 1979-11-26
MX5788E (en) 1984-07-11
DK177079A (en) 1979-11-26
GB2021582B (en) 1982-10-20
CH641804A5 (en) 1984-03-15
DK149313C (en) 1986-10-20
DK149313B (en) 1986-04-28
CA1128882A (en) 1982-08-03
FR2426688A1 (en) 1979-12-21
IT7922957A0 (en) 1979-05-24
IT1115245B (en) 1986-02-03
DE2917000C2 (en) 1985-10-03
SU906388A3 (en) 1982-02-15
DE2954197C2 (en) 1990-09-27
SE443576B (en) 1986-03-03
ES480384A1 (en) 1980-04-01
FR2426688B1 (en) 1982-03-12
NL7903318A (en) 1979-11-27
DE2917000A1 (en) 1979-11-29
NL182231C (en) 1988-02-01
HU192741B (en) 1987-07-28
NL182231B (en) 1987-09-01

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Legal Events

Date Code Title Description
732 Registration of transactions, instruments or events in the register (sect. 32/1977)
PCNP Patent ceased through non-payment of renewal fee

Effective date: 19960518