CH639843A5 - Procede pour la fabrication en serie de comprimes a usage medical et appareil pour sa mise en oeuvre. - Google Patents
Procede pour la fabrication en serie de comprimes a usage medical et appareil pour sa mise en oeuvre. Download PDFInfo
- Publication number
- CH639843A5 CH639843A5 CH518080A CH518080A CH639843A5 CH 639843 A5 CH639843 A5 CH 639843A5 CH 518080 A CH518080 A CH 518080A CH 518080 A CH518080 A CH 518080A CH 639843 A5 CH639843 A5 CH 639843A5
- Authority
- CH
- Switzerland
- Prior art keywords
- lubricant
- punches
- tablets
- point
- cavity
- Prior art date
Links
- 238000000034 method Methods 0.000 title claims description 15
- 238000004519 manufacturing process Methods 0.000 title claims description 9
- 239000000314 lubricant Substances 0.000 claims description 60
- 239000003826 tablet Substances 0.000 claims description 49
- 238000002347 injection Methods 0.000 claims description 16
- 239000007924 injection Substances 0.000 claims description 16
- 230000006835 compression Effects 0.000 claims description 9
- 238000007906 compression Methods 0.000 claims description 9
- 239000011159 matrix material Substances 0.000 claims description 8
- 239000007932 molded tablet Substances 0.000 claims description 5
- 239000000428 dust Substances 0.000 claims description 4
- 239000000463 material Substances 0.000 claims description 3
- 230000000630 rising effect Effects 0.000 claims 1
- 239000000843 powder Substances 0.000 description 13
- HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 description 10
- 239000000203 mixture Substances 0.000 description 10
- 238000000465 moulding Methods 0.000 description 7
- CJZGTCYPCWQAJB-UHFFFAOYSA-L calcium stearate Chemical compound [Ca+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O CJZGTCYPCWQAJB-UHFFFAOYSA-L 0.000 description 5
- 239000008116 calcium stearate Substances 0.000 description 5
- 235000013539 calcium stearate Nutrition 0.000 description 5
- 235000019359 magnesium stearate Nutrition 0.000 description 5
- 239000002245 particle Substances 0.000 description 5
- 230000008021 deposition Effects 0.000 description 3
- 239000008187 granular material Substances 0.000 description 3
- 238000005507 spraying Methods 0.000 description 3
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 description 2
- GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 description 2
- 229920000168 Microcrystalline cellulose Polymers 0.000 description 2
- 239000003814 drug Substances 0.000 description 2
- 239000008101 lactose Substances 0.000 description 2
- 235000019813 microcrystalline cellulose Nutrition 0.000 description 2
- 239000008108 microcrystalline cellulose Substances 0.000 description 2
- 229940016286 microcrystalline cellulose Drugs 0.000 description 2
- BSYNRYMUTXBXSQ-UHFFFAOYSA-N Aspirin Chemical compound CC(=O)OC1=CC=CC=C1C(O)=O BSYNRYMUTXBXSQ-UHFFFAOYSA-N 0.000 description 1
- 239000002211 L-ascorbic acid Substances 0.000 description 1
- 235000000069 L-ascorbic acid Nutrition 0.000 description 1
- FYYHWMGAXLPEAU-UHFFFAOYSA-N Magnesium Chemical compound [Mg] FYYHWMGAXLPEAU-UHFFFAOYSA-N 0.000 description 1
- 229920002472 Starch Polymers 0.000 description 1
- 238000009825 accumulation Methods 0.000 description 1
- 229960001138 acetylsalicylic acid Drugs 0.000 description 1
- MANKSFVECICGLK-UHFFFAOYSA-K aloxiprin Chemical compound [OH-].[Al+3].CC(=O)OC1=CC=CC=C1C([O-])=O.CC(=O)OC1=CC=CC=C1C([O-])=O MANKSFVECICGLK-UHFFFAOYSA-K 0.000 description 1
- 229940024544 aluminum aspirin Drugs 0.000 description 1
- 229960005070 ascorbic acid Drugs 0.000 description 1
- 238000007664 blowing Methods 0.000 description 1
- 239000007891 compressed tablet Substances 0.000 description 1
- 238000010276 construction Methods 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- 238000004090 dissolution Methods 0.000 description 1
- 239000012530 fluid Substances 0.000 description 1
- 210000004051 gastric juice Anatomy 0.000 description 1
- 238000010030 laminating Methods 0.000 description 1
- 238000003475 lamination Methods 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 229910052749 magnesium Inorganic materials 0.000 description 1
- 239000011777 magnesium Substances 0.000 description 1
- QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 description 1
- 238000005192 partition Methods 0.000 description 1
- 238000003825 pressing Methods 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 239000008107 starch Substances 0.000 description 1
- 235000019698 starch Nutrition 0.000 description 1
- 239000000454 talc Substances 0.000 description 1
- 229910052623 talc Inorganic materials 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B30—PRESSES
- B30B—PRESSES IN GENERAL
- B30B15/00—Details of, or accessories for, presses; Auxiliary measures in connection with pressing
- B30B15/0005—Details of, or accessories for, presses; Auxiliary measures in connection with pressing for briquetting presses
- B30B15/0011—Details of, or accessories for, presses; Auxiliary measures in connection with pressing for briquetting presses lubricating means
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B30—PRESSES
- B30B—PRESSES IN GENERAL
- B30B11/00—Presses specially adapted for forming shaped articles from material in particulate or plastic state, e.g. briquetting presses, tabletting presses
- B30B11/005—Control arrangements
Landscapes
- Engineering & Computer Science (AREA)
- Mechanical Engineering (AREA)
- Medicinal Preparation (AREA)
- Medical Preparation Storing Or Oral Administration Devices (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP8940779A JPS5614098A (en) | 1979-07-13 | 1979-07-13 | Externally lubricating tablet making machine |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CH639843A5 true CH639843A5 (fr) | 1983-12-15 |
Family
ID=13969782
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CH518080A CH639843A5 (fr) | 1979-07-13 | 1980-07-07 | Procede pour la fabrication en serie de comprimes a usage medical et appareil pour sa mise en oeuvre. |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US4373888A (enExample) |
| JP (1) | JPS5614098A (enExample) |
| CH (1) | CH639843A5 (enExample) |
| DE (1) | DE3026058A1 (enExample) |
| FR (1) | FR2460662B1 (enExample) |
| GB (1) | GB2053787B (enExample) |
| IT (1) | IT1141602B (enExample) |
Families Citing this family (41)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3131402A1 (de) * | 1981-08-07 | 1983-02-24 | Kilian & Co GmbH, 5000 Köln | Verfahren und tablettenpresse zum aufeinanderfolgenden herstellen einer vielzahl von tabletten mit gleichem gewicht |
| FR2575406B1 (fr) * | 1984-12-28 | 1987-04-10 | Pont A Mousson | Machine pour la fabrication de bouteilles en matiere plastique avec mise en place de coupelles stabilisatrices et pressurisation interne au moyen d'un gaz |
| DE3520203A1 (de) * | 1985-06-05 | 1986-12-11 | Wilhelm Fette Gmbh, 2053 Schwarzenbek | Rundlaeufer-tablettiermaschine und verfahren zur steuerung ihrer druckrollen |
| GB8530365D0 (en) * | 1985-12-10 | 1986-01-22 | Univ Bath | Manufacture of moulded products |
| JPS6410857U (enExample) * | 1987-07-07 | 1989-01-20 | ||
| DE3930127A1 (de) * | 1989-09-09 | 1991-03-21 | Fette Wilhelm Gmbh | Rundlauf-tablettiermaschine |
| US5158728A (en) * | 1991-04-12 | 1992-10-27 | Elizabeth-Hata International, Inc. | Multi-layer medicinal tablet forming machine and method for using the same |
| JP2681601B2 (ja) * | 1993-11-01 | 1997-11-26 | 協和醗酵工業株式会社 | 外部滑沢式打錠機 |
| DE4412117A1 (de) * | 1994-04-08 | 1995-10-12 | Fette Wilhelm Gmbh | Verfahren und Vorrichtung zum Aufbringen von pulverförmigem Schmier- oder Trennmittel auf die Preßwerkzeuge in Tablettiermaschinen |
| US5838571A (en) * | 1996-01-29 | 1998-11-17 | Alza Corporation | Tablet press monitoring and controlling method and apparatus |
| PT914818E (pt) * | 1996-06-14 | 2005-08-31 | Kyowa Hakko Kogyo Kk | Comprimido de desintegracao rapida por via intraoral |
| US8071128B2 (en) | 1996-06-14 | 2011-12-06 | Kyowa Hakko Kirin Co., Ltd. | Intrabuccally rapidly disintegrating tablet and a production method of the tablets |
| DE19647089A1 (de) * | 1996-11-14 | 1998-05-28 | Bayer Ag | Vorrichtung zum kontrollierten Aufsprühen von pulverförmigen Schmiermitteln auf Stempel und Matrizen von Tablettenpressen |
| JPH11169437A (ja) | 1997-12-03 | 1999-06-29 | Kyowa Hakko Kogyo Co Ltd | 錠剤の製造方法 |
| WO1999052491A1 (en) | 1998-04-08 | 1999-10-21 | Kyowa Hakko Kogyo Co., Ltd. | Tablet manufacturing method and tablet |
| AU764325B2 (en) | 1998-04-10 | 2003-08-14 | Kyowa Hakko Kirin Co., Ltd. | Tablet manufacturing methods and tablet |
| PT1121103E (pt) | 1998-05-18 | 2007-02-28 | Takeda Pharmaceutical | Comprimidos de desintegração oral compreendendo um benzimidazole |
| JP3983476B2 (ja) * | 1998-10-13 | 2007-09-26 | 協和醗酵工業株式会社 | 粉体材料の塗布方法、錠剤の製造方法、上杵用の粉体材料の塗布装置、下杵用の粉体材料の塗布装置、粉体材料の塗布装置、及び外部滑沢式打錠機 |
| US6482349B1 (en) | 1998-11-02 | 2002-11-19 | Sumitomo Special Metals Co., Ltd. | Powder pressing apparatus and powder pressing method |
| JP3737331B2 (ja) * | 1999-03-31 | 2006-01-18 | Ｓｐｓシンテックス株式会社 | 粉体の自動充填方法及び装置 |
| CA2367406A1 (en) * | 1999-04-19 | 2000-10-26 | Shuji Morimoto | Rotary type powder compression molding machine |
| GB2361453B (en) * | 2000-01-27 | 2003-10-15 | Victor Ken Seng Wu | Lubrication device adapted to be used in a punching machine |
| DE60142853D1 (enExample) | 2000-12-08 | 2010-09-30 | Kyowa Hakko Kirin Co Ltd | |
| US9358214B2 (en) | 2001-10-04 | 2016-06-07 | Adare Pharmaceuticals, Inc. | Timed, sustained release systems for propranolol |
| WO2003041698A1 (fr) * | 2001-11-13 | 2003-05-22 | Kyowa Hakko Kogyo Co., Ltd. | Comprimes contenant des acides amines se desintegrant rapidement dans la cavite buccale et procede de fabrication de ces comprimes |
| IL166360A0 (en) * | 2002-07-19 | 2006-01-16 | Smi Inc | Method and apparatus for making miniature tablets |
| US8367111B2 (en) | 2002-12-31 | 2013-02-05 | Aptalis Pharmatech, Inc. | Extended release dosage forms of propranolol hydrochloride |
| US8747895B2 (en) | 2004-09-13 | 2014-06-10 | Aptalis Pharmatech, Inc. | Orally disintegrating tablets of atomoxetine |
| EP1944006A3 (en) * | 2004-09-24 | 2008-07-23 | BioProgress Technology Limited | Additional improvements in powder compaction and enrobing |
| EP1807040A1 (en) * | 2004-09-24 | 2007-07-18 | BioProgress Technology Limited | Additional improvements in powder compaction and enrobing |
| US9884014B2 (en) | 2004-10-12 | 2018-02-06 | Adare Pharmaceuticals, Inc. | Taste-masked pharmaceutical compositions |
| WO2006047493A2 (en) | 2004-10-21 | 2006-05-04 | Eurand Pharmaceuticals Limited | Taste-masked pharmaceutical compositions with gastrosoluble pore-formers |
| US9161918B2 (en) | 2005-05-02 | 2015-10-20 | Adare Pharmaceuticals, Inc. | Timed, pulsatile release systems |
| JP5750266B2 (ja) * | 2008-02-28 | 2015-07-15 | アッヴィ・インコーポレイテッド | 錠剤およびその調製 |
| SG10201407965XA (en) | 2009-12-02 | 2015-02-27 | Aptalis Pharma Ltd | Fexofenadine microcapsules and compositions containing them |
| CN102582111A (zh) * | 2012-01-18 | 2012-07-18 | 金坛市威克压片机械制造有限公司 | 一种压片机装料深度微调装置 |
| DE102016123279B4 (de) * | 2016-12-01 | 2019-02-21 | Fette Compacting Gmbh | Verfahren und System zum Zuführen eines Schmier- oder Trennmittels zu Presswerkzeugen einer Tablettenpresse |
| JP2019111565A (ja) | 2017-12-25 | 2019-07-11 | 株式会社菊水製作所 | 制御装置、制御方法 |
| EP3662898A1 (en) | 2018-12-07 | 2020-06-10 | Tillotts Pharma AG | Solid composition comprising mesalazine |
| USD959696S1 (en) | 2020-03-18 | 2022-08-02 | Laura Patricia Matamoros Vargas | Mold for vaginal ovules |
| USD947406S1 (en) | 2020-03-18 | 2022-03-29 | Laura Patricia Matamoros Vargas | Mold for vaginal ovules |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE265970C (enExample) * | ||||
| US3158111A (en) * | 1962-06-06 | 1964-11-24 | Smith Kline French Lab | Method and apparatus for forming tablets |
| US3255716A (en) * | 1962-12-10 | 1966-06-14 | Upjohn Co | Measurement of forces within a tableting machine |
| US3332367A (en) * | 1965-07-15 | 1967-07-25 | Upjohn Co | Apparatus for making tablets |
| GB1335153A (en) * | 1971-09-02 | 1973-10-24 | Purex Corp | Method of tabletting halocyanuric acid |
| DE2520662C3 (de) * | 1975-05-09 | 1983-11-03 | Wilhelm Fette Gmbh, 2053 Schwarzenbek | Einrichtung zum Überwachen der Preßkräfte der Stempel einer Tablettenpresse |
| US4047866A (en) * | 1976-11-22 | 1977-09-13 | The Dow Chemical Company | Automatic self-lubricating rotary tablet press |
| DD136026A5 (de) * | 1977-04-20 | 1979-06-13 | Thomae Gmbh Dr K | Verfahren zum bespruehen der verdichtungswerkzeuge mit schmiermitteln |
| DE2742572B1 (de) * | 1977-09-22 | 1979-03-29 | Fette Wilhelm Gmbh | Verfahren zum Herstellen von Tabletten und Tablettenpresse |
-
1979
- 1979-07-13 JP JP8940779A patent/JPS5614098A/ja active Granted
-
1980
- 1980-07-02 US US06/165,399 patent/US4373888A/en not_active Expired - Lifetime
- 1980-07-07 CH CH518080A patent/CH639843A5/fr not_active IP Right Cessation
- 1980-07-09 DE DE19803026058 patent/DE3026058A1/de active Granted
- 1980-07-11 GB GB8022804A patent/GB2053787B/en not_active Expired
- 1980-07-11 FR FR8015459A patent/FR2460662B1/fr not_active Expired
- 1980-07-11 IT IT68105/80A patent/IT1141602B/it active
Also Published As
| Publication number | Publication date |
|---|---|
| JPS5614098A (en) | 1981-02-10 |
| IT1141602B (it) | 1986-10-01 |
| FR2460662B1 (fr) | 1985-10-04 |
| JPS6219278B2 (enExample) | 1987-04-27 |
| DE3026058A1 (de) | 1981-06-04 |
| GB2053787B (en) | 1983-10-19 |
| GB2053787A (en) | 1981-02-11 |
| IT8068105A0 (it) | 1980-07-11 |
| US4373888A (en) | 1983-02-15 |
| FR2460662A1 (fr) | 1981-01-30 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PL | Patent ceased | ||
| PL | Patent ceased |