CH639843A5 - Procede pour la fabrication en serie de comprimes a usage medical et appareil pour sa mise en oeuvre. - Google Patents
Procede pour la fabrication en serie de comprimes a usage medical et appareil pour sa mise en oeuvre. Download PDFInfo
- Publication number
- CH639843A5 CH639843A5 CH518080A CH518080A CH639843A5 CH 639843 A5 CH639843 A5 CH 639843A5 CH 518080 A CH518080 A CH 518080A CH 518080 A CH518080 A CH 518080A CH 639843 A5 CH639843 A5 CH 639843A5
- Authority
- CH
- Switzerland
- Prior art keywords
- lubricant
- punches
- tablets
- point
- cavity
- Prior art date
Links
- 238000000034 method Methods 0.000 title claims description 15
- 238000004519 manufacturing process Methods 0.000 title claims description 9
- 239000000314 lubricant Substances 0.000 claims description 60
- 239000003826 tablet Substances 0.000 claims description 49
- 238000002347 injection Methods 0.000 claims description 16
- 239000007924 injection Substances 0.000 claims description 16
- 230000006835 compression Effects 0.000 claims description 9
- 238000007906 compression Methods 0.000 claims description 9
- 239000011159 matrix material Substances 0.000 claims description 8
- 239000007932 molded tablet Substances 0.000 claims description 5
- 239000000428 dust Substances 0.000 claims description 4
- 239000000463 material Substances 0.000 claims description 3
- 230000000630 rising effect Effects 0.000 claims 1
- 239000000843 powder Substances 0.000 description 13
- HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 description 10
- 239000000203 mixture Substances 0.000 description 10
- 238000000465 moulding Methods 0.000 description 7
- CJZGTCYPCWQAJB-UHFFFAOYSA-L calcium stearate Chemical compound [Ca+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O CJZGTCYPCWQAJB-UHFFFAOYSA-L 0.000 description 5
- 239000008116 calcium stearate Substances 0.000 description 5
- 235000013539 calcium stearate Nutrition 0.000 description 5
- 235000019359 magnesium stearate Nutrition 0.000 description 5
- 239000002245 particle Substances 0.000 description 5
- 230000008021 deposition Effects 0.000 description 3
- 239000008187 granular material Substances 0.000 description 3
- 238000005507 spraying Methods 0.000 description 3
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 description 2
- GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 description 2
- 229920000168 Microcrystalline cellulose Polymers 0.000 description 2
- 239000003814 drug Substances 0.000 description 2
- 239000008101 lactose Substances 0.000 description 2
- 235000019813 microcrystalline cellulose Nutrition 0.000 description 2
- 239000008108 microcrystalline cellulose Substances 0.000 description 2
- 229940016286 microcrystalline cellulose Drugs 0.000 description 2
- BSYNRYMUTXBXSQ-UHFFFAOYSA-N Aspirin Chemical compound CC(=O)OC1=CC=CC=C1C(O)=O BSYNRYMUTXBXSQ-UHFFFAOYSA-N 0.000 description 1
- 239000002211 L-ascorbic acid Substances 0.000 description 1
- 235000000069 L-ascorbic acid Nutrition 0.000 description 1
- FYYHWMGAXLPEAU-UHFFFAOYSA-N Magnesium Chemical compound [Mg] FYYHWMGAXLPEAU-UHFFFAOYSA-N 0.000 description 1
- 229920002472 Starch Polymers 0.000 description 1
- 238000009825 accumulation Methods 0.000 description 1
- 229960001138 acetylsalicylic acid Drugs 0.000 description 1
- MANKSFVECICGLK-UHFFFAOYSA-K aloxiprin Chemical compound [OH-].[Al+3].CC(=O)OC1=CC=CC=C1C([O-])=O.CC(=O)OC1=CC=CC=C1C([O-])=O MANKSFVECICGLK-UHFFFAOYSA-K 0.000 description 1
- 229940024544 aluminum aspirin Drugs 0.000 description 1
- 229960005070 ascorbic acid Drugs 0.000 description 1
- 238000007664 blowing Methods 0.000 description 1
- 239000007891 compressed tablet Substances 0.000 description 1
- 238000010276 construction Methods 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- 238000004090 dissolution Methods 0.000 description 1
- 239000012530 fluid Substances 0.000 description 1
- 210000004051 gastric juice Anatomy 0.000 description 1
- 238000010030 laminating Methods 0.000 description 1
- 238000003475 lamination Methods 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 229910052749 magnesium Inorganic materials 0.000 description 1
- 239000011777 magnesium Substances 0.000 description 1
- QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 description 1
- 238000005192 partition Methods 0.000 description 1
- 238000003825 pressing Methods 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 239000008107 starch Substances 0.000 description 1
- 235000019698 starch Nutrition 0.000 description 1
- 239000000454 talc Substances 0.000 description 1
- 229910052623 talc Inorganic materials 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B30—PRESSES
- B30B—PRESSES IN GENERAL
- B30B15/00—Details of, or accessories for, presses; Auxiliary measures in connection with pressing
- B30B15/0005—Details of, or accessories for, presses; Auxiliary measures in connection with pressing for briquetting presses
- B30B15/0011—Details of, or accessories for, presses; Auxiliary measures in connection with pressing for briquetting presses lubricating means
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B30—PRESSES
- B30B—PRESSES IN GENERAL
- B30B11/00—Presses specially adapted for forming shaped articles from material in particulate or plastic state, e.g. briquetting presses, tabletting presses
- B30B11/005—Control arrangements
Landscapes
- Engineering & Computer Science (AREA)
- Mechanical Engineering (AREA)
- Medical Preparation Storing Or Oral Administration Devices (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP8940779A JPS5614098A (en) | 1979-07-13 | 1979-07-13 | Externally lubricating tablet making machine |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CH639843A5 true CH639843A5 (fr) | 1983-12-15 |
Family
ID=13969782
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CH518080A CH639843A5 (fr) | 1979-07-13 | 1980-07-07 | Procede pour la fabrication en serie de comprimes a usage medical et appareil pour sa mise en oeuvre. |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US4373888A (enExample) |
| JP (1) | JPS5614098A (enExample) |
| CH (1) | CH639843A5 (enExample) |
| DE (1) | DE3026058A1 (enExample) |
| FR (1) | FR2460662B1 (enExample) |
| GB (1) | GB2053787B (enExample) |
| IT (1) | IT1141602B (enExample) |
Families Citing this family (41)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3131402A1 (de) * | 1981-08-07 | 1983-02-24 | Kilian & Co GmbH, 5000 Köln | Verfahren und tablettenpresse zum aufeinanderfolgenden herstellen einer vielzahl von tabletten mit gleichem gewicht |
| FR2575406B1 (fr) * | 1984-12-28 | 1987-04-10 | Pont A Mousson | Machine pour la fabrication de bouteilles en matiere plastique avec mise en place de coupelles stabilisatrices et pressurisation interne au moyen d'un gaz |
| DE3520203A1 (de) * | 1985-06-05 | 1986-12-11 | Wilhelm Fette Gmbh, 2053 Schwarzenbek | Rundlaeufer-tablettiermaschine und verfahren zur steuerung ihrer druckrollen |
| GB8530365D0 (en) * | 1985-12-10 | 1986-01-22 | Univ Bath | Manufacture of moulded products |
| JPS6410857U (enExample) * | 1987-07-07 | 1989-01-20 | ||
| DE3930127A1 (de) * | 1989-09-09 | 1991-03-21 | Fette Wilhelm Gmbh | Rundlauf-tablettiermaschine |
| US5158728A (en) * | 1991-04-12 | 1992-10-27 | Elizabeth-Hata International, Inc. | Multi-layer medicinal tablet forming machine and method for using the same |
| JP2681601B2 (ja) * | 1993-11-01 | 1997-11-26 | 協和醗酵工業株式会社 | 外部滑沢式打錠機 |
| DE4412117A1 (de) * | 1994-04-08 | 1995-10-12 | Fette Wilhelm Gmbh | Verfahren und Vorrichtung zum Aufbringen von pulverförmigem Schmier- oder Trennmittel auf die Preßwerkzeuge in Tablettiermaschinen |
| US5838571A (en) * | 1996-01-29 | 1998-11-17 | Alza Corporation | Tablet press monitoring and controlling method and apparatus |
| AU733032C (en) * | 1996-06-14 | 2002-01-03 | Kyowa Hakko Kirin Co., Ltd. | Intraorally rapidly disintegrable tablet |
| US8071128B2 (en) | 1996-06-14 | 2011-12-06 | Kyowa Hakko Kirin Co., Ltd. | Intrabuccally rapidly disintegrating tablet and a production method of the tablets |
| DE19647089A1 (de) * | 1996-11-14 | 1998-05-28 | Bayer Ag | Vorrichtung zum kontrollierten Aufsprühen von pulverförmigen Schmiermitteln auf Stempel und Matrizen von Tablettenpressen |
| JPH11169437A (ja) | 1997-12-03 | 1999-06-29 | Kyowa Hakko Kogyo Co Ltd | 錠剤の製造方法 |
| AU763143B2 (en) * | 1998-04-08 | 2003-07-17 | Kyowa Hakko Kirin Co., Ltd. | Tablet manufacturing method and tablet |
| KR20010042593A (ko) | 1998-04-10 | 2001-05-25 | 히라타 다다시 | 정제의 제조방법 및 정제 |
| EP1736144B1 (en) | 1998-05-18 | 2015-11-11 | Takeda Pharmaceutical Company Limited | Orally disintegrable tablets |
| AU6006899A (en) * | 1998-10-13 | 2000-05-01 | Kyowa Hakko Kogyo Co. Ltd. | Method of applying powder material, tablet production method, powder material application device for upper punch, powder material application device for lower punch, powder material application device, and external lubrication compressing machine |
| US6482349B1 (en) | 1998-11-02 | 2002-11-19 | Sumitomo Special Metals Co., Ltd. | Powder pressing apparatus and powder pressing method |
| JP3737331B2 (ja) * | 1999-03-31 | 2006-01-18 | Ｓｐｓシンテックス株式会社 | 粉体の自動充填方法及び装置 |
| WO2000063006A1 (en) * | 1999-04-19 | 2000-10-26 | Kikusui Seisakusyo Ltd. | Rotary type powder compression molding machine |
| GB2361453B (en) * | 2000-01-27 | 2003-10-15 | Victor Ken Seng Wu | Lubrication device adapted to be used in a punching machine |
| DE60142853D1 (enExample) | 2000-12-08 | 2010-09-30 | Kyowa Hakko Kirin Co Ltd | |
| US9358214B2 (en) | 2001-10-04 | 2016-06-07 | Adare Pharmaceuticals, Inc. | Timed, sustained release systems for propranolol |
| WO2003041698A1 (fr) * | 2001-11-13 | 2003-05-22 | Kyowa Hakko Kogyo Co., Ltd. | Comprimes contenant des acides amines se desintegrant rapidement dans la cavite buccale et procede de fabrication de ces comprimes |
| JP2005533563A (ja) * | 2002-07-19 | 2005-11-10 | エスエムアイ インコーポレイテッド | ミニチュア・タブレットを製造する方法と装置 |
| US8367111B2 (en) | 2002-12-31 | 2013-02-05 | Aptalis Pharmatech, Inc. | Extended release dosage forms of propranolol hydrochloride |
| US8747895B2 (en) | 2004-09-13 | 2014-06-10 | Aptalis Pharmatech, Inc. | Orally disintegrating tablets of atomoxetine |
| KR20070057977A (ko) * | 2004-09-24 | 2007-06-07 | 바이오프로그레스 테크놀로지 리미티드 | 분말 압착 및 피복에 있어서의 추가 개량 |
| EP1944007A3 (en) * | 2004-09-24 | 2008-07-23 | BioProgress Technology Limited | Additional improvements in powder compaction and enrobing |
| US9884014B2 (en) | 2004-10-12 | 2018-02-06 | Adare Pharmaceuticals, Inc. | Taste-masked pharmaceutical compositions |
| EP1802285B1 (en) | 2004-10-21 | 2013-02-27 | Aptalis Pharmatech, Inc. | Taste-masked pharmaceutical compositions with gastrosoluble pore-formers |
| US9161918B2 (en) | 2005-05-02 | 2015-10-20 | Adare Pharmaceuticals, Inc. | Timed, pulsatile release systems |
| US20100021540A1 (en) * | 2008-02-28 | 2010-01-28 | Abbott Laboratories | Tablets and Preparation Thereof |
| MX2012006240A (es) | 2009-12-02 | 2012-10-03 | Aptalis Pharma Ltd | Microcapsulas de fexofenadina y composiciones que contienen las mismas. |
| CN102582111A (zh) * | 2012-01-18 | 2012-07-18 | 金坛市威克压片机械制造有限公司 | 一种压片机装料深度微调装置 |
| DE102016123279B4 (de) * | 2016-12-01 | 2019-02-21 | Fette Compacting Gmbh | Verfahren und System zum Zuführen eines Schmier- oder Trennmittels zu Presswerkzeugen einer Tablettenpresse |
| JP2019111565A (ja) | 2017-12-25 | 2019-07-11 | 株式会社菊水製作所 | 制御装置、制御方法 |
| EP3662898A1 (en) * | 2018-12-07 | 2020-06-10 | Tillotts Pharma AG | Solid composition comprising mesalazine |
| USD947406S1 (en) | 2020-03-18 | 2022-03-29 | Laura Patricia Matamoros Vargas | Mold for vaginal ovules |
| USD959696S1 (en) | 2020-03-18 | 2022-08-02 | Laura Patricia Matamoros Vargas | Mold for vaginal ovules |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE265970C (enExample) * | ||||
| US3158111A (en) * | 1962-06-06 | 1964-11-24 | Smith Kline French Lab | Method and apparatus for forming tablets |
| US3255716A (en) * | 1962-12-10 | 1966-06-14 | Upjohn Co | Measurement of forces within a tableting machine |
| US3332367A (en) * | 1965-07-15 | 1967-07-25 | Upjohn Co | Apparatus for making tablets |
| GB1335153A (en) * | 1971-09-02 | 1973-10-24 | Purex Corp | Method of tabletting halocyanuric acid |
| DE2520662C3 (de) * | 1975-05-09 | 1983-11-03 | Wilhelm Fette Gmbh, 2053 Schwarzenbek | Einrichtung zum Überwachen der Preßkräfte der Stempel einer Tablettenpresse |
| US4047866A (en) * | 1976-11-22 | 1977-09-13 | The Dow Chemical Company | Automatic self-lubricating rotary tablet press |
| CH628572A5 (de) * | 1977-04-20 | 1982-03-15 | Thomae Gmbh Dr K | Verfahren zum bespruehen der verdichtungswerkzeuge von maschinen zur herstellung von formlingen. |
| DE2742572B1 (de) * | 1977-09-22 | 1979-03-29 | Fette Wilhelm Gmbh | Verfahren zum Herstellen von Tabletten und Tablettenpresse |
-
1979
- 1979-07-13 JP JP8940779A patent/JPS5614098A/ja active Granted
-
1980
- 1980-07-02 US US06/165,399 patent/US4373888A/en not_active Expired - Lifetime
- 1980-07-07 CH CH518080A patent/CH639843A5/fr not_active IP Right Cessation
- 1980-07-09 DE DE19803026058 patent/DE3026058A1/de active Granted
- 1980-07-11 FR FR8015459A patent/FR2460662B1/fr not_active Expired
- 1980-07-11 IT IT68105/80A patent/IT1141602B/it active
- 1980-07-11 GB GB8022804A patent/GB2053787B/en not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| JPS5614098A (en) | 1981-02-10 |
| US4373888A (en) | 1983-02-15 |
| FR2460662A1 (fr) | 1981-01-30 |
| FR2460662B1 (fr) | 1985-10-04 |
| GB2053787A (en) | 1981-02-11 |
| GB2053787B (en) | 1983-10-19 |
| IT1141602B (it) | 1986-10-01 |
| DE3026058A1 (de) | 1981-06-04 |
| JPS6219278B2 (enExample) | 1987-04-27 |
| IT8068105A0 (it) | 1980-07-11 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PL | Patent ceased | ||
| PL | Patent ceased |