CH632930A5 - Verfahren zur herstellung eines vernetzten wasserunloeslichen haptoglobinpraeparates. - Google Patents
Verfahren zur herstellung eines vernetzten wasserunloeslichen haptoglobinpraeparates. Download PDFInfo
- Publication number
- CH632930A5 CH632930A5 CH890677A CH890677A CH632930A5 CH 632930 A5 CH632930 A5 CH 632930A5 CH 890677 A CH890677 A CH 890677A CH 890677 A CH890677 A CH 890677A CH 632930 A5 CH632930 A5 CH 632930A5
- Authority
- CH
- Switzerland
- Prior art keywords
- haptoglobin
- hemoglobin
- reaction
- preparations
- bifunctional compound
- Prior art date
Links
- 102000014702 Haptoglobin Human genes 0.000 title claims description 94
- 108050005077 Haptoglobin Proteins 0.000 title claims description 94
- 238000002360 preparation method Methods 0.000 title claims description 49
- 238000004519 manufacturing process Methods 0.000 title claims description 5
- 102000008946 Fibrinogen Human genes 0.000 claims description 30
- 108010049003 Fibrinogen Proteins 0.000 claims description 30
- 229940012952 fibrinogen Drugs 0.000 claims description 30
- 238000000034 method Methods 0.000 claims description 28
- 108010054147 Hemoglobins Proteins 0.000 claims description 27
- 102000001554 Hemoglobins Human genes 0.000 claims description 27
- BWGVNKXGVNDBDI-UHFFFAOYSA-N Fibrin monomer Chemical compound CNC(=O)CNC(=O)CN BWGVNKXGVNDBDI-UHFFFAOYSA-N 0.000 claims description 25
- 150000001875 compounds Chemical class 0.000 claims description 24
- 102000009123 Fibrin Human genes 0.000 claims description 23
- 108010073385 Fibrin Proteins 0.000 claims description 23
- 230000001588 bifunctional effect Effects 0.000 claims description 23
- 238000006243 chemical reaction Methods 0.000 claims description 23
- 229950003499 fibrin Drugs 0.000 claims description 23
- 108090000190 Thrombin Proteins 0.000 claims description 22
- 229960004072 thrombin Drugs 0.000 claims description 22
- 239000000203 mixture Substances 0.000 claims description 11
- 210000004369 blood Anatomy 0.000 claims description 10
- 239000008280 blood Substances 0.000 claims description 10
- SXRSQZLOMIGNAQ-UHFFFAOYSA-N Glutaraldehyde Chemical compound O=CCCCC=O SXRSQZLOMIGNAQ-UHFFFAOYSA-N 0.000 claims description 7
- 150000001718 carbodiimides Chemical class 0.000 claims description 5
- 230000004087 circulation Effects 0.000 claims description 5
- 238000004132 cross linking Methods 0.000 claims description 5
- 201000006370 kidney failure Diseases 0.000 claims description 5
- 238000011282 treatment Methods 0.000 claims description 5
- 239000012736 aqueous medium Substances 0.000 claims description 4
- 208000017169 kidney disease Diseases 0.000 claims description 4
- 239000000376 reactant Substances 0.000 claims description 4
- 230000008929 regeneration Effects 0.000 claims description 4
- 238000011069 regeneration method Methods 0.000 claims description 4
- 239000003463 adsorbent Substances 0.000 claims description 3
- 239000000969 carrier Substances 0.000 claims description 3
- 239000011541 reaction mixture Substances 0.000 claims description 3
- 229920002994 synthetic fiber Polymers 0.000 claims description 3
- 239000012209 synthetic fiber Substances 0.000 claims description 3
- 229920000936 Agarose Polymers 0.000 claims description 2
- 230000002949 hemolytic effect Effects 0.000 claims description 2
- 229920002239 polyacrylonitrile Polymers 0.000 claims description 2
- 229920000728 polyester Polymers 0.000 claims description 2
- 229920000098 polyolefin Polymers 0.000 claims description 2
- 229920002451 polyvinyl alcohol Polymers 0.000 claims description 2
- 230000002035 prolonged effect Effects 0.000 claims description 2
- 238000011084 recovery Methods 0.000 claims description 2
- 206010018910 Haemolysis Diseases 0.000 claims 5
- 230000008588 hemolysis Effects 0.000 claims 5
- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 claims 4
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 3
- 210000004185 liver Anatomy 0.000 claims 3
- 230000004060 metabolic process Effects 0.000 claims 3
- 229910052742 iron Inorganic materials 0.000 claims 2
- 210000003734 kidney Anatomy 0.000 claims 2
- 230000003907 kidney function Effects 0.000 claims 2
- 210000000738 kidney tubule Anatomy 0.000 claims 2
- 102000004506 Blood Proteins Human genes 0.000 claims 1
- 108010017384 Blood Proteins Proteins 0.000 claims 1
- 208000001647 Renal Insufficiency Diseases 0.000 claims 1
- 230000017531 blood circulation Effects 0.000 claims 1
- 230000002612 cardiopulmonary effect Effects 0.000 claims 1
- 230000001364 causal effect Effects 0.000 claims 1
- 210000004027 cell Anatomy 0.000 claims 1
- 238000004587 chromatography analysis Methods 0.000 claims 1
- 201000010099 disease Diseases 0.000 claims 1
- 238000001914 filtration Methods 0.000 claims 1
- 108010071602 haptoglobin-hemoglobin complex Proteins 0.000 claims 1
- 238000001727 in vivo Methods 0.000 claims 1
- 238000010253 intravenous injection Methods 0.000 claims 1
- 238000010606 normalization Methods 0.000 claims 1
- 210000002381 plasma Anatomy 0.000 claims 1
- 230000002265 prevention Effects 0.000 claims 1
- 230000001225 therapeutic effect Effects 0.000 claims 1
- 210000002700 urine Anatomy 0.000 claims 1
- 239000000243 solution Substances 0.000 description 9
- 239000002504 physiological saline solution Substances 0.000 description 6
- 239000002245 particle Substances 0.000 description 5
- 101001078385 Homo sapiens Haptoglobin Proteins 0.000 description 4
- 239000004677 Nylon Substances 0.000 description 4
- 238000002474 experimental method Methods 0.000 description 4
- 102000050796 human HP Human genes 0.000 description 4
- 229920001778 nylon Polymers 0.000 description 4
- 230000008569 process Effects 0.000 description 4
- 238000005406 washing Methods 0.000 description 4
- 108090000790 Enzymes Proteins 0.000 description 3
- 102000004190 Enzymes Human genes 0.000 description 3
- 230000004888 barrier function Effects 0.000 description 3
- 239000003431 cross linking reagent Substances 0.000 description 3
- 229940088598 enzyme Drugs 0.000 description 3
- 239000008187 granular material Substances 0.000 description 3
- 239000012528 membrane Substances 0.000 description 3
- 239000008363 phosphate buffer Substances 0.000 description 3
- 239000000047 product Substances 0.000 description 3
- 238000012360 testing method Methods 0.000 description 3
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 2
- OAKJQQAXSVQMHS-UHFFFAOYSA-N Hydrazine Chemical compound NN OAKJQQAXSVQMHS-UHFFFAOYSA-N 0.000 description 2
- TWRXJAOTZQYOKJ-UHFFFAOYSA-L Magnesium chloride Chemical compound [Mg+2].[Cl-].[Cl-] TWRXJAOTZQYOKJ-UHFFFAOYSA-L 0.000 description 2
- 230000009471 action Effects 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 150000002148 esters Chemical class 0.000 description 2
- 239000000835 fiber Substances 0.000 description 2
- 125000000524 functional group Chemical group 0.000 description 2
- 239000012210 heat-resistant fiber Substances 0.000 description 2
- 208000006454 hepatitis Diseases 0.000 description 2
- 231100000283 hepatitis Toxicity 0.000 description 2
- 229940106780 human fibrinogen Drugs 0.000 description 2
- 239000007788 liquid Substances 0.000 description 2
- 229920002401 polyacrylamide Polymers 0.000 description 2
- 230000035484 reaction time Effects 0.000 description 2
- 239000007858 starting material Substances 0.000 description 2
- XZMCDFZZKTWFGF-UHFFFAOYSA-N Cyanamide Chemical compound NC#N XZMCDFZZKTWFGF-UHFFFAOYSA-N 0.000 description 1
- PIICEJLVQHRZGT-UHFFFAOYSA-N Ethylenediamine Chemical compound NCCN PIICEJLVQHRZGT-UHFFFAOYSA-N 0.000 description 1
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 1
- 241000700605 Viruses Species 0.000 description 1
- XUGUHTGSMPZQIW-UHFFFAOYSA-N [[4-(4-diazonioiminocyclohexa-2,5-dien-1-ylidene)cyclohexa-2,5-dien-1-ylidene]hydrazinylidene]azanide Chemical compound C1=CC(N=[N+]=[N-])=CC=C1C1=CC=C(N=[N+]=[N-])C=C1 XUGUHTGSMPZQIW-UHFFFAOYSA-N 0.000 description 1
- 150000001413 amino acids Chemical class 0.000 description 1
- 125000003277 amino group Chemical group 0.000 description 1
- 238000004159 blood analysis Methods 0.000 description 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 239000012295 chemical reaction liquid Substances 0.000 description 1
- 239000007795 chemical reaction product Substances 0.000 description 1
- 230000015271 coagulation Effects 0.000 description 1
- 238000005345 coagulation Methods 0.000 description 1
- 230000000052 comparative effect Effects 0.000 description 1
- 238000007796 conventional method Methods 0.000 description 1
- FJBFPHVGVWTDIP-UHFFFAOYSA-N dibromomethane Chemical compound BrCBr FJBFPHVGVWTDIP-UHFFFAOYSA-N 0.000 description 1
- 238000001035 drying Methods 0.000 description 1
- 230000002349 favourable effect Effects 0.000 description 1
- 239000012530 fluid Substances 0.000 description 1
- 239000011888 foil Substances 0.000 description 1
- 238000005194 fractionation Methods 0.000 description 1
- 239000011521 glass Substances 0.000 description 1
- 238000010438 heat treatment Methods 0.000 description 1
- FBPFZTCFMRRESA-UHFFFAOYSA-N hexane-1,2,3,4,5,6-hexol Chemical compound OCC(O)C(O)C(O)C(O)CO FBPFZTCFMRRESA-UHFFFAOYSA-N 0.000 description 1
- 230000000951 immunodiffusion Effects 0.000 description 1
- 230000000415 inactivating effect Effects 0.000 description 1
- 239000007924 injection Substances 0.000 description 1
- 238000002347 injection Methods 0.000 description 1
- 229910001629 magnesium chloride Inorganic materials 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 239000011259 mixed solution Substances 0.000 description 1
- 238000002156 mixing Methods 0.000 description 1
- 230000006855 networking Effects 0.000 description 1
- 230000007935 neutral effect Effects 0.000 description 1
- ISWSIDIOOBJBQZ-UHFFFAOYSA-N phenol group Chemical group C1(=CC=CC=C1)O ISWSIDIOOBJBQZ-UHFFFAOYSA-N 0.000 description 1
- 239000011148 porous material Substances 0.000 description 1
- 238000001556 precipitation Methods 0.000 description 1
- 238000011321 prophylaxis Methods 0.000 description 1
- 230000005855 radiation Effects 0.000 description 1
- 239000012429 reaction media Substances 0.000 description 1
- 230000000717 retained effect Effects 0.000 description 1
- 239000011780 sodium chloride Substances 0.000 description 1
- 239000010935 stainless steel Substances 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
- 230000009385 viral infection Effects 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/795—Porphyrin- or corrin-ring-containing peptides
- C07K14/805—Haemoglobins; Myoglobins
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N11/00—Carrier-bound or immobilised enzymes; Carrier-bound or immobilised microbial cells; Preparation thereof
- C12N11/02—Enzymes or microbial cells immobilised on or in an organic carrier
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
- Y10S530/81—Carrier - bound or immobilized peptides or proteins and the preparation thereof, e.g. biological cell or cell fragment as carrier
- Y10S530/812—Peptides or proteins is immobilized on, or in, an organic carrier
- Y10S530/815—Carrier is a synthetic polymer
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Genetics & Genomics (AREA)
- Zoology (AREA)
- Biochemistry (AREA)
- Wood Science & Technology (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Medicinal Chemistry (AREA)
- Biomedical Technology (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Biophysics (AREA)
- Gastroenterology & Hepatology (AREA)
- General Engineering & Computer Science (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- External Artificial Organs (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP10276376A JPS5329908A (en) | 1976-08-27 | 1976-08-27 | Immobilized haptoglobin preparation |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CH632930A5 true CH632930A5 (de) | 1982-11-15 |
Family
ID=14336221
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CH890677A CH632930A5 (de) | 1976-08-27 | 1977-07-19 | Verfahren zur herstellung eines vernetzten wasserunloeslichen haptoglobinpraeparates. |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US4113853A (enExample) |
| JP (1) | JPS5329908A (enExample) |
| BE (1) | BE857021A (enExample) |
| CA (1) | CA1085291A (enExample) |
| CH (1) | CH632930A5 (enExample) |
| DE (1) | DE2732437C3 (enExample) |
| ES (1) | ES460861A1 (enExample) |
| FR (1) | FR2362861A1 (enExample) |
| GB (1) | GB1551646A (enExample) |
| LU (1) | LU77802A1 (enExample) |
| NL (1) | NL176637C (enExample) |
| SE (1) | SE446430B (enExample) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4462989A (en) * | 1981-05-04 | 1984-07-31 | Evreka, Inc. | Method and agents for arresting infection |
| US4442655A (en) * | 1981-06-25 | 1984-04-17 | Serapharm Michael Stroetmann | Fibrinogen-containing dry preparation, manufacture and use thereof |
| US5464814A (en) * | 1986-06-20 | 1995-11-07 | Northfield Laboratories, Inc. | Acellular red blood cell substitute |
| JP4583510B2 (ja) * | 1997-02-28 | 2010-11-17 | ザ リージェンツ オブ ザ ユニバーシティー オブ カリフォルニア | 無細胞系による酸素輸送の最適化のための方法と組成物 |
| US20030153491A1 (en) * | 2002-01-11 | 2003-08-14 | Winslow Robert M. | Methods and compositions for oxygen transport comprising a high oxygen affinity modified hemoglobin |
| US20050164915A1 (en) * | 2002-04-01 | 2005-07-28 | Sangart, Inc. | Compositions for oxygen transport comprising a high oxygen affinity modified hemoglobin |
| JP3912206B2 (ja) * | 2002-07-05 | 2007-05-09 | 株式会社日立製作所 | 筒内直接燃料噴射装置用燃料ポンプ |
| JP2006516994A (ja) * | 2003-01-29 | 2006-07-13 | ノースフィールド ラボラトリーズ、インコーポレイテッド | テトラマーの量を低下させた重合ヘモグロビン溶液及び調製するための方法 |
| US20090004159A1 (en) * | 2006-01-24 | 2009-01-01 | The Board Of Trustees Of The University Of Illinoi | Polymerized Hemoglobin Media and Its Use in Isolation and Transplantation of Islet Cells |
| WO2007087570A2 (en) * | 2006-01-24 | 2007-08-02 | Northfield Laboratories, Inc. | Polymerized hemoglobin media and its use in isolation and transplantation of islet cells |
-
1976
- 1976-08-27 JP JP10276376A patent/JPS5329908A/ja active Granted
-
1977
- 1977-06-28 GB GB27054/77A patent/GB1551646A/en not_active Expired
- 1977-07-06 SE SE7707889A patent/SE446430B/xx not_active IP Right Cessation
- 1977-07-06 US US05/813,419 patent/US4113853A/en not_active Expired - Lifetime
- 1977-07-18 DE DE2732437A patent/DE2732437C3/de not_active Expired
- 1977-07-19 NL NLAANVRAGE7708024,A patent/NL176637C/xx not_active IP Right Cessation
- 1977-07-19 FR FR7722068A patent/FR2362861A1/fr active Granted
- 1977-07-19 CH CH890677A patent/CH632930A5/de not_active IP Right Cessation
- 1977-07-19 ES ES460861A patent/ES460861A1/es not_active Expired
- 1977-07-20 LU LU77802A patent/LU77802A1/xx unknown
- 1977-07-20 CA CA283,177A patent/CA1085291A/en not_active Expired
- 1977-07-22 BE BE179528A patent/BE857021A/xx not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| LU77802A1 (enExample) | 1977-10-25 |
| BE857021A (fr) | 1977-11-14 |
| NL176637C (nl) | 1985-05-17 |
| FR2362861A1 (fr) | 1978-03-24 |
| FR2362861B1 (enExample) | 1980-02-15 |
| CA1085291A (en) | 1980-09-09 |
| DE2732437A1 (de) | 1978-03-02 |
| JPS5329908A (en) | 1978-03-20 |
| DE2732437C3 (de) | 1979-09-27 |
| ES460861A1 (es) | 1978-04-16 |
| US4113853A (en) | 1978-09-12 |
| SE446430B (sv) | 1986-09-15 |
| SE7707889L (sv) | 1978-02-28 |
| DE2732437B2 (de) | 1979-02-01 |
| JPS5523806B2 (enExample) | 1980-06-25 |
| NL7708024A (nl) | 1978-03-01 |
| GB1551646A (en) | 1979-08-30 |
| NL176637B (nl) | 1984-12-17 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PL | Patent ceased | ||
| PL | Patent ceased |