CH622350A5 - - Google Patents
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- Publication number
- CH622350A5 CH622350A5 CH857075A CH857075A CH622350A5 CH 622350 A5 CH622350 A5 CH 622350A5 CH 857075 A CH857075 A CH 857075A CH 857075 A CH857075 A CH 857075A CH 622350 A5 CH622350 A5 CH 622350A5
- Authority
- CH
- Switzerland
- Prior art keywords
- solution
- fibrin
- protamine sulfate
- weight
- test combination
- Prior art date
Links
- BWGVNKXGVNDBDI-UHFFFAOYSA-N Fibrin monomer Chemical compound CNC(=O)CNC(=O)CN BWGVNKXGVNDBDI-UHFFFAOYSA-N 0.000 claims description 49
- 108010073385 Fibrin Proteins 0.000 claims description 47
- 102000009123 Fibrin Human genes 0.000 claims description 47
- 229950003499 fibrin Drugs 0.000 claims description 47
- 238000012360 testing method Methods 0.000 claims description 42
- 102000007327 Protamines Human genes 0.000 claims description 36
- 108010007568 Protamines Proteins 0.000 claims description 36
- 239000002245 particle Substances 0.000 claims description 36
- 229950008679 protamine sulfate Drugs 0.000 claims description 36
- 239000000243 solution Substances 0.000 claims description 28
- 210000002381 plasma Anatomy 0.000 claims description 23
- 239000012266 salt solution Substances 0.000 claims description 23
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 claims description 19
- 239000000178 monomer Substances 0.000 claims description 17
- 108010058861 Fibrin Fibrinogen Degradation Products Proteins 0.000 claims description 13
- 239000000208 fibrin degradation product Substances 0.000 claims description 13
- 238000001514 detection method Methods 0.000 claims description 12
- 238000002360 preparation method Methods 0.000 claims description 9
- 239000000725 suspension Substances 0.000 claims description 9
- 239000004071 soot Substances 0.000 claims description 7
- 238000000034 method Methods 0.000 claims description 5
- 239000006233 lamp black Substances 0.000 claims description 4
- 238000004519 manufacturing process Methods 0.000 claims description 4
- 239000006229 carbon black Substances 0.000 claims description 3
- 230000015271 coagulation Effects 0.000 description 27
- 238000005345 coagulation Methods 0.000 description 27
- 239000000835 fiber Substances 0.000 description 16
- 239000000499 gel Substances 0.000 description 14
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 12
- 239000000047 product Substances 0.000 description 12
- 108010049003 Fibrinogen Proteins 0.000 description 9
- 102000008946 Fibrinogen Human genes 0.000 description 9
- 229940012952 fibrinogen Drugs 0.000 description 9
- 238000013207 serial dilution Methods 0.000 description 9
- 201000010099 disease Diseases 0.000 description 6
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 6
- 108090000190 Thrombin Proteins 0.000 description 5
- 230000015556 catabolic process Effects 0.000 description 5
- 239000002504 physiological saline solution Substances 0.000 description 5
- 238000010998 test method Methods 0.000 description 5
- 229960004072 thrombin Drugs 0.000 description 5
- 239000011780 sodium chloride Substances 0.000 description 4
- 230000002159 abnormal effect Effects 0.000 description 3
- 238000003745 diagnosis Methods 0.000 description 3
- 238000010790 dilution Methods 0.000 description 3
- 239000012895 dilution Substances 0.000 description 3
- 239000002244 precipitate Substances 0.000 description 3
- 230000015572 biosynthetic process Effects 0.000 description 2
- 210000004369 blood Anatomy 0.000 description 2
- 239000008280 blood Substances 0.000 description 2
- 230000036765 blood level Effects 0.000 description 2
- 238000006243 chemical reaction Methods 0.000 description 2
- 239000007795 chemical reaction product Substances 0.000 description 2
- 229940079593 drug Drugs 0.000 description 2
- 239000003814 drug Substances 0.000 description 2
- 238000002474 experimental method Methods 0.000 description 2
- 108010073651 fibrinmonomer Proteins 0.000 description 2
- 239000000282 fibrinogen degradation product Substances 0.000 description 2
- 229940012957 plasmin Drugs 0.000 description 2
- 238000003860 storage Methods 0.000 description 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 2
- LVOJOIBIVGEQBP-UHFFFAOYSA-N 4-[[2-chloro-4-[3-chloro-4-[(5-hydroxy-3-methyl-1-phenylpyrazol-4-yl)diazenyl]phenyl]phenyl]diazenyl]-5-methyl-2-phenylpyrazol-3-ol Chemical compound CC1=NN(C(O)=C1N=NC1=CC=C(C=C1Cl)C1=CC(Cl)=C(C=C1)N=NC1=C(O)N(N=C1C)C1=CC=CC=C1)C1=CC=CC=C1 LVOJOIBIVGEQBP-UHFFFAOYSA-N 0.000 description 1
- 235000004391 Chenopodium capitatum Nutrition 0.000 description 1
- 244000038022 Chenopodium capitatum Species 0.000 description 1
- 108090000790 Enzymes Proteins 0.000 description 1
- 102000004190 Enzymes Human genes 0.000 description 1
- 241000295644 Staphylococcaceae Species 0.000 description 1
- 239000008135 aqueous vehicle Substances 0.000 description 1
- IRERQBUNZFJFGC-UHFFFAOYSA-L azure blue Chemical compound [Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Al+3].[Al+3].[Al+3].[Al+3].[Al+3].[Al+3].[S-]S[S-].[O-][Si]([O-])([O-])[O-].[O-][Si]([O-])([O-])[O-].[O-][Si]([O-])([O-])[O-].[O-][Si]([O-])([O-])[O-].[O-][Si]([O-])([O-])[O-].[O-][Si]([O-])([O-])[O-] IRERQBUNZFJFGC-UHFFFAOYSA-L 0.000 description 1
- 239000003153 chemical reaction reagent Substances 0.000 description 1
- 238000007865 diluting Methods 0.000 description 1
- 238000003113 dilution method Methods 0.000 description 1
- 239000006185 dispersion Substances 0.000 description 1
- 238000013399 early diagnosis Methods 0.000 description 1
- 229940088598 enzyme Drugs 0.000 description 1
- YOBAEOGBNPPUQV-UHFFFAOYSA-N iron;trihydrate Chemical compound O.O.O.[Fe].[Fe] YOBAEOGBNPPUQV-UHFFFAOYSA-N 0.000 description 1
- 238000002156 mixing Methods 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 230000001575 pathological effect Effects 0.000 description 1
- 230000007170 pathology Effects 0.000 description 1
- 239000000049 pigment Substances 0.000 description 1
- 238000001556 precipitation Methods 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 239000000375 suspending agent Substances 0.000 description 1
- 239000012085 test solution Substances 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
- 230000000451 tissue damage Effects 0.000 description 1
- 231100000827 tissue damage Toxicity 0.000 description 1
- 230000009092 tissue dysfunction Effects 0.000 description 1
- 235000013799 ultramarine blue Nutrition 0.000 description 1
- 238000012800 visualization Methods 0.000 description 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/86—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving blood coagulating time or factors, or their receptors
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
- G01N2333/745—Assays involving non-enzymic blood coagulation factors
- G01N2333/75—Fibrin; Fibrinogen
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Hematology (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Urology & Nephrology (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- Cell Biology (AREA)
- Food Science & Technology (AREA)
- Medicinal Chemistry (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Microbiology (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Investigating Or Analyzing Non-Biological Materials By The Use Of Chemical Means (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US495161A US3915640A (en) | 1974-08-06 | 1974-08-06 | Method and composition for detecting fibrin monomers and fibrin degradation products |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CH622350A5 true CH622350A5 (OSRAM) | 1981-03-31 |
Family
ID=23967507
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CH857075A CH622350A5 (OSRAM) | 1974-08-06 | 1975-07-01 |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US3915640A (OSRAM) |
| JP (1) | JPS5119589A (OSRAM) |
| CA (1) | CA1035679A (OSRAM) |
| CH (1) | CH622350A5 (OSRAM) |
| DK (1) | DK296475A (OSRAM) |
| FR (1) | FR2281568A1 (OSRAM) |
| GB (1) | GB1462591A (OSRAM) |
| IT (1) | IT1039554B (OSRAM) |
| NO (1) | NO145356C (OSRAM) |
| SE (1) | SE419135B (OSRAM) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4090846A (en) * | 1976-10-20 | 1978-05-23 | Fisher Scientific Company | Indirect latex test for determination of fibrinogen degradation products |
| US4197088A (en) * | 1977-09-23 | 1980-04-08 | Akro-Medic Engineering, Inc. | Method for qualitative and quantitative determination of immunological reactions |
| US4411518A (en) * | 1977-09-23 | 1983-10-25 | Gamma Biologicals, Inc. | Apparatus for use in qualitative determination of immunological reactions |
| US4210420A (en) * | 1978-11-13 | 1980-07-01 | Ortho Diagnostics Inc. | Detection of fibrin monomer and composition therefor |
| CN1091315A (zh) * | 1992-10-08 | 1994-08-31 | E·R·斯奎布父子公司 | 血纤维蛋白封闭剂组合物及其使用方法 |
| US6436655B1 (en) * | 1998-02-09 | 2002-08-20 | Medical Devices Corporation | Rapid quantitative measurement of soluble fibrin in opaque body fluids |
| CN103604779B (zh) * | 2013-07-30 | 2016-04-13 | 青岛九龙生物医药有限公司 | 一种硫酸鱼精蛋白效价测定方法 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3797999A (en) * | 1970-05-20 | 1974-03-19 | Aerojet General Co | Method and apparatus for indicating micro-organic matter by means of chemiluminescence |
| US3778352A (en) * | 1973-02-23 | 1973-12-11 | Baxter Laboratories Inc | Plasminogen assay system |
| US3783103A (en) * | 1973-02-23 | 1974-01-01 | Baxter Laboratories Inc | Thrombin assay system |
| US3849653A (en) * | 1973-09-27 | 1974-11-19 | Bausch & Lomb | Multichannel bioluminescent sensors |
-
1974
- 1974-08-06 US US495161A patent/US3915640A/en not_active Expired - Lifetime
-
1975
- 1975-05-29 NO NO751910A patent/NO145356C/no unknown
- 1975-06-13 FR FR7518520A patent/FR2281568A1/fr active Granted
- 1975-06-17 CA CA229,570A patent/CA1035679A/en not_active Expired
- 1975-06-20 JP JP50075433A patent/JPS5119589A/ja active Granted
- 1975-06-30 SE SE7507478A patent/SE419135B/xx unknown
- 1975-06-30 DK DK296475A patent/DK296475A/da not_active Application Discontinuation
- 1975-06-30 IT IT24938/75A patent/IT1039554B/it active
- 1975-07-01 CH CH857075A patent/CH622350A5/de not_active IP Right Cessation
- 1975-07-28 GB GB3145875A patent/GB1462591A/en not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| JPS5119589A (en) | 1976-02-16 |
| US3915640A (en) | 1975-10-28 |
| CA1035679A (en) | 1978-08-01 |
| NO145356B (no) | 1981-11-23 |
| FR2281568A1 (fr) | 1976-03-05 |
| SE419135B (sv) | 1981-07-13 |
| DE2528381B2 (de) | 1976-09-16 |
| JPS5433877B2 (OSRAM) | 1979-10-23 |
| IT1039554B (it) | 1979-12-10 |
| GB1462591A (en) | 1977-01-26 |
| NO145356C (no) | 1982-03-03 |
| SE7507478L (sv) | 1976-02-09 |
| AU8189775A (en) | 1976-12-09 |
| NO751910L (OSRAM) | 1976-02-09 |
| DK296475A (da) | 1976-02-07 |
| FR2281568B1 (OSRAM) | 1978-03-17 |
| DE2528381A1 (de) | 1976-02-26 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PL | Patent ceased | ||
| PL | Patent ceased |