CH619969A5 - Process for the preparation of new halogenated derivatives of the 16alpha-methylpregnane series - Google Patents

Process for the preparation of new halogenated derivatives of the 16alpha-methylpregnane series Download PDF

Info

Publication number
CH619969A5
CH619969A5 CH264177A CH264177A CH619969A5 CH 619969 A5 CH619969 A5 CH 619969A5 CH 264177 A CH264177 A CH 264177A CH 264177 A CH264177 A CH 264177A CH 619969 A5 CH619969 A5 CH 619969A5
Authority
CH
Switzerland
Prior art keywords
compounds
formula
prepared
atom
chlorine atom
Prior art date
Application number
CH264177A
Other languages
English (en)
French (fr)
Inventor
Jean Georges Teutsch
Germain Costerousse
Roger Deraedt
Original Assignee
Roussel Uclaf
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Roussel Uclaf filed Critical Roussel Uclaf
Publication of CH619969A5 publication Critical patent/CH619969A5/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J5/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond
    • C07J5/0007—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond not substituted in position 17 alfa
    • C07J5/0023—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond not substituted in position 17 alfa substituted in position 16
    • C07J5/003—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond not substituted in position 17 alfa substituted in position 16 by a saturated or unsaturated hydrocarbon group including 16-alkylidene substitutes
    • C07J5/0038—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond not substituted in position 17 alfa substituted in position 16 by a saturated or unsaturated hydrocarbon group including 16-alkylidene substitutes by an alkyl group
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/38—Drugs for disorders of the endocrine system of the suprarenal hormones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J43/00—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C07J43/003—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton not condensed

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Endocrinology (AREA)
  • Diabetes (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
CH264177A 1976-03-02 1977-03-02 Process for the preparation of new halogenated derivatives of the 16alpha-methylpregnane series CH619969A5 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR7605854A FR2342738A1 (fr) 1976-03-02 1976-03-02 Nouveaux derives halogenes de la serie du 16a-methyl pregnane

Publications (1)

Publication Number Publication Date
CH619969A5 true CH619969A5 (en) 1980-10-31

Family

ID=9169832

Family Applications (1)

Application Number Title Priority Date Filing Date
CH264177A CH619969A5 (en) 1976-03-02 1977-03-02 Process for the preparation of new halogenated derivatives of the 16alpha-methylpregnane series

Country Status (16)

Country Link
JP (1) JPS52106855A (sv)
AT (1) AT355237B (sv)
AU (1) AU509948B2 (sv)
BE (1) BE851944A (sv)
CA (1) CA1082170A (sv)
CH (1) CH619969A5 (sv)
DE (1) DE2709078C2 (sv)
DK (1) DK156401C (sv)
FR (1) FR2342738A1 (sv)
GB (1) GB1530975A (sv)
IE (1) IE44866B1 (sv)
LU (1) LU76867A1 (sv)
NL (1) NL7702166A (sv)
PT (1) PT66261B (sv)
SE (1) SE7702250L (sv)
ZA (1) ZA771078B (sv)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2462443A1 (fr) * 1979-07-26 1981-02-13 Roussel Uclaf Nouveau derive halogene de la serie du 16a-methyl pregnane, son procede de preparation et son application comme medicament
FR2533928A1 (fr) * 1982-10-05 1984-04-06 Roussel Uclaf Nouveaux derives dichlores de la serie du 16a-methyl pregnane, leur procede de preparation et leur application comme medicaments
DE4433374A1 (de) * 1994-09-20 1996-03-21 Hoechst Ag 17-Desoxi-corticosteroid-21-/O/-Carbonsäure- ester, Verfahren zu deren Herstellung und diese enthaltende Arzneimittel

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB928301A (en) * 1958-06-20 1963-06-12 Scherico Ltd 9, 11-dihalogeno steroids
US3049554A (en) * 1959-06-01 1962-08-14 Schering Corp 9, 11-dihalogeno-3, 20-diketopregnanes and processes for their manufacture

Also Published As

Publication number Publication date
ATA136577A (de) 1979-07-15
FR2342738B1 (sv) 1979-10-12
AT355237B (de) 1980-02-25
AU509948B2 (en) 1980-06-05
NL7702166A (nl) 1977-09-06
PT66261B (fr) 1979-01-17
JPS52106855A (en) 1977-09-07
DK156401C (da) 1990-01-08
IE44866B1 (en) 1982-04-21
DE2709078C2 (de) 1986-09-11
AU2280877A (en) 1978-09-07
LU76867A1 (sv) 1977-09-26
DE2709078A1 (de) 1977-09-08
DK156401B (da) 1989-08-14
FR2342738A1 (fr) 1977-09-30
CA1082170A (fr) 1980-07-22
DK88277A (da) 1977-09-03
JPS6150960B2 (sv) 1986-11-06
SE7702250L (sv) 1977-09-03
IE44866L (en) 1977-09-02
ZA771078B (en) 1978-04-26
PT66261A (fr) 1977-04-01
GB1530975A (en) 1978-11-01
BE851944A (fr) 1977-09-01

Similar Documents

Publication Publication Date Title
EP0389369B1 (fr) Nouveaux stéroides 3-céto comportant une chaîne en 17 aminosubstituée, leur procédé de préparation et les intermédiaires de ce procédé, leur application comme médicaments et les compositions les contenant
EP0389370B1 (fr) Nouveaux stéroides 19-Nor 3-céto comportant une chaîne en 17 aminosubstituée, leur procédé de préparation et les intermédiaires de ce procédé,leur application comme médicaments et les compositions pharmaceutiques les contenant
LU88001A1 (fr) Nouveaux esters pregna-1,4-diene-3,20-dione-16-17-acetal-21,procede pour leur preparation,et methodes pour le traitement des conditions inflammatoires
EP0389368B1 (fr) Nouveaux dérivés de la 6-(1-pipérazinyl) 2,5-pyridine diamine N,N,N',N'-substituée, leur procédé de préparation et les intermédiaires de ce procédé, leur application comme médicaments et les compositions pharmaceutiques les renfermant
CA1203234A (fr) PROCEDE DE PREPARATION DE NOUVEAUX DERIVES DICHLORES DE LA SERIE 16.alpha.-METHYL PREGNANE
CA1140110A (fr) Procede de preparation de nouveaux derives de l'androst-4-ene
EP0072268B1 (fr) Stéroides estérifiés en la position 17 et thioestérifiés en la position 21, leur procédé de préparation et leur application comme médicament
CH619969A5 (en) Process for the preparation of new halogenated derivatives of the 16alpha-methylpregnane series
FR2510583A1 (fr) Derives nouveaux d'acide ursodesoxycholique, leur procede de preparation et leur application en therapeutique
EP0141684B1 (fr) 17-oxo-21-thioesters d'hydrocortisone, leur préparation et leurs applications comme médicament
FR2510558A1 (fr) Derives nouveaux d'acide chenodesoxycholique
CA1096372A (fr) Procede de preparation de nouveaux 2,2-dimethyl 19- nor steroides
CH641814A5 (fr) Derives acetyleniques de l'androst-4-ene, leurs procedes de preparation et medicaments les renfermant.
CA1114366A (fr) PROCEDE DE PREPARATION DE DERIVES 17.alpha.-ACETYLENIQUES DE L'ANDROST 4-ENE
CA1146531A (fr) Procede de preparation de nouveaux derives 2,2- dimethyl 19-nor steroides
CA1141751A (fr) PROCEDE DE PREPARATION D'UN NOUVEAU DERIVE HALOGENE DE LA SERIE DU 16.alpha.-METHYL PREGNANE
EP0003090B1 (fr) Nouveaux dérivés stéroides 17 alpha-aryle ou 17 alpha-hétéroaryle, leur procédé de préparation et leur application comme médicaments et les compositions pharmaceutiques les renfermant
EP0055170B1 (fr) Nouveaux dérivés stéroides 3-céto delta 4 ou delta 1-4 substitués en position 7, leur préparation, leur application comme médicaments et les compositions les renfermant
CA1072540A (fr) Procede de preparation de nouveaux 2,2-dimethyl steroides
CH646983A5 (fr) Derives acetyleniques chlores de l'androst-4-ene, leur preparation et medicaments les renfermant.
CA1121342A (fr) Procede de preparation de nouveaux derives du pregn 4-ene
EP0394118B1 (fr) Nouveaux dérivés insaturés de l'acide 2,6-amino heptanedioique, leur procédé de préparation et leur application comme médicaments
CA1175415A (fr) Procede de preparation de nouveaux derives steroides 3-amino substitue
CH627193A5 (sv)
CH598285A5 (en) Steroid 21-(4-acetamidomethylcyclohexane carboxylates)

Legal Events

Date Code Title Description
PL Patent ceased