CH618170A5 - - Google Patents

Download PDF

Info

Publication number
CH618170A5
CH618170A5 CH9274A CH9274A CH618170A5 CH 618170 A5 CH618170 A5 CH 618170A5 CH 9274 A CH9274 A CH 9274A CH 9274 A CH9274 A CH 9274A CH 618170 A5 CH618170 A5 CH 618170A5
Authority
CH
Switzerland
Prior art keywords
amino
dihydro
triazin
methyl
radical
Prior art date
Application number
CH9274A
Other languages
German (de)
English (en)
Inventor
Robert William Clarke
David Hartley
Alexander William Oxford
Original Assignee
Allen & Hanburys Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Allen & Hanburys Ltd filed Critical Allen & Hanburys Ltd
Publication of CH618170A5 publication Critical patent/CH618170A5/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D253/00—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00
    • C07D253/02—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00 not condensed with other rings
    • C07D253/06—1,2,4-Triazines
    • C07D253/065—1,2,4-Triazines having three double bonds between ring members or between ring members and non-ring members
    • C07D253/07—1,2,4-Triazines having three double bonds between ring members or between ring members and non-ring members with hetero atoms, or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D253/075—Two hetero atoms, in positions 3 and 5
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/53—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
CH9274A 1973-01-04 1974-01-02 CH618170A5 (ja)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB55373*[A GB1457873A (en) 1973-01-04 1973-01-04 Imidazotriazines

Publications (1)

Publication Number Publication Date
CH618170A5 true CH618170A5 (ja) 1980-07-15

Family

ID=9706420

Family Applications (1)

Application Number Title Priority Date Filing Date
CH9274A CH618170A5 (ja) 1973-01-04 1974-01-02

Country Status (19)

Country Link
US (1) US3941785A (ja)
JP (1) JPS4995994A (ja)
AT (1) AT336029B (ja)
AU (1) AU474078B2 (ja)
BE (1) BE809369A (ja)
CA (1) CA1005057A (ja)
CH (1) CH618170A5 (ja)
DE (1) DE2364076A1 (ja)
ES (1) ES422001A1 (ja)
FI (1) FI57260C (ja)
FR (1) FR2213058B1 (ja)
GB (1) GB1457873A (ja)
IE (1) IE38681B1 (ja)
IL (1) IL43872A (ja)
LU (1) LU69099A1 (ja)
NL (1) NL7400095A (ja)
NO (1) NO140301C (ja)
SE (1) SE408179B (ja)
ZA (1) ZA739534B (ja)

Families Citing this family (39)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK109578A (da) * 1977-03-25 1978-09-26 Allen & Hanburys Ltd Fremgangsmaade til fremstilling af heterocycliske forbindelser
US4096257A (en) * 1977-05-23 1978-06-20 American Cyanamid Company Substituted imidazo [1,2-d]-as-triazines
US4107309A (en) * 1977-05-23 1978-08-15 American Cyanamid Company Substituted imidazo[1,2-d]-as-triazines
US4126444A (en) * 1977-11-22 1978-11-21 American Cynamid Company Substituted imidazo (1,5-D)-as-triazin-4-ols, and herbicidal use thereof
US4308384A (en) * 1978-09-18 1981-12-29 Glaxo Group Limited Production of triazinones
DD244681A3 (de) * 1985-12-02 1987-04-15 Zeiss Jena Veb Carl Vorrichtung zur positionierung von enden flexibler lichtleitelemente
US6624181B1 (en) * 1997-02-28 2003-09-23 Altana Pharma Ag Synergistic combination
ATE213246T1 (de) * 1997-11-12 2002-02-15 2-phenyl-substituierte imidazotriazinone als phosphodiesterase inhibitoren
DE19827640A1 (de) * 1998-06-20 1999-12-23 Bayer Ag 7-Alkyl- und Cycloalkyl-substituierte Imidazotriazinone
IL141335A0 (en) 1998-08-26 2002-03-10 Smithkline Beecham Corp Therapies for treating pulmonary diseases
EA006685B1 (ru) 1999-08-21 2006-02-24 Алтана Фарма Аг Синергетическая композиция
DK1392314T3 (da) * 2001-05-09 2007-03-12 Bayer Healthcare Ag Hidtil ukendt anvendelse af 2-[2-ethoxy-5-(4-methyl-piperazin-1-sulfonyl)-phenyl]-5-methyl-7-propyl-3H-imidazo[5,1-f][1,2,4]-triazin-4-on
GB0113343D0 (en) * 2001-06-01 2001-07-25 Bayer Ag Novel Heterocycles 2
GB0113344D0 (en) * 2001-06-01 2001-07-25 Bayer Ag Novel heterocycles 3
DE10130167A1 (de) * 2001-06-22 2003-01-02 Bayer Ag Imidazotriazine
DE10135815A1 (de) 2001-07-23 2003-02-06 Bayer Ag Verwendung von 2-Alkoxyphenyl-substituierten Imidazotriazinonen
DE10230604A1 (de) * 2002-07-08 2004-01-29 Bayer Ag Heterocyclisch substituierte Imidazotriazine
DE10230605A1 (de) * 2002-07-08 2004-01-29 Bayer Ag Substituierte Imidazotriazine
DE10232113A1 (de) 2002-07-16 2004-01-29 Bayer Ag Vardenafil Hydrochlorid Trihydrat enthaltende Arzneimittel
ES2326808T3 (es) * 2003-04-01 2009-10-20 Smithkline Beecham Corporation Compuestos de imidazotriazina para el tratamiento de enfermedades cancerosas.
DE102005001989A1 (de) * 2005-01-15 2006-07-20 Bayer Healthcare Ag Intravenöse Formulierungen von PDE-Inhibitoren
DE102005009240A1 (de) * 2005-03-01 2006-09-07 Bayer Healthcare Ag Arzneiformen mit verbesserten pharmakokinetischen Eigenschaften
DE102005009241A1 (de) * 2005-03-01 2006-09-07 Bayer Healthcare Ag Arzneiformen mit kontrollierter Bioverfügbarkeit
EP2275095A3 (en) 2005-08-26 2011-08-17 Braincells, Inc. Neurogenesis by muscarinic receptor modulation
EP2258358A3 (en) 2005-08-26 2011-09-07 Braincells, Inc. Neurogenesis with acetylcholinesterase inhibitor
BRPI0616633A2 (pt) * 2005-09-29 2011-06-28 Bayer Healthcare Ag inibidores de pde e combinações dos mesmos para o tratamento de transtornos urológicos
JP2009512711A (ja) 2005-10-21 2009-03-26 ブレインセルス，インコーポレイティド Ｐｄｅ阻害による神経新生の調節
CA2625210A1 (en) 2005-10-31 2007-05-10 Braincells, Inc. Gaba receptor mediated modulation of neurogenesis
US20070244143A1 (en) * 2006-03-08 2007-10-18 Braincells, Inc Modulation of neurogenesis by nootropic agents
US20100216734A1 (en) * 2006-03-08 2010-08-26 Braincells, Inc. Modulation of neurogenesis by nootropic agents
JP2009536667A (ja) * 2006-05-09 2009-10-15 ブレインセルス，インコーポレイティド ５ｈｔ受容体介在性の神経新生
AU2007249399A1 (en) 2006-05-09 2007-11-22 Braincells, Inc. Neurogenesis by modulating angiotensin
US20100009983A1 (en) * 2006-05-09 2010-01-14 Braincells, Inc. 5 ht receptor mediated neurogenesis
KR20090064418A (ko) * 2006-09-08 2009-06-18 브레인셀즈 인코퍼레이션 4-아실아미노피리딘 유도체 포함 조합물
US20100184806A1 (en) 2006-09-19 2010-07-22 Braincells, Inc. Modulation of neurogenesis by ppar agents
WO2008036678A2 (en) * 2006-09-19 2008-03-27 Braincells, Inc. Combination comprising a peroxisome proliferator activated receptor agent and a second neurogenic agent for treating a nervous system disorder, increasing neurodifferentiation and increasing neurogenesis
KR20100029762A (ko) * 2007-06-13 2010-03-17 바이엘 쉐링 파마 악티엔게젤샤프트 청력 장애 치료용 ｐｄｅ 억제제
WO2010099217A1 (en) 2009-02-25 2010-09-02 Braincells, Inc. Modulation of neurogenesis using d-cycloserine combinations
WO2013106547A1 (en) 2012-01-10 2013-07-18 President And Fellows Of Harvard College Beta-cell replication promoting compounds and methods of their use

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE791025A (fr) * 1971-11-19 1973-05-07 Allen & Hanburys Ltd Composes heterocycliques

Also Published As

Publication number Publication date
IE38681B1 (en) 1978-05-10
BE809369A (fr) 1974-07-03
FI57260C (fi) 1980-07-10
US3941785A (en) 1976-03-02
NO140301B (no) 1979-04-30
SE408179B (sv) 1979-05-21
AU6377473A (en) 1975-06-19
AT336029B (de) 1977-04-12
CA1005057A (en) 1977-02-08
JPS4995994A (ja) 1974-09-11
ZA739534B (en) 1974-11-27
AU474078B2 (en) 1976-07-15
IL43872A (en) 1979-01-31
IE38681L (en) 1974-07-04
NL7400095A (ja) 1974-07-08
NO140301C (no) 1979-08-08
ES422001A1 (es) 1976-08-01
LU69099A1 (ja) 1974-04-02
GB1457873A (en) 1976-12-08
FI57260B (fi) 1980-03-31
ATA2374A (de) 1976-08-15
IL43872A0 (en) 1974-03-14
FR2213058A1 (ja) 1974-08-02
DE2364076A1 (de) 1974-07-18
FR2213058B1 (ja) 1977-07-01

Similar Documents

Publication Publication Date Title
CH618170A5 (ja)
DE69918528T2 (de) Bicyclische heteroaromatische verbindungen als protein tyrosine kinase inhibitoren
EP0287907B1 (de) Pyrazolo[3,4-d]pyrimidine, Verfahren zu ihrer Herstellung und Verwendung als Arzneimittel
DE1445151A1 (de) Verfahren zur Herstellung chemischer Verbindungen
DE1493955A1 (de) Verfahren zur Herstellung substituierter Sulfonanilide
US4201860A (en) Purine derivatives
EP0072932A2 (de) Neue Piperazinone, ihre Herstellung und Verwendung
DE1670849B2 (de) Verfahren zur herstellung von 8-acylamino-1,2,3,4-tetrahydroisochinolinen
EP0165422B1 (de) Neue substituierte Bis(4-aminophenyl)sulfone, ihre Herstellung und ihre Verwendung als Arzneimittel
DE2918261C2 (ja)
DE1620694B2 (de) Verfahren zur Herstellung von 5-Methyl-7-diäthylamino-s-triazolo [1,5-a] pyrimidin und seinen Salzen mit Säuren
DE2505297B2 (de) Verfahren zur Herstellung von in 2- und 6-Stellung des Phenylkerns substituierten 2-Phenylamino-2-imidazolin-Derivaten
DE1770372A1 (de) Neue Indolinderivate und Verfahren zu ihrer Herstellung
CH626351A5 (ja)
DE3328636A1 (de) Xanthinderivate, Verfahren zu ihrer Herstellung und ihre Verwendung
EP0271099A2 (de) Substituierte Aminopropionsäureamide, Verfahren zu ihrer Herstellung, diese enthaltende Mittel und ihre Verwendung sowie die bei der Herstellung anfallenden neuen Zwischenprodukte
DE69017627T2 (de) Isochinolinderivate und ihre Salze als Proteasehemmer.
DE2526795A1 (de) Sulfonamide
DE3816634A1 (de) Cyclobuten-3,4-dion-zwischenverbindungen, verfahren zu ihrer herstellung und ihre verwendung
DE1620342C3 (ja)
DE2854341C2 (ja)
AT299202B (de) Verfahren zur Herstellung von neuen substituierten Isochinolinen und von deren Säureadditionssalzen
DE3245950A1 (de) Verfahren zur herstellung substituierter pyridine
DE2824291A1 (de) Neue benzylalkoholderivate und verfahren zu ihrer herstellung
DE2354327B2 (de) 2-amino-1,2,3,4-tetrahydronaphthalin- derivate, verfahren zu deren herstellung und verfahren zur herstellung von 6,7- benzomorphanen ausgehend von jenen

Legal Events

Date Code Title Description
PL Patent ceased