CH616959A5 - - Google Patents
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- Publication number
- CH616959A5 CH616959A5 CH1590874A CH1590874A CH616959A5 CH 616959 A5 CH616959 A5 CH 616959A5 CH 1590874 A CH1590874 A CH 1590874A CH 1590874 A CH1590874 A CH 1590874A CH 616959 A5 CH616959 A5 CH 616959A5
- Authority
- CH
- Switzerland
- Prior art keywords
- strain
- virus
- culture
- parent
- attenuated
- Prior art date
Links
- 241000700605 Viruses Species 0.000 claims description 77
- 230000002238 attenuated effect Effects 0.000 claims description 28
- 238000000034 method Methods 0.000 claims description 27
- 238000012360 testing method Methods 0.000 claims description 25
- 210000002966 serum Anatomy 0.000 claims description 16
- 239000000427 antigen Substances 0.000 claims description 15
- 108091007433 antigens Proteins 0.000 claims description 15
- 102000036639 antigens Human genes 0.000 claims description 15
- 230000006798 recombination Effects 0.000 claims description 12
- 238000005215 recombination Methods 0.000 claims description 11
- 230000035931 haemagglutination Effects 0.000 claims description 10
- 208000037797 influenza A Diseases 0.000 claims description 10
- 238000004519 manufacturing process Methods 0.000 claims description 10
- 208000015181 infectious disease Diseases 0.000 claims description 9
- 238000010790 dilution Methods 0.000 claims description 8
- 239000012895 dilution Substances 0.000 claims description 8
- 230000000521 hyperimmunizing effect Effects 0.000 claims description 8
- 238000011534 incubation Methods 0.000 claims description 8
- 239000000203 mixture Substances 0.000 claims description 8
- 241000287828 Gallus gallus Species 0.000 claims description 7
- 235000013330 chicken meat Nutrition 0.000 claims description 7
- 230000005764 inhibitory process Effects 0.000 claims description 7
- 101710154606 Hemagglutinin Proteins 0.000 claims description 5
- 102000005348 Neuraminidase Human genes 0.000 claims description 5
- 108010006232 Neuraminidase Proteins 0.000 claims description 5
- 101710093908 Outer capsid protein VP4 Proteins 0.000 claims description 5
- 101710135467 Outer capsid protein sigma-1 Proteins 0.000 claims description 5
- 101710176177 Protein A56 Proteins 0.000 claims description 5
- 230000000890 antigenic effect Effects 0.000 claims description 5
- 230000000694 effects Effects 0.000 claims description 5
- 239000000185 hemagglutinin Substances 0.000 claims description 5
- 241000712461 unidentified influenza virus Species 0.000 claims description 5
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 claims description 4
- 230000015572 biosynthetic process Effects 0.000 claims description 4
- 244000309466 calf Species 0.000 claims description 4
- 238000004140 cleaning Methods 0.000 claims description 4
- 230000002779 inactivation Effects 0.000 claims description 4
- 241000282341 Mustela putorius furo Species 0.000 claims description 3
- 241000283973 Oryctolagus cuniculus Species 0.000 claims description 3
- 210000003743 erythrocyte Anatomy 0.000 claims description 3
- 210000003292 kidney cell Anatomy 0.000 claims description 3
- 230000007505 plaque formation Effects 0.000 claims description 3
- 239000012264 purified product Substances 0.000 claims description 3
- 230000005855 radiation Effects 0.000 claims description 3
- 238000002604 ultrasonography Methods 0.000 claims description 2
- 238000010438 heat treatment Methods 0.000 claims 1
- 239000012535 impurity Substances 0.000 claims 1
- 230000000415 inactivating effect Effects 0.000 claims 1
- 235000013601 eggs Nutrition 0.000 description 42
- 229960005486 vaccine Drugs 0.000 description 17
- 206010022000 influenza Diseases 0.000 description 11
- 239000012530 fluid Substances 0.000 description 10
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 6
- LOKCTEFSRHRXRJ-UHFFFAOYSA-I dipotassium trisodium dihydrogen phosphate hydrogen phosphate dichloride Chemical compound P(=O)(O)(O)[O-].[K+].P(=O)(O)([O-])[O-].[Na+].[Na+].[Cl-].[K+].[Cl-].[Na+] LOKCTEFSRHRXRJ-UHFFFAOYSA-I 0.000 description 5
- 201000010099 disease Diseases 0.000 description 5
- 238000003973 irrigation Methods 0.000 description 5
- 230000002262 irrigation Effects 0.000 description 5
- 239000002953 phosphate buffered saline Substances 0.000 description 5
- 210000004027 cell Anatomy 0.000 description 4
- 238000006243 chemical reaction Methods 0.000 description 4
- 230000028327 secretion Effects 0.000 description 4
- UCSJYZPVAKXKNQ-HZYVHMACSA-N streptomycin Chemical group CN[C@H]1[C@H](O)[C@@H](O)[C@H](CO)O[C@H]1O[C@@H]1[C@](C=O)(O)[C@H](C)O[C@H]1O[C@@H]1[C@@H](NC(N)=N)[C@H](O)[C@@H](NC(N)=N)[C@H](O)[C@H]1O UCSJYZPVAKXKNQ-HZYVHMACSA-N 0.000 description 4
- 101710186708 Agglutinin Proteins 0.000 description 3
- 101710146024 Horcolin Proteins 0.000 description 3
- 101710189395 Lectin Proteins 0.000 description 3
- 101710179758 Mannose-specific lectin Proteins 0.000 description 3
- 101710150763 Mannose-specific lectin 1 Proteins 0.000 description 3
- 101710150745 Mannose-specific lectin 2 Proteins 0.000 description 3
- 239000000910 agglutinin Substances 0.000 description 3
- 230000002068 genetic effect Effects 0.000 description 3
- 230000036039 immunity Effects 0.000 description 3
- 229960003971 influenza vaccine Drugs 0.000 description 3
- 238000011081 inoculation Methods 0.000 description 3
- 239000007788 liquid Substances 0.000 description 3
- 238000002360 preparation method Methods 0.000 description 3
- 238000011160 research Methods 0.000 description 3
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 description 2
- 108010010803 Gelatin Proteins 0.000 description 2
- 101710133291 Hemagglutinin-neuraminidase Proteins 0.000 description 2
- 229930182555 Penicillin Natural products 0.000 description 2
- JGSARLDLIJGVTE-MBNYWOFBSA-N Penicillin G Chemical group N([C@H]1[C@H]2SC([C@@H](N2C1=O)C(O)=O)(C)C)C(=O)CC1=CC=CC=C1 JGSARLDLIJGVTE-MBNYWOFBSA-N 0.000 description 2
- 206010037660 Pyrexia Diseases 0.000 description 2
- 239000003242 anti bacterial agent Substances 0.000 description 2
- 229940088710 antibiotic agent Drugs 0.000 description 2
- 210000000991 chicken egg Anatomy 0.000 description 2
- 239000003085 diluting agent Substances 0.000 description 2
- 238000002474 experimental method Methods 0.000 description 2
- 229920000159 gelatin Polymers 0.000 description 2
- 239000008273 gelatin Substances 0.000 description 2
- 235000019322 gelatine Nutrition 0.000 description 2
- 235000011852 gelatine desserts Nutrition 0.000 description 2
- 150000003278 haem Chemical class 0.000 description 2
- 230000003053 immunization Effects 0.000 description 2
- 238000002649 immunization Methods 0.000 description 2
- 230000002163 immunogen Effects 0.000 description 2
- 230000002458 infectious effect Effects 0.000 description 2
- 238000002955 isolation Methods 0.000 description 2
- 230000008520 organization Effects 0.000 description 2
- 229940049954 penicillin Drugs 0.000 description 2
- 108090000623 proteins and genes Proteins 0.000 description 2
- 239000000243 solution Substances 0.000 description 2
- 239000000600 sorbitol Substances 0.000 description 2
- 239000003381 stabilizer Substances 0.000 description 2
- 229960005322 streptomycin Drugs 0.000 description 2
- 208000024891 symptom Diseases 0.000 description 2
- 238000002255 vaccination Methods 0.000 description 2
- 230000003612 virological effect Effects 0.000 description 2
- 241000894006 Bacteria Species 0.000 description 1
- 206010019233 Headaches Diseases 0.000 description 1
- 235000003332 Ilex aquifolium Nutrition 0.000 description 1
- 235000002296 Ilex sandwicensis Nutrition 0.000 description 1
- 235000002294 Ilex volkensiana Nutrition 0.000 description 1
- 241000124008 Mammalia Species 0.000 description 1
- 206010049565 Muscle fatigue Diseases 0.000 description 1
- 208000000112 Myalgia Diseases 0.000 description 1
- 206010068319 Oropharyngeal pain Diseases 0.000 description 1
- 229910019142 PO4 Inorganic materials 0.000 description 1
- 201000007100 Pharyngitis Diseases 0.000 description 1
- 101100188438 Rattus norvegicus Oat gene Proteins 0.000 description 1
- 208000036071 Rhinorrhea Diseases 0.000 description 1
- 206010039101 Rhinorrhoea Diseases 0.000 description 1
- 108010008038 Synthetic Vaccines Proteins 0.000 description 1
- 230000001154 acute effect Effects 0.000 description 1
- 239000000443 aerosol Substances 0.000 description 1
- 210000000601 blood cell Anatomy 0.000 description 1
- 235000019994 cava Nutrition 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 238000007865 diluting Methods 0.000 description 1
- 238000003113 dilution method Methods 0.000 description 1
- 231100000869 headache Toxicity 0.000 description 1
- 230000036541 health Effects 0.000 description 1
- 238000010348 incorporation Methods 0.000 description 1
- 239000002054 inoculum Substances 0.000 description 1
- 210000003734 kidney Anatomy 0.000 description 1
- 229960001226 live attenuated influenza Drugs 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 208000013465 muscle pain Diseases 0.000 description 1
- 239000002245 particle Substances 0.000 description 1
- 230000007918 pathogenicity Effects 0.000 description 1
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 1
- 239000010452 phosphate Substances 0.000 description 1
- 239000002504 physiological saline solution Substances 0.000 description 1
- 239000000047 product Substances 0.000 description 1
- 230000005180 public health Effects 0.000 description 1
- 238000000746 purification Methods 0.000 description 1
- 229940124551 recombinant vaccine Drugs 0.000 description 1
- 210000002345 respiratory system Anatomy 0.000 description 1
- 230000000717 retained effect Effects 0.000 description 1
- 238000009666 routine test Methods 0.000 description 1
- 239000008279 sol Substances 0.000 description 1
- 238000003892 spreading Methods 0.000 description 1
- 238000010561 standard procedure Methods 0.000 description 1
- 238000003860 storage Methods 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
- 238000011144 upstream manufacturing Methods 0.000 description 1
- 210000000605 viral structure Anatomy 0.000 description 1
- 230000001018 virulence Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
- A61K39/145—Orthomyxoviridae, e.g. influenza virus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/525—Virus
- A61K2039/5254—Virus avirulent or attenuated
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/54—Medicinal preparations containing antigens or antibodies characterised by the route of administration
- A61K2039/541—Mucosal route
- A61K2039/543—Mucosal route intranasal
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
- C12N2760/00011—Details
- C12N2760/16011—Orthomyxoviridae
- C12N2760/16111—Influenzavirus A, i.e. influenza A virus
- C12N2760/16134—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Virology (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Immunology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pulmonology (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB55469/73A GB1488800A (en) | 1973-11-29 | 1973-11-29 | Influenza vaccines |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CH616959A5 true CH616959A5 (en, 2012) | 1980-04-30 |
Family
ID=10474009
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CH1590874A CH616959A5 (en, 2012) | 1973-11-29 | 1974-11-29 |
Country Status (19)
| Country | Link |
|---|---|
| US (1) | US3991179A (en, 2012) |
| JP (1) | JPS5094115A (en, 2012) |
| AT (1) | AT331980B (en, 2012) |
| AU (1) | AU498810B2 (en, 2012) |
| BE (1) | BE822736A (en, 2012) |
| CA (1) | CA1044138A (en, 2012) |
| CH (1) | CH616959A5 (en, 2012) |
| CS (1) | CS199569B2 (en, 2012) |
| DE (1) | DE2456636A1 (en, 2012) |
| DK (1) | DK139807B (en, 2012) |
| ES (1) | ES432385A1 (en, 2012) |
| FR (1) | FR2253535B1 (en, 2012) |
| GB (1) | GB1488800A (en, 2012) |
| HU (1) | HU173548B (en, 2012) |
| IE (1) | IE40221B1 (en, 2012) |
| NL (1) | NL7415614A (en, 2012) |
| PL (1) | PL97723B1 (en, 2012) |
| SE (1) | SE422154B (en, 2012) |
| ZA (1) | ZA747602B (en, 2012) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS6042209B2 (ja) * | 1974-05-31 | 1985-09-20 | 北里研究所（社団法人） | インフルエンザウイルスの新鮮分離株を発育鶏卵へ短期間で順化させる方法 |
| US4318903A (en) * | 1978-07-12 | 1982-03-09 | Smithkline-Rit | Live influenza virus vaccine and the preparation thereof |
| US4278662A (en) * | 1979-10-16 | 1981-07-14 | Smith Kline - Rit | Attenuated influenza type A virus vaccine |
| US4338296A (en) * | 1979-10-16 | 1982-07-06 | Smithkline-Rit | Influenza virus and process of producing a vaccine therefrom |
| US4554159A (en) * | 1981-11-12 | 1985-11-19 | Institute Merieux | Vaccine and method of immunizing against herpes simplex virus (types 1 and 2) |
| US4743553A (en) * | 1984-07-18 | 1988-05-10 | W. R. Grace & Co. | Synthetic genes for bovine parainfluenza virus |
| US4783411A (en) * | 1984-10-22 | 1988-11-08 | Janis Gabliks | Influenza-A virus vaccine from fish cell cultures |
| WO2005112463A2 (en) * | 2004-05-19 | 2005-11-24 | Alza Corporation | Method and formulation for transdermal delivery of immunologically active agents |
| US7468187B2 (en) | 2005-10-18 | 2008-12-23 | Iowa State University Research Foundation, Inc. | Canine influenza virus and related compositions and methods of use |
-
1973
- 1973-11-29 GB GB55469/73A patent/GB1488800A/en not_active Expired
-
1974
- 1974-11-28 HU HU74WE514A patent/HU173548B/hu unknown
- 1974-11-28 AU AU75876/74A patent/AU498810B2/en not_active Expired
- 1974-11-28 DK DK618274AA patent/DK139807B/da not_active IP Right Cessation
- 1974-11-28 IE IE2447/74A patent/IE40221B1/xx unknown
- 1974-11-28 PL PL1974176013A patent/PL97723B1/pl unknown
- 1974-11-28 ZA ZA00747602A patent/ZA747602B/xx unknown
- 1974-11-28 BE BE150978A patent/BE822736A/xx not_active IP Right Cessation
- 1974-11-28 CS CS748153A patent/CS199569B2/cs unknown
- 1974-11-28 ES ES432385A patent/ES432385A1/es not_active Expired
- 1974-11-28 AT AT953774A patent/AT331980B/de not_active IP Right Cessation
- 1974-11-28 SE SE7414918A patent/SE422154B/xx unknown
- 1974-11-28 CA CA214,815A patent/CA1044138A/en not_active Expired
- 1974-11-29 US US05/528,555 patent/US3991179A/en not_active Expired - Lifetime
- 1974-11-29 DE DE19742456636 patent/DE2456636A1/de not_active Ceased
- 1974-11-29 CH CH1590874A patent/CH616959A5/de not_active IP Right Cessation
- 1974-11-29 NL NL7415614A patent/NL7415614A/xx not_active Application Discontinuation
- 1974-11-29 JP JP49137613A patent/JPS5094115A/ja active Pending
- 1974-12-26 FR FR7442881A patent/FR2253535B1/fr not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| DK139807C (en, 2012) | 1979-09-24 |
| PL97723B1 (pl) | 1978-03-30 |
| GB1488800A (en) | 1977-10-12 |
| DK618274A (en, 2012) | 1975-07-28 |
| DK139807B (da) | 1979-04-23 |
| AU7587674A (en) | 1976-06-03 |
| AU498810B2 (en) | 1979-03-29 |
| FR2253535B1 (en, 2012) | 1978-07-21 |
| AT331980B (de) | 1976-09-10 |
| CA1044138A (en) | 1978-12-12 |
| IE40221L (en) | 1975-05-29 |
| ZA747602B (en) | 1976-07-28 |
| FR2253535A1 (en, 2012) | 1975-07-04 |
| BE822736A (fr) | 1975-05-28 |
| CS199569B2 (en) | 1980-07-31 |
| ES432385A1 (es) | 1977-06-16 |
| SE7414918L (en, 2012) | 1975-05-30 |
| HU173548B (hu) | 1979-06-28 |
| US3991179A (en) | 1976-11-09 |
| DE2456636A1 (de) | 1975-06-05 |
| JPS5094115A (en, 2012) | 1975-07-26 |
| SE422154B (sv) | 1982-02-22 |
| NL7415614A (nl) | 1975-06-02 |
| IE40221B1 (en) | 1979-04-11 |
| ATA953774A (de) | 1975-12-15 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PL | Patent ceased | ||
| PL | Patent ceased |