CH403749A - Verfahren zur Herstellung von 1-Cyclohexyl-3-(p-trifluormethyl-benzolsulfonyl)-harnstoff - Google Patents
Verfahren zur Herstellung von 1-Cyclohexyl-3-(p-trifluormethyl-benzolsulfonyl)-harnstoffInfo
- Publication number
- CH403749A CH403749A CH442865A CH442865A CH403749A CH 403749 A CH403749 A CH 403749A CH 442865 A CH442865 A CH 442865A CH 442865 A CH442865 A CH 442865A CH 403749 A CH403749 A CH 403749A
- Authority
- CH
- Switzerland
- Prior art keywords
- trifluoromethyl
- cyclohexyl
- urea
- preparation
- benzenesulfonyl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/12—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms
- C07D295/125—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
- C07D295/13—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/50—Compounds containing any of the groups, X being a hetero atom, Y being any atom
- C07C311/52—Y being a hetero atom
- C07C311/54—Y being a hetero atom either X or Y, but not both, being nitrogen atoms, e.g. N-sulfonylurea
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/36—Radicals substituted by singly-bound nitrogen atoms
- C07D213/40—Acylated substituent nitrogen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C07D213/74—Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C07D213/75—Amino or imino radicals, acylated by carboxylic or carbonic acids, or by sulfur or nitrogen analogues thereof, e.g. carbamates
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/12—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms
Description
Verfahren zur Herstellung von 1-Cyclohexyl-3- (p-trifluormethyl-benzolsulfonyl)-harnstoff Die vorliegende Erfindung betrifft ein Verfahren zur Herstellung von l-Cyclohexyl-3- (p-trifluor methyl-benzolsulfonyl)-harnstoff. Diese neue Verbindung der Formel EMI1.1 weist hypoglykämische Wirksamkeit auf und eignet sich zur Behandlung gewisser Diabetiker. Das erfindungsgemässe Verfahren verläuft in zwei Stufen und ist dadurch gekennzeichnet, dass man 4-Trifluormethyl-benzolsulfonamid mit einem Alkylchlorformiat in das entsprechende Carbamat überführt und letzteres mit Cyclohexylamin umsetzt. Vorzugsweise lässt man hierbei das Sulfonamid mehrere Stunden lang mit dem Chlorformiat reagieren und verwendet einen Chlorameisensäureester mit niedriger Alkylgruppe. Das als Ausgangssubstanz für das erfindungsgemässe Verfahren verwendete 4-Trifluormethyl- benzolsulfonamid ist eine neue Substanz, die sich nach einer im Schweiz. Patent Nr. 399 434 beschriebenen Arbeitsweise herstellen lässt. Beispiel Zu 225 g (1,0 Mol) 4-Trifluormethyl-benzolsulfonamid und 358 g (2,6 Mol) einer wasserfreien Lösung von Kaliumcarbonat in 1,2 Liter Aceton wird langsam unter Rühren 163 g (1,32 Mol) Äthylchlorformiat im Verlauf von 3 Stunden zugegeben. Nach dem Abkühlen in einem Eisbad wird das Reaktionsgemenge filtriert und das Filtrat unter vermindertem Druck eingeengt. Der Rückstand wird in 3 Liter Wasser aufgenommen. Die erhaltene Lösung wird filtriert und langsam unter Kühlen angesäuert, wobei das weisse kristalline Carbamat entsteht. Zu 29,7 g (0,1 Mol) des getrockneten derart hergestellten Carbamats werden 29,0 g (0,3 Mol) Cyclohexylamin zugefügt. Das Gemisch wird in Benzol auf dem Wasserbad während ungefähr 10 Minuten erhitzt, worauf Auflösung eintritt. Das Benzol wird hierauf aus dem Gemenge bei 120 bis 140 C unter vermindertem Druck abgetrieben und der Rückstand aus einem Wachsbad während unge fähr 3 Stunden auf 135 bis 140 erwärmt. Der Rückstand wird aufgelöst in ungefähr 175 ml siedenden Isopropanols und die Lösung hierauf filtriert, wonach das Filtrat auf 500 ml mit Wasser bei unge fähr 100 verdünnt wird. Das erhaltene verdünnte Filtrat, welches das gewünschte Produkt enthält, wird abkühlen und über Nacht stehengelassen, worauf das ausgefallene feste Produkt abfiltriert wird. Die kristalline Substanz wird hierauf in 500 ml einer wässrigen Lösung von Natriumcarbonat (5 %) gelöst und die Lösung filtriert, wonach die unlösliche feste Substanz mit zwei Portionen von je 100 ml Wasser gewaschen wird. Das Filtrat wird angesäuert und abgekühlt, worauf das Produkt ausfällt, abfiltriert wird und aus Isopropanol/Wasser umkristallisiert wird. Man erhältfarbloseKristalledes l-Cyclohexyl-3- (p-trifluormethyl-benzolsulfonyl)-harnstoffs mit einem Smp. von 181 bis 183 . Analyse : Berechnet für CsgHi7FsNS03S (Molekulargewicht 350,36) : C 48,00% H 4,90% % Gefunden : C 47,94% H 4,81% Das erhaltene Präparat, das ebenfalls als l- (p- Trifluormethyl-benzolsulfonyl)-3-cyclohexyl-harnstoff bezeichnet werden kann, erweist sich bei oraler Verabreichung als wirksames hypoglykämisches Agens von geringer Toxizität.
Claims (1)
- PATENTANSPRUCH Verfahren zur Herstellung von l-Cyclohexyl-3- (p-trifluormethyl-benzolsulfonyl)-harnstoff, dadurch gekennzeichnet, dal3 man 4-Trifluormethyl-benzolsulfonamid mit einem Alkylchlorformiat in das entsprechende Carbamat überführt und letzteres mit Cyclohexylamin umsetzt.UNTERANSPRÜCHE 1. Verfahren nach Patentanspruch, dadurch gekennzeichnet, dass man das Sulfonamid mehrere Stunden lang mit dem Chlorameisensäureester reagieren lässt.2. Verfahren nach Patentanspruch, dadurch gekennzeichnet, dass man ein niedriges Alkylchlorformiat verwendet.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US79483259A | 1959-02-24 | 1959-02-24 |
Publications (1)
Publication Number | Publication Date |
---|---|
CH403749A true CH403749A (de) | 1965-12-15 |
Family
ID=25163812
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CH442865A CH403749A (de) | 1959-02-24 | 1960-02-24 | Verfahren zur Herstellung von 1-Cyclohexyl-3-(p-trifluormethyl-benzolsulfonyl)-harnstoff |
CH209860A CH399434A (de) | 1959-02-24 | 1960-02-24 | Verfahren zur Herstellung therapeutisch wirksamer Sulfonylharnstoffe |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CH209860A CH399434A (de) | 1959-02-24 | 1960-02-24 | Verfahren zur Herstellung therapeutisch wirksamer Sulfonylharnstoffe |
Country Status (5)
Country | Link |
---|---|
CH (2) | CH403749A (de) |
ES (1) | ES256000A1 (de) |
FR (1) | FR611M (de) |
GB (2) | GB899583A (de) |
SE (1) | SE302964B (de) |
-
1960
- 1960-02-23 GB GB6408/60A patent/GB899583A/en not_active Expired
- 1960-02-23 GB GB2719/62A patent/GB899584A/en not_active Expired
- 1960-02-24 ES ES0256000A patent/ES256000A1/es not_active Expired
- 1960-02-24 CH CH442865A patent/CH403749A/de unknown
- 1960-02-24 CH CH209860A patent/CH399434A/de unknown
- 1960-08-31 FR FR837428A patent/FR611M/fr active Active
-
1966
- 1966-07-26 SE SE1014466A patent/SE302964B/xx unknown
Also Published As
Publication number | Publication date |
---|---|
FR611M (de) | 1961-06-19 |
SE302964B (sv) | 1968-08-12 |
CH399434A (de) | 1965-09-30 |
GB899584A (en) | 1962-06-27 |
ES256000A1 (es) | 1960-09-01 |
GB899583A (en) | 1962-06-27 |
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