CH311596A - Process for making a new salt. - Google Patents

Process for making a new salt.

Info

Publication number
CH311596A
CH311596A CH311596DA CH311596A CH 311596 A CH311596 A CH 311596A CH 311596D A CH311596D A CH 311596DA CH 311596 A CH311596 A CH 311596A
Authority
CH
Switzerland
Prior art keywords
new salt
making
chloro
acid
anilide
Prior art date
Application number
Other languages
German (de)
Inventor
Aktiengesellschaft Cilag
Original Assignee
Cilag Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cilag Ag filed Critical Cilag Ag
Publication of CH311596A publication Critical patent/CH311596A/en

Links

Landscapes

  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Description

  

  Verfahren zur Herstellung eines neuen     Salzes.       Gegenstand des vorliegenden Patentes ist  ein Verfahren zur Herstellung eines neuen  Salzes, welches dadurch gekennzeichnet. ist,  dass man     N-Pyrrolidinoessigsäure-(2-chlor-6-          methyl-anilid)    mit     Chlorwasserstoffsäure    zur  Reaktion bringt. Man kann die Umsetzung in  einem Lösungsmittel, wie z. B. Alkohol, Äther,  Benzol,     Dioxan,    Wasser,     Wasser-Alkohol-          gemisehen,    vornehmen.  



  Das so erhaltene     N-Pyrrolidinoessigsäure-          (2-ehlor-6-meth@=1-anilid)-hydrochlorid    bildet  farblose Kristalle, die bei     194-l.95     schmel  zen. Das neue Salz soll als Lokalanästhetikum       verwendet    werden.  



  <I>Beispiel:</I>  25 g     N-Pyrrolidinoessigsäure-(2-chlor        -6-          met.hyl-anilid)    in 300     em3    Äther werden mit    einer Lösung von     Chlorwasserstoffsäure    in  Äther versetzt. Nach kurzer Zeit tritt Kri  stallisation ein. Nach einiger Zeit werden die  gebildeten Kristalle abgesaugt, mit Äther ge  waschen und dann getrocknet. Man erhält  <B>28</B> g des bei     194--195     schmelzenden     Pyrroli-          dinoessigsäure-        (2-ehlor-6-rnethyl-anilids).  



  Process for making a new salt. The present patent is a process for the production of a new salt, which is characterized. is that you bring N-pyrrolidinoacetic acid- (2-chloro-6-methyl-anilide) with hydrochloric acid to the reaction. You can do the reaction in a solvent, such as. B. alcohol, ether, benzene, dioxane, water, water-alcohol mixed.



  The N-pyrrolidinoacetic acid (2-chloro-6-meth @ = 1-anilide) hydrochloride thus obtained forms colorless crystals which melt at 194-1.95. The new salt is intended to be used as a local anesthetic.



  <I> Example: </I> 25 g of N-pyrrolidinoacetic acid (2-chloro-6-met.hyl-anilide) in 300 em3 ether are mixed with a solution of hydrochloric acid in ether. Crystallization occurs after a short time. After a while, the crystals formed are filtered off with suction, washed with ether and then dried. 28 g of pyrrolidinoacetic acid (2-chloro-6-methylanilide) melting at 194-195 are obtained.

Claims (1)

PATENTANSPRUCH: Verfahren zur Herstellung eines neuen Salzes, dadurch gekennzeichnet, dass man X- Pyrrolidinoessigsäure-(2-ehlor-6-methyl.-anilid) mit Chlorwasserstoffsäure zur Reaktion bringt.. Das resultierende N-Pyrrolidinoessigsäure- (2-chlor-6-methyl-anilid)-hydroehlorid bildet farblose, bei 194-195 schmelzende Kristalle; es soll als Lokalanästhetikum verwendet wer den. PATENT CLAIM: Process for the production of a new salt, characterized in that X-pyrrolidinoacetic acid (2-chloro-6-methyl.-anilide) is reacted with hydrochloric acid. The resulting N-pyrrolidinoacetic acid (2-chloro-6- methyl anilide) hydrochloride forms colorless crystals that melt at 194-195; it is intended to be used as a local anesthetic.
CH311596D 1952-02-25 1952-02-25 Process for making a new salt. CH311596A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CH311596T 1952-02-25
CH306793T 1955-04-30

Publications (1)

Publication Number Publication Date
CH311596A true CH311596A (en) 1955-11-30

Family

ID=25735214

Family Applications (1)

Application Number Title Priority Date Filing Date
CH311596D CH311596A (en) 1952-02-25 1952-02-25 Process for making a new salt.

Country Status (1)

Country Link
CH (1) CH311596A (en)

Similar Documents

Publication Publication Date Title
CH311596A (en) Process for making a new salt.
CH311587A (en) Process for making a new salt.
CH311594A (en) Process for making a new salt.
CH311593A (en) Process for making a new salt.
CH311591A (en) Process for making a new salt.
CH306793A (en) Process for making a new salt.
CH311589A (en) Process for making a new salt.
CH311592A (en) Process for making a new salt.
CH311590A (en) Process for making a new salt.
CH311588A (en) Process for making a new salt.
CH311586A (en) Process for making a new salt.
CH256767A (en) Process for the production of a new half-ester.
CH311595A (en) Process for making a new salt.
CH156307A (en) Process for the preparation of a sulfuric acid ester.
DE890047C (en) Process for the preparation of the racemic and optically active threo-2-dichloromethyl-4-chloromethyl-5- (4&#39;-nitrophenyl) -oxazoline- (2)
CH207672A (en) Process for preparing an aminobenzenesulfonic acid amide compound.
CH240726A (en) Process for the preparation of a p-amino-benzenesulfonamide.
CH300831A (en) Process for the preparation of an N-acyl derivative of iminodibenzyl.
CH191411A (en) Process for the preparation of a Py-3-oxytetrahydro-10-oxynaphthoquinoline.
CH206629A (en) Process for preparing an aminobenzenesulfonic acid amide compound.
CH308212A (en) Process for the preparation of a new pyrimidine derivative.
CH204382A (en) Process for preparing an aminobenzenesulfonic acid amide compound.
CH179442A (en) Process for the production of a new textile auxiliary.
CH180581A (en) Process for the preparation of a new sulfonic acid.
CH210977A (en) Process for the production of a new condensation product.